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Studies have indicated that 7-Keto is stable (does not convert to testosterone or estrogens), safe and effective as part of a weight loss program (Lardy et al., 1995, Davidson et al., 2000; Humanetics Corps, 2005, respectively). In fact, 7-Keto has shown in studies to activate 3 thermogenic enzymes, known to help the body convert stored fat to energy (Zenk et al., 2007, 2004). But since levels of DHEA and 7-Keto decline in our body with age, supplementation with 7-Keto helps maintain healthy levels for weight management (Lardy et al., 1998; 1995).*\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003e7-Keto DHEA turns on fat burning mechanism and supports sustained energy. Take 1-2 capsules a half hour before meals.*\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\" style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\"\u003e7-Keto DHEA has no fillers, binders, or other additives, it is purely 7-Keto. \u003c\/p\u003e\n\u003ch5 data-mce-fragment=\"1\" style=\"font-weight: 400;\" data-mce-style=\"font-weight: 400;\"\u003e\u003cstrong\u003eDescription\u003c\/strong\u003e\u003c\/h5\u003e\n\u003cp style=\"font-weight: 400;\"\u003eIn the pre-clinical development (see Bobyleva et al., 1993), 7-Keto was found to behave similarly to the thyroid hormone which also activates the thermogenic enzymes in our body. 7-Keto DHEA showed similar ability to restore mitochondrial function (Bobyleva et al., 1997) and support weight loss by enhancing thermogenic enzyme activity.*\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eClinical trials have been ongoing since 1999, in specific, two randomized, double-blinded, placebo-controlled (“RDBPC”) in 1999 and 2000 have shown that 7-keto significantly increased weight loss over a period of eight weeks compared to the placebo group (Zenk et al., 2002; see also Kaiman et al., 2000; Bobyleva et al., 1997).*\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eThermogenesis is the creation of heat in the body; a form of energy that is produced when we eat and metabolize food. Kaiman et al. (2000; see also Zenk et al., 2002) conducted a RDBPC study of 30 healthy overweight adults for 8 weeks. The group taking the supplement of 7-Keto showed a significantly reduced body weight. The study included exercise (three times a week) and a reduced caloric diet for both placebo and 7-Keto groups. Zenk et al. (2004; 2007) similarly found that 7-Keto increased metabolism, which is shown in research to promote weight lose and support the management of weight overall. By up-regulating the activity of fat burning enzymes (the thermogenic effect), energy expenditure is increased, enhancing the process of weight loss (Gomez et al., 2002).*\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eMoreover, 7-Keto DHEA is also shown in research to enhance memory in young and old rats (Shi et al., 2000), immune modulation in older men (Hampl et al., 2000), and significantly enhance depressive symptoms and hypo-immunity of mice when induced by chronic mild stress (Liu et al., 2003).*\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eBioImmersion's 7-Keto is encapsulated without any other additives (binders, fillers of any kind). It is in its pure form, active, powerful, and at the same time, gentle. \u003c\/p\u003e\n\u003ch5 style=\"font-weight: 400;\"\u003e\n\u003cstrong\u003eresearch \u003c\/strong\u003e\u003cbr\u003e\n\u003c\/h5\u003e\n\u003cp style=\"font-weight: 400;\"\u003eBobyleva, V., Bellei, M., Kneer, N., \u0026amp; Lardy, H. (1997). The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. \u003cem\u003eArchives of biochemistry and biophysics\u003c\/em\u003e, \u003cem\u003e341\u003c\/em\u003e(1), 122-128. \u003ca href=\"https:\/\/doi.org\/10.1006\/abbi.1997.9955\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eDavidson, M., Marwah, A., Sawchuk, R. J., \u0026amp; Maki, K. (2000). Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. \u003cem\u003eClinical and investigative medicine\u003c\/em\u003e, \u003cem\u003e23\u003c\/em\u003e(5), 300. \u003ca href=\"http:\/\/cat.inist.fr\/?aModele=afficheN\u0026amp;cpsidt=1536086\"\u003eAbstract [French]\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eHampl, R., Lapcik, O., Hill, M., Klak, J., Kasal, A., Novacek, A., ... \u0026amp; Starka, L. (2000). 7-Hydroxydehydroepiandrosterone-a natural antiglucocorticoid and a candidate for steroid replacement therapy? \u003cem\u003ePhysiological Research\u003c\/em\u003e, \u003cem\u003e49\u003c\/em\u003e, S107-S112. \u003ca href=\"http:\/\/www.biomed.cas.cz\/physiolres\/pdf\/49%20Suppl%201\/49_S107.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eHumanetics Corporation (2005). 7 Keto Innovative Weight Loss. Retrieved from \u003ca href=\"http:\/\/www.humaneticscorp.com\/\"\u003ewww.humaneticscorp.com\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eKaiman, D. S., Colker, C. M., Swain, M. A., Torina, G. C., \u0026amp; Shi, Q. (2000). A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. \u003cem\u003eCurrent therapeutic research\u003c\/em\u003e, \u003cem\u003e61\u003c\/em\u003e(7), 435-442. \u003ca href=\"https:\/\/doi.org\/10.1016\/S0011-393X(00)80026-0\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eLardy, H., Kneer, N., Wei, Y., Partridge, B., \u0026amp; Marwah, P. (1998). Ergosteroids II: biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. \u003cem\u003eSteroids\u003c\/em\u003e, \u003cem\u003e63\u003c\/em\u003e(3), 158-165. \u003ca href=\"https:\/\/doi.org\/10.1016\/S0039-128X(97)00159-1\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eLardy, H., Partridge, B., Kneer, N., \u0026amp; Wei, Y. (1995). Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. \u003cem\u003eProceedings of the National Academy of Sciences\u003c\/em\u003e, \u003cem\u003e92\u003c\/em\u003e(14), 6617-6619. \u003ca href=\"http:\/\/www.pnas.org\/content\/92\/14\/6617.short\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eLamont, B. J., Waters, M. F., \u0026amp; Andrikopoulos, S. (2016). A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice. \u003cem\u003eNutrition \u0026amp; diabetes\u003c\/em\u003e, \u003cem\u003e6\u003c\/em\u003e(2), e194. DOI: \u003ca href=\"http:\/\/www.nature.com\/nutd\/journal\/v6\/n2\/full\/nutd20162a.html?foxtrotcallback=true\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eLiu, Y. Y., Yang, N., Kong, L. N., \u0026amp; Zuo, P. P. (2003). Effects of 7-oxo-DHEA treatment on the immunoreactivity of BALB\/c mice subjected to chronic mild stress. \u003cem\u003eYao xue xue bao= Acta pharmaceutica Sinica\u003c\/em\u003e,\u003cem\u003e38\u003c\/em\u003e(12), 881-884. \u003ca href=\"http:\/\/europepmc.org\/abstract\/med\/15040075\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eShi, J., Schulze, S., \u0026amp; Lardy, H. A. (2000). The effect of 7-oxo-DHEA acetate on memory in young and old C57BL\/6 mice. \u003cem\u003eSteroids\u003c\/em\u003e, \u003cem\u003e65\u003c\/em\u003e(3), 124-129. \u003ca href=\"https:\/\/doi.org\/10.1016\/S0039-128X(99)00094-X\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eŠulcová, J., Hill, M., Mašek, Z., Češka, R., Nováček, A., Hampl, R., \u0026amp; Starka, L. (2001). Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men. \u003cem\u003ePhysiol Res\u003c\/em\u003e, \u003cem\u003e50\u003c\/em\u003e, 9-18. \u003ca href=\"http:\/\/www.biomed.cas.cz\/physiolres\/2001\/issue1\/pdf\/sulcova.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eZenk, J. L., Helmer, T. R., Kassen, L. J., \u0026amp; Kuskowski, M. A. (2002). The effect of 7-Keto Naturalean™ on weight loss: A randomized, double-blind, placebo-controlled trial. \u003cem\u003eCurrent therapeutic research\u003c\/em\u003e, \u003cem\u003e63\u003c\/em\u003e(4), 263-272. \u003ca href=\"https:\/\/doi.org\/10.1016\/S0011-393X(02)80031-5\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eZenk, J. L., Helmer, T. R., \u0026amp; Kuskowski, M. A. (2004, March). The use of 3-acetyl-7-oxo-dehydroepiandrosterone for augmenting immune response in the elderly. In \u003cem\u003eFASEB JOURNAL\u003c\/em\u003e (Vol. 18, No. 5, pp. A794-A794). 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA: FEDERATION AMER SOC EXP BIOL.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eZenk, J. L., Frestedt, J. L., \u0026amp; Kuskowski, M. A. (2007). HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. \u003cem\u003eThe Journal of nutritional biochemistry\u003c\/em\u003e , \u003cem\u003e18\u003c\/em\u003e(9), 629-634. \u003ca href=\"https:\/\/doi.org\/10.1016\/j.jnutbio.2006.11.008\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003ch5\u003eIngredients \u003cbr\u003e\n\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eOne Capsule Contains:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e7-Keto DHEA 25mg\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5 style=\"font-weight: 400;\"\u003e\u003cstrong\u003eprotocol\u003c\/strong\u003e\u003c\/h5\u003e\n\u003cp\u003eFor weight Loss Support: Start with 1-2 capsules three times a day, preferably, 10-20 minutes before the meal. 7-Keto is known to activate fat burning mechanism in the body.\u003c\/p\u003e\n\u003cp\u003eAdd \u003cstrong\u003eWeight Less\u003c\/strong\u003e to lower glycemic levels of meals, 1-2 capsules, preferably 10-20 minutes before the meal or snack. \u003c\/p\u003e\n\u003cp\u003eFor Energy and Exercise: Take 1 capsule of \u003cstrong\u003e7-Keto\u003c\/strong\u003e and 1 capsule of\u003cstrong\u003e Energy. \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003e \u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"7 Keto \/ Green","offer_id":44051449184300,"sku":"TF028","price":49.98,"currency_code":"USD","in_stock":true},{"title":"7 Keto \/ Tan","offer_id":44051449217068,"sku":"TF029","price":49.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/7-KETO-DHEA---Front.jpg?v=1723214710"},{"product_id":"recharge","title":"Recharge Protocol","description":"\u003cp\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe Famous Morning Drink\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e: Beta Glucan (100.98), Staff of Life (94.98), No 7 Systemic Booster (99.98).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eThe Recharge protocol is a combination of three powerful products, all powders, and hence easily mixed together into a wonderful drink. \u003c\/p\u003e\n\u003cp\u003eThis famous morning drink (or afternoon booster) has a cult following. It can actually revolutionize your morning constitution, enhance your gut microbiome, and boost your heart health, immunity, and the feeling of well-being. \u003c\/p\u003e\n\u003cp\u003eIt is truly that good. And you will learn more about the Beta Glucan, part of this protocol next week, with Dr. Artemis Morris. \u003c\/p\u003e\n\u003cp\u003eHow to make this famous drink?? \u003c\/p\u003e\n\u003cp\u003eIn a blender:\u003c\/p\u003e\n\u003cp\u003eThe base of the drink: 1 tablespoon of Beta Glucan, 1 tablespoon of Be Regular, and 1 teaspoon of No 7 Systemic Booster.\u003c\/p\u003e\n\u003cp\u003eFruits: 1 Banana, 1 cup of frozen or fresh berries, and any fruit you would like (fresh or frozen, e.g., pineapple, melons, mango, peaches, nectarines).\u003c\/p\u003e\n\u003cp\u003eLiquids: 1. Choose any juice (diluted or not) or combine different juices: apple, pineapple, prune, watermelon juice, sweet green juices with apple, carrots, and beets, or any berry juice: 1\/3 cup of juice \u0026amp; 2\/3 cup water (if you need more liquids add a little of both). 2. Coconut water: dilute half\/half with water. 3. Nut milks, oat milk, soy, or hemp (half\/half or use the whole plant-milk). 4. Just water.\u003c\/p\u003e\n\u003cp\u003eOptional and so healthy: 1 tablespoon of Flax Seeds, 1 heaping teaspoon of Bee Pollen - if you are not allergic to bees or honey. Keep in the freezer for freshness. Bee pollen contains a host of nutrients such as antioxidant, protein, vitamins, minerals, enzymes and coenzymes, etc.\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eOptional- one or two of the following:\u003cspan\u003e  \u003c\/span\u003eNut butter: 1 heaping teaspoon of nut butter - almond or cashew butters, peanut butter occasionally and if you are not allergic.\u003cspan\u003e  \u003c\/span\u003eDates: 1 date or 1 tsp date powder (extra minerals, sweetness, and iron); 1-2 tsp cacao powder (organic, potent, keep in freezer), 1-2 tsp yogurt (goat, sheep, cow, or plant-based, according to your dietary program).\u003c\/p\u003e\n\u003cp\u003eExtra protein: Plant-based protein powder, 1-2 tbs (peas, seeds, hemp, lentils, soy, etc.). Or 1 tbs of Whey (according to your dietary program). Or 1 tbs Collagen Peptide with amino acids. * Be aware: rice has high levels of arsenic. \u003cspan\u003e \u003c\/span\u003eWe typically get plenty of proteins but not enough fiber. We need 35-50 grams of fiber daily!\u003c\/p\u003e\n\u003cp\u003eBlend until smooth and drink. Enjoy!\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712313065516,"sku":"RECHARGE","price":266.35,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Recharge-Protocol.jpg?v=1723214727"},{"product_id":"immune-booster","title":"Immune Booster Protocol","description":"\u003cp style=\"font-weight: 400;\"\u003e\u003cem\u003eColds \u0026amp; Flu\u003c\/em\u003e: Garlic (46.98), No 7 Systemic Booster (99.98), Energy (63.98), Glucosinolates \u0026amp; Sulforaphanes (61.98).  \u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eGarlic has been shown in research to do so much and mostly, to really go after microbes that are not harmonious with your body, in other words, they don’t play nice, and make you feel terrible. Energy is intelligent, powerful, and so effective, a formula that goes the distance to give you actual energy, to manage detox, to boost your immunity, and keep your body humming. Glucosinolates \u0026amp; Sulforaphanes is a beautiful formula of the most potent broccoli sprouts that manage to calm your liver, detox very gently (Phase II detox), supports a health DNA and protects you against chronic and infectious dis-eases.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eLet’s roll our sleeves and get into it in more details, and of course, you can further read and empower yourself with knowledge on each product page, and in \u003ca href=\"https:\/\/www.youtube.com\/@bioimmersioninc\"\u003eShare the Power\u003c\/a\u003e – interviewing doctors and patients, sharing our knowledge and expertise.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eGarlic blocks viral entry into the host cells! It has the ability to modulate the immune system, preventing the spread of many kinds of viral infections (Rouf et al., 2020). \u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eOur organic\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.bioimmersion.com\/collections\/all\/products\/garlic-organic\" data-mce-fragment=\"1\" data-mce-href=\"https:\/\/www.bioimmersion.com\/collections\/all\/products\/garlic-organic\"\u003eGarlic\u003c\/a\u003e is an exceptionally potent supplement, and it boasts four to five cloves of organic garlic in every capsule.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eKnown as the\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eRussian Penicillin\u003c\/em\u003e, garlic has been used for centuries therapeutically as an antimicrobial and over the last thirty years this has been our focus as well.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eSourcing garlic cloves with exceptional antimicrobial potential, along with utilizing the most advanced air\/belt drying and manufacturing technologies enable us to provide the most therapeutically potent garlic in the market.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003e\u003cstrong\u003e\u003ca href=\"https:\/\/www.bioimmersion.com\/collections\/all\/products\/energy-ultra-minerals-with-apple-extract\"\u003eEnergy\u003c\/a\u003e\u003c\/strong\u003e is an intelligent healthy booster. With a unique combination of 72 plant-based Ultra Minerals and Apple Extracts, \u003cstrong\u003eEnergy\u003c\/strong\u003e increases our production of ATP, an important molecule that energizes and fuels every metabolic process in our body.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003e\u003cem\u003eUltra-Minerals\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003ein Energy is a unique blend of 72 cold-water extracted plant-based minerals. Derived from deeply buried flora and plants dated back to the ancient Mesozoic Era, the ultra-minerals deliver \u003cem\u003ea full spectrum\u003c\/em\u003e of important elements and trace minerals, most of which are absent from foods and supplements currently on the market.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eMinerals and ultra (or trace) minerals are essential nutrients for human health (Davidson, 2017), playing a central role in regulating cardiovascular function (Mohammadifard et al., 2017), metabolic functions, internal antioxidant defense mechanism, bone formation, immune function, and much more (Pappas et al., 2018). The soil lacks many nutrients, in particular minerals and trace minerals, all due to ongoing poor farming methods, overuse of herbicides and pesticides, mono crops, inadequate fertilizers, and other shortsighted agricultural practices.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eApple and apple extracts are associated with numerous health benefits (Hyson, 2011), including longevity, cognition, and energy (Hodgson et al., 2016; Flanagan et al., 2016, respectively). As an energy booster, apple is found to be as energizing as coffee! In fact, apples offer equivalent energy as caffeinated drinks. More so, due to the different polyphenols in apples, athletes and sports players enjoy improved endurance during intense exercise while keeping their muscles flexible and pain free (Deley et al., 2017; Flanagan et al., 2016).\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eWe have learned that the polyphenols in berries boost the immune system against Covid 19 in the new book (2021): \u003cstrong\u003e\u003cem\u003eImmunity Boosting Functional Foods to Combat COVID-19\u003c\/em\u003e\u003c\/strong\u003e.\u003cem\u003e \u003c\/em\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eAs research advances, we learn how different food medicines affect the immune system, and \u003cstrong\u003e\u003cem\u003ebroccoli\u003c\/em\u003e\u003c\/strong\u003e\u003cem\u003e has found to offer an amazing immune booster against Covid-19 (Saha \u0026amp; Agrawal, 2021)\u003c\/em\u003e. What is in broccoli (and even more in broccoli sprouts) that is so powerful? \u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eIn Saha and Agrawal (2021) own words: Broccoli, a member of the cruciferous family, is a nutrient-packed powerhouse that can boost our immune system. It is a tremendous source of phytochemical including glucosinolates, sulforaphane, glucoraphanin, S-methyl cysteine sulfoxide, isothiocyanates etc. Moreover, it contains vitamin like C, E and K and minerals like iron, zinc and selenium. It confers desirable health benefits by providing antioxidants, regulating enzyme, apoptosis and cell cycle and reducing the risk of diseases including Type-2 diabetes.\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eThis is the power of \u003ca href=\"https:\/\/www.bioimmersion.com\/collections\/all\/products\/glucosinolates-sulforaphanes-organic-broccoli-sprouts\"\u003eGlucosinolates \u0026amp; Sulforaphanes\u003c\/a\u003e. Amazing isn’t it?\u003cspan\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eAnd there you have it – a power filled protocol to protect and go after viruses and bacteria, to strengthen the immune system, lower inflammation (you know the achy feeling you have when you get a cold or flu, that is inflammation!), and give you a sustained energy to boost your ability to fight infections and to come back to equilibrium.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eEnjoy!\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003e \u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eReferences\u003c\/p\u003e\n\u003cul style=\"font-weight: 400;\"\u003e\n\u003cli\u003eDavison, K. M. (2017). Mineral Nutrients: From Macro-Level to Ultra Trace. In \u003cem\u003eNutrition Guide for Physicians and Related Healthcare Professionals\u003c\/em\u003e (pp. 261-272). Humana Press, Cham. \u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-319-49929-1_26\"\u003eAbstract\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eDeley, G., Guillemet, D., Allaert, F. A., \u0026amp; Babault, N. (2017). An acute dose of specific grape and apple polyphenols improves endurance performance: a randomized, crossover, double-blind versus placebo controlled study. \u003cem\u003eNutrients\u003c\/em\u003e, \u003cem\u003e9\u003c\/em\u003e(8), 917. \u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/9\/8\/917\/htm\"\u003eArticle\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eFlanagan, E. K., Jimenez, L. Q., Flanagan, C. P., Arwari, B., \u0026amp; Smith, W. N. (2016). Apple versus Caffeinated Beverages as Ergogenic Aids During Physical and Cognitive Performance: A Pilot Study. \u003cem\u003eMedicine \u0026amp; Science in Sports \u0026amp; Exercise\u003c\/em\u003e, \u003cem\u003e48\u003c\/em\u003e(5S), 63. \u003ca href=\"https:\/\/journals.lww.com\/acsm-msse\/fulltext\/2016\/05001\/Apple_versus_Caffeinated_Beverages_as_Ergogenic.192.aspx\"\u003eAbstract\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eHodgson, J. M., Prince, R. L., Woodman, R. J., Bondonno, C. P., Ivey, K. L., Bondonno, N., ... \u0026amp; Lewis, J. R. (2016). Apple intake is inversely associated with all-cause and disease-specific mortality in elderly women. \u003cem\u003eBritish Journal of Nutrition\u003c\/em\u003e, \u003cem\u003e115\u003c\/em\u003e(5), 860-867.\u003c\/li\u003e\n\u003cli\u003eHyson, D. A. (2011). A comprehensive review of apples and apple components and their relationship to human health. \u003cem\u003eAdvances in nutrition\u003c\/em\u003e, \u003cem\u003e2\u003c\/em\u003e(5), 408-420. \u003ca href=\"https:\/\/academic.oup.com\/advances\/article\/2\/5\/408\/4557935\"\u003eArticle\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eMohammadifard, N., Humphries, K. H., Gotay, C., Mena-Sánchez, G., Salas-Salvadó, J., Esmaillzadeh, A., ... \u0026amp; Sarrafzadegan, N. (2017). Trace minerals intake: risks and benefits for cardiovascular health. \u003cem\u003eCritical reviews in food science and nutrition\u003c\/em\u003e, 1-13. \u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/10408398.2017.1406332\"\u003eAbstract\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003ePappas, A. C., Godlewska, K., \u0026amp; Surai, P. F. (2018). Dietary Food and Feed Supplements with Trace Elements. \u003cem\u003eRecent Advances in Trace Elements\u003c\/em\u003e, 421441. \u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=AWxODwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PA421\u0026amp;dq=trace-minerals+and+human+health\u0026amp;ots=SSfRNUDo8R\u0026amp;sig=5dmZgNMWPcyNYtgNlsxb0EzOU0Y#v=onepage\u0026amp;q=trace-minerals%20and%20human%20health\u0026amp;f=false\"\u003eChapter20\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eRouf, R., Uddin, S. J., Sarker, D. K., Islam, M. T., Ali, E. S., Shilpi, J. A., ... \u0026amp; Sarker, S. D. (2020). Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data.\u003cem\u003eTrends in food science \u0026amp; technology\u003c\/em\u003e, \u003cem\u003e104\u003c\/em\u003e, 219-234. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7434784\/\"\u003eArticle\/\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul style=\"font-weight: 400;\"\u003e\n\u003cli\u003eSaha, J., \u0026amp; Agrawal, S. (2021). Broccoli-As Immunity Booster Against COVID-19. In \u003cem\u003eImmunity Boosting Functional Foods to Combat COVID-19\u003c\/em\u003e (pp. 133-141). CRC Press. \u003ca href=\"https:\/\/www.taylorfrancis.com\/chapters\/edit\/10.1201\/9781003242604-11\/broccoli-immunity-booster-covid-19-juthi-saha-shruti-agrawal?context=ubx\"\u003eAbstract\u003c\/a\u003e\n\u003c\/li\u003e\n\u003cli\u003eSilva, C. S., Moutinho, C., Ferreira da Vinha, A., \u0026amp; Matos, C. (2019). Trace minerals in human health: Iron, zinc, copper, manganese and fluorine. \u003cem\u003eInternational Journal of Science and Research Methodology\u003c\/em\u003e, \u003cem\u003e13\u003c\/em\u003e(3), 57-80. \u003ca href=\"https:\/\/bdigital.ufp.pt\/bitstream\/10284\/8105\/1\/5.Customer-IJSRM_HUMAN-13_8-19-27-08-2019%20%282%29.pdf\"\u003eArticle\u003c\/a\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp style=\"font-weight: 400;\"\u003e \u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712313262124,"sku":"IMMUNE","price":245.63,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Immune-Booster-Protocol.jpg?v=1723214731"},{"product_id":"beautiful-skin","title":"Beautiful Skin Protocol","description":"\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFructo Borate (63.98), Phyto Power (89.98), No 7 Systemic Booster (99.98)\u003c\/span\u003e\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712313458732,"sku":"BEAUTIFUL","price":228.55,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Beautiful-Skin-Protocol.jpg?v=1723214736"},{"product_id":"weight-less-no-4-systemic-booster","title":"Weight-Less","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eA Smart Formula for Less Weight and More Energy\u003c\/p\u003e\n\u003cp\u003eWeight Less is a smart formula that healthily promotes weight loss and sustained energy levels throughout the day.*\u003c\/p\u003e\n\u003cp\u003eA powerful mix of wild crafted brown seaweed extracts of\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAscophyllum nodosum\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(kelp) and\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFucus vesiculosus\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(bladderwrack) are shown in research to manage weight reduction and support metabolic health. Moreover, wild brown seaweeds are found to contain potent marine anti-inflammatory and antioxidant factors. Together with 7-Keto DHEA, the mix turns on fat burning mechanism, lowers the glycemic level of meals, and supports sustained energy. Take 1-2 capsules a half hour before meals.*\u003c\/p\u003e\n\u003cp\u003eWeight-Less is Wild Crafted (seaweeds), Organic (seaweeds), Vegan, Kosher, Non GMO, and Gluten Free.\u003c\/p\u003e\n\u003ch6\u003eDescription \u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eWeight-Less is a smart formula for less weight and more energy. Comprised of wild-crafted brown seaweed,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAscophyllum nodosum\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(kelp) and\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFucus vesiculosus\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e(bladderwrack), along with 7-Keto DHEA, Weight-Less\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eis unique and effective.*\u003c\/p\u003e\n\u003cp\u003eMarine algae, in particular, wild brown seaweed such as kelp and bladderwrack are shown to lower the glycemic load of complex and simple carbohydrates for better insulin management, as well as offer a power-filled phenolic activity for antioxidant and anti-inflammation effect (Roy et al., 2011). 7-Keto has been used for many years to turn on fat burning mechanism and offer an effective and safe way to lose weight (Bobyleva et al., 1997). Together, Weight-Less promotes a sustained energy level throughout the day as it\u003cspan\u003e \u003c\/span\u003e\u003cem\u003emodulates carbohydrate digestion and absorption for better weight management and metabolic health (\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eGabbia et al., 2017; Catarino et al., 2017).*\u003c\/p\u003e\n\u003cp\u003eWeight management is essential to our health, yet difficult to achieve. Research has correlated excess body fat with metabolic syndrome, which includes high blood sugar, high blood pressure, high cholesterol and triglycerides. These metabolic syndrome factors are found to increase the risk for cardiovascular issues, obesity, diabetes, and cancer (American Heart Association, 2017; National Cancer Institute, 2017). In fact, metabolic syndrome is now a growing public health concern worldwide (Wright et al., 2017; Calton et al., 2014).*\u003c\/p\u003e\n\u003cp\u003eInflammation is also shown in research to link obesity and cardio–metabolic risks for obese and non-obese individuals (Phillips \u0026amp; Perry, 2013). Hence, a diet of whole plants rich in phenols is shown in research to offer anti-inflammatory benefits (Wright et al., 2017; McAnulty et al., 2014). Weight-Less is comprised of wildcrafted brown seaweeds shown in research to offer potent phenols with high total antioxidant potency, antidiabetic properties, and anti-inflammatory potential (Gabbia et al., 2017; Catarino et al., 2017; Pantidos et al., 2014; Bahar et al., 2012).*\u003c\/p\u003e\n\u003cp\u003eStudies have linked low glycemic index to improved cardiovascular health, blood sugar control, weight control, and even skin health (McMillan-Price et al., 2006, Barclay et al., 2008, Hare-Bruun et al., 2006; Smith et al., 2007, respectively). For this reason, 250 mg of brown seaweed extracts of kelp and bladderwrack is used half an hour before meals to aid carbohydrate digestion and assimilation; shifting high glycemic index food to one typical of a low glycemic index food (Paradis et al., 2011; Roy et al., 2011; Bérubé et al., 2014). Studies find supplementing with brown seaweed before meals to help slow down the digestion of whole or simple carbs to significantly reduce blood glucose for overall glycemic control (Gabbia et al., 2017; Bérubé et al., 2014; Kim et al., 2014; Lamarche et al., 2010). Glycemic control supports a consistent metabolic health and weight management.*\u003c\/p\u003e\n\u003cp\u003e7-Keto DHEA, or 7-Keto DHEA is named after the compound 3-acetyl-7-oxo dehydroepiandrosterone, a substance found naturally in the body that is metabolized from the hormone DHEA (Marwah et al., 2002). Studies have indicated that 7-Keto is stable (does not convert to testosterone or estrogens), safe and effective as part of a weight loss program (Lardy et al., 1995, Davidson et al., 2000; Humanetics Corps, 2005, respectively). In fact, 7-Keto has shown in studies to activate 3 thermogenic enzymes, known to help the body convert stored fat to energy (Zenk et al., 2007, 2004). But since levels of DHEA and 7-Keto decline in our body with age, supplementation with 7-Keto helps maintain healthy levels for weight management (Lardy et al., 1998; 1995).*\u003c\/p\u003e\n\u003cp\u003eIn the pre-clinical development (see Bobyleva et al., 1993), 7-Keto was found to behave similarly to the thyroid hormone which also activates the thermogenic enzymes in our body. 7-Keto DHEA showed similar ability to restore mitochondrial function (Bobyleva et al., 1997) and support weight loss by enhancing thermogenic enzyme activity.*\u003c\/p\u003e\n\u003cp\u003eClinical trials have been ongoing since 1999, in specific, two randomized, double-blinded, placebo-controlled (“RDBPC”) in 1999 and 2000 have shown that 7-keto significantly increased weight loss over a period of eight weeks compared to the placebo group (Zenk et al., 2002; see also Kaiman et al., 2000; Bobyleva et al., 1997).*\u003c\/p\u003e\n\u003cp\u003eThermogenesis is the creation of heat in the body; a form of energy that is produced when we eat and metabolize food. Kaiman et al. (2000; see also Zenk et al., 2002) conducted a RDBPC study of 30 healthy overweight adults for 8 weeks. The group taking the supplement of 7-Keto showed a significantly reduced body weight. The study included exercise (three times a week) and a reduced caloric diet for both placebo and 7-Keto groups. Zenk et al. (2004; 2007) similarly found that 7-Keto increased metabolism, which is shown in research to promote weight lose and support the management of weight overall. By up-regulating the activity of fat burning enzymes (the thermogenic effect), energy expenditure is increased, enhancing the process of weight loss (Gomez et al., 2002).*\u003c\/p\u003e\n\u003cp\u003eMoreover, 7-Keto DHEA is also shown in research to enhance memory in young and old rats (Shi et al., 2000), immune modulation in older men (Hampl et al., 2000), and significantly enhance depressive symptoms and hypo-immunity of mice when induced by chronic mild stress (Liu et al., 2003).*\u003c\/p\u003e\n\u003cp\u003eWhat is an ideal diet for weight loss and good health? Research studies link the emerging global pattern of metabolic syndrome and weight gain to the prevalence of Westernized diet: the daily consumption of meats, dairy, eggs, simple and processed carbohydrates, and too much sugar (Chai et al., 2017; Azadbakht \u0026amp; Esmaillzadeh, 2009; Lutsey et al., 2008). Although there are conflicting views on dietary guidelines, many scientists and health organizations have come to the conclusion that a focus on whole food, plant-based diet is the healthiest guideline for metabolic syndrome and weight loss (Yokoyama et al., 2017; Satija et al., 2017; Kahleova et al., 2017; Hever et al., 2017; Turner et al., 2017; UN Report, 2016; Wang et al., 2015; Tilman \u0026amp; Clark, 2014; WHO\/FAO, 2003).*\u003c\/p\u003e\n\u003cp\u003eIn fact, low carbohydrate diets with high fat content is shown to increase metabolic syndrome (Lamont et al., 2017; UN Report, 2016). Hence, the type and nature of carbohydrates we chose for our diet is important. To improve our metabolic health (and guard against obesity, cardiovascular, and diabetes), our carbohydrates should be comprised of whole plants with fiber (Wright et al., 2017).*\u003c\/p\u003e\n\u003cp\u003eThe\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.fao.org\/documents\/card\/en\/c\/d8dfeaf1-f859-4191-954f-e8e1388cd0b7\/\"\u003ePlates, Pyramids, Planet\u003cspan\u003e \u003c\/span\u003e\u003c\/a\u003ereport, compiled in collaboration with the Food Climate Research Network (FCRN) at the University of Oxford, concludes that a plant-based diet has many advantages for our health, the environment, and our planet (UN Report, 2016). Many organizations teach and support the transition into a whole food, plant-based diet.*\u003c\/p\u003e\n\u003cp\u003eWeight-Less offers a unique combination of wild brown seaweed extracts of kelp and bladderwrack with 7-Keto DHEA. The formula is potent with antioxidants, smartly supports weight loss and management, enhances the body’s ability to burn fat more efficiently, creates energy, and promotes metabolic health. Together with a focus on whole food plant-based diet and a reasonable exercise program, managing weight becomes effective, healthy, and even joyful. *\u003c\/p\u003e\n\u003ch5\u003eREFERENCES\u003c\/h5\u003e\n\u003cp\u003eAmerican Heart Association. (2017). About metabolic syndrome.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.heart.org\/HEARTORG\/Conditions\/More\/MetabolicSyndrome\/About-Metabolic-Syndrome_UCM_301920_Article.jsp\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAmine, E., Baba, N., Belhadj, M., Deurenbery-Yap, M., Djazayery, A., Forrester, T., ... \u0026amp; Katan, M. (2002).\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eDiet, nutrition and the prevention of chronic diseases: report of a Joint WHO\/FAO Expert Consultation\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e. World Health Organization.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.google.com\/url?sa=t\u0026amp;rct=j\u0026amp;q=\u0026amp;esrc=s\u0026amp;source=web\u0026amp;cd=4\u0026amp;ved=0ahUKEwjXmOn1rNXWAhVJ3GMKHeWZApMQFgg5MAM\u0026amp;url=http%3A%2F%2Fwhqlibdoc.who.int%2Ftrs%2FWHO_TRS_916.pdf\u0026amp;usg=AOvVaw0aKiuOPb8HB3SRsz_NJ3v1\"\u003eDiet, nutrition and the prevention of chronic diseases - World Health ...\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAzadbakht, L., \u0026amp; Esmaillzadeh, A. (2009). Red meat intake is associated with metabolic syndrome and the plasma C-reactive protein concentration in women.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe Journal of nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e139\u003c\/em\u003e(2), 335-339. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/jn.108.096297\"\u003e10.3945\/jn.108.096297\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBarclay, A. W., Petocz, P., McMillan-Price, J., Flood, V. M., Prvan, T., Mitchell, P., \u0026amp; Brand-Miller, J. C. (2008). Glycemic index, glycemic load, and chronic disease risk—a meta-analysis of observational studies.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe American journal of clinical nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e87\u003c\/em\u003e(3), 627-637.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18326601\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBahar, B., O’Doherty, J. V., Hayes, M., \u0026amp; Sweeney, T. (2012). Extracts of brown seaweeds can attenuate the bacterial lipopolysaccharide-induced pro-inflammatory response in the porcine colon ex vivo.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of animal science\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e90\u003c\/em\u003e(Supplement_4), 46-48.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dl.sciencesocieties.org\/publications\/jas\/abstracts\/90\/Supplement_4\/46\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBobyleva, V., Bellei, M., Kneer, N., \u0026amp; Lardy, H. (1997). The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eArchives of biochemistry and biophysics\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e341\u003c\/em\u003e(1), 122-128.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1006\/abbi.1997.9955\"\u003ehttps:\/\/doi.org\/10.1006\/abbi.1997.9955\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCalton, Emily K., Anthony P. James, Poonam K. Pannu, and Mario J. Soares. \"Certain dietary patterns are beneficial for the metabolic syndrome: reviewing the evidence.\"\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrition Research\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e34, no. 7 (2014): 559-568. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.nutres.2014.06.012\"\u003e10.1016\/j.nutres.2014.06.012\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCatarino, M. D., Silva, A., \u0026amp; Cardoso, S. M. (2017). Fucaceae: A source of bioactive phlorotannins. \u003cem\u003eInternational journal of molecular sciences\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e18\u003c\/em\u003e(6), 1327.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.mdpi.com\/1422-0067\/18\/6\/1327\/htm\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChai, W., Morimoto, Y., Cooney, R. V., Franke, A. A., Shvetsov, Y. B., Le Marchand, L., ... \u0026amp; Maskarinec, G. (2017). Dietary Red and Processed Meat Intake and Markers of Adiposity and Inflammation: The Multiethnic Cohort Study.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of the American College of Nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e36\u003c\/em\u003e(5), 378-385. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/07315724.2017.1318317\"\u003e10.1080\/07315724.2017.1318317\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDavidson, M., Marwah, A., Sawchuk, R. J., \u0026amp; Maki, K. (2000). Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. \u003cem\u003eClinical and investigative medicine\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e23\u003c\/em\u003e(5), 300.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11055323\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGabbia, D., Dall’Acqua, S., Di Gangi, I. M., Bogialli, S., Caputi, V., Albertoni, L., ... \u0026amp; De Martin, S. (2017). The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH. \u003cem\u003eMarine drugs\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e15\u003c\/em\u003e(2), 41. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/md15020041\"\u003e10.3390\/md15020041\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGonzalez Fischer, C., \u0026amp; Garnett, T. (2016). Plates, pyramids, planet. Oxford, UK: Oxford University.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/agris.fao.org\/agris-search\/search.do?recordID=XF2017002095\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGomez, F. E., Miyazaki, M., Kim, Y. C., Marwah, P., Lardy, H. A., Ntambi, J. M., \u0026amp; Fox, B. G. (2002). Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBiochemistry\u003c\/em\u003e,\u003cem\u003e41\u003c\/em\u003e(17), 5473-5482.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11969408\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHare-Bruun, H., Flint, A., \u0026amp; Heitmann, B. L. (2006). Glycemic index and glycemic load in relation to changes in body weight, body fat distribution, and body composition in adult Danes.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe American journal of clinical nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e84\u003c\/em\u003e(4), 871-879.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Glycemic+index+and+glycemic+load+in+relation+to+changes+in+body+weight%2C+body+fat+distribution%2C+and+body+composition+in+adult+Danes\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHampl, R., Lapcik, O., Hill, M., Klak, J., Kasal, A., Novacek, A., ... \u0026amp; Starka, L. (2000). 7-Hydroxydehydroepiandrosterone-a natural antiglucocorticoid and a candidate for steroid replacement therapy? \u003cem\u003ePhysiological Research\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e49\u003c\/em\u003e, S107-S112.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.biomed.cas.cz\/physiolres\/pdf\/49%20Suppl%201\/49_S107.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHever, J., \u0026amp; Cronise, R. J. (2017). Plant-based nutrition for healthcare professionals: implementing diet as a primary modality in the prevention and treatment of chronic disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of Geriatric Cardiology: JGC\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e14\u003c\/em\u003e(5), 355. 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Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePhytochemistry\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e98\u003c\/em\u003e, 27-33.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.phytochem.2013.12.003\"\u003ehttps:\/\/doi.org\/10.1016\/j.phytochem.2013.12.003\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLamarche, B., Paradis, M. È., \u0026amp; Couture, P. (2010). 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(1999). Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe. Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eLancet\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e354\u003c\/em\u003e(9179), 617-21.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11011220\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eD'Orazio, N., Gammone, M. A., Gemello, E., De Girolamo, M., Cusenza, S., \u0026amp; Riccioni, G. (2012). Marine bioactives: Pharmacological properties and potential applications against inflammatory diseases.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMarine drugs\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e10\u003c\/em\u003e(4), 812-833. 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Study of the acute impact of polyphenols from brown seaweeds on glucose control in healthy men and women.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe FASEB Journal\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e24\u003c\/em\u003e(1 Supplement), 209-4.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.fasebj.org\/content\/24\/1_Supplement\/209.4.short\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLutsey, P. L., Steffen, L. M., \u0026amp; Stevens, J. (2008). Dietary intake and the development of the metabolic syndrome. The Atherosclerosis risk in communities study.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCirculation\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e117\u003c\/em\u003e(6), 754-761. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.716159\"\u003e10.1161\/CIRCULATIONAHA.107.716159\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMurugan, A. C., Karim, M. R., Yusoff, M. B. M., Tan, S. H., Asras, M. F. B. F., \u0026amp; Rashid, S. S. (2015). New insights into seaweed polyphenols on glucose homeostasis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePharmaceutical biology\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e53\u003c\/em\u003e(8), 1087-1097. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3109\/13880209.2014.959615\"\u003e10.3109\/13880209.2014.959615\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePangestuti, R., \u0026amp; Kim, S. K. (2017). Bioactive peptide of marine origin for the prevention and treatment of non-communicable diseases.\u003cem\u003eMarine drugs\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e15\u003c\/em\u003e(3), 67. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.3390\/md15030067\"\u003e10.3390\/md15030067\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePantidos, N., Boath, A., Lund, V., Conner, S., \u0026amp; McDougall, G. J. (2014). Phenolic-rich extracts from the edible seaweed, ascophyllum nodosum, inhibit α-amylase and α-glucosidase: Potential anti-hyperglycemic effects.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of Functional Foods\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e10\u003c\/em\u003e, 201-209.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jff.2014.06.018\"\u003ehttps:\/\/doi.org\/10.1016\/j.jff.2014.06.018\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eParadis, M. E., Couture, P., \u0026amp; Lamarche, B. (2011). A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eApplied Physiology, Nutrition, and Metabolism\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e36\u003c\/em\u003e(6), 913-919. DOI:\u003ca href=\"https:\/\/doi.org\/10.1139\/h11-115\"\u003e10.1139\/h11-115\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePhillips, C. M., \u0026amp; Perry, I. J. (2013). Does inflammation determine metabolic health status in obese and nonobese adults?\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe Journal of Clinical Endocrinology \u0026amp; Metabolism\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e98\u003c\/em\u003e(10), E1610-E1619.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1210\/jc.2013-2038\"\u003ehttps:\/\/doi.org\/10.1210\/jc.2013-2038\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRoy, M. C., Anguenot, R., Fillion, C., Beaulieu, M., Bérubé, J., \u0026amp; Richard, D. (2011). Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFood research international\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e44\u003c\/em\u003e(9), 3026-3029.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.foodres.2011.07.023\"\u003ehttps:\/\/doi.org\/10.1016\/j.foodres.2011.07.023\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSharifuddin, Y., Chin, Y. X., Lim, P. E., \u0026amp; Phang, S. M. (2015). Potential bioactive compounds from seaweed for diabetes management. \u003cem\u003eMarine drugs\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e13\u003c\/em\u003e(8), 5447-5491. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/md13085447\"\u003e10.3390\/md13085447\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWan-Loy, C., \u0026amp; Siew-Moi, P. (2016). Marine algae as a potential source for anti-obesity agents.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMarine drugs\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e14\u003c\/em\u003e(12), 222. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.3390%2Fmd14120222\"\u003e10.3390\/md14120222\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003e7-Keto DHEA: Metabolism, Weight-Loss and Management\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eBobyleva, V., Bellei, M., Kneer, N., \u0026amp; Lardy, H. (1997). The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eArchives of biochemistry and biophysics\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e341\u003c\/em\u003e(1), 122-128.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1006\/abbi.1997.9955\"\u003ehttps:\/\/doi.org\/10.1006\/abbi.1997.9955\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDavidson, M., Marwah, A., Sawchuk, R. J., \u0026amp; Maki, K. (2000). Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eClinical and investigative medicine\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e23\u003c\/em\u003e(5), 300.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/cat.inist.fr\/?aModele=afficheN\u0026amp;cpsidt=1536086\"\u003eAbstract [French]\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHampl, R., Lapcik, O., Hill, M., Klak, J., Kasal, A., Novacek, A., ... \u0026amp; Starka, L. 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Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eProceedings of the National Academy of Sciences\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e92\u003c\/em\u003e(14), 6617-6619.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.pnas.org\/content\/92\/14\/6617.short\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLamont, B. J., Waters, M. F., \u0026amp; Andrikopoulos, S. (2016). A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrition \u0026amp; diabetes\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e6\u003c\/em\u003e(2), e194. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.nature.com\/nutd\/journal\/v6\/n2\/full\/nutd20162a.html?foxtrotcallback=true\"\u003e10.1038\/nutd.2016.2\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLiu, Y. Y., Yang, N., Kong, L. N., \u0026amp; Zuo, P. P. (2003). Effects of 7-oxo-DHEA treatment on the immunoreactivity of BALB\/c mice subjected to chronic mild stress.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eYao xue xue bao= Acta pharmaceutica Sinica\u003c\/em\u003e,\u003cem\u003e38\u003c\/em\u003e(12), 881-884.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/europepmc.org\/abstract\/med\/15040075\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShi, J., Schulze, S., \u0026amp; Lardy, H. A. (2000). The effect of 7-oxo-DHEA acetate on memory in young and old C57BL\/6 mice.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eSteroids\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e65\u003c\/em\u003e(3), 124-129.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/S0039-128X(99)00094-X\"\u003ehttps:\/\/doi.org\/10.1016\/S0039-128X(99)00094-X\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eŠulcová, J., Hill, M., Mašek, Z., Češka, R., Nováček, A., Hampl, R., \u0026amp; Starka, L. (2001). Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePhysiol Res\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e50\u003c\/em\u003e, 9-18.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.biomed.cas.cz\/physiolres\/2001\/issue1\/pdf\/sulcova.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZenk, J. L., Helmer, T. R., Kassen, L. J., \u0026amp; Kuskowski, M. A. (2002). The effect of 7-Keto Naturalean™ on weight loss: A randomized, double-blind, placebo-controlled trial.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCurrent therapeutic research\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e63\u003c\/em\u003e(4), 263-272.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/S0011-393X(02)80031-5\"\u003ehttps:\/\/doi.org\/10.1016\/S0011-393X(02)80031-5\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZenk, J. L., Helmer, T. R., \u0026amp; Kuskowski, M. A. (2004, March). The use of 3-acetyl-7-oxo-dehydroepiandrosterone for augmenting immune response in the elderly. In\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFASEB JOURNAL\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(Vol. 18, No. 5, pp. A794-A794). 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA: FEDERATION AMER SOC EXP BIOL.\u003c\/p\u003e\n\u003cp\u003eZenk, J. L., Frestedt, J. L., \u0026amp; Kuskowski, M. A. (2007). HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe Journal of nutritional biochemistry\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e18\u003c\/em\u003e(9), 629-634.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jnutbio.2006.11.008\"\u003ehttps:\/\/doi.org\/10.1016\/j.jnutbio.2006.11.008\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eDietary Guidelines and Metabolic Syndrome\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eAmerican Heart Association. (2017). About metabolic syndrome.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.heart.org\/HEARTORG\/Conditions\/More\/MetabolicSyndrome\/About-Metabolic-Syndrome_UCM_301920_Article.jsp\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAmine, E., Baba, N., Belhadj, M., Deurenbery-Yap, M., Djazayery, A., Forrester, T., ... \u0026amp; Katan, M. (2002).\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eDiet, nutrition and the prevention of chronic diseases: report of a Joint WHO\/FAO Expert Consultation\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e. 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W., Petocz, P., McMillan-Price, J., Flood, V. M., Prvan, T., Mitchell, P., \u0026amp; Brand-Miller, J. C. (2008). Glycemic index, glycemic load, and chronic disease risk-a meta-analysis of observational studies.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe American journal of clinical nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e87\u003c\/em\u003e(3), 627-637.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18326601\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCalton, Emily K., Anthony P. James, Poonam K. Pannu, and Mario J. Soares. \"Certain dietary patterns are beneficial for the metabolic syndrome: reviewing the evidence.\"\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrition Research\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e34, no. 7 (2014): 559-568. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.nutres.2014.06.012\"\u003e10.1016\/j.nutres.2014.06.012\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGonzalez Fischer, C., \u0026amp; Garnett, T. (2016). Plates, pyramids, planet. Oxford, UK: Oxford University.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/agris.fao.org\/agris-search\/search.do?recordID=XF2017002095\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHare-Bruun, H., Flint, A., \u0026amp; Heitmann, B. L. (2006). Glycemic index and glycemic load in relation to changes in body weight, body fat distribution, and body composition in adult Danes.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe American journal of clinical nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e84\u003c\/em\u003e(4), 871-879.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Glycemic+index+and+glycemic+load+in+relation+to+changes+in+body+weight%2C+body+fat+distribution%2C+and+body+composition+in+adult+Danes\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHever, J., \u0026amp; Cronise, R. J. (2017). Plant-based nutrition for healthcare professionals: implementing diet as a primary modality in the prevention and treatment of chronic disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of Geriatric Cardiology: JGC\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e14\u003c\/em\u003e(5), 355. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.11909%2Fj.issn.1671-5411.2017.05.012\"\u003e10.11909\/j.issn.1671-5411.2017.05.012\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKahleova, H., Levin, S., \u0026amp; Barnard, N. (2017). Cardio-Metabolic Benefits of Plant-Based Diets.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e9\u003c\/em\u003e(8), 848. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu9080848\"\u003e10.3390\/nu9080848\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLamont, B. J., Waters, M. F., \u0026amp; Andrikopoulos, S. (2016). A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrition \u0026amp; diabetes\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e6\u003c\/em\u003e(2), e194. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.nature.com\/nutd\/journal\/v6\/n2\/full\/nutd20162a.html?foxtrotcallback=true\"\u003e10.1038\/nutd.2016.2\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLutsey, P. L., Steffen, L. M., \u0026amp; Stevens, J. (2008). Dietary intake and the development of the metabolic syndrome. The Atherosclerosis risk in communities study.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCirculation\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e117\u003c\/em\u003e(6), 754-761. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.716159\"\u003e10.1161\/CIRCULATIONAHA.107.716159\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMcMillan-Price, J., Petocz, P., Atkinson, F., O'Neill, K., Samman, S., Steinbeck, K., ... \u0026amp; Brand-Miller, J. (2006). Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: a randomized controlled trial.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eArchives of internal medicine\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e166\u003c\/em\u003e(14), 1466-1475.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/jamanetwork.com\/data\/Journals\/INTEMED\/5546\/ioi60038.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSatija, A., Bhupathiraju, S. N., Spiegelman, D., Chiuve, S. E., Manson, J. E., Willett, W., ... \u0026amp; Hu, F. B. (2017). Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of the American College of Cardiology\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e70\u003c\/em\u003e(4), 411-422.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jacc.2017.05.047\"\u003ehttps:\/\/doi.org\/10.1016\/j.jacc.2017.05.047\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTilman, D., \u0026amp; Clark, M. (2014). Global diets link environmental sustainability and human health.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNature\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e515\u003c\/em\u003e(7528), 518-522.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.nature.com\/articles\/nature13959.epdf?referrer_access_token=OPvIRTiQL-YV0DGjSvtLsdRgN0jAjWel9jnR3ZoTv0PGdh-SWpKH6GvtYOFzpWBvvcumdq0GItSLlihXu7fCEC2Kzb5w9JsWGW3krZfBsJPmCMI8SPypf3AGsRPR-lsG51DB55YlrE-XEkXUFyzVuQvvYaxXrEc9xWb8ygrjXhHfL3GA4A89nHqVHQJZ2O8zXG1tTwBeRZovDc45n99jDS9lqN-YFvE3EGZiS8kU_eyKZDNgVKRmMQTdS8-WUHOd\u0026amp;tracking_referrer=www.cnn.com\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTurner, K. M., Keogh, J. B., Meikle, P. J., \u0026amp; Clifton, P. M. (2017). Changes in Lipids and Inflammatory Markers after Consuming Diets High in Red Meat or Dairy for Four Weeks.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e9\u003c\/em\u003e(8). DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.3390%2Fnu9080886\"\u003e10.3390\/nu9080886\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eUnited Nation News Centre. (2016). UN study urges governments to develop guidelines that promote 'win-win' diets.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.un.org\/apps\/news\/story.asp?NewsID=53984\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWang, F., Zheng, J., Yang, B., Jiang, J., Fu, Y., \u0026amp; Li, D. (2015). Effects of vegetarian diets on blood lipids: a systematic review and meta‐analysis of randomized controlled trials.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of the American Heart Association\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e4\u003c\/em\u003e(10), e002408. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1161\/JAHA.115.002408\"\u003e10.1161\/JAHA.115.002408\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWright, N., Wilson, L., Smith, M., Duncan, B., \u0026amp; McHugh, P. (2017). The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes.\u003cem\u003eNutrition \u0026amp; diabetes\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e7\u003c\/em\u003e(3), e256. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1038\/nutd.2017.3\"\u003e10.1038\/nutd.2017.3\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYokoyama, Y., Levin, S. M., \u0026amp; Barnard, N. D. (2017). Association between plant-based diets and plasma lipids: a systematic review and meta-analysis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrition Reviews\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e75\u003c\/em\u003e(9), 683-698.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1093\/nutrit\/nux030\"\u003ehttps:\/\/doi.org\/10.1093\/nutrit\/nux030\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003eIngredients\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eOne Capsule Contains:\u003cbr\u003e7-Keto DHEA 25mg\u003cbr\u003eDemineralized Brown Sea Weed Extract 200mg\u003cbr\u003e(from Kelp and Bladderwrack)\u003c\/p\u003e\n\u003cp\u003eOther ingredients:\u003cbr\u003ecellulose \u0026amp; water (capsule shell)\u003c\/p\u003e\n\u003ch6\u003eProtocol\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eWEIGHT-LESS\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— Weight-Less is a smart formula designed to promote weight-loss\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eand\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003esustained energy.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eWeight Loss\u003c\/i\u003e: Take 1-2 capsules 15-20 minutes before meals. The powerful mix of brown seaweed extract and 7-Keto turns on the fat burning mechanism in the body, lowers the glycemic load of meals, and supports a steady energy level.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eEnergy\u003c\/i\u003e: Kelp and Bladderwrack extracts are strong high active antioxidants. This combination offers a great protection against oxidation in the mitochondria, and hence helping a sustained energy level in the body.  Take 1caps first thing in the morning with a glass of water. Take another one in the afternoon, before 3 pm.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eAntimicrobial\u003c\/i\u003e: Kelp and Bladderwrack are powerful antimicrobial agents, going after one of the most insidious bacterial pathogens,\u003cem\u003e\u003cspan\u003e \u003c\/span\u003ePseudomonas aerugiosa\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eStaphylococcus aureus\u003c\/em\u003e. \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOur Favorite\u003c\/i\u003e: The Weight-Less is a great traveling companion as it naturally boosts our energy and at the same time has a powerhouse anti-inflammatory and antimicrobial ability, something we all need on the road. Take with\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eEnergy\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e(Ultra Minerals \u0026amp; Apple Extract) to acclimate to time changes and different schedule, and\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eCranberry Pomegranate\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eto reduce bloating (or achy bladder).*\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712314015788,"sku":"TF029","price":99.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Weightless-Front_e15c25cb-d9e2-47fd-93d5-5f53f3803622.jpg?v=1723214746"},{"product_id":"supernatant-synbiotic-formula","title":"Supernatant Synbiotic","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eThe Supernatant Synbiotic Formula is an effective antimicrobial.*\u003c\/p\u003e\n\u003cp\u003eBioImmersion’s advanced Super Blend of naturally occurring whole probiotic organisms with their Supernatant metabolites and microRNA (ORNs - Oligoribonucleotides) contains important nutrients and factors that help protect and balance the gut microbiota. 34 billion CFU per gram.*\u003c\/p\u003e\n\u003cp\u003eSupernatant (or as some call it postbiotic or parabiotic) is the fermented “soup” that contains powerful probiotic metabolites: enzymes, such as bile hydrolase, lactase, and others, peptides, proteins, vitamins, short chain fatty acids, bacteriocins, biosurfactants, microRNA or ORNs, and other nutritional substances. Supernatant and microRNAs are the power behind the new emerging research on immune-biotics: the antimicrobial qualities exerted by probiotics and their metabolites (Arena et al., 2018).*\u003c\/p\u003e\n\u003cp\u003eLearn the science of probiotics and their Supernatant in the Research tab.\u003c\/p\u003e\n\u003cp\u003eThe Supernatant Synbiotic is vegan, nonGMO, kosher, and gluten, soy, and dairy free.\u003c\/p\u003e\n\u003ch6\u003eDescription \u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eSUPERNATANT SYNBIOTIC FORMULA\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eBioImmersion’s Probiotic Super Blend\u003c\/i\u003e\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eis an advanced formulation of naturally occurring whole probiotic organisms with their Supernatant metabolites and Oligoribonucleotides (ORNs or MicroRNA). 30 billion CFU per gram.*\u003c\/p\u003e\n\u003cp\u003eThe super blend includes:\u003cb\u003e\u003cspan\u003e \u003c\/span\u003eProbiotics-\u003c\/b\u003e\u003ci\u003eBifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus, Streptococcus thermophilus\u003c\/i\u003e;\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ePrebiotics-\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eInulin from Chicory root;\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eSupernatant\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003e[or postbiotic]\u003cb\u003e-\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003ea nutritional metabolites “soup” that is created from\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eeach\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eof the probiotic organisms, which include their lactic acid, enzymes, vitamins, short-chain fatty acids, bacteriocins, bio-surfactants, bile salt hydrolase, and their\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eORNs\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003e(Oligoribonucleotides;\u003cspan\u003e \u003c\/span\u003e\u003cb\u003emicroRNA\u003c\/b\u003e). The supernatant is freeze-dried along with the good bacteria to form a powerful antimicrobial formula.*\u003c\/p\u003e\n\u003cp\u003eShort chain fatty acids are also known to be the main nutritive energy source for the enterocytes (cells of the intestinal lining), hence, increasing production of short chain fatty acids improves the overall integrity of the GI tract membrane and tightening up cell junctions.*\u003c\/p\u003e\n\u003cp\u003eOur probiotics are\u003cspan\u003e \u003c\/span\u003e\u003ci\u003enaturally occurring,\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ewhole organisms\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003ewith their microRNAs (what ORNs are made of), they wake up quickly and are ready to multiply and build a robust healthy ecosystem in our alimentary canal, from mouth to anus. In order for probiotic to multiply, they need particular foods: dietary fiber and prebiotics they can metabolized in the GI Tract. Inulin, polyphenols, and beta glucan have been found to be excellent sources of fiber and prebiotic for microbes to ferment and metabolize (Holscher \u0026amp; Holscher et al., 2017; 2015, Etxeberria et al., 2013). The Supernatant Synbiotic formula is Vegan, Kosher, Non GMO, and free of Dairy, Soy, and Gluten.*\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eSupernatant Synbiotic Formula\u003c\/i\u003e\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003ewas developed to address the mounting problem of life-threatening hospital generated infections (nosocomal infections) from organisms such as \u003cem\u003eC. difficele, Staph aureus, Klebseilla\u003c\/em\u003e, and vancomycin-resistant Enterococcus faecium. The formula is comprised of supernatant’s many nutrients including the well-researched antibacterial substances such as bacteriocins, which suppress the growth of pathogenic bacteria (Cotter \u0026amp; Hill, 2013). Probiotics and their supernatant’s metabolites, including microRNA (or ORNs) are shown in research to regulate a balanced ecosystem in the GI tract and protect against bacterial pathogens (Aguilar et al., 2019; Chenoll et al., 2017; Goldenberg et al., 2013; Górska et al., 2016; Kawahara et al., 2015).*\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eA synbiotic\u003c\/i\u003e:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eSynbiotic is defined as a “mixture of a prebiotic and a probiotic that beneficially affects the host by enhancing the survival and the implantation of live microbial dietary supplements in the gut, by selectively stimulating growth and\/or activating the metabolism of a specific or few number of health-promoting bacteria” (Gibson \u0026amp; Roberfroid, 1995; Roberfroid, 2002). Most of BioImmersion’s probiotics formulas are synbiotics, which means they include prebiotics from plant fibers and inulin from chicory root. Inulin is naturally found in many different plant foods, such as garlic, onions, asparagus, chicory, artichokes, bananas, and more (Gibson et al., 1994; 2010).*\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eThe\u003c\/i\u003e\u003c\/b\u003e\u003ci\u003e\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eMicrobiome Project\u003c\/b\u003e\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003ehas taught us thathuman microbiota, the microorganisms that live inside us (GI Tract, mouth, vagina) and on us (skin), consist of trillion symbiotic microbes (Ursell et al., 2012). First coined as “microbiome” by Joshua Lederberg in 2001, microbiome is the combined genes of the microbiota, and signifies “the ecological community of commensal, symbiotic, and pathogenic microorganism that literally share our body space and have been all but ignored as determinants of health and disease.” In other words, the microbial communities. Rob Knight emphasizes that there are10 trillion human cells to 100 trillion microbial cells (2017, TED talk) – which means, there are more of ‘them’ than of ‘us.’ Aptly, Turnbaugh et al. (2012) describes this amazing genome collective of human and ‘other’ as a human “supra-organism.”\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eSupra-Organism:\u003c\/i\u003e\u003c\/b\u003e  How do we achieve harmony and health as a human supra-organism? Just like plants rely on their microbiome for life-support functions (e.g., nutrients acquisition and protection against stressors and pathogens), so do humans rely on their microbiome for better health (Pérez-Jaramillo et al., 2018). Since each person embodies a unique system of human genes as well as harbors a “\u003ci\u003ecore\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eset of specific bacterial taxa” (Qin et al., 2010), researchers are coming to the conclusion that plant-based foods healthily build our body cells and contribute the right nutrients and fiber to our core microbiota. In essence, researchers of traditional tribes find that the ‘hunter-gather’ still eats more plant-based diet, high in fiber, and very low animal meat, while the Western or modern societies eat protein and meat intensive diets (Caprara, 2018; Desmond et al., 2018; Gomez et al., 2016; Obregon-Tito et al., 2015; Schnorr et al., 2016, 2014; Turnbaugh et al., 2009; Ley et al., 2006).\u003c\/p\u003e\n\u003cp\u003eHence, achieving a healthy ‘supra-organism’ requires a combination of plant-based foods that nourishes and healthily feed both micro-organisms and human beings -- precisely the principles that BioImmersion employ in the super blend and other formulations. To quickly form healthy colonies, organisms must have the type of foods they need – plant fiber and polyphenols. Food \u0026amp; microbial science show a special interactive relationship between polyphenols from plant-foods and probiotics–a ‘two-way relationship between polyphenols ←→ microbiotia,’ each helps the other, and together they modulate the gut microbiota to benefit human health (Cardona et al., 2013; Pathak et al., 2018).\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMICROBIAL ECOLOGY\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eHistory:\u003c\/i\u003e\u003c\/b\u003e  Probiotics are transient organisms found in a variety of fermented foods, from grains, to fruits, vegetables, legumes like soy, and dairy. Historically, these foods were consumed daily in every part of the world. Probiotic microorganisms belong mostly to the following genera:\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eLactobacillu\u003c\/i\u003es,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eBifidobacterium\u003c\/i\u003e, and \u003ci\u003eLactococus\u003c\/i\u003e, \u003ci\u003eStreptococcus\u003c\/i\u003e, \u003ci\u003eEnterococcus\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e(Markowiak \u0026amp; Śliżewska, 2017).\u003c\/p\u003e\n\u003cp\u003eIn 1965, Lilly \u0026amp; Stillwell defined the meaning of probiotics as substances produced by protozoan which stimulated another organism, in opposition to antibiotic which inhibits or kills other organisms. Parker (1974) later defined probiotics as ‘organisms and substances which contribute to intestinal microbial balance,’ while Savage (1977) described the microbial ecology of the gastrointestinal tract as “10\u003csup\u003e14\u003cspan\u003e \u003c\/span\u003e\u003c\/sup\u003e[100 trillion] indigenous prokaryotic and eukaryotic microbial cells” (p. 107). Microbial organisms were further described by Fuller (1989; 1992) as a supplemental food, ‘live microbial feed supplement’ that effect the host (animal or human) by improving intestinal microbial ecology and balance.  The World Health Organization (WHO) and the Food and Agriculture Organization (FAO) of the United Nations defined probiotics as “live microorganisms which when administered in adequate amount confer a health benefits on the host” (2001; see also Tufarelli \u0026amp; laudadio, 2016).\u003c\/p\u003e\n\u003cp\u003eIn October 2013, the International Scientific Association gathered an expert panel to redefine and discuss probiotics. The agreement that probiotics confer health benefits was reinforced, and a more accurate wording was used to describe probiotics as, “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host” (Hill et al., 2014). In this way, the panel differentiated between probiotics as microorganisms and the commensals that are natural in the gut microbiota. However, when these commensal strains are collected from the gut, isolated, and characterized as giving health benefits, they can then be referred to as probiotics. In other words, probiotics need to show they are effective. Unfortunately, the term probiotic is used to sell skin care, shampoos and all sorts of other products, without the due diligence that signify the effectiveness of the probiotic, and therefore, misleading the public. To use the term ‘probiotic’ – a\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ehealth effect\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003emust be shown (Hill et al., 2014).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eLactic acid bacterial (LAB)\u003c\/i\u003e:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eLAB species typically produce lactic acid as a main end-product of carbohydrate and fiber fermentation. LAB organisms are known for their adhesion to the mucus layer of the GI tract. This mucus layer plays an important role in protecting the intestinal epithelial cells against pathogens and damage, as well as provide a perfect milieu for LAB organisms to attach, grow and form their communities (Nishiyama et al., 2016). Streptococcus thermophilus is not part of the Lactobacillus species although this microorganism is also considered a lactic acid bacterium (Kechagia et al., 2012). Bifidobacterium uses a different metabolic pathway, and its name is actually a ‘misnomer’ as very few Bifidobacterium adopt a bifid morphology (even when exposed to stressful conditions), while the rod structure is the intrinsic morphology of the majority (Rajashekharan et al., 2017).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eBeneficial Microbiota Milieu:\u003c\/i\u003e\u003c\/b\u003e  Probiotic organisms have the potential to shift the gut microbiota milieu (composition) from a pathogenic predominance to a more beneficial micro-biotic ecosystem (Costello et al., 2012; Schnorr et al., 2016; Zitvogel et al., 2017). The fermentation process by probiotics in the gut microbiota keep at bay harmful pathogens by preventing their growth (Anzaku \u0026amp; Pedro, 2017). They assist the body’s immune system and contribute to a host of other positive health benefits. When the balance in the microbiome shifts toward a pathogenic community, it weakens the abilities of the helpful microbiota communities. An impaired microbiome is repeatedly shown in research to lead into conditions such as obesity, inflammatory bowel diseases, and other chronic illnesses (Patil et al., 2012; Schnorr et al., 2016; Kobyliak et al., 2016).\u003c\/p\u003e\n\u003cp\u003eAn important conversation in the scientific community is the role probiotic play in creating or modifying the composition of the gut microbiota toward better health (Sanders et al., 2018; Bron et al., 2017; Sanders, 2016). Globally, obesity is progressing and almost at the level of a pandemic, causing other chronic metabolic diseases to manifest (Dahiya et al., 2017). Since probiotics are transient in nature, and the gut lining continues to shed and renew its cells, how long do probiotic microbes stay in the gastrointestinal tract? And does a shorter duration have a power to create a healthy microbiome? Some say that although probiotics may not reside in the gut longer than two weeks, they do offer many benefits (Sanders et al., 2018), while others see a need for more specific research on fecal microbiota and probiotics (Kristensen et al., 2016).\u003c\/p\u003e\n\u003cp\u003eAt the core of this discussion is the need for a unified global regulatory frameworks and research methods, including a universal classification (nomenclature) of probiotic organisms to decrease consumer confusion and improve the scientific requirement for the commercial industry at large (Sanders et al., 2011). The gut microbial community includes bacteria (anaerobic and aerobic), viruses, fungi, with a variety of disease-causing pathogens and parasites (Howarth \u0026amp; Wang, 2013). Some microorganisms are shown to be helpful for human health, while others cause much distress. We have discussed how our diet, in particular, heavy consumption of meat, eggs, and dairy, change the composition of the microbiome (Matthews et al., 2018; Singh et al., 2017), but moreover, exposure to pesticides and herbicides (Stanaway et al., 2017), and other foods and environmental chemicals (Roca-Saavedra et al., 2017), create a heavy burden on the body’s ability to function well. As research continues to uncover new facets of research on micro-organisms, including probiotics, we will update this document. Stay tune also to Seann Bardell’s Forward Thinking emails found in the News within the Resources tab:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/blog.bioimmersion.com\/\"\u003ehttp:\/\/blog.bioimmersion.com\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eWhat do probiotic achieve in our GI Tract?\u003c\/i\u003e\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eAlthough the gut microbiome is a complex ecosystem of microorganisms, probiotics have exhibited many health benefits, including weight loss and improvement of metabolic diseases (Dahiya et al., 2017), boosting and supporting the immune system (de Vos et al., 2017), strengthening the intestinal barrier function (Blackwood et al., 2017), supporting colicky babies (Rhoads et al., 2018; Pärtty et al., 2012), and of course competing against pathogenic bacteria (Szajewska et al., 2016; Ayala et al., 2014; Johnston et al., 2012; Manzoni et al., 2006).\u003c\/p\u003e\n\u003cp\u003eEven more so, probiotic organisms perform multitudes of other beneficial functions in the body: research shows that probiotics help to lower toxins (Yu et al., 2016; Qixiao et al., 2015; Amalaradjou \u0026amp; Bhunia, 2012), keep cholesterol down (Cani et al., 2011, 2009), assist in weight management (Everard \u0026amp; Cani, 2013), digestion and absorption of nutrients (Wang \u0026amp; Ji, 2018; Francavilla et al., 2017), elimination (Eskesen et al., 2015; Dimidi et al., 2014), and even function as anti-aging mediators (Buford, 2017; Nagpal et al., 2018). In other words, probiotics are shown in research to maintain a healthy ecological balance in the human gut and perform many beneficial functions.\u003cb\u003e\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSUPERNATAT\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eWhat is supernatant?\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003e  Supernatant is the fermented medium created during the culturing process of probiotics. Supernatant is the fermented “soup” that contains important probiotic metabolites, such as enzymes, peptides, proteins, vitamins, short chain fatty acids, and other nutrients and factors, including antimicrobials such as Bacteriocins that may be used as a possible alternative to antibiotics (Cotter, Ross, \u0026amp; Hill, 2013; Yang et al., 2014). Supernatant, or as some call it, “postbiotic” (Auilar-Toalá et al., 2018), or “parabiotic” (Choudhury \u0026amp; Kamilya, 2018), is shown in research to have powerful antimicrobial properties with the potential to block adhesion, invasion and translocation of\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eE. coli\u003c\/i\u003e, yet it is gentle enough to be used to ‘enhance neonatal resistance to systemic\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eEscherichia coli\u003cspan\u003e \u003c\/span\u003e\u003c\/i\u003eK1 infection by accelerating development of intestinal defense’ (He et al., 2017). In fact, Lazar et al.’s (2009) in vitro study concluded that the soluble probiotic metabolites, or supernatant, might actually interfere with the beginning stages of adherence and colonization of selected\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eE. coli\u003c\/i\u003e. This means that the supernatant itself exudes protective effects (Lazar et al., 2009), as well as work synergistically with probiotic organisms to stimulate the immune system against pathogenic invasion (Ditu et al., 2014).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eImmunobiotics\u003c\/i\u003e:\u003c\/b\u003e  The combination of lactic acid bacteria (LAB) and their metabolites is given much consideration as a method to improve human immune response against viral and fungal overgrowth. The term “immunobiotic” is a relatively new way to describe the antimicrobial qualities exerted by probiotics and their metabolites (Arena et al., 2018). The term ‘immunobiotic’ has been proposed to define beneficial microbes with the ability to regulate the immune system and lower inflammation of the gut tissue (Villena \u0026amp; Kitazawa, 2017; Villena et al., 2016). For example, the probiotics\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eL. rhamnosus\u003cspan\u003e \u003c\/span\u003e\u003c\/i\u003eand\u003ci\u003e\u003cspan\u003e \u003c\/span\u003eL. plantarum\u003cspan\u003e \u003c\/span\u003e\u003c\/i\u003ecarry immunobiotic properties and are shown to increase protection against viral intestinal infections (Albarracin et al., 2017). In a different study on mice, Kikuchi et al. (2014) discovered that oral administration of\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eL. plantarum\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eenhanced IgA secretion in both intestine and lung tissues, supporting against influenza virus infection. Immunobiotics, the combination of probiotics and their supernatant metabolites, have been found to support and benefit respiratory immunity (Zelaya et al., 2016), modulate mucosal cytokine profiles, IgA levels, and more, in various conditions of gastrointestinal inflammation (Carvalho et al., 2017).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eBacteriocins and Antimicrobial Properties\u003c\/i\u003e: \u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003eOne of the properties that is given much attention is the bacterially produced antimicrobial peptides of bacteriocins (e.g., Cotter \u0026amp; Hill, 2013; Yang et al., 2014; Cotter et al., 2005). Already in 2005, Cotter \u0026amp; Hill observed that bacteriocin nisin functions by binding to lipid II, which is also the target of vancomycin antibiotic. This led to the suggestion that ‘bacteriocin nisin’ could be used as a template to design novel drugs. In 2018, the research to discover the mechanism of bacteriocin against pathogenic activity, including\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eStaphylococcus aureus\u003c\/i\u003e, continued with the discovery of critical features in the structure of bacteriocins that gives it such a ‘potent activity against pathogenic\u003cspan\u003e \u003c\/span\u003e\u003ci\u003estaphylococci\u003c\/i\u003e’ (O’Connor et al., 2018).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eMetabolic Disorders\u003c\/i\u003e:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e Intestinal dysbiosis and endotoxemia have been linked to metabolic disorders: obesity, insulin resistance, and type 2 diabetes (Leite et al., 2017). Bacterial lipopolysaccharides (LPS) is a molecular element of the outer membrane of Gram-negative bacteria, and typically consist of lipid A (or endotoxin), a ‘core’ oligosaccharide, and a distal polysaccharide, (or O-antigen). LPS also are found in diverse Gram-negative bacteria, many of which are pathogenic to both humans and plants (Raetz \u0026amp; Whitfield, 2002). LPS (also termed endotoxin) serves as a shield from the environment and at the same time is recognized by the immune system as a marker for the entrance (or invasion) of pathogens, which in turn causes inflammatory response, and in an extreme response can bring about endotoxic shock (Rosenfeld \u0026amp; Shai, 2006).  LPS causes inflammatory immunogens that circulate at low grade levels in healthy individuals, while high continuous levels instigate pro-inflammatory markers in the blood, e.g., interleukin-6, interleukin-1-alpha, interferon-gamma, triglycerides and post-prandial insulin. Proinflammatory markers are correlated with the risk of developing a variety of chronic illness, including increase risk of atherosclerosis (Erridge et al., 2007; see Cani et al., 2007).\u003c\/p\u003e\n\u003cp\u003eSince the body is a mechanism of many interactive systems and components, a reaction in one system can instigate a positive or a negative chain of events in another. For example, in a clinical study, Leite et al. (2017) demonstrated that Gram-negative species (e.g.,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eBacteroides vulgatus\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003ci\u003erodentium\u003c\/i\u003e) were found in stools of individuals with type 2 diabetes, as well as an increase of pro-inflammatory interleukin-6 (IL-6) in their plasma. In other words, gut dysbiosis and metabolic endotoxemia have been linked to metabolic disorders, such as obesity, diabetes, and insulin resistance (van Olden et al., 2015). The gut microbiota contributes to many processes in the human host’s body, and the host provides a place of residence for the survival of the microorganisms (Leite et al., 2017). This give and take relationship has to be delicately balanced.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eEpigenetic Changes\u003c\/i\u003e:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eBhat et al. (2017) considers dietary metabolites that are derived from the gut microbiotic population as critical modulators of epigenetic changes in both animals and humans.  Nutrients in the gut are produced by microbial metabolisms of fiber, which means that short-chain fatty acids, polyamines, polyphenols, vitamins, and other metabolites, participate in “various epigenomic mechanisms that reprogram the genome by altering the transcriptional machinery of a cell in response to environmental stimuli” (Bhat et al., 2017). In other words, what we eat does modulate our gut which in turn can influence our health through modulations of genes.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003ePotent Immune Boosting Nutrients\u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eAdding the natural supernatant metabolic ‘soup’ of potent nutrients that probiotic organisms create while they grow and multiply is showing great potential for human health. Immunobiotics is a study field that endeavors to understand how microorganisms and their supernatant interact with the immune system to support a healthy functioning body (e.g., Górska et al., 2016). Studies on probiotics and their supernatant metabolites are ongoing and add much to our understanding of Turnbaugh et al. (2012) “supra-organism” description of our bodies as an amazing genome collective of human cells and ‘other’ cells.\u003c\/p\u003e\n\u003cp\u003eContinue to learn what supernatant and probiotics do by reading articles in the Research tab.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003emicroRNA or ORNs (Oligoribonucleotides)\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eHistory\u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e Probiotics have had a long history in helping farmed animals combat gut disfunctions caused by overuse of antibiotics to stimulate faster growth. In the 1950s the readily available antibiotics gave rise to the concern that using it as a substance to promote growth was creating resistant populations of bacteria, which means that antibiotics would lose effectiveness against infections from bacteria. Although in 1969 antibiotics were restricted as a growth promotor, the use has not subsided until very recently with the rise of organic and grass-fed animal farms. Fuller (1989) noted that antibiotics have a long-lasting upsetting effect in the gut because of the imbalance caused in the indigenous gut flora. In today’s language, antibiotics disrupt the natural microbiome, causing various diseases (Langdon et al., 2016). Probiotics offer a practical solution as an alternative therapy. For example, they exert antimicrobial properties by inhibiting adhesion of pathogens to the mucosa (Salas-Jara et al., 2016; Chenoll et al., 2011), or produce bacteriocins lethal to the pathogens, as we have seen above in the supernatant section (Reid \u0026amp; Burton, 2002)\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eMicroRNA Immune-Modulating\u003c\/i\u003e:\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eBacteria release immune-modulating molecules when entering the mouth, such as ribonucleic acid or RNA, as though they are ready to defend themselves. Small pieces of RNA, called MicroRNA (miRNA) or oligoribonucleotides (ORNs), are released by pathogenic bacteria as well as a beneficial bacterium such as\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eLactobacillus casei\u003c\/i\u003e, which we find in fermented foods like yogurts. Other lactobacillus organism occurs naturally in fruits and vegetables. Marshall (2010) tested\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eL. Casei\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eamong other beneficial probiotics to assess their readiness to fight pathogenic organisms in case of invasion and found that these small pieces of RNA or ORNs control the expression of growth genes in the pathogen’s genomes. The bacteria grow faster after releasing the ORNs, mounting a better defense system to invading bacterial infections (Marshall, 2014).\u003c\/p\u003e\n\u003cp\u003eMicroRNA (or ORNs) play important regulatory role in physiological processes in animals (and plants), and is studied for miRNA-based therapeutics (Wahid et al., 2010). miRNA regulate gene expression in all aspects of biology, with certain endogenous miRNAs participating in antiviral defense mechanisms, such as miR-32 with inhibitory effects against the retrovirus type 1 (PFV-1; similar to human immunodeficiency virus such as Epstein-Barr and others) and protects human cells from PFV-1 (Lecellier et al., 2005). Other studies, such as Ma et al. (2011) found another miRNA (miR-29) controlling innate and adaptive immune response to intracellular bacterial infection. With dysbiosis of the gut, inflammation hasten immunological imbalances, influencing the onset of many chronic illnesses, including cancer. The opposite is also a viable solution – maintaining the health of the microbiome (Cianci et al., 2019).\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eLactobacillus acidophillus\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eBifidobacterium bifidum\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eregulate and modulate the GI-tract, increasing production of certain microRNA that improve colon cancer treatment (Heydari et al., 2018). From the GI-tract to the brain, Zhao et al. (2019) have shown that probiotics protect against inflammatory neurodegeneration caused by neurotoxins in the gut, contributing to a healthier brain function. Probiotics with their supernatant and microRNA or ORNs regulate and support a balanced function of the GI-tract. MicroRNA have emerged as major players in the interaction between host (human body) and bacterial pathogens, with an integral part in the host immune response to bacterial infection (Aguilar et al., 2019; Sunkavali et al., 2017).\u003c\/p\u003e\n\u003cp\u003eRead more on supernatant, chronic illnesses and the science of healthy longevity in our No 7 Systemic Booster: The New Longevity,\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/bioimmersion.com\/products\/no-7-systemic-booster\"\u003eHere.\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePREBIOTIC \u0026amp; FIBER\u003cbr\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eDefinition\u003c\/i\u003e:\u003c\/b\u003e  “A prebiotic is a selectively fermented ingredient that allows specific changes, both in the composition and\/or activity in the gastrointestinal microbiota that confers benefits upon host well-being and health” (Tufarelli \u0026amp; Laudadio, 2016; Gibson et al., 2017; 2014; Macfarlane et al., 2006). A prebiotic is a fiber that resists digestion in the upper bowel and ferments easily in the colon by probiotic organisms. Prebiotic fibers are imperative for the survival and success of microorganisms, without adequate amounts of prebiotic fiber, probiotic cannot successfully grow and replicate in the gut (Holscher, 2016). To positively modulate the composition and ecosystem of the gut, fiber, both plant fibers and prebiotic fibers that are designated as ‘prebiotic’ are a must have\u003cspan\u003e \u003c\/span\u003e\u003ci\u003edaily\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003enutritional food (David et al., 2014).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eHistory\u003c\/i\u003e:\u003c\/b\u003e  In 1995, Gibson \u0026amp; Roberfroid introduced the concept of prebiotic as a useful non-digestible fiber such as oligosaccharides, and in particular, fructo-oligosaccharides. In 2017, the International Scientific Association for Probiotics and Prebiotics (ISAPP) released a consensus statement on the definition of scope of prebiotics: The realization that prebiotic fibers stimulate probiotic bacteria’s growth and ability to replicate successfully, and in turn, a healthy community of probiotics modulates the colon’s microbiota by positively changing the ecosystem balance in the GI Tract (Gibson et al., 2017).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003ePrebiotic Criteria\u003c\/i\u003e:\u003c\/b\u003e  Following this consensus, three criteria are required for a prebiotic: 1. That the fiber resists digestion by host (fibers that humans cannot digest in the stomach, such as inulin), 2. that the fiber can be fermented by intestinal microorganisms, and 3. The fibers can stimulate the growth and activity of intestinal bacteria associated with health and well-being (Gibson et al., 2017, p. 492). In other words, adding inulin or other non-digestible fibers to a probiotic formula makes sense. Not only do the fibers help selective organisms grow, a prebiotic also must ‘evoke a net health benefit’ (p. 493). Prebiotics, in fact, activates the bacteria in the gut and improve ‘distant sites’ in the body, such as effecting bone strength, supporting neural and cognitive processes, immune function, skin and more (Collins \u0026amp; Reid, 2016).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eFood for Microbes\u003c\/i\u003e:\u003c\/b\u003e  Human beings cannot digest most complex carbohydrates and plant polysaccharides, but microbes do – they metabolize the polysaccharides into short-chain fatty acids (SCFAs), including butyrate (Holscher, 2017). Delcour et al. (2016) examine the metabolites (or supernatant) formed by digesting the fiber and concluded that prebiotic increases production of SCFAs is a viable link between prebiotic, probiotics and health benefit. SCFAs are shown in research to regulate glucose metabolism and control body weight (Canfora et al., 2015), produce anti-inflammatory properties to calm inflammatory bowel disease (Tedelind et al., 2007; Vinolo et al., 2011).\u003c\/p\u003e\n\u003cp\u003eStudies show that when we combine prebiotics with probiotics, many other health benefits follow, such as, prevention of insulin resistance, prevention of obesity, and reduction of FPG (fasting plasma glucose) and plasma insulin (Beserra et al., 2015; Cerdó et al., 2019; Razmpoosh et al, 2019, respectively), all markers for cardiovascular, diabetes, and weight management and control.\u003c\/p\u003e\n\u003cp\u003eOther substances that regulate gastrointestinal health are the oligosaccharides in human milk, important in the development of the newborn intestinal microbiota, metabolic, and immunological systems, all important for health later in life. Similar to the oligosaccharides in human milk, short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides have been found to effect early microbiota and increase Bifidobacterium growth, and reduces inflammation in the bowel and skin of babies and the young (Oozeer et al., 2013; Wopereis et al., 2018), reduce weight and inflammatory markers in both young and older individuals (Sahlitin et al., 2019; Fernandes et al., 2017, respectively), and generally contribute to healthy ageing (Tihonen, 2010; Buford, 2017).\u003c\/p\u003e\n\u003cp\u003eNot all dietary fibers are characterized as prebiotics, however, they do contribute positive health effects. For example, microbes are unable to ferment cellulose well, but cellulose increases gut transit time. Psyllium is non-fermentable, yet it is shown to improve glycemic control and reduce cholesterol. Fibers, whether prebiotic or not, are healthy for human health.\u003c\/p\u003e\n\u003cp\u003e Read more on fiber in the description tab of Be Regular, and see the bibliography in the Research tab.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eReferences\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAguilar, C., Mano, M., \u0026amp; Eulalio, A. (2018). MicroRNAs at the Host–Bacteria Interface: Host Defense or Bacterial Offense. \u003ci\u003eTrends in microbiology\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0966842X18302348\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAguilar-Toalá, J. E., Garcia-Varela, R., Garcia, H. S., Mata-Haro, V., González-Córdova, A. F., Vallejo-Cordoba, B., \u0026amp; Hernández-Mendoza, A. (2018). Postbiotics: An evolving term within the functional foods field. \u003ci\u003eTrends in Food Science \u0026amp; Technology\u003c\/i\u003e, \u003ci\u003e75\u003c\/i\u003e, 105-114.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924224417302765\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAlbarracin, L., Kobayashi, H., Iida, H., Sato, N., Nochi, T., Aso, H., ... \u0026amp; Villena, J. (2017). Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells: influence of immunobiotic lactobacilli. \u003ci\u003eFrontiers in immunology\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e, 57.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2017.00057\/full\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAmalaradjou, M.A., \u0026amp; Bhunia, A.K. (2012). Modern approaches in probiotics research to control foodborne pathogens.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eAdv. Food Nutr. Res\u003c\/i\u003e, 67, 185–239.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/B978-0-12-394598-3.00005-8\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/B978-0-12-394598-3.00005-8\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAnzaku, A. A., \u0026amp; Pedro, A. (2017). Antimicrobial Effect of Probiotic Lactobacilli on Candida Spp. \u003ci\u003eIsolated from Oral Thrush of AIDS Defining Ill Patients. J Prob Health\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e(171), 2.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Abbas_Abel_Anzaku\/publication\/323880263_Antimicrobial_Effect_of_Probiotic_Lactobacilli_on_Candida_Spp_Isolated_from_Oral_Thrush_of_AIDS_Defining_Ill_Patients\/links\/5ab111a8aca2721710fec43f\/Antimicrobial-Effect-of-Probiotic-Lactobacilli-on-Candida-Spp-Isolated-from-Oral-Thrush-of-AIDS-Defining-Ill-Patients.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eArena, M. P., Capozzi, V., Russo, P., Drider, D., Spano, G., \u0026amp; Fiocco, D. (2018). Immunobiosis and probiosis: antimicrobial activity of lactic acid bacteria with a focus on their antiviral and antifungal properties. \u003ci\u003eApplied microbiology and biotechnology\u003c\/i\u003e, \u003ci\u003e102\u003c\/i\u003e(23), 9949-9958.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00253-018-9403-9\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBeserra, B. T., Fernandes, R., do Rosario, V. A., Mocellin, M. C., Kuntz, M. G., \u0026amp; Trindade, E. B. (2015). A systematic review and meta-analysis of the prebiotics and synbiotics effects on glycaemia, insulin concentrations and lipid parameters in adult patients with overweight or obesity. \u003ci\u003eClinical nutrition\u003c\/i\u003e, \u003ci\u003e34\u003c\/i\u003e(5), 845-858.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0261561414002568\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBhat, M. I., \u0026amp; Kapila, R. (2017). Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. \u003ci\u003eNutrition reviews\u003c\/i\u003e, \u003ci\u003e75\u003c\/i\u003e(5), 374-389.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1093\/nutrit\/nux001\"\u003ehttps:\/\/doi.org\/10.1093\/nutrit\/nux001\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBron, P. A., Kleerebezem, M., Brummer, R. J., Cani, P. D., Mercenier, A., MacDonald, T. T., ... \u0026amp; Wells, J. M. (2017). Can probiotics modulate human disease by impacting intestinal barrier function?. \u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e, \u003ci\u003e117\u003c\/i\u003e(1), 93-107.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.cambridge.org\/core\/journals\/british-journal-of-nutrition\/article\/can-probiotics-modulate-human-disease-by-impacting-intestinal-barrier-function\/DEF63ACAC72D015CADD2E6EB35D4AD59\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBuford, T. W. (2017). (Dis) Trust your gut: the gut microbiome in age-related inflammation, health, and disease. \u003ci\u003eMicrobiome\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e(1), 80.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/s40168-017-0296-0\"\u003ehttps:\/\/doi.org\/10.1186\/s40168-017-0296-0\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCanfora, E. E., Jocken, J. W., \u0026amp; Blaak, E. E. (2015). Short-chain fatty acids in control of body weight and insulin sensitivity. \u003ci\u003eNature Reviews Endocrinology\u003c\/i\u003e, \u003ci\u003e11\u003c\/i\u003e(10), 577.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.nature.com\/articles\/nrendo.2015.128\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani PD, Delzenne NM. (2011).The gut microbiome as therapeutic target.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ePharmacol Ther, 130\u003c\/i\u003e(2), 202-12.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.pharmthera.2011.01.012\"\u003e10.1016\/j.pharmthera.2011.01.012\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P.D., Pssemiers, S., Van de Wiele, T., Guiot, Y., Everad, A., Rottier, O…. Delzenne, N.M. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eGut\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e58\u003c\/i\u003e(8), 1091-1103. DOI:\u003ca href=\"https:\/\/doi.org\/10.1136\/gut.2008.165886\"\u003e10.1136\/gut.2008.165886\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCaprara, G. (2018). Diet and longevity: The effects of traditional eating habits on human lifespan extension. \u003ci\u003eMediterranean Journal of Nutrition and Metabolism\u003c\/i\u003e, (Preprint), 1-34. \u003ca href=\"https:\/\/content.iospress.com\/articles\/mediterranean-journal-of-nutrition-and-metabolism\/mnm180225\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCardona, F., Andrés-Lacueva, C., Tulipani, S., Tinahones, F. J., \u0026amp; Queipo-Ortuño, M. I. (2013). Benefits of polyphenols on gut microbiota and implications in human health. \u003ci\u003eThe Journal of nutritional biochemistry\u003c\/i\u003e, \u003ci\u003e24\u003c\/i\u003e(8), 1415-1422.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0955286313000946\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCarvalho, R. D., do Carmo, F. L., de Oliveira Junior, A., Langella, P., Chatel, J. M., Bermúdez-Humarán, L. G., ... \u0026amp; de Azevedo, M. S. (2017). Use of wild type or recombinant lactic acid bacteria as an alternative treatment for gastrointestinal inflammatory diseases: a focus on inflammatory bowel diseases and mucositis. \u003ci\u003eFrontiers in microbiology\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e, 800.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2017.00800\/full\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCerdó, T., García-Santos, J. A., G Bermúdez, M., \u0026amp; Campoy, C. (2019). The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e11\u003c\/i\u003e(3), 635.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/11\/3\/635\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChenoll, E., Casinos, B., Bataller, E., Astals, P., Echevarría, J., Iglesias, J. R., ... \u0026amp; Genovés, S. (2011). Novel probiotic Bifidobacterium bifidum CECT 7366 strain active against the pathogenic bacterium Helicobacter pylori. \u003ci\u003eApplied and environmental microbiology\u003c\/i\u003e, \u003ci\u003e77\u003c\/i\u003e(4), 1335-1343. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/aem.asm.org\/content\/77\/4\/1335.short\"\u003e10.1128\/AEM.0182-10\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChoudhury, T. G., \u0026amp; Kamilya, D. (2018). Paraprobiotics: an aquaculture perspective. \u003ci\u003eReviews in Aquaculture\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/raq.12290\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCianci, R., Franza, L., Schinzari, G., Rossi, E., Ianiro, G., Tortora, G., ... \u0026amp; Cammarota, G. (2019). The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer. \u003ci\u003eInternational journal of molecular sciences\u003c\/i\u003e, \u003ci\u003e20\u003c\/i\u003e(3), 501.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/1422-0067\/20\/3\/501\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCollins, S., \u0026amp; Reid, G. (2016). Distant site effects of ingested prebiotics. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(9), 523.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/8\/9\/523\/htm\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCostello, E. K., Stagaman, K., Dethlefsen, L., Bohannan, B. J., \u0026amp; Relman, D. A. (2012). 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Immunoreactive proteins of Bifidobacterium longum ssp. longum CCM 7952 and Bifidobacterium longum ssp. longum CCDM 372 Identified by gnotobiotic mono-colonized mice sera, immune rabbit sera and non-immune human sera. \u003ci\u003eFrontiers in microbiology\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e, 1537.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2016.01537\/full\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHe, X., Zeng, Q., Puthiyakunnon, S., Zeng, Z., Yang, W., Qiu, J… Cao H...(2017). 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Nutr,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e137\u003c\/i\u003e, 830–837.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/jn\/article\/137\/3\/830S\/4664774\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRoberfroid, M. B. (2002). Functional foods: concepts and application to inulin and oligofructose. \u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e, \u003ci\u003e87\u003c\/i\u003e(S2), S139-S143.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1079\/BJN\/2002529\"\u003ehttps:\/\/doi.org\/10.1079\/BJN\/2002529\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSirisinha, S. (2016). The potential impact of gut microbiota on your health: Current status and future challenges. \u003ci\u003eAsian Pac J Allergy Immunol\u003c\/i\u003e, \u003ci\u003e34\u003c\/i\u003e(4), 249-264.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/apjai-journal.org\/wp-content\/uploads\/2016\/12\/1ThepotentialimpactAPJAIVol34No4December2016P249.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eThomas, L. V., Suzuki, K., \u0026amp; Zhao, J. (2015). Probiotics: a proactive approach to health. A symposium report. \u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e, \u003ci\u003e114\u003c\/i\u003e(S1), S1-S15.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.cambridge.org\/core\/journals\/british-journal-of-nutrition\/article\/probiotics-a-proactive-approach-to-health-a-symposium-report\/C6A85D180824F61586B404FA8D45EB75\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTufarelli, V., \u0026amp; Laudadio, V. (2016). An overview on the functional food concept: prospectives and applied researches in probiotics, prebiotics and synbiotics. \u003ci\u003eJ Exp Bioland Agric Sci\u003c\/i\u003e, \u003ci\u003e4\u003c\/i\u003e(3), 273-8.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/c296\/024b076f84faf2f1b963abb5820469733c21.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTsilingiri, K., \u0026amp; Rescigno, M. (2012). Postbiotics: what else?. \u003ci\u003eBeneficial microbes\u003c\/i\u003e, \u003ci\u003e4\u003c\/i\u003e(1), 101-107.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23271068\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVitetta L., Sali A. (2008). Probiotics, prebiotics and gastrointestinal health. Med. 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Early-life host–microbiome interphase: the key frontier for immune development. \u003ci\u003eFrontiers in pediatrics\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e, 111. DOI:\u003ca href=\"https:\/\/doi.org\/10.3389\/fped.2017.00111\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.3389\/fped.2017.00111\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBlanton, L. V., Barratt, M. J., Charbonneau, M. R., Ahmed, T., \u0026amp; Gordon, J. I. (2016). Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics. \u003ci\u003eScience\u003c\/i\u003e, \u003ci\u003e352\u003c\/i\u003e(6293), 1533-1533. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/science.sciencemag.org\/content\/352\/6293\/1533\"\u003e10.1126\/science.aad9359\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCox, M. J., Huang, Y. J., Fujimura, K. E., Liu, J. T., McKean, M., Boushey, H. A., ... \u0026amp; Lynch, S. V. (2010). 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Probiotics for the prevention of pediatric antibiotic‐associated diarrhea.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eThe Cochrane Library\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/14651858.CD004827.pub4\/full\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHodzic, Z., Bolock, A. M., \u0026amp; Good, M. (2017). The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis. \u003ci\u003eFrontiers in pediatrics\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e, 40.\u003ca href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2017.00040\/full\"\u003e\u003ci\u003eArticle\u003c\/i\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHayes, S. R., \u0026amp; Vargas, A. J. (2016). Probiotics for the Prevention of Pediatric Antibiotic-Associated Diarrhea.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eExplore: The Journal of Science and Healing\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e12\u003c\/i\u003e(6), 463-466.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.explore.2016.08.015\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.explore.2016.08.015\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKang, D. W., Ilhan, Z. E., Isern, N. G., Hoyt, D. W., Howsmon, D. P., Shaffer, M., ... \u0026amp; Krajmalnik-Brown, R. (2018). Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders. \u003ci\u003eAnaerobe\u003c\/i\u003e, \u003ci\u003e49\u003c\/i\u003e, 121-131.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1075996417302305\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePatel, R.M., \u0026amp; Denning, P.W. (2013). Therapeutic use of prebiotics, probiotics, and postbiotics to prevent necrotizing enterocolitis: What is the current evidence?\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eClin Perinatol, 40\u003c\/i\u003e(1), 11-25.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3575601\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShankar, V., Gouda, M., Moncivaiz, J., Gordon, A., Reo, N. V., Hussein, L., \u0026amp; Paliy, O. (2017). Differences in gut metabolites and microbial composition and functions between Egyptian and US children are consistent with their diets. \u003ci\u003eMsystems\u003c\/i\u003e, \u003ci\u003e2\u003c\/i\u003e(1), e00169-16.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/msystems.asm.org\/content\/msys\/2\/1\/e00169-16.full.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSubramanian, S., Huq, S., Yatsunenko, T., Haque, R., Mahfuz, M., Alam, M. A., ... \u0026amp; Barratt, M. J. (2014). Persistent gut microbiota immaturity in malnourished Bangladeshi children. \u003ci\u003eNature\u003c\/i\u003e, \u003ci\u003e510\u003c\/i\u003e(7505), 417.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.nature.com\/articles\/nature13421\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"dx-doi\"\u003eWegh, C. A., Schoterman, M. H., Vaughan, E. E., Belzer, C., \u0026amp; Benninga, M. A. (2017). The effect of fiber and prebiotics on children’s gastrointestinal disorders and microbiome. \u003ci\u003eExpert review of gastroenterology \u0026amp; hepatology\u003c\/i\u003e, \u003ci\u003e11\u003c\/i\u003e(11), 1031-1045.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/17474124.2017.1359539\"\u003ehttps:\/\/doi.org\/10.1080\/17474124.2017.1359539\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"dx-doi\"\u003eZhang, M., Ma, W., Zhang, J., He, Y., \u0026amp; Wang, J. (2018). Analysis of gut microbiota profiles and microbe-disease associations in children with autism spectrum disorders in China. \u003ci\u003eScientific reports\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(1), 13981.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.nature.com\/articles\/s41598-018-32219-2\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eMetabolic Support: Cardiovascular, Diabetes, Cancer, and Weight\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P.D., Pssemiers, S., Van de Wiele, T., Guiot, Y., Everad, A., Rottier, O…. Delzenne, N.M. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eGut\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e58\u003c\/i\u003e(8), 1091-1103. 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The role of the gut microbiota in energy metabolism and metabolic disease. \u003ci\u003eCurrent pharmaceutical design\u003c\/i\u003e, \u003ci\u003e15\u003c\/i\u003e(13), 1546-1558.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/s3.amazonaws.com\/academia.edu.documents\/37821655\/0009B.pdf?AWSAccessKeyId=AKIAIWOWYYGZ2Y53UL3A\u0026amp;Expires=1553625551\u0026amp;Signature=irilDNOVKxL13VYPmTXDeXs2qr4%3D\u0026amp;response-content-disposition=inline%3B%20filename%3DThe_Role_of_the_Gut_Microbiota_in_Energy.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., \u0026amp; Burcelin, R. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet–induced obesity and diabetes in mice. \u003ci\u003eDiabetes\u003c\/i\u003e, \u003ci\u003e57\u003c\/i\u003e(6), 1470-1481.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/diabetes.diabetesjournals.org\/content\/diabetes\/57\/6\/1470.full.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., ... \u0026amp; Waget, A. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. \u003ci\u003eDiabetes\u003c\/i\u003e, \u003ci\u003e56\u003c\/i\u003e(7), 1761-1772.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/diabetes.diabetesjournals.org\/content\/diabetes\/56\/7\/1761.full.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R. G., Tuohy, K. M., ... \u0026amp; Delzenne, N. M. (2007). Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. \u003ci\u003eDiabetologia\u003c\/i\u003e, \u003ci\u003e50\u003c\/i\u003e(11), 2374-2383.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00125-007-0791-0?__hstc=209342221.cad23cdf89637a97c833078f3dec9d96.1462492800047.1462492800048.1462492800049.1\u0026amp;__hssc=209342221.1.1462492800050\u0026amp;__hsfp=1314462730\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDruat, C., Alligier, M., Salazar, N., Neyrinck, A.M., \u0026amp; Delzenne, N.M. (2014). Modulation of the gut microbiota by nutrients with prebiotic and probiotic properties.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eAdv Nur, 5\u003c\/i\u003e(5), 624S-633S. 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Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish. \u003ci\u003eScientific reports\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(1), 5512.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.nature.com\/articles\/s41598-017-05147-w\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFrazier, T. H., DiBaise, J. K., \u0026amp; McClain, C. J. (2011). Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. \u003ci\u003eJournal of Parenteral and Enteral Nutrition\u003c\/i\u003e, \u003ci\u003e35\u003c\/i\u003e(5_suppl), 14S-20S.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.immuron.com.au\/assets\/files\/Gut-microbiome-and-NASH.PDF\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHan, J. L., \u0026amp; Lin, H. L. (2014). Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective. \u003ci\u003eWorld journal of gastroenterology: WJG\u003c\/i\u003e, \u003ci\u003e20\u003c\/i\u003e(47), 17737.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4273124\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKorkmaz, O. A., Sadi, G., Kocabas, A., Yildirim, O. G., Sumlu, E., Koca, H. B., ... \u0026amp; Bilgehan, M. Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Goekhan_Sadi\/publication\/331348421_Lactobacillus_helveticus_and_Lactobacillus_plantarum_modulate_renal_antioxidant_status_in_a_rat_model_of_fructose-induced_metabolic_syndrome\/links\/5c7932ba299bf1268d2f7c5d\/Lactobacillus-helveticus-and-Lactobacillus-plantarum-modulate-renal-antioxidant-status-in-a-rat-model-of-fructose-induced-metabolic-syndrome.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMacfarlane, S., Cleary, S., Bahrami, B., Reynolds, N., \u0026amp; Macfarlane, G. T. (2013). Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double‐blind, placebo‐controlled crossover study. \u003ci\u003eAlimentary pharmacology \u0026amp; therapeutics\u003c\/i\u003e, \u003ci\u003e38\u003c\/i\u003e(7), 804-816.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12453\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMarques, F. Z., Mackay, C. R., \u0026amp; Kaye, D. M. (2018). Beyond gut feelings: how the gut microbiota regulates blood pressure. \u003ci\u003eNature Reviews Cardiology\u003c\/i\u003e, \u003ci\u003e15\u003c\/i\u003e(1), 20.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.nature.com\/articles\/nrcardio.2017.120\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eQin, Y., Roberts, J. D., Grimm, S. A., Lih, F. B., Deterding, L. J., Li, R., ... \u0026amp; Wade, P. A. (2018). An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression. \u003ci\u003eGenome biology\u003c\/i\u003e, \u003ci\u003e19\u003c\/i\u003e(1), 7.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/s13059-018-1389-1\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRoberfroid, M., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R., Rowland, I., ... \u0026amp; Guarner, F. (2010). Prebiotic effects: metabolic and health benefits. \u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e, \u003ci\u003e104\u003c\/i\u003e(S2), S1-S63.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.cambridge.org\/core\/journals\/british-journal-of-nutrition\/article\/prebiotic-effects-metabolic-and-health-benefits\/F644C98393E2B3EB64A562854115D368\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSerino, M., Blasco-Baque, V., Nicolas, S., \u0026amp; Burcelin, R. (2014). Managing the manager: gut microbes, stem cells and metabolism. \u003ci\u003eDiabetes \u0026amp; metabolism\u003c\/i\u003e, \u003ci\u003e40\u003c\/i\u003e(3), 186-190.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1262363613002346\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYan Q, Li X, Feng B. (2015). The efficacy and safety of probiotics intervention in preventing conversion of impaired glucose tolerance to diabetes: study protocol for a randomized, double-blinded, placebo controlled trial of the Probiotics Prevention Diabetes Programme (PPDP).\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBMC Endocr Discord\u003c\/em\u003e; 15(1): 74.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-015-0071-9\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eCardiovascular and Fatty Liver Support\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eÁlvarez-Mercado, A. I., Navarro-Oliveros, M., Robles-Sánchez, C., Plaza-Díaz, J., Sáez-Lara, M. J., Muñoz-Quezada, S., ... \u0026amp; Abadía-Molina, F. (2019). Microbial Population Changes and Their Relationship with Human Health and Disease. \u003ci\u003eMicroorganisms\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(3), 68.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2076-2607\/7\/3\/68\/htm\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDelzenne, N. M., Knudsen, C., Beaumont, M., Rodriguez, J., Neyrinck, A. M., \u0026amp; Bindels, L. B. (2019). Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut–liver axis. \u003ci\u003eProceedings of the Nutrition Society\u003c\/i\u003e, 1-10.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.cambridge.org\/core\/journals\/proceedings-of-the-nutrition-society\/article\/contribution-of-the-gut-microbiota-to-the-regulation-of-host-metabolism-and-energy-balance-a-focus-on-the-gutliver-axis\/9C58A0E320AB35547FE219EDF19F9AE6\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFernandes, R., do Rosario, V. A., Mocellin, M. C., Kuntz, M. G., \u0026amp; Trindade, E. B. (2017). Effects of inulin-type fructans, galacto-oligosaccharides and related synbiotics on inflammatory markers in adult patients with overweight or obesity: A systematic review. \u003ci\u003eClinical Nutrition\u003c\/i\u003e, \u003ci\u003e36\u003c\/i\u003e(5), 1197-1206.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0261561416312754\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eIacono, A., Raso, G. M., Canani, R. B., Calignano, A., \u0026amp; Meli, R. (2011). Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms. \u003ci\u003eThe Journal of nutritional biochemistry\u003c\/i\u003e, \u003ci\u003e22\u003c\/i\u003e(8), 699-711.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0955286310002408\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJohnson-Henry et al. (2008). Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli 0157:H7- Induced changes in epithelial barrier function. Infect Immun; 76:1340-1348.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/iai.asm.org\/content\/76\/4\/1340.short\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLee et al. (2006). Human originated bacteria,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eLactobacillus rhamnosus\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003ePL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBiochim Biophys Acta\u003c\/em\u003e; 1761: 736-744.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/eanimal.snu.ac.kr\/Aboutus\/paper\/papers\/bbalip.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSafari, Z., \u0026amp; Gérard, P. (2019). The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD). \u003ci\u003eCellular and Molecular Life Sciences\u003c\/i\u003e, 1-18.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00018-019-03011-w\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShalitin, S., Battelino, T., \u0026amp; Moreno, L. A. (2019). Obesity, Metabolic Syndrome and Nutrition. \u003ci\u003eNutrition and Growth: Yearbook 2019\u003c\/i\u003e, \u003ci\u003e119\u003c\/i\u003e, 13-42. \u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=Y-OGDwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PT23\u0026amp;dq=+meta-analysis+of+the+prebiotics+and+synbiotics+effects+on+glycaemia,+insulin+concentrations+and+lipid+parameters+in+adult+patients+with+overweight+or+obesity.\u0026amp;ots=yJ9bP-ZUDn\u0026amp;sig=GtbpOFXdGAGvm9drVMb4rQHclPc#v=onepage\u0026amp;q\u0026amp;f=false\"\u003eChapter\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWang et al. (2009). Effects of\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eLactobacillus plantarum\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eMA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet. Appl Microbiol Biotechnol; 84: 341-347.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00253-009-2012-x\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYadav et al. (2007). Antidiabetic effect of probiotic dahl containing\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eLactobacillus acidophilus\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eLactobacillus casei\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003ein high fructose fed rats.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrition\u003c\/em\u003e; 23: 62-68.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Hariom_Yadav2\/publication\/6711708_Antidiabetic_effect_of_probiotic_dahi_containing_Lactobacillus_acidophilus_and_Lactobacillus_casei_in_high_fructose_fed_rats\/links\/5b22d73faca272277faf9632\/Antidiabetic-effect-of-probiotic-dahi-containing-Lactobacillus-acidophilus-and-Lactobacillus-casei-in-high-fructose-fed-rats.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYari, Z., \u0026amp; Hekmatdoost, A. (2019). Dietary Interventions in Fatty Liver. In \u003ci\u003eDietary Interventions in Gastrointestinal Diseases\u003c\/i\u003e (pp. 245-255). Academic Press.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B978012814468800020X\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eThe Microbiome \u0026amp; Support During Cancer\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAlexander, J. L., Kohoutova, D., \u0026amp; Powell, N. (2019). Science in Focus: The Microbiome and Cancer Therapy. \u003ci\u003eClinical Oncology\u003c\/i\u003e, \u003ci\u003e31\u003c\/i\u003e(1), 1-4.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.clinicaloncologyonline.net\/article\/S0936-6555(18)30440-0\/abstract\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eArora, M., Baldi, A., Kapila, N., Bhandari, S., \u0026amp; Jeet, K. (2019). Impact of Probiotics and Prebiotics on Colon Cancer: Mechanistic Insights and Future Approaches. \u003ci\u003eCurrent Cancer Therapy Reviews\u003c\/i\u003e, \u003ci\u003e15\u003c\/i\u003e(1), 27-36.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ingentaconnect.com\/contentone\/ben\/cctr\/2019\/00000015\/00000001\/art00005\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBanerjee, S., \u0026amp; Robertson, E. S. (2019). Future Perspectives: Microbiome, Cancer and Therapeutic Promise. In \u003ci\u003eMicrobiome and Cancer\u003c\/i\u003e (pp. 363-389). Humana Press, Cham.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-030-04155-7_17\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBelcheva, A., Irrazabal, T., \u0026amp; Martin, A. (2015). Gut microbial metabolism and colon cancer: can manipulations of the microbiota be useful in the management of gastrointestinal health?. \u003ci\u003eBioessays\u003c\/i\u003e, \u003ci\u003e37\u003c\/i\u003e(4), 403-412.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/bies.201400204\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBuford, T. W. (2017). (Dis) Trust your gut: the gut microbiome in age-related inflammation, health, and disease. \u003ci\u003eMicrobiome\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e(1), 80.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/microbiomejournal.biomedcentral.com\/articles\/10.1186\/s40168-017-0296-0\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChen, B., Du, G., Guo, J., \u0026amp; Zhang, Y. (2019). Bugs, drugs, and cancer: can the microbiome be a potential therapeutic target for cancer management?. \u003ci\u003eDrug discovery today\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Md_Khan68\/publication\/331574670_The_microbiome_cancer_and_cancer_therapy\/links\/5c83e38e299bf1268d4b3269\/The-microbiome-cancer-and-cancer-therapy.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDe Almeida, C. V., de Camargo, M. R., Russo, E., \u0026amp; Amedei, A. (2019). Role of diet and gut microbiota on colorectal cancer immunomodulation. \u003ci\u003eWorld journal of gastroenterology, 25\u003c\/i\u003e(2), 151. \u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6337022\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDewar, M., Izawa, J., Li, F., Chanyi, R. M., Reid, G., \u0026amp; Burton, J. P. (2018). Microbiome.In\u003ci\u003e \u003c\/i\u003e\u003ci\u003eBladder Cancer\u003c\/i\u003e\u003ci\u003e \u003c\/i\u003e(pp. 615-628). Academic Press.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128099391000321\"\u003eChapter32\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDrago, L. (2019). Probiotics and Colon Cancer. \u003ci\u003eMicroorganisms\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(3), 66.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2076-2607\/7\/3\/66\/htm\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFemia, A. P., Luceri, C., Dolara, P., Giannini, A., Biggeri, A., Salvadori, M., ... \u0026amp; Caderni, G. (2002). Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. \u003ci\u003eCarcinogenesis\u003c\/i\u003e, \u003ci\u003e23\u003c\/i\u003e(11), 1953-1960.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/carcin\/article\/23\/11\/1953\/2608318\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHan, C. Dai, Y.Q., Hua, Z-C., Fu, G.F., Yin, Y., Hu, B., \u0026amp; Xu, G.X. (2019). Bifidobacterium as a delivery system of functional genes for cancer therapy. In A.M. Chakrabarty \u0026amp; A.M. Fialho (Eds.),\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eMicrobial infections and cancer therapy\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e(pp. 1-32). Singapore: Pan Stanford Publishing Pte. Ltd.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=CTyIDwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PA1\u0026amp;dq=Antitumorigenic+activity+of+the+prebiotic+inulin+enriched+with+oligofructose+in+combination+with+the+probiotics+Lactobacillus+rhamnosus+and+Bifidobacterium+lactis+on+azoxymethane-induced+colon+carcinogenesis+in+rats\u0026amp;ots=fqb00ow2O5\u0026amp;sig=f1qVQTikKtRRINm3R0tytETixIA#v=onepage\u0026amp;q=Antitumorigenic%20activity%20of%20the%20prebiotic%20inulin%20enriched%20with%20oligofructose%20in%20combination%20with%20the%20probiotics%20Lactobacillus%20rhamnosus%20and%20Bifidobacterium%20lactis%20on%20azoxymethane-induced%20colon%20carcin\"\u003eChapter1\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHelmink, B. A., Khan, M. W., Hermann, A., Gopalakrishnan, V., \u0026amp; Wargo, J. A. (2019). The microbiome, cancer, and cancer therapy. \u003ci\u003eNature medicine\u003c\/i\u003e, 1.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Md_Khan68\/publication\/331574670_The_microbiome_cancer_and_cancer_therapy\/links\/5c83e38e299bf1268d4b3269\/The-microbiome-cancer-and-cancer-therapy.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHibberd, A. A., Lyra, A., Ouwehand, A. C., Rolny, P., Lindegren, H., Cedgård, L., \u0026amp; Wettergren, Y. (2017). Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention. \u003ci\u003eBMJ open gastroenterology\u003c\/i\u003e, \u003ci\u003e4\u003c\/i\u003e(1), e000145.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/bmjopengastro.bmj.com\/content\/4\/1\/e000145?utm_campaign=bmjog\u0026amp;utm_term=1-A\u0026amp;utm_medium=cpc\u0026amp;utm_source=trendmd\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLi, W., Deng, Y., Chu, Q., \u0026amp; Zhang, P. (2019). Gut microbiome and cancer immunotherapy. \u003ci\u003eCancer letters\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0304383519300278\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLiong, M. T. (2008). Roles of probiotics and prebiotics in colon cancer prevention: postulated mechanisms and in-vivo evidence. \u003ci\u003eInternational journal of molecular sciences\u003c\/i\u003e, \u003ci\u003e9\u003c\/i\u003e(5), 854-863.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/1422-0067\/9\/5\/854\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMazraeh, R., Azizi-Soleiman, F., Jazayeri, S. M. H. M., \u0026amp; Noori, S. M. A. (2019). Effect of inulin-type fructans in patients undergoing cancer treatments: A systematic review. \u003ci\u003ePakistan Journal of Medical Sciences\u003c\/i\u003e, \u003ci\u003e35\u003c\/i\u003e(2).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/pjms.org.pk\/index.php\/pjms\/article\/view\/701\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNicoletti, A., Pompili, M., Gasbarrini, A., \u0026amp; Ponziani, F. R. (2019). Going with the gut: probiotics as a novel therapy for hepatocellular carcinoma. \u003ci\u003eHepatobiliary Surgery and Nutrition\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/hbsn.amegroups.com\/article\/viewFile\/23774\/22620\"\u003eEditorial\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRaza, M. H., Gul, K., Arshad, A., Riaz, N., Waheed, U., Rauf, A., ... \u0026amp; Arshad, M. (2019). Microbiota in cancer development and treatment. \u003ci\u003eJournal of cancer research and clinical oncology\u003c\/i\u003e, \u003ci\u003e145\u003c\/i\u003e(1), 49-63.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00432-018-2816-0\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSharma, A. (2019). Importance of Probiotics in Cancer Prevention and Treatment. In \u003ci\u003eRecent Developments in Applied Microbiology and Biochemistry\u003c\/i\u003e (pp. 33-45). Academic Press.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128163283000040\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSethi, V., Vitiello,\u003c\/p\u003e\n\u003ch6\u003eIngredients\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eBioImmersion Probiotic Master Blend\u003c\/b\u003e – \u003cb\u003eProbiotics\u003c\/b\u003e- \u003ci\u003eBifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus and streptococcus thermophilus\u003c\/i\u003e; \u003cb\u003ePrebiotic\u003c\/b\u003e- Inulin from chicory Root; \u003cb\u003eSupernatant\u003c\/b\u003e- probiotic metabolites, and \u003cb\u003eORNs\u003c\/b\u003e. 15 billion CFU.\u003c\/p\u003e\n\u003cp\u003eCapsule- Cellulose \u0026amp; Water\u003c\/p\u003e\n\u003ch6\u003eSuggested Use\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eSUPERNATANT\u003c\/b\u003e— The supernatant is designed to address hospital generated infections.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eHospital generated infections\u003c\/i\u003e: Take 2-4 during a hospital stay, or if infected with organisms such as C. difficile (causing diarrhea). It is used to address salmonella, food poisoning, yeast overgrowth, etc. It is also supportive with colitis, diverticulitis, and Crohn’s disease.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eColds and flu\u003c\/i\u003e: Take 1-2 capsules a day. Add 1 teaspoon of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eLact ORNs\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eand dissolve in mouth. Add 1-2 capsules of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eGarlic\u003c\/b\u003e.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eASD (autistic spectrum disorder)\u003c\/i\u003e: many health care providers find the Supernatant is well tolerated by children with ASD. If 1 capsule is too much, open up the capsule and mix half the amount of the powder with water.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eAn everyday probiotic\u003c\/i\u003e: Due to its strong protection and ability colonize and compete against pathogens, the Supernatant is an excellent choice for everyday probiotic. Take 1-2 daily as maintenance.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOur Favorite\u003c\/i\u003e: The Supernatant is such an advanced probiotic product. Our CEO, Seann Bardell, considers it his most favorite product, alongside the\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eGarlic\u003c\/b\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ePhyto Power\u003c\/b\u003e,and\u003cb\u003e\u003cspan\u003e \u003c\/span\u003eFructo Borate\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp\u003eAs a probiotic mix it helps even the most sensitive people!*\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712314212396,"sku":"TF018","price":69.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Supernatant-Synbiotic---Front.jpg?v=1723214756"},{"product_id":"photo-power","title":"Phyto Power","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003ePhyto Power is formulated to support DNA and cellular integrity.\u003c\/p\u003e\n\u003cp\u003eA wildcrafted wonder from remote, pure, and fertile regions of Alaska, Phyto Power is filled with biologically high actives, creating a phenolic powerhouse.\u003c\/p\u003e\n\u003cp\u003eBlueberries, rose hip, and dandelion are shown in research to help maintain cellular integrity, suppressing or interfering with oncogenic transformation, bolstering antioxidant and anti-inflammatory defenses, and contributing significant re-generative health benefits.*\u003c\/p\u003e\n\u003cp\u003eSee the Research tab below for just a small fraction of the exciting science on Blueberry, Rose hip, and Dandelion.\u003c\/p\u003e\n\u003cp\u003ePhyto Power is wildcrafted, Vegan, Kosher, Non GMO, and Gluten Free.\u003c\/p\u003e\n\u003ch6\u003eDescription \u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003ePhyto Power\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eis comprised of several species of wildcrafted blueberries, Rose hip, and Dandelion, including their leaves, stems, roots, and flowers. Growing wild and strong in remote areas of Alaska, these berries and plants are handpicked at the peak of their phytonutrient potential. For centuries, indigenous tribes of Alaskan Natives have used these power-filled berries and plants for their daily nourishment as well as ceremonial and medicinal purposes.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003eThree species of Rosehip, wildcrafted, whole fruit and seeds (100% w\/w), refractory dried, three Rosa species, 200mg per capsule.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eFour species of Dandelion, wildcrafted, aerial parts (90% w\/w), root (10% w\/w) with flower, refractory dried, four Taraxacum species, 200mg per capsule.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eFour species of Blueberry, wildcrafted, fruit (\u0026gt;90% w\/w), leaves and stem (\u0026lt;5% w\/w), refractory dried, four Vaccinium species, 100mg per capsule.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAlaskan wildcrafted berries and plants supply ample antioxidants, anti-inflammatory, and anti-microbial factors shown to promote and maintain a healthy functioning body (Grace et al., 2014; Youself et al., 2013).*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003ePhyto Power\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eis indeed powerful. In fact, Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.*\u003c\/p\u003e\n\u003cp\u003eThe Alaskan red Rose hip fruit and seeds, blue-purple blueberries, with twigs and leaves, and the Dandelion’s green leaves, stems, roots, and yellow flowers are filled with potent phytonutrients. These vibrant and nutritious phytochemicals protect and enhance the health of both plants and humans (Joseph, Nadeau, \u0026amp; Underwood, 2003). James Duke’s (2000) substantial USDA phytochemical database illustrates the mechanism of the world of plants in the support and maintenance of our health (p. 2).*\u003c\/p\u003e\n\u003cp\u003eScientific evidence links the lack of sufficient nutrients and colorful phytochemicals in our daily diets to the rise of chronic inflammation, one of the causes of metabolic syndrome, which includes cardiovascular, type 2 diabetes, as well as various cancers (Joseph, 2003; Ridker et al., 2000, 2003; Kristo et al., 2016; Ovadje et al., 2016; respectively). For this reason, García-Lafuente et al. (2009) conclude that flavonoids from berries and plants behave as\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eanti-inflammatory\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eagents\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003ein our body, calling for more research on the implication of these effects as protection against cancer and cardiovascular issues.*\u003c\/p\u003e\n\u003cp\u003eThe effects of Blueberries, Rose hip, and Dandelion on Metabolic Syndrome risk markers are well documented and researched (Choi et al., 2010; Basu et al., 2012). For example, Andersson et al. (2011) demonstrated in a randomized, double-blind, crossover study with 31 obese individuals that daily consumption of rose hip (drink) significantly decreased plasma cholesterol and systolic blood pressure, effecting the risk markers of type 2 diabetes and cardiovascular disease. Andersson et al. (2012) conducted a study with lean and obese mice that were fed high-fat diet and a dietary supplement of rose hip powder. The supplement of rose hip prevented and reversed the increase in body weight. Andersson et al. (2012) concluded that rose hip supports the prevention of diabetic state in the mouse and that downregulation of the hepatic lipogenic program is one of the mechanisms underlying this antidiabetic effect.*\u003c\/p\u003e\n\u003cp\u003eChoi et al. (2010) demonstrated that supplementing rabbits that are fed with high cholesterol diets with dandelion leaf and root positively changed plasma antioxidant enzyme activities and lipid profiles, offering “hypolipidemic and antioxidant effects.”*\u003c\/p\u003e\n\u003cp\u003eThese research findings are not new amongst scientists. Johnson et al. (1994) discovered that plants and their biologically active constituents contribute protective and anti-carcinogenic effects (Table 1, p. 193). These ‘dietary phytoprotectants’ in foods (p. 194) have continually shown in research to impart an important anti-inflammatory effect (Vendrame et al., 2015; Joseph et al., 2014), act as powerful anti-oxidants (Jedrejek et al.,2017;Skrovankova et al., 2015), and offer protection and inhibition of certain cancers (Zhan et al., 2016; Yang \u0026amp; Li, 2015; Li et al., 2009; Seeram, 2008; Sigstedt et al., 2008).*\u003c\/p\u003e\n\u003cp\u003eAlthough the exact mechanisms and reasons (the why) of these promising effects are still in the process of discovery, the findings suggest a regular habit of dietary supplementation with these plants and berries.*\u003c\/p\u003e\n\u003cp\u003eBlueberries, Rose hip, and Dandelion demonstrate in research a potential effect on different cancers. For example, blueberries are shown to inhibit growth and metastatic potential (Adams et al., 2010; Liu et al., 2013), and manage gastrointestinal tract cancers (Bishayee et al., 2016). Rose hip has shown to effect human brain cell proliferation (Cagle et al., 2012) and offer antiproliferation effect on Caco-2 human colon cancer (Jiménez et al., 2016). Dandelion was found to induce apoptosis in drug-resistant human melanoma cells (Chatterjee et al., 2011; see also Jeon et al., 2008 and Hu et al., 2003 for further reading on dandelion).*\u003c\/p\u003e\n\u003cp\u003eThe Rose hip has a rich phytochemical profile shown to also support many different mechanisms in the human body. For example, the red berry of Rose hip is known for its antioxidant protection (Widen et al., 2012), supporting weight loss with a potential mechanism that decreases abdominal visceral fat (Nagatomo et al., 2015). Andersson et al. (2011) examined the Rose hip anti-diabetic effect, as well as the effect of Rose hip on the risk markers of type 2 diabetes and cardiovascular disease in obese persons (Andersson et al., 2012). Rose hip is also found to support the liver (Nagatomo et al., 2013; Sadeghi et al., 2016), and offer relief from joint pain (Christensen et al., 2008; Willich et al., 2010; Winther et al., 2005).*\u003c\/p\u003e\n\u003cp\u003eFor further study of the Rosa canina see Chrubasik et al. for a systemic review and clinical efficacy of the Rose hip (2008; 2006, respectively).*\u003c\/p\u003e\n\u003cp\u003eDandelion is shown to have a great antioxidant activity (Hu et al., 2003), exhibiting diverse biological activities that promote energy, weight loss, and reduced risk of metabolic syndrome (Jedrejek et al., 2017; González-Castejón et al., 2012; Jeon et al., 2008). Ovadje et al. (2016) conclude that dandelion root extract effects colorectal cancer proliferation which may occur through the activation of ‘multiple death signalling pathways,’ and a selective induction of apoptosis and autophagy in human pancreatic cancer cells (2012; 2012a). Signstedt (2008) found similar results with extract of Taraxacum officinale (common dandelion) on the growth and invasion of breast and prostate cancer cells, while Yang et al. (2015) demonstrated that Dandelion extract protects human skin fibroblasts from uvb damage.*\u003c\/p\u003e\n\u003cp\u003eFor further study of the Taraxacum (Dandelion), see Schütz, Carle, \u0026amp; Schieber (2006) for a systemic review on its phytochemical and pharmacological profile.*\u003c\/p\u003e\n\u003cp\u003eBlueberries are rich with anthocyanins and a wide variety of phytochemicals that have been shown to effect neuro-generation (Albarracin et al., 2012). Studies demonstrate that a neuro-generative effect also supports those with Parkinson (Chao et al., 2012; Gao et al., 2012; Strathearn et al., 2014). Blueberries regenerate neuronal aging (Shukitt-Hale, 2012), and support memory (Krikorian et al., 2010). For more on nerve regeneration, see the Research tab of\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eBlueberry Extract\u003c\/strong\u003e\u003c\/em\u003e.*\u003c\/p\u003e\n\u003cp\u003eA daily consumption of blueberries is shown in research to support a lower blood pressure and arterial stiffness (Johnson et al., 2015), increase natural killer cell counts (McAnulty et al., 2014), down-regulate hepatic lipogentic program (Andersson et al., 2011), and impact insulin resistance and glucose intolerance (Stull, 2016). Zhan et al. (2016) discovered the importance of blueberries on the migration, invasion, proliferation of hepatocellular carcinoma cells. Yang et al. has shown in 2001 the inhibition of carcinogenesis by dietary polyphenolic compounds.*\u003c\/p\u003e\n\u003cp\u003eThese impressive findings support dietary supplementation with berries as a healthy approach to various Metabolic Syndrome concerns, including cancer (Vendrame et al., 2015; Seeram, N.P., 2008; Seeram et al., 2006, respectively).*\u003c\/p\u003e\n\u003cp\u003eThe hormetic mechanism of phyto-nutrients is an exciting area of research. Scientists have discovered that small amounts of phytochemicals offer much more than nutrients. Phytochemicals offer a hormetic mechanism; a stimulation of many pathways in our body that prevents, repairs, or reverses aging and disease (Lee et al., 2014; Davinelli et al., 2012). The concept of hormesis is defined as an adoptive response of cells and organism to low dosages of phytochemicals. This adoptive response stimulates a beneficial effect in the body (Mattson, 2008, 2008a). Calabrese et al. conducted many studies on hormetic phytochemicals and vitagenes in aging and longevity, including the effect of antioxidants such as polyphenols on neuro-generation (2012, 2011, 2009). The vitagene network of genes involved in the process of repair and maintenance is thought of as the longevity assurance processes (Rattan, 1998; see also Cornelius et al., 2013; Calabrese et al., 2010; Rattan, 2010; 2004).*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003ePhyto Power\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eas a dietary supplement offers a regular serving of several species of Blueberries, Rose hip, and Dandelion, including the leaves, stems, flower, and root.\u003c\/p\u003e\n\u003cp\u003eSee the Research tab for additional bibliography to further understand the research, findings, application and use of Blueberries, Rose hip, and Dandelion. Visit Resources on the tool bar to find helpful protocols (Library) and summaries (News).*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA double blind, crossover study: in a double blind study the participants and those in contract with them (assistants) are blind to the details of the study. A crossover is when at one point in the study the participants switch from taking an active substance (such as rose hip in the Andersson study) to a placebo or vice versa.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cstrong\u003eREFERENCES\u003c\/strong\u003e\u003c\/h5\u003e\n\u003cp\u003eAdams, L.S., Phung, S. Yee, N., Sheeram, N.P., Li, L., \u0026amp; Chen, S. (2010).Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCancer Res, 70\u003c\/em\u003e(9), 3594-605.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1158\/0008-5472.CAN-09-3565\"\u003e10.1158\/0008-5472.CAN-09-3565\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAlbarracin, S.L., Stab, B., Casas, Z., Sutachan, J.J., Samudio, I., Gonzalez, J….Barreto, G.E. (2012). Effects of natural antioxidants in neurodegenerative disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Neurosci,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e15\u003c\/em\u003e, 1–9. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1179\/1476830511Y.0000000028\"\u003e10.1179\/1476830511Y.0000000028\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAndersson, U., Berger, K., Hogberg, A., Landin-Olsson, M., \u0026amp; Holm, C. (2012). Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr, 66, 585–590. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1038\/ejcn.2011.203\"\u003e10.1038\/ejcn.2011.203\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAndersson, U., Henriksson, E., Strom, K., Alenfall, J., Goransson, O., Holm, C. (2011). Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program. Am J Physiol Endocrinol Metab, 300, E111–121. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1152\/ajpendo.00268.2010\"\u003e10.1152\/ajpendo.00268.2010\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBasu, A., \u0026amp; Lyons, T.J. (2012). Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives.\u003cem\u003eJ Agric Food Chem\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e60\u003c\/em\u003e: 5687-92. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf203488k\"\u003e10.1021\/jf203488k\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBishayee, A., Haskell, Y., Do, C., Siveen, K.S., Mohandas, N., Sethi, \u0026amp; G., Stoner, G.D. (2016). Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCrit Rev Food Sci Nutr, 56\u003c\/em\u003e(10), 1753-75. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/10408398.2014.982243\"\u003e10.1080\/10408398.2014.982243\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCagle, P., Idassi, O., Carpenter, J., Minor, R., Goktepe, I., \u0026amp; Martin, P. (2012). Effect of Rosehip (\u003cem\u003eRosa canina\u003c\/em\u003e) extracts on human brain tumor cell proliferation and apoptosis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of Cancer Therapy\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e3\u003c\/em\u003e(5), 13. .\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=23446\"\u003eDOI:10.4236\/jct.2012.35069\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCalabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Iavicoli, I., Di Paola, R., Koverech, A. … Calabrese, E.J. (2012).Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBiochim Biophys Acta, 1822\u003c\/em\u003e(5), 753-83\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.bbadis.2011.11.002\"\u003e10.1016\/j.bbadis.2011.11.002\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCalabrese, V., Cornelius, C., Cuzzocrea, S., Iavicoli, I., Rizzarell,i E., Calabrese, E.J. (2011). Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMol Aspects Med, 32\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(4-6):279-304. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.mam.2011.10.007\"\u003e10.1016\/j.mam.2011.10.007\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCalabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Calabrese, E.J., Mattson, M.P. (2010). Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAntioxid Redox Signal, 13\u003c\/em\u003e(11), 1763-811. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.1089\/ars.2009.3074\"\u003e10.1089\/ars.2009.3074\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCalabrese, V., Cornelius, C., Mancuso, C., Barone, E., Calafato, S., Bates, T., Rizzarelli, E., Kostova, A.T. (2009). Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases.\u003cem\u003eFront Biosci, 14\u003c\/em\u003e, 376-397.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19273073\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChao, J., Leung, Y., Wang, M., \u0026amp; Chang, R.C. (2012). Nutraceuticals and their preventive or potential therapeutic value in Parkinson’s disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Rev,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e70\u003c\/em\u003e, 373–86. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1111\/j.1753-4887.2012.00484.x\"\u003e10.1111\/j.1753-4887.2012.00484.x\u003cspan\u003e \u003c\/span\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eChatterjee, S.J., Ovadje, P. Mousa, M., Hamm, C., \u0026amp; Pandey, S. (2011). The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEvid Based Complement Alternat Med, 129045\u003c\/em\u003e.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1155\/2011\/129045\"\u003e10.1155\/2011\/129045\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChoi, U.K., Lee, O.H., Yim, J.H., Ch,o C.W., Rhee, Y.K., Lim, S.I., \u0026amp; Kim, Y.C. (2010). Hypolipidemic and Antioxidant Effects of Dandelion (\u003cem\u003eTaraxacum officinale\u003c\/em\u003e) Root and Leaf on Cholesterol-Fed Rabbits.\u003cem\u003eInt Mol Sci, 11\u003c\/em\u003e(1), 67-78. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.3390\/ijms11010067\"\u003e10.3390\/ijms11010067\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eChristensen, R., Bartels, E.M., Altman, R.D., Astrup, A., Bliddal, H. (2008). Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?--a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e16\u003c\/em\u003e, 965–972. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.joca.2008.03.001\"\u003e10.1016\/j.joca.2008.03.001\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChrubasik, C., Roufogalis, B.D. Muller-Lander, U., \u0026amp; Chrubasik, S. (2008). A systematic review on the Rosa canina effect and efficacy profiles.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePhytother Res, 22\u003c\/em\u003e(6), 725-33. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/ptr.2400\"\u003e10.1002\/ptr.2400\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChrubasik, C., Duke, R.K., Chrubasik, S. (2006). The evidence for clinical efficacy of rose hip and seed: a systematic review.\u003cem\u003ePhytother Res, 20\u003c\/em\u003e(1), 1-3. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/ptr.1729\"\u003e10.1002\/ptr.1729\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDinstel R.R., Cascio J., \u0026amp; Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eInt J Circumpolar Health\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e72\u003c\/em\u003e. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3402\/ijch.v72i0.21188\"\u003e10.3402\/ijch.v72i0.21188\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCornelius, C., Perrota, R., graziano, A., Calbrese, E.J., Calabrese, V. (2013). Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondrea as a “chi.”\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eImmunity \u0026amp; Aging\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1742-4933-10-15\"\u003ehttps:\/\/doi.org\/10.1186\/1742-4933-10-15\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDavinelli, S., Willcox, D.C., \u0026amp; Scapagnini, G. (2012). Extending healthy aging: nutrient sensitive pathway and centenarian population. Immun Ageing, 9, 9. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1742-4933-9-9\"\u003e10.1186\/1742-4933-9-9\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eGao, X., Cassidy, A., Schwarzschild, M.A., Rimm, E.B., \u0026amp; Ascherio, A. (2012). Habitual intake of dietary flavonoids and risk of Parkinson disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNeurology,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e78\u003c\/em\u003e, 1138–45. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1212%2FWNL.0b013e31824f7fc4\"\u003e10.1212\/WNL.0b013e31824f7fc4\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGarcía-Lafuente, A., Guillamón, E., Villares, A., Rostagno, M.A., \u0026amp; Martínez, J.A. (2009). Flavonoids as antiinflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e58\u003c\/em\u003e, 537–552. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s00011-009-0037-3\"\u003e10.1007\/s00011-009-0037-3\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGonzalez-Castejon, M., Visioli, F., \u0026amp; Rodriguez-Casado, A. (2012). Diverse biological activities of dandelion.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Rev, 70\u003c\/em\u003e(9), 534-47.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1111\/j.1753-4887.2012.00509.x\"\u003e10.1111\/j.1753-4887.2012.00509.x\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGrace, M.H., Esposito D., Dunlap K.L., \u0026amp; Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e62\u003c\/em\u003e(18), 4007-17.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/258501201_Comparative_Analysis_of_Phenolic_Content_and_Profile_Antioxidant_Capacity_and_Anti-inflammatory_Bioactivity_in_Wild_Alaskan_and_Commercial_Vaccinium_Berries\"\u003edoi:10.1021\/jf403810y\u003cspan\u003e \u003c\/span\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eHu, C., \u0026amp; Kitts, D.D. (2003). Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of Agricultural and Food Chemistry, 51,\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(1), 301–310.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf0258858\"\u003e10.1021\/jf0258858\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDuke, J. (2000).\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe green pharmacy herbal handbook\u003c\/em\u003e. Emmaus, PA: Rodale Inc.\u003c\/p\u003e\n\u003cp\u003eJedrejek, D., Kontek, B., Lis, B., Stochmal, A., Olas, B. (2017). Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2\/Fe.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eChem Biol Interact, 262\u003c\/em\u003e, 29-37. 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Annals of the New York Academy of Sciences, 854, 54-60. doi:10.1111\/j.1749-6632.1998.tb09891.x\u003c\/p\u003e\n\u003cp\u003eRidker, P.M., Buring, J.E., Cook, N.R., \u0026amp; Rifai, N. (2003). C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation, 107(3), 391-7.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/circ.ahajournals.org\/content\/107\/3\/391.long\"\u003eDOI:org\/10.1161\/01.CIR.0000055014.62083.05\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRidker, P.M., Hennekens, C.H., Buring, J.E., \u0026amp; Rifai, N. (2000). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEngl J Med, 342\u003c\/em\u003e(12), 836-43. 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Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem, 54\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(25), 9329-39.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf061750g\"\u003e10.1021\/jf061750g\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShukitt-Hale, B. (2012). Blueberries and neuronal aging.\u003cem\u003eGerontology\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e58\u003c\/em\u003e, 518-523. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1159\/000341101\"\u003e10.1159\/000341101\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSigstedt, S.C., Hooten, C.J., Callewaert, M.C., Jenkins, A.R., Romero, A.E., Pullin, M.J…. Steelant, W.F. (2008). 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Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAnticancer Res, 24\u003c\/em\u003e(5A), 2783-840.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/ar.iiarjournals.org\/content\/24\/5A\/2783.short\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBishayee, A., Haskell, Y., Do, C., Siveen, K.S., Mohandas, N., Sethi, \u0026amp; G., Stoner, G.D. (2016). Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCrit Rev Food Sci Nutr, 56\u003c\/em\u003e(10), 1753-75. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/10408398.2014.982243\"\u003e10.1080\/10408398.2014.982243\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCagle, P., Idassi, O., Carpenter, J., Minor, R., Goktepe, I., \u0026amp; Martin, P. (2012). Effect of Rosehip (\u003cem\u003eRosa canina\u003c\/em\u003e) extracts on human brain tumor cell proliferation and apoptosis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of Cancer Therapy\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e3\u003c\/em\u003e(5), 13. .\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.scirp.org\/journal\/PaperInformation.aspx?PaperID=23446\"\u003eDOI:10.4236\/jct.2012.35069\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChatterjee, S.J., Ovadje, P. Mousa, M., Hamm, C., \u0026amp; Pandey, S. (2011). The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEvid Based Complement Alternat Med, 129045\u003c\/em\u003e.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1155\/2011\/129045\"\u003e10.1155\/2011\/129045\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHu, C., \u0026amp; Kitts, D.D. (2003). 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Eugenia jambolana Lam. [purple berries] berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem, 57\u003c\/em\u003e(3), 826-31. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf803407q\"\u003e10.1021\/jf803407q\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLiu, W., Lu, X., He, G., Gao, X., Xu, M., Zhang, J… Luo, C. (2013). Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Int Mol Sci, 14(11), 21447-62. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/ijms141121447\"\u003e10.3390\/ijms141121447\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eManach, C., Scalbert, A., Morand, C., Remesy, C., \u0026amp; Jimenez, L. (2004). Polyphenols: food sources and bioavailablity..\u003cem\u003eAm. J. Clin. Nutr, 79\u003c\/em\u003e, 727-747.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/ajcn.nutrition.org\/content\/79\/5\/727.full\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKristo, A.S., Klimis-Zacas, D., Sikalidis, A.K. (2016). Protective Role of Dietary Berries in Cancer.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAntioxidants (Basel), 5\u003c\/em\u003e(4), 37. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/antiox5040037\"\u003e10.3390\/antiox5040037\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eOvadje, P., Ammar, S., Guerrero, J.A., Arnason, J.T., Pandey, S. (2016). Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eOncotarget, 7\u003c\/em\u003e(45):73080-73100. 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Food Chem\u003c\/em\u003e\u003cem\u003e,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e60\u003c\/em\u003e, 5547-5555. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf205325p\"\u003e10.1021\/jf205325p\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRossi, M., Lugo, A., Lagiou, P., Zucchetto, A., Polesel, J., Serraino, D., Negri, E., Trichopoulos, D., La Vecchia, C. (2012). Proanthocyanidins and other flavonoids in relation to pancreatic cancer: A case-control study in Italy.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAnn. Oncol, 23\u003c\/em\u003e, 1488-1493. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1093\/annonc\/mdr475\"\u003e10.1093\/annonc\/mdr475\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRossi, M., Rosato, V., Bosetti, C., Lagiou, P., Parpinel, M., Bertuccio, P., Negri, E., (2010). La Vecchia, C. 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The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMetabolism,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e60\u003c\/em\u003e, 1551-1559\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI: \u003ca href=\"https:\/\/doi.org\/10.1016\/j.metabol.2011.04.001\"\u003e10.1016\/j.metabol.2011.04.001\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNagatomo, A., Nishida, N., Fukuhara, I., Noro, A., Kozai, Y., Sato, H., \u0026amp; Matsuura, Y. (2015). Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eDiabetes Metab Syndr Obes,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e8\u003c\/em\u003e, 147-156.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.2147\/DMSO.S78623\"\u003e10.2147\/DMSO.S78623\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eStull, A.J. (2016). Blueberries' Impact on Insulin Resistance and Glucose Intolerance. \u003cem\u003eAntioxidants (Basel), 5\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(4). doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/antiox5040044\"\u003e10.3390\/antiox5040044\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTorronen, R., Kolehmainen, M., Sarkkinen, E., Mykkanen, H., \u0026amp; Niskanen, L. (2012). Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAm J Clin Nutr\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e96\u003c\/em\u003e: 527-33. DOI:\u003ca href=\"https:\/\/doi.org\/10.3945\/ajcn.112.042184\"\u003e10.3945\/ajcn.112.042184\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVendrame, S., Del Bo', C., Ciappellano, S., Riso, P., \u0026amp; Klimis-Zacas, D. (2016). Berry Fruit Consumption and Metabolic Syndrome.\u003cem\u003eAntioxidants (Basel), 30\u003c\/em\u003e, 5(4). doi:\u003ca href=\"http:\/\/dx.doi.org\/10.3390\/antiox5040034\"\u003e10.3390\/antiox5040034\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWan, C., Yuan, T., Cirello, A.L., \u0026amp; Seeram, N.P. (2012). Antioxidant and α-glucosidase inhibitory phenolics isolated from highbush blueberry flowers.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFood Chem, 135\u003c\/em\u003e(3), 1929-37.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/doi.org\/10.1016\/j.foodchem.2012.06.056\"\u003ehttp:\/\/doi.org\/10.1016\/j.foodchem.2012.06.056\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWiden, C., Ekholm, A., Coleman, M.D., Renvert, S., Rumpunen, K. (2012). Erythrocyte antioxidant protection of rose hips (Rosa spp.)\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eOxid Med Cell Longev,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e621579\u003c\/em\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.1155\/2012\/621579\"\u003ehttp:\/\/dx.doi.org\/10.1155\/2012\/621579\u003cspan\u003e \u003c\/span\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e*\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eSee\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eSystemic Booster No. 4, Weight-Less\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eResearch tab for more bibliography on Weight Loss.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eAnthocyanin, Phenolic Acids, Flavonoids\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e:\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFatty Liver Support\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eGuo, H., Dan, L., Wenhua, L., Xiang, F., \u0026amp; Min, X. (2011). Anthocyanin inhibits high glucose-induced hepatic mtGRAT1 activation and prevents fatty acid synthesis through PKC.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of Lipid Research\u003c\/em\u003e, 52(5), 908-922. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1194%2Fjlr.M013375\"\u003e10.1194\/jlr.M013375\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNagatomo, A., Nishida, N., Matsuura, Y., \u0026amp; Shibata, N. (2013). Rosehip Extract Inhibits Lipid Accumulation in White Adipose Tissue by Suppressing the Expression of Peroxisome Proliferator-activated Receptor Gamma. Prev Nutr Food Sci,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e18\u003c\/em\u003e, 85-91. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.3746%2Fpnf.2013.18.2.085\"\u003e10.3746\/pnf.2013.18.2.085\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSadeghi, H., Hosseinzadeh, S., Akbartabar Touri, M., Ghavamzadeh, M., Jafari Barmak, M., Sayahi, M., \u0026amp; Sadeghi, H. (2016). Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAvicenna J Phytomed, 6\u003c\/em\u003e(2), 181-8. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.22038\/ajp.2016.5481\"\u003e10.22038\/ajp.2016.5481\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSchutz, K., Kammerer, D.R., carle, R., \u0026amp; Schieber, A. (2005). Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography\/electrospray ionization mass spectrometry.\u003cem\u003eRapid commun Mass Spectrom, 19\u003c\/em\u003e(2), 179-86. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/rcm.1767\"\u003e10.1002\/rcm.1767\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eValenti, L., Riso, P., Mazzocchi, A., Porrini, M., Fargion, S., \u0026amp; Agostoni, C. (2013). Dietary Anthocyanins as Nutritional Therapy for Non alcoholic Fatty Liver Disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eOxidative Medicine and Cellular Longevity\u003c\/em\u003e; Volume 2013:Article ID 145421.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.1155\/2013\/145421\"\u003ehttp:\/\/dx.doi.org\/10.1155\/2013\/145421\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVendrame, S., Daugherty, A. Kristo, A.S, \u0026amp; Klimis-Zacas, D. (2014). Wild Blueberry (Vaccinium angustifolium)-enriched diet improves dyslipidaemia and modulates the expression of genes related to lipid metabolism in obese Zucker rats.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBritish Journal of Nutrition\u003c\/em\u003e, 111(2), 194-200. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S0007114513002390\"\u003e10.1017\/S0007114513002390\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYou, Y., Yoo, S., Yoon, H.G., Park, J., Lee, Y.H., Kim, S…. Jun, W. (2010). In vitro and in vivo hepatoprotective effects of the aqueous extract from Taraxacum officinale (dandelion) root against alcohol-induced oxidative stress. Food Chem toico, 48(6), 1632-7.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.fct.2010.03.037\"\u003e10.1016\/j.fct.2010.03.037\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZhu, W., Jia, Q., wang, Y., Zhang, Y., \u0026amp; Xia, M. (2012). The anthocyanin cyaniding-3-O-beta-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: involvement of a cAMP-PKA-dependent signaling pathway.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFree Radical Biology and Medicine\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e52\u003c\/em\u003e(2), 314-327. 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Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e62\u003c\/em\u003e(18), 4007-17.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/258501201_Comparative_Analysis_of_Phenolic_Content_and_Profile_Antioxidant_Capacity_and_Anti-inflammatory_Bioactivity_in_Wild_Alaskan_and_Commercial_Vaccinium_Berries\"\u003edoi:10.1021\/jf403810y\u003cspan\u003e \u003c\/span\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eMcAnulty, L.S., Nieman, D.C., Dumke, C.L., Shooter, L.A., Henson, D.A., Utter, A.C… McAnulty, S.R. (2011). Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running.\u003cem\u003eAppl Physiol Nutr Metab\u003c\/em\u003e\u003cem\u003e; 36\u003c\/em\u003e(6), 976-84. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1139\/h11-120\"\u003e10.1139\/h11-120\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDinstel R.R., Cascio J., \u0026amp; Koukel S. (2013). The antioxidant level of Alaska's wild berries: high, higher and highest.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eInt J Circumpolar Health\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e72\u003c\/em\u003e. doi:10.3402\/ijch.v7210.21188. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.3402%2Fijch.v72i0.21188\"\u003e10.3402\/ijch.v72i0.21188\u003cspan\u003e \u003c\/span\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eYousef, G.G., Brown, A.F., Funakoshi, Y., Mbeunkui, F., Grace, M.H., Ballington, J.R., Loraine, A., \u0026amp; Lila, M.A. (2013). Efficeint quantification of the health-relevant anthocyanin and phenolic acid profiles in commercial cultivars and breeding selections of blueberries (Vaccinium spp.).\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem\u003c\/em\u003e\u003cem\u003e, 61\u003c\/em\u003e(20), 4806-15. DOI\u003ca href=\"https:\/\/doi.org\/10.1021\/jf400823s\"\u003e10.1021\/jf400823s\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eRose hip\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003e:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eJoint Health*\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eAllam, G., Mahdi, E.A., Alzahrani, A.M., Abuelsaad, A.S. (2016). Ellagic acid alleviates adjuvant induced arthritis by modulation of pro- and anti-inflammatory cytokines. \u003cem\u003eCent Eur J Immunol, 41\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(4), 339-349. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.5114\/ceji.2016.65132\"\u003e10.5114\/ceji.2016.65132\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChristensen, R., Bartels, E.M., Altman, R.D., Astrup, A., Bliddal, H. (2008). Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?--a meta-analysis of randomized controlled trials.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eOsteoarthritis Cartilage,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e16\u003c\/em\u003e, 965-972. DOI:\u003ca href=\"https:\/\/doi.org\/10.1016\/j.joca.2008.03.001\"\u003e10.1016\/j.joca.2008.03.001\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLattanzio, F., Greco, E., Carretta, D., Cervellati, R., Govoni, P., \u0026amp; Speroni E. (2011). In vivo anti-inflammatory effect of Rosa canina L. extract.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Ethnopharmacol\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e137\u003c\/em\u003e, 880-885. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jep.2011.07.006\"\u003e10.1016\/j.jep.2011.07.006\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLarsen, E., Kharazmi, A., Christensen, L.P., \u0026amp; Christensen, S.B. (2003). An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Nat Prod, 66\u003c\/em\u003e(7), 994-5. DOI:\u003ca href=\"https:\/\/doi.org\/10.1021\/np0300636\"\u003e10.1021\/np0300636\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRossnagel, K., Roll, S., Willich, S.N. (2007). [The clinical effectiveness of rosehip powder in patients with osteoarthritis. A systematic review].\u003cem\u003eMMW Fortschr Med\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e149\u003c\/em\u003e(27-28), 51-6.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/europepmc.org\/abstract\/med\/17619600\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSchwager, J., Hoeller, U., Wolfram, S., Richard, N. (2011). Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBMC Complement Altern Med,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e11, 105. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1472-6882-11-105\"\u003e10.1186\/1472-6882-11-105\u003cspan\u003e \u003c\/span\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eWillich, S.N., Rossnagel, K., Roll, S., Wagner, A., Mune, O., Erlendson, J…Winther, K. (2010). Rose hip herbal remedy in patients with rheumatoid arthritis - a randomised controlled trial.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePhytomedicine, 17\u003c\/em\u003e(2), 87-93. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.phymed.2009.09.003\"\u003e10.1016\/j.phymed.2009.09.003\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWinther, K., Apel, K., \u0026amp; Thamsborg, G. (2005). A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eScand J Rheumatol, 34\u003c\/em\u003e(4), 302-8. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/03009740510018624\"\u003e10.1080\/03009740510018624\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWarholm, O., Skaar, S., Hedman, E., Molmen, H.M., \u0026amp; Eik, L. (2003). The Effects of a Standardized Herbal Remedy Made from a Subtype of Rosa canina in Patients with Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. Curr\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eTher Res Clin Exp,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e64\u003c\/em\u003e, 21-31. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/S0011-393X%2803%2900004-3\"\u003e10.1016\/S0011-393X(03)00004-3\u003cspan\u003e \u003c\/span\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003e*\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eSee the\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eFructo Borate\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eResearch tab for more bibliography on joint health.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eRose hip\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003e:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eFolate Content\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eStralsjo, L., Alklint, C., Olsson, M.E., \u0026amp; Sjoholm, I. (2003). Total folate content and retention in rosehips (Rosa ssp.) after drying.\u003cem\u003eJ.Agric Food Chem\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e51\u003c\/em\u003e(15), 4291-5.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf034208q\"\u003e10.1021\/jf034208q\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eDandelion: Antimicrobial effect\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eCowan, M.M. (1999). Plant products as antimicrobial agents.\u003cem\u003eClin Microbiol Rev\u003c\/em\u003e,\u003cem\u003e\u003cspan\u003e \u003c\/span\u003e12\u003c\/em\u003e, 564-582.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/cmr.asm.org\/content\/12\/4\/564.long\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKenny, O., Brunton, N.P., Walsh, D., Hewage, C.M., McLoughlin, P., \u0026amp; Smyth, T.J. (2015). Characterisation of antimicrobial extracts from dandelion root (Taraxacum officinale) using LC-SPE-NMR.\u003cem\u003ePhytother Res, 29\u003c\/em\u003e(4), 526-32.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/ptr.5276\"\u003e10.1002\/ptr.5276\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSchütz, K, Reinhold, C., \u0026amp; Schieber, A. (2006). Taraxacum-A review on its phytochemical and pharmacological profile.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Ethnopharmacol\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e,\u003cem\u003e\u003cspan\u003e \u003c\/span\u003e107\u003c\/em\u003e, 313-323. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jep.2006.07.021\"\u003e10.1016\/j.jep.2006.07.021\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eDandelion: Lung Support\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eLiu, L., Xiong, H., Ping, J., Ju, Y. \u0026amp; Zhang, X. (2010). Taraxacum officinale protects against lipopolysaccharide-induced acute lung injury in mice.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of Ethnopharmacology\u003c\/em\u003e,\u003cem\u003e130\u003c\/em\u003e(2), 392-397. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jep.2010.05.029\"\u003e10.1016\/j.jep.2010.05.029\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eDandelion and Blueberries (fruit \u0026amp; leaves): Eye Support\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBeatty, S., Murray, I.J., Henson, D.B., Carden, D., Koh, H., \u0026amp; Boulton, M.E. (2001). Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eInvest Ophthalomo Vis Sci, 42\u003c\/em\u003e(2), 439-46.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/iovs.arvojournals.org\/article.aspx?articleid=2123005\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLiu, Y., Song, X., Zhang, D., Zhou, F., Wang, D., Wei, Y., Gao, F., … Wu, W., \u0026amp; Ji, B. (2012). Blueberry anthocyanins: protection against ageing and light-induced damage in retinal pigment epithelial cells.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBr J Nutr\u003c\/em\u003e, 108(1), 16-27. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S000711451100523X\"\u003e10.1017\/S000711451100523X\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMa, L., Dou, H.L., Wu, Y.Q., Huang, Y.M., Huang, Y.B., Xu, X.R., Zou, Z.Y., \u0026amp; Lin, X.M. (2012). Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systemic review and meta-analysis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBr J Nutr, 107\u003c\/em\u003e(3), 350-9. DOI:\u003ca href=\"https:\/\/doi.org\/10.1017\/S0007114511004260\"\u003e10.1017\/S0007114511004260\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWegner, A., \u0026amp; Khoramnia R. (2011). Cataract is a self-defence reaction to protect the retina from oxidative damage.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMed Hypotheses, 76\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(5), 741-4. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.mehy.2011.02.013\"\u003e10.1016\/j.mehy.2011.02.013\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eAnthocyanin, Proanthocyanidin\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e:\u003cem\u003e\u003cspan\u003e \u003c\/span\u003eNeurodegenerative Support*\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAlbarracin, S.L., Stab, B., Casas, Z., Sutachan, J.J., Samudio, I., Gonzalez, J….Barreto, G.E. (2012). Effects of natural antioxidants in neurodegenerative disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Neurosci,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e15\u003c\/em\u003e, 1-9. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1179\/1476830511Y.0000000028\"\u003e10.1179\/1476830511Y.0000000028\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChao, J., Leung, Y., Wang, M., \u0026amp; Chang, R.C. (2012). Nutraceuticals and their preventive or potential therapeutic value in Parkinson's disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Rev,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e70\u003c\/em\u003e, 373-86. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1111\/j.1753-4887.2012.00484.x\"\u003e10.1111\/j.1753-4887.2012.00484.x\u003cspan\u003e \u003c\/span\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eDel Rio, D., Rodriguez-Mateos, A., Spencer, J.P., Tognolini, M., Borges, G., \u0026amp; Crozier, A. (2013). Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAntioxid Redox Signal,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e18\u003c\/em\u003e, 1818-92. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1089%2Fars.2012.4581\"\u003e10.1089\/ars.2012.4581\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGao, X., Cassidy, A., Schwarzschild, M.A., Rimm, E.B., \u0026amp; Ascherio, A. (2012). Habitual intake of dietary flavonoids and risk of Parkinson disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNeurology,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e78\u003c\/em\u003e, 1138-45. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1212%2FWNL.0b013e31824f7fc4\"\u003e10.1212\/WNL.0b013e31824f7fc4\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKrikorian, R., Shidler, M.D., Nash, T.A., Kalt, W., Vingvist-tymchuk, M.R., Shukitt-Hale, B., Joseph, J.A. (2010). Blueberry supplementation improves memory in older adults.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ. Agric Food Chem, 58\u003c\/em\u003e, 3996-4000. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf9029332\"\u003e10.1021\/jf9029332\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMilbury, P.E., \u0026amp; Kalt, W. (2010). Xenobiotic metabolism and berry flavonoid transport across the blood-brain barrier.\u003cem\u003eJ Agric Food Chem,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e58\u003c\/em\u003e, 3950-6. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf903529m\"\u003e10.1021\/jf903529m\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRamassamy, C. (2006). Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEur J Pharmacol,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e545\u003c\/em\u003e, 51-64. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.ejphar.2006.06.025\"\u003e10.1016\/j.ejphar.2006.06.025\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShukitt-Hale, B. (2012). Blueberries and neuronal aging.\u003cem\u003eGerontology\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e58\u003c\/em\u003e, 518-523. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1159\/000341101\"\u003e10.1159\/000341101\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSong, J.X., Sze, S.C., Ng, T.B., Lee, C.K., Leung, G.P., Shaw, P.C., Tong, Y., Zhang, Y.B. (2012). Anti-Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models?\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Ethnopharmacol,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e139\u003c\/em\u003e, 698-711. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jep.2011.12.030\"\u003e10.1016\/j.jep.2011.12.030\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eStrathearn, K.E., Youself, G.G., Grace, M.H., Roy S.L., Tambe, M.A., Ferruzzi, M.G., Wu, Q.L., … Rochet, J.C. (2014). Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson's disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBrain\u003c\/em\u003e\u003cem\u003eResearch\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e1555(25),\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e60-77. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.brainres.2014.01.047\"\u003e10.1016\/j.brainres.2014.01.047\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e*See the\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBlueberry Extract\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eResearch tab for more bibliography on the neuro-regenerative effect of blueberries.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eThe Hormetic Mechanism of Phytochemicals (plant nutrients) for Better Health\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMattson, M.P. (2008). Hormesis defined.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAgeing Res Rev, 7\u003c\/em\u003e(1), 1-7. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1016%2Fj.arr.2007.08.007\"\u003e10.1016\/j.arr.2007.08.007\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCalabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Calabrese, E.J., Mattson, M.P. (2010). Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAntioxid Redox Signal, 13\u003c\/em\u003e(11), 1763-811. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.1089\/ars.2009.3074\"\u003e10.1089\/ars.2009.3074\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCalabrese, V., Cornelius, C., Trovato, A., Cavallaro, M., Mancuso, C., Di Rienzo, L. … Calabrese EJ. (2010).The hormetic role of dietary antioxidants in free radical-related diseases.\u003cem\u003eCurr Pharm Des,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e16(7), 877-83.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20388101\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCalabrese, V., Cornelius, C., Mancuso, C., Pennisi, G., Calafato, S., Bellia, F… Rizzareli, E. (2008). Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. \u003cem\u003eNeurochem Res, 33\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(12), 2444-71. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s11064-008-9775-9\"\u003e10.1007\/s11064-008-9775-9\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCornelius, C., Perrota, R., graziano, A., Calbrese, E.J., Calabrese, V. (2013). Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondrea as a \"chi.\"\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eImmunity \u0026amp; Aging\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1742-4933-10-15\"\u003ehttps:\/\/doi.org\/10.1186\/1742-4933-10-15\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLee, J., Jo, D.G., Park, D., Chung, H.Y., Mattson, M.P. (2014). Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system. \u003cem\u003ePharmacol Rev, 66\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(3), 815-68. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1124\/pr.113.007757\"\u003e10.1124\/pr.113.007757\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eMattson, M.P. (2008). Dietary factors, hormesis and health.\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAgeing Res Rev. 7\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e(1):43-8.\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.arr.2007.08.004\"\u003e10.1016\/j.arr.2007.08.004\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMurugaiyah, V., \u0026amp; Mattson, M.P. (2015). Neurohormetic phytochemicals: An evolutionary-bioenergetic perspective.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNeurochem Int, 89\u003c\/em\u003e, 271-80.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4586293\/\"\u003eArticle\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003e. DOI:\u003ca href=\"https:\/\/doi.org\/10.1016\/j.neuint.2015.03.009\"\u003e10.1016\/j.neuint.2015.03.009\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRattan SI. (2010). Targeting the age-related occurrence, removal, and accumulation of molecular damage by hormesis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAnn N Y Acad Sci, 1197\u003c\/em\u003e, 28-32. DOI:\u003ca href=\"https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05193.x\"\u003e10.1111\/j.1749-6632.2010.05193.x\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003eIngredients \u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eOne capsule contains:\u003c\/p\u003e\n\u003cp\u003eRosehip, wildcrafted, Whole Fruit and seeds   200mg\u003cbr\u003e  Refractory dried Mult-\u003cem\u003eRosa\u003c\/em\u003e species (3)\u003cbr\u003eDandelion, wildcrafted, aerial parts, roots and flowers   200mg \u003cbr\u003e  Refractory dried Multi-\u003cem\u003eTaraxacum\u003c\/em\u003e species (4) \u003cbr\u003eBlueberry, wildcrafted, Fruit (\u0026gt;95%) Leaves and stems (\u0026lt;5%) 100mg  \u003cbr\u003e  Refractory dried Multi-\u003cem\u003eVaccinium\u003c\/em\u003e species (4)\u003c\/p\u003e\n\u003cp\u003eOther ingredients: Cellulose \u0026amp; water (capsule shell)\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003ch6\u003e\n\u003cspan\u003eProtocol\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003ePHYTO POWER\u003c\/b\u003e— The Phyto Power is designed to support DNA and cellular integrity.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eDNA and cellular integrity\u003c\/i\u003e: Take 1-4 capsules a day to support cellular and DNA integrity during cancer treatment. Consult a health care provider.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eAntioxidant \u0026amp; anti-inflammatory\u003c\/i\u003e: The wildcrafted Alaskan blueberries, rose hips, and dandelions have some of the most powerful amounts of antioxidants. Take 1 a day.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eBrain and nervous system\u003c\/i\u003e: Take 1-2 capsules a day to maintain brain health. Add the\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eBlueberry Extract\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eHigh ORAC\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eto support repair and regeneration of neural tissue. These products offer support after a stroke.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eGI Tract (second brain)\u003c\/i\u003e: Take 2 caps to protect against toxic environments, calming down the GI Tract (our second brain), and regenerating nerves in the brain and GI Tract.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eLiver support\u003c\/i\u003e: Dandelion is an excellent food for liver detoxification. Especially supportive during cancer treatment. Take 1-2 capsules during or after exposure to smoke, chemicals, drugs, and toxins. Add\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eGlucosinolates \u0026amp; Sulforaphanes\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e(broccoli cruciferous sprouts) for phase II liver detox.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOur favorite\u003c\/i\u003e:  The blueberries, rose hips, and dandelions are all collected by indigenous Alaskans. These Alaskan plants are shown in research to have some of the highest anthocyanins levels in the world! We add the Phyto Power to many of our protocols due to its gentle yet potent nature.\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712314474540,"sku":"TF025","price":89.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Phyto-Power---Front.jpg?v=1723214766"},{"product_id":"original-synbiotic-formula","title":"Original Synbiotic","description":"\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe Original Synbiotic Formula is the gold standard of probiotic formulas. Five pedigree ATCC probiotic lactic acid bacteria are grown for hardiness and stability. The Original is a powerfully elegant mix of prebiotic and probiotic.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eAdd one teaspoon to your daily routine.\u003c\/p\u003e\n\u003ch6\u003eDescription \u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e20 billion cfu\/tsp of certified strains of pedigreed probiotic with Therapeutic Foods in a synbiotic formula of L. acidophilus, B. longum, L. rhamnosus, L. plantarum, S. thermophilus and 4 grams of inulin derived from organic chicory fiber. Advanced freeze-drying technology. 120 grams\/bottle. 4 grams\/ tsp. Dairy free.  Soy free. Gluten free. No excipients.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMicrobiome Technology creates hardy and viable pedigreed strains of \u003cem\u003eL. acidophilus, B. longum, L. rhamnosus, L. plantarum, S. thermophilus\u003c\/em\u003e.\u003c\/li\u003e\n\u003cli\u003eOriginal strains of lactic acid bacteria are based on ATCC prototypical strains and confirmed routinely by 16sRNA sequencing to provide highest quality probiotic material.\u003c\/li\u003e\n\u003cli\u003eThe Original Strains are chosen for their strength, compatibility, safety and their 40 years of proven ability to neutralize food borne pathogens and xenobiotics.\n\u003cul\u003e\n\u003cli\u003eStrains selected to protect, counteract and neutralize dietary toxins, mutagens, carcinogens and infectious organisms.\u003c\/li\u003e\n\u003cli\u003eThe contamination of food with aflatoxins is a worldwide problem. Mold mycotoxins compromise the blood-brain barrier and induce neurodegenerative processes. \u003cem\u003eL rhamnosus\u003c\/em\u003e binds AFB1 in vivo and reduces bio-absorption of the toxin from the gut. \u003cem\u003eL. acidophilus\u003c\/em\u003e and \u003cem\u003eB. longum\u003c\/em\u003e neutralize AFB1 and AFM1 by binding mechanisms. \u003cem\u003eS. thermophilus\u003c\/em\u003e reduces content of ochratoxin A.\u003c\/li\u003e\n\u003cli\u003eMutagens cause impaired cell function, cell death or cell transformation into cancer cells. \u003cem\u003eL. acidophilus, B. longum, L. rhamnosus, S. thermophilus\u003c\/em\u003e and \u003cem\u003eL. plantarum\u003c\/em\u003e neutralize heterocyclic amines and nitrosamines, two of the most common and powerful mutagenic molecules found in our diet.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003eOur home is a global environment. Infectious organisms come from all corners of the world.\n\u003cul\u003e\n\u003cli\u003eVerocytotoxin producing E. coli s0157 are emerging food borne pathogens worldwide. \u003cem\u003eB. longum\u003c\/em\u003eneutralizes this toxin.\u003c\/li\u003e\n\u003cli\u003eThe collective ability of the Original probiotic organisms to protect the frontline border of our GI tract membrane from the aggressive enterovirulent pathogens is accomplished via: the production of bactercins, creation of an acid barrier, stimulation of the cell mediated immune system and protective colonization of enterocytes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe lactic acid bacterial strains in the Original Synbiotic Formula have demonstrated the ability to inhibit the formation of precancerous colon lesions. Numerous trials performed validate findings.\u003c\/li\u003e\n\u003cli\u003ePure inulin, derived from chicory fiber, provides support as a Therapeutic Foods carrier and prebiotic. Provides an ideal food source for the lactic acid organisms to grow, thrive and to protect.\u003c\/li\u003e\n\u003cli\u003eIn the process of fermentation, inulin produces butyric acid and therefore:\n\u003cul\u003e\n\u003cli\u003eCorrects GI permeability- establishes tight junctions.\u003c\/li\u003e\n\u003cli\u003eInhibits colon cancer: stimulating the differentiation of stem cells.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003eImproves habit of bowel regularity\u003c\/li\u003e\n\u003cli\u003eNo fillers, flowing agents or excipients of any kind.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch6\u003eIngredients\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e1 Teaspoon Contains: \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eCalories 5 \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eTotal Carbohydrate 3g \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eDietary fiber 3g \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eSoluble fiber 3g \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eProprietary Probiotic Blend 20billion CFU    3.38g \u003c\/span\u003e\u003cbr\u003e\u003cem\u003e  L. acidophilus \u003cbr\u003e  L. casei rhamnosus \u003cbr\u003e  L. plantarum \u003cbr\u003e  S. thermophilus \u003cbr\u003e  B. longum \u003cbr\u003e\u003c\/em\u003e\u003cspan\u003eInulin (from organic chicory root)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eContainer:  120 grams\u003c\/span\u003e\u003c\/p\u003e\n\u003ch6\u003e\u003cspan mce-data-marked=\"1\"\u003eResearch\u003c\/span\u003e\u003c\/h6\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003e\u003ci\u003eImmune Support\u003c\/i\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eAFRC, R. F. (1989). Probiotics in man and animals. \u003ci\u003eJournal of applied bacteriology\u003c\/i\u003e, \u003ci\u003e66\u003c\/i\u003e(5), 365-378. \u003ca href=\"https:\/\/doi.org\/10.1111\/j.1365-2672.1989.tb05105.x\"\u003e\u003cspan class=\"s2\"\u003ehttps:\/\/doi.org\/10.1111\/j.1365-2672.1989.tb05105.x\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eAguilar, C., Mano, M., \u0026amp; Eulalio, A. (2018). MicroRNAs at the Host–Bacteria Interface: Host Defense or Bacterial Offense. \u003ci\u003eTrends in microbiology\u003c\/i\u003e. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0966842X18302348\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eAzcarate-Peril, M.A., Sikes, M., Bruno-Barcena, J.M. (2011). The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer? \u003ci\u003eAm J Physiol Gastrointest Liver Physiol\u003c\/i\u003e, \u003ci\u003e301\u003c\/i\u003e, G401-G424. doi:10.1152\/ajpgi.00110.2011.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eBocci V. (1992). The neglected organ: Bacterial flora has a crucial immunostimulatory role. \u003ci\u003ePerspectives in Biology and Medince\u003c\/i\u003e, \u003ci\u003e35\u003c\/i\u003e(2), 251–260. \u003ca href=\"https:\/\/muse.jhu.edu\/article\/402661\/summary\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eCianci, R., Franza, L., Schinzari, G., Rossi, E., Ianiro, G., Tortora, G., ... \u0026amp; Cammarota, G. (2019). The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer. \u003ci\u003eInternational journal of molecular sciences\u003c\/i\u003e, \u003ci\u003e20\u003c\/i\u003e(3), 501. \u003ca href=\"https:\/\/www.mdpi.com\/1422-0067\/20\/3\/501\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eDargahi, N., Johnson, J., Donkor, O., Vasiljevic, T., \u0026amp; Apostolopoulos, V. (2018). Immunomodulatory effects of Streptococcus thermophilus on U937 monocyte cell cultures. \u003ci\u003eJournal of Functional Foods\u003c\/i\u003e, \u003ci\u003e49\u003c\/i\u003e, 241-249. \u003ca href=\"https:\/\/doi.org\/10.1016\/j.jff.2018.08.038\"\u003e\u003cspan class=\"s2\"\u003ehttps:\/\/doi.org\/10.1016\/j.jff.2018.08.038\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eGaldeano, C. M., Cazorla, S. I., Dumit, J. M. L., Vélez, E., \u0026amp; Perdigón, G. (2019). Beneficial Effects of Probiotic Consumption on the Immune System. \u003ci\u003eAnnals of Nutrition and Metabolism\u003c\/i\u003e, \u003ci\u003e74\u003c\/i\u003e(2), 115-124. \u003ca href=\"https:\/\/www.karger.com\/Article\/Abstract\/496426\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eGern, J.E. (2015). Promising candidates for allergy prevention. \u003ci\u003eJournal of Allergy and Clinical Immunology, 136\u003c\/i\u003e (1), 23–28. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0091674915007216\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eHarata, G., He, F., Takahashi, K., Hosono, A., Miyazawa, K., Yoda, K., ... \u0026amp; Kaminogawa, S. (2016). Human Lactobacillus strains from the intestine can suppress IgE-mediated degranulation of rat basophilic leukaemia (RBL-2H3) cells. \u003ci\u003eMicroorganisms\u003c\/i\u003e, \u003ci\u003e4\u003c\/i\u003e(4), 40. doi:\u003ca href=\"http:\/\/dx.doi.org\/10.3390\/microorganisms4040040\"\u003e\u003cspan class=\"s2\"\u003e10.3390\/microorganisms4040040\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eLecellier, C. H., Dunoyer, P., Arar, K., Lehmann-Che, J., Eyquem, S., Himber, C., ... \u0026amp; Voinnet, O. (2005). A cellular microRNA mediates antiviral defense in human cells. \u003ci\u003eScience\u003c\/i\u003e, \u003ci\u003e308\u003c\/i\u003e(5721), 557-560. \u003ca href=\"https:\/\/www.researchgate.net\/publication\/7891502_A_Cellular_MicroRNA_Mediates_Antiviral_Defense_in_Human_Cells\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eLilly, D. M., \u0026amp; Stillwell, R. H. (1965). Probiotics: growth-promoting factors produced by microorganisms. \u003ci\u003eScience\u003c\/i\u003e, \u003ci\u003e147\u003c\/i\u003e(3659), 747-748. \u003ca href=\"https:\/\/doi.org\/10.1126\/science.147.3659.747\"\u003e\u003cspan class=\"s2\"\u003ehttps:\/\/doi.org\/10.1126\/science.147.3659.747\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMa, F., Xu, S., Liu, X., Zhang, Q., Xu, X., Liu, M., ... \u0026amp; Cao, X. (2011). The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ. \u003ci\u003eNature immunology\u003c\/i\u003e, \u003ci\u003e12\u003c\/i\u003e(9), 861. \u003ca href=\"https:\/\/www.nature.com\/articles\/ni.2073\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMadsen, K. (2006). Probiotics and the immune response. \u003ci\u003eJ Clin Gastroenterol\u003c\/i\u003e, \u003ci\u003e40\u003c\/i\u003e, 232–4. \u003ca href=\"https:\/\/journals.lww.com\/jcge\/Abstract\/2006\/03000\/Probiotics_and_the_Immune_Response.14.aspx\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMarshall, W.E. (2014). Bacterial ORNs, a new paradigm to prevent infection. In Weston A. Price Foundation, online \u003ca href=\"https:\/\/www.westonaprice.org\/health-topics\/farm-ranch\/bacterial-orns-a-new-paradigm-to-prevent-infections\/\"\u003e\u003cspan class=\"s2\"\u003eArticle.\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMarshall, W. E. (2010). Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection. \u003ci\u003eU.S. Patent No. 7,678,557\u003c\/i\u003e. Washington, DC: U.S. Patent and Trademark Office. \u003ca href=\"https:\/\/patents.google.com\/patent\/US7189834B2\/en\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eNakata, K., Sugi, Y., Narabayashi, H., Kobayakawa, T., Nakanishi, Y., Tsuda, M., ... \u0026amp; Takahashi, K. (2017). Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4. \u003ci\u003eJournal of Biological Chemistry\u003c\/i\u003e, \u003ci\u003e292\u003c\/i\u003e(37), 15426-15433. \u003ca href=\"http:\/\/www.jbc.org\/content\/292\/37\/15426.short\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eNishiyama, K., Sugiyama, M., \u0026amp; Mukai, T. (2016). Adhesion properties of lactic acid bacteria on intestinal mucin. \u003ci\u003eMicroorganisms\u003c\/i\u003e, \u003ci\u003e4\u003c\/i\u003e(3), 34. \u003ca href=\"https:\/\/www.mdpi.com\/2076-2607\/4\/3\/34\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eParker, R. B. (1974). Probiotics, the other half of the antibiotic story. \u003ci\u003eAnim Nutr Health\u003c\/i\u003e, \u003ci\u003e29\u003c\/i\u003e, 4-8.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eParvez, S., Malik, K.A., Kang, S., \u0026amp; Kim, H.Y. (2006). Probiotics and their fermented food products are beneficial for health. J Appl Microbiol. \u003ci\u003e100\u003c\/i\u003e, 1171–85. \u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/j.1365-2672.2006.02963.x\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eRoberfroid, M.B. (2000). Prebiotics and probiotics: Are they functional foods? Am J Clin Nutr, \u003ci\u003e71\u003c\/i\u003e, 1682S–7S. \u003ca href=\"https:\/\/academic.oup.com\/ajcn\/article\/71\/6\/1682S\/4729644\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSaini, R., Saini, S., Sugandha. (2009). Probiotics: The health boosters. J Cutan Aesthet Surg, \u003ci\u003e2\u003c\/i\u003e, 112. \u003ca href=\"http:\/\/www.jcasonline.com\/article.asp?issn=0974-2077;year=2009;volume=2;issue=2;spage=112;epage=112;aulast=Saini\"\u003e\u003cspan class=\"s2\"\u003eLetter\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSalas-Jara, M. J., Ilabaca, A., Vega, M., \u0026amp; García, A. (2016). 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New approaches for bacteriotherapy: prebiotics, new-generation probiotics, and synbiotics. \u003ci\u003eClinical Infectious Diseases\u003c\/i\u003e, \u003ci\u003e60\u003c\/i\u003e(suppl_2), S108-S121. \u003ca href=\"https:\/\/doi.org\/10.1093\/cid\/civ177\"\u003e\u003cspan class=\"s2\"\u003ehttps:\/\/doi.org\/10.1093\/cid\/civ177\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003ePedersen, G. (2000). Development, validation and implementation of an in vitro model for the study of metabolic and im-mune function in normal and inflamed human co-lonic epithelium. \u003ci\u003eAutoimmunity\u003c\/i\u003e, \u003ci\u003e32\u003c\/i\u003e, 255-263. \u003ca href=\"https:\/\/pdfs.semanticscholar.org\/c101\/1722f7005f79cb87571908bf7b7a738589c4.pdf\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eVanderpool, C., Yan, F., \u0026amp; Polk, B. D. (2008). 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Beneficial effects of probiotics, prebiotics, synbiotics, and psychobiotics in inflammatory bowel disease. \u003ci\u003eInflammatory bowel diseases\u003c\/i\u003e, \u003ci\u003e21\u003c\/i\u003e(7), 1674-1682. \u003ca href=\"https:\/\/academic.oup.com\/ibdjournal\/article-abstract\/21\/7\/1674\/4604272\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eZhang, Y., Li, L., Guo, C., Mu, D., Feng, B., Zuo, X., \u0026amp; Li, Y. (2016). Effects of probiotic type, dose and treatment duration on irritable bowel syndrome diagnosed by Rome III criteria: a meta-analysis. \u003ci\u003eBMC gastroenterology\u003c\/i\u003e, \u003ci\u003e16\u003c\/i\u003e(1), 62. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27296254\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003e\u003ci\u003eModulating a Healthy Microbiome: Immunity, Intestinal Barrier \u0026amp; Brain\u003c\/i\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eArora, T., \u0026amp; Bäckhed, F. (2016). The gut microbiota and metabolic disease: current understanding and future perspectives. \u003ci\u003eJournal of internal medicine\u003c\/i\u003e, \u003ci\u003e280\u003c\/i\u003e(4), 339-349. \u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/joim.12508\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eBlackwood, B. P., Yuan, C. Y., Wood, D. R., Nicolas, J. D., Grothaus, J. S., \u0026amp; Hunter, C. J. (2017). 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Food-based strategies to modulate the composition of the microbiota and their associated health effects. \u003ci\u003eJournal of physiology and pharmacology\/Polish Physiological Society.-Kraków, 1991, currens\u003c\/i\u003e, \u003ci\u003e60\u003c\/i\u003e(S: 6), 5-11. \u003ca href=\"https:\/\/repository.uantwerpen.be\/docman\/irua\/4e8086\/7495.pdf\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eBron, P. A., Kleerebezem, M., Brummer, R. J., Cani, P. D., Mercenier, A., MacDonald, T. T., ... \u0026amp; Wells, J. M. (2017). 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DOI:\u003ca href=\"https:\/\/doi.org\/10.1136\/gut.2008.165886\"\u003e\u003cspan class=\"s2\"\u003e10.1136\/gut.2008.165886\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eCani, P. D. (2019). Severe obesity and gut microbiota: does bariatric surgery really reset the system?. \u003ci\u003eGut\u003c\/i\u003e, \u003ci\u003e68\u003c\/i\u003e(1), 5-6. \u003ca href=\"https:\/\/gut.bmj.com\/content\/68\/1\/5.short\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eCani, P. D., \u0026amp; Delzenne, N. M. (2009). The role of the gut microbiota in energy metabolism and metabolic disease. \u003ci\u003eCurrent pharmaceutical design\u003c\/i\u003e, \u003ci\u003e15\u003c\/i\u003e(13), 1546-1558. \u003ca href=\"https:\/\/s3.amazonaws.com\/academia.edu.documents\/37821655\/0009B.pdf?AWSAccessKeyId=AKIAIWOWYYGZ2Y53UL3A\u0026amp;Expires=1553625551\u0026amp;Signature=irilDNOVKxL13VYPmTXDeXs2qr4%253D\u0026amp;response-content-disposition=inline%253B%2520filename%253DThe_Role_of_the_Gut_Microbiota_in_Energy.pdf\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eCani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., \u0026amp; Burcelin, R. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet–induced obesity and diabetes in mice. \u003ci\u003eDiabetes\u003c\/i\u003e, \u003ci\u003e57\u003c\/i\u003e(6), 1470-1481. \u003ca href=\"http:\/\/diabetes.diabetesjournals.org\/content\/diabetes\/57\/6\/1470.full.pdf\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eCani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., ... \u0026amp; Waget, A. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. \u003ci\u003eDiabetes\u003c\/i\u003e, \u003ci\u003e56\u003c\/i\u003e(7), 1761-1772. \u003ca href=\"http:\/\/diabetes.diabetesjournals.org\/content\/diabetes\/56\/7\/1761.full.pdf\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eCani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R. G., Tuohy, K. M., ... \u0026amp; Delzenne, N. M. (2007). Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. \u003ci\u003eDiabetologia\u003c\/i\u003e, \u003ci\u003e50\u003c\/i\u003e(11), 2374-2383. \u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00125-007-0791-0?__hstc=209342221.cad23cdf89637a97c833078f3dec9d96.1462492800047.1462492800048.1462492800049.1\u0026amp;__hssc=209342221.1.1462492800050\u0026amp;__hsfp=1314462730\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eDruat, C., Alligier, M., Salazar, N., Neyrinck, A.M., \u0026amp; Delzenne, N.M. (2014). Modulation of the gut microbiota by nutrients with prebiotic and probiotic properties. \u003ci\u003eAdv Nur, 5\u003c\/i\u003e(5), 624S-633S. DOI:\u003ca href=\"https:\/\/doi.org\/10.3945\/an.114.005835\"\u003e\u003cspan class=\"s2\"\u003e10.3945\/an.114.005835\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eEverard, A., \u0026amp; Cani, P. (2013). Diabetes, obesity and gut microbiota. \u003ci\u003eBest Pract. Res. Clin. Gastroenterol\u003c\/i\u003e, \u003ci\u003e27\u003c\/i\u003e, 73–83. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1521691813000619?via%253Dihub\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eFalcinelli, S., Rodiles, A., Hatef, A., Picchietti, S., Cossignani, L., Merrifield, D. L., ... \u0026amp; Carnevali, O. (2017). Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish. \u003ci\u003eScientific reports\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(1), 5512. \u003ca href=\"https:\/\/www.nature.com\/articles\/s41598-017-05147-w\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eFrazier, T. H., DiBaise, J. K., \u0026amp; McClain, C. J. (2011). Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. \u003ci\u003eJournal of Parenteral and Enteral Nutrition\u003c\/i\u003e, \u003ci\u003e35\u003c\/i\u003e(5_suppl), 14S-20S. \u003ca href=\"https:\/\/www.immuron.com.au\/assets\/files\/Gut-microbiome-and-NASH.PDF\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eHan, J. L., \u0026amp; Lin, H. L. (2014). Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective. \u003ci\u003eWorld journal of gastroenterology: WJG\u003c\/i\u003e, \u003ci\u003e20\u003c\/i\u003e(47), 17737. \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4273124\/\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eKorkmaz, O. A., Sadi, G., Kocabas, A., Yildirim, O. G., Sumlu, E., Koca, H. B., ... \u0026amp; Bilgehan, M. Lactobacillus helveticus and Lactobacillus plantarum modulate renal antioxidant status in a rat model of fructose-induced metabolic syndrome. \u003ca href=\"https:\/\/www.researchgate.net\/profile\/Goekhan_Sadi\/publication\/331348421_Lactobacillus_helveticus_and_Lactobacillus_plantarum_modulate_renal_antioxidant_status_in_a_rat_model_of_fructose-induced_metabolic_syndrome\/links\/5c7932ba299bf1268d2f7c5d\/Lactobacillus-helveticus-and-Lactobacillus-plantarum-modulate-renal-antioxidant-status-in-a-rat-model-of-fructose-induced-metabolic-syndrome.pdf\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMacfarlane, S., Cleary, S., Bahrami, B., Reynolds, N., \u0026amp; Macfarlane, G. T. (2013). Synbiotic consumption changes the metabolism and composition of the gut microbiota in older people and modifies inflammatory processes: a randomised, double\u003c\/span\u003e\u003cspan class=\"s4\"\u003e‐\u003c\/span\u003e\u003cspan class=\"s1\"\u003eblind, placebo\u003c\/span\u003e\u003cspan class=\"s4\"\u003e‐\u003c\/span\u003e\u003cspan class=\"s1\"\u003econtrolled crossover study. \u003ci\u003eAlimentary pharmacology \u0026amp; therapeutics\u003c\/i\u003e, \u003ci\u003e38\u003c\/i\u003e(7), 804-816. \u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.12453\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eMarques, F. Z., Mackay, C. R., \u0026amp; Kaye, D. M. (2018). Beyond gut feelings: how the gut microbiota regulates blood pressure. \u003ci\u003eNature Reviews Cardiology\u003c\/i\u003e, \u003ci\u003e15\u003c\/i\u003e(1), 20. \u003ca href=\"https:\/\/www.nature.com\/articles\/nrcardio.2017.120\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eQin, Y., Roberts, J. D., Grimm, S. A., Lih, F. B., Deterding, L. J., Li, R., ... \u0026amp; Wade, P. A. (2018). An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression. \u003ci\u003eGenome biology\u003c\/i\u003e, \u003ci\u003e19\u003c\/i\u003e(1), 7. \u003ca href=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/s13059-018-1389-1\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eRoberfroid, M., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R., Rowland, I., ... \u0026amp; Guarner, F. (2010). Prebiotic effects: metabolic and health benefits. \u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e, \u003ci\u003e104\u003c\/i\u003e(S2), S1-S63. \u003ca href=\"https:\/\/www.cambridge.org\/core\/journals\/british-journal-of-nutrition\/article\/prebiotic-effects-metabolic-and-health-benefits\/F644C98393E2B3EB64A562854115D368\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSerino, M., Blasco-Baque, V., Nicolas, S., \u0026amp; Burcelin, R. (2014). Managing the manager: gut microbes, stem cells and metabolism. \u003ci\u003eDiabetes \u0026amp; metabolism\u003c\/i\u003e, \u003ci\u003e40\u003c\/i\u003e(3), 186-190. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1262363613002346\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eYan Q, Li X, Feng B. (2015). The efficacy and safety of probiotics intervention in preventing conversion of impaired glucose tolerance to diabetes: study protocol for a randomized, double-blinded, placebo controlled trial of the Probiotics Prevention Diabetes Programme (PPDP). \u003ci\u003eBMC Endocr Discord\u003c\/i\u003e; 15(1): 74. \u003ca href=\"https:\/\/bmcendocrdisord.biomedcentral.com\/articles\/10.1186\/s12902-015-0071-9\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003e\u003ci\u003eCardiovascular and Fatty Liver Support\u003c\/i\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eÁlvarez-Mercado, A. I., Navarro-Oliveros, M., Robles-Sánchez, C., Plaza-Díaz, J., Sáez-Lara, M. J., Muñoz-Quezada, S., ... \u0026amp; Abadía-Molina, F. (2019). Microbial Population Changes and Their Relationship with Human Health and Disease. \u003ci\u003eMicroorganisms\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(3), 68. \u003ca href=\"https:\/\/www.mdpi.com\/2076-2607\/7\/3\/68\/htm\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eDelzenne, N. M., Knudsen, C., Beaumont, M., Rodriguez, J., Neyrinck, A. M., \u0026amp; Bindels, L. B. (2019). Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut–liver axis. \u003ci\u003eProceedings of the Nutrition Society\u003c\/i\u003e, 1-10. \u003ca href=\"https:\/\/www.cambridge.org\/core\/journals\/proceedings-of-the-nutrition-society\/article\/contribution-of-the-gut-microbiota-to-the-regulation-of-host-metabolism-and-energy-balance-a-focus-on-the-gutliver-axis\/9C58A0E320AB35547FE219EDF19F9AE6\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eFernandes, R., do Rosario, V. A., Mocellin, M. C., Kuntz, M. G., \u0026amp; Trindade, E. B. (2017). Effects of inulin-type fructans, galacto-oligosaccharides and related synbiotics on inflammatory markers in adult patients with overweight or obesity: A systematic review. \u003ci\u003eClinical Nutrition\u003c\/i\u003e, \u003ci\u003e36\u003c\/i\u003e(5), 1197-1206. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0261561416312754\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eIacono, A., Raso, G. M., Canani, R. B., Calignano, A., \u0026amp; Meli, R. (2011). Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms. \u003ci\u003eThe Journal of nutritional biochemistry\u003c\/i\u003e, \u003ci\u003e22\u003c\/i\u003e(8), 699-711. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0955286310002408\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eJohnson-Henry et al. (2008). Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli 0157:H7- Induced changes in epithelial barrier function. Infect Immun; 76:1340-1348. \u003ca href=\"https:\/\/iai.asm.org\/content\/76\/4\/1340.short\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eLee et al. (2006). Human originated bacteria, \u003ci\u003eLactobacillus rhamnosus\u003c\/i\u003e PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. \u003ci\u003eBiochim Biophys Acta\u003c\/i\u003e; 1761: 736-744. \u003ca href=\"http:\/\/eanimal.snu.ac.kr\/Aboutus\/paper\/papers\/bbalip.pdf\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eSafari, Z., \u0026amp; Gérard, P. (2019). The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD). \u003ci\u003eCellular and Molecular Life Sciences\u003c\/i\u003e, 1-18. \u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00018-019-03011-w\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eShalitin, S., Battelino, T., \u0026amp; Moreno, L. A. (2019). Obesity, Metabolic Syndrome and Nutrition. \u003ci\u003eNutrition and Growth: Yearbook 2019\u003c\/i\u003e, \u003ci\u003e119\u003c\/i\u003e, 13-42.  \u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=Y-OGDwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PT23\u0026amp;dq=+meta-analysis+of+the+prebiotics+and+synbiotics+effects+on+glycaemia,+insulin+concentrations+and+lipid+parameters+in+adult+patients+with+overweight+or+obesity.\u0026amp;ots=yJ9bP-ZUDn\u0026amp;sig=GtbpOFXdGAGvm9drVMb4rQHclPc#v=onepage\u0026amp;q\u0026amp;f=false\"\u003e\u003cspan class=\"s2\"\u003eChapter\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eWang et al. (2009). Effects of \u003ci\u003eLactobacillus plantarum\u003c\/i\u003e MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet. Appl Microbiol Biotechnol; 84: 341-347. \u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00253-009-2012-x\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eYadav et al. (2007). Antidiabetic effect of probiotic dahl containing \u003ci\u003eLactobacillus acidophilus\u003c\/i\u003e and \u003ci\u003eLactobacillus casei\u003c\/i\u003e in high fructose fed rats. \u003ci\u003eNutrition\u003c\/i\u003e; 23: 62-68. \u003ca href=\"https:\/\/www.researchgate.net\/profile\/Hariom_Yadav2\/publication\/6711708_Antidiabetic_effect_of_probiotic_dahi_containing_Lactobacillus_acidophilus_and_Lactobacillus_casei_in_high_fructose_fed_rats\/links\/5b22d73faca272277faf9632\/Antidiabetic-effect-of-probiotic-dahi-containing-Lactobacillus-acidophilus-and-Lactobacillus-casei-in-high-fructose-fed-rats.pdf\"\u003e\u003cspan class=\"s2\"\u003eArticle\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eYari, Z., \u0026amp; Hekmatdoost, A. (2019). Dietary Interventions in Fatty Liver. In \u003ci\u003eDietary Interventions in Gastrointestinal Diseases\u003c\/i\u003e (pp. 245-255). Academic Press. \u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B978012814468800020X\"\u003e\u003cspan class=\"s2\"\u003eAbstract\u003c\/span\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch6\u003e\n\u003cspan\u003eProtocol\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eORIGINAL\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— The Original is designed as a foundational probiotic formula for the whole family.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eHard working probiotic\u003c\/i\u003e: The Original is designed to handle and neutralize carcinogens, toxins, molds, yeasts, and food pathogens (e.g., salmonella). The probiotic mix binds heavy metals. Take 1 teaspoon a day. For babies, start with a few grains (mothers can dip their pinkie in the mix to feed the baby). Sensitive individuals start with ¼ teaspoon and gradually up the dosage.* \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eleaky gut\u003c\/i\u003e: The Original creates a slightly acidic pH level in the GI Tract to protect the gut membrane from pathogens like yeast. The mix produces amazingly high amounts of the short chain fatty acid butyrate, which facilitate the tightening of the gut membrane. Take 1 teaspoon daily (can take 1 teaspoon three times day during acute bouts of gastric distress).*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eDigestion\u003c\/i\u003e: Take 1 teaspoon to improve digestion, dissolve in mouth slowly. The Original in fact helps the digestion of polyphenols from fruits, berries, veggies, and greens into bioavailable shorter chains of phenolic molecules. The Original also helps digest complex carbohydrates into short chain fatty acids, important for gut health.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eMicrobiome and healthy diversity\u003c\/i\u003e: The Original has team playing organisms that help to build healthier communities in the gut.\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712314540076,"sku":"TF013","price":47.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Original-Synbiotic-4.6---Front.jpg?v=1723214776"},{"product_id":"no-7-systemic-booster","title":"No 7 Systemic Booster","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e65% of Americans suffer with one or more chronic ill-health conditions, and are caught within a frustrating cycle of having just enough energy for work, but barely a sustained vigor (or oomph) for much else.\u003c\/p\u003e\n\u003cp\u003eIt is time to change your health strategy.\u003c\/p\u003e\n\u003cp\u003eScience tells us that enjoying good health, energy, and longevity is dependent upon\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ethe correct nutritional strategy\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eto facilitate and educate the body’s defense, repair, adaptation and renewal functions (Calder et al., 2017).\u003c\/p\u003e\n\u003cp\u003eThe No 7 Systemic Booster offers a new strategy for healthy longevity. A defiantly powerful booster, the No 7 is a comprehensive anti-aging formula with advanced nutritional properties that are precisely measured according to scientific data, just for you.*\u003c\/p\u003e\n\u003cp\u003eThe No 7 Systemic Booster is a serious, uncompromisingly healthy drink: Plant-Based, Organic, Kosher, Free of Gluten, Dairy, and Natural Flavors. Mix 1 teaspoon with a shot of diluted juice, or water. Every day.\u003c\/p\u003e\n\u003ch6\u003eDescription\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eThe\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eNo 7 Systemic Booster: The New Longevity\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eis a formula based on the science of Longevity:  fighting against, and preventing the epidemic of chronic illnesses.*\u003c\/p\u003e\n\u003cp\u003eAre you amongst the 85% of people who are over 65 years old and suffer from one or two chronic illnesses? Do you have a child under 17 that already has one or more chronic conditions?\u003c\/p\u003e\n\u003cp\u003eAlmost half of our population, from young adult age of 18 and all the way to mature adults of 64, is experiencing one or more chronic illnesses (2018,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eLiving Well - Dying Well\u003c\/i\u003e, p. 120). That means that half of us do not feel good most of our lives, and almost all of us have at least one illness to weigh us down in our older years.\u003c\/p\u003e\n\u003cp\u003eThe No 7 Booster is a serious, uncompromisingly healthy drink. There are no sweeteners, fillers, or natural flavors to muck up the real power of the blend. Typically, artificial, natural, or even organic flavors have from 100-500 different components that are not required to be listed on the label. The No 7 is as pure as it is powerful. Take on tsp, mush it in your mouth, or dissolve it in a little glass of water.*\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePotent Phytonutrient\u003c\/b\u003e- Organic berries, fruits, hardy vegetables, and green leafy vegetables: strawberry, raspberry, blueberry, tart cherry, elderberry, cranberry, apple extract, pineapple, beet, broccoli florets, kale leaves, spinach leaves.\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eBioImmersion Super Blend\u003c\/b\u003e:\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eProbiotics\u003c\/i\u003e- \u003cem\u003eLactobacillus plantarum, Lactobacillus paracasei, Lactobacillus reuteri, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium lactic, Bifidobacterium longum, Streptococcus thermophilus and Lactobacillus bulgaricus\u003c\/em\u003e.\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e\u003ci\u003eSupernatant\u003c\/i\u003e\u003c\/b\u003e- probiotic metabolites, and\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e\u003ci\u003eORNs\u003c\/i\u003e\u003c\/b\u003e.\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e\u003ci\u003ePrebiotics\u003c\/i\u003e-\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003eInulin from Chicory Root along with\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eFibers-\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003efrom organic veggies, greens, fruits, and berries.\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eVital\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eNutriceuticals\u003c\/b\u003e- Fructo Borate, Vitamin B12, Vitamin D3, Folate, Chromium.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eLiterature Review\u003c\/b\u003e:\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eThe Science of Longevity: Examining the root causes, nature, and solutions of chronic illnesses\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eWhat is longevity? What brings on the glow of a robust health in both younger and older people? According to the US National Institute of Aging (NIA), longevity is about measured strategies to extend the healthy functioning of our body (Nadon et al., 2008) – these strategies aim to prevent diseases, especially chronic illnesses like cardiovascular and cancer, among others (Caprara, 2018).*\u003c\/p\u003e\n\u003cp\u003eGlobally, while the average life span has increased in both developed and developing nations, in the next 30 years the aging population will double to 22%, or about 2 billion people. Since there are about 7.7 billion people in the world, this means that almost a quarter of the world will be over 60 years old. Chronic illnesses around the world are responsible for about 35 million deaths each year (United Nations, Ageing, 2017;\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eLiving Well - Dying Well\u003c\/i\u003e, 2018, p. 119).\u003c\/p\u003e\n\u003cp\u003eIn the United States, 85% of people who are over 65 years of age suffer from one or two chronic illnesses, and nearly a quarter of children that are under 17 years old suffer one or more chronic conditions, with almost half of young to mature adults (18 to 64 years old) having one or more chronic illnesses (2018,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eLiving Well - Dying Well\u003c\/i\u003e, p. 120).\u003c\/p\u003e\n\u003cp\u003eOld age causes a variety of biological and cognitive degeneration, yet the decline does not have to be debilitating. Just the opposite, with the correct approach toward prevention, healthy longevity can be achieved (Jin et al., 2015). The World Health Organization (WHO) has focused their efforts on addressing non-communicable diseases, or chronic illnesses, such as cancer, ischemic heart diseases, stroke, type 2 diabetes, Alzheimer’s disease and other illnesses, as a preventative approach and a path toward longevity (WHO, 2014; see also Lim et al., 2012 global assessment of both infectious and NCDs diseases).\u003c\/p\u003e\n\u003cp\u003eIn the developed world, longevity was thought of as an anti-aging approach that emphasized looks rather than health. Skin care, makeup, supplements, and medicines were created to hide age and stimulate our bodies into producing more energy and higher hormone levels. Merchandise was fused with procedures to tighten or erase wrinkles and skin discolorations, sucking or adding fat, depending on the area treated, to name a few (e.g., Ganceviciene et al., 2012). Mostly, the anti-aging movement was aimed to make women look younger and men more virile.*\u003c\/p\u003e\n\u003cp\u003eThe\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eNo 7\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eNew Longevity\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003erepresents a comprehensive approach to health and long life (Jin et al., 2015). This new approach to longevity (or healthy ‘anti-aging’) does not solely focus on how we look but\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ehow our\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ebodies function healthily\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e(Fontana et al., 2014).\u003c\/p\u003e\n\u003cp\u003eKey to longevity and anti-aging is the approach to calming inflammation, micro and macro inflammation, seen as the intrinsic biological aging clock (Luo et al., 2011). In 1913, Dr. Arnold Lorand seminal work,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eHealth and Longevity through Rational Diet\u003c\/i\u003e, explains the connection between inflammation and disease:\u003c\/p\u003e\n\u003cp\u003e“The majority of the diseases with which mankind is afflicted usually creep in through the accumulated effects of successive slight irritation, by the operation of apparently insignificant factors which are just sufficient to take part in some chemical reaction.” (p. 115)\u003c\/p\u003e\n\u003cp\u003eCalder et al. (2017) characterize aging as an\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eincrease\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003ein the concentration of\u003cspan\u003e \u003c\/span\u003e\u003ci\u003einflammatory markers in the blood stream, a phenomenon that has been termed “inflammageing”\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e(see Franceschi \u0026amp; Campisi, 2014; Franceschi et al., 2007; Franceschi et al., 2000).*\u003c\/p\u003e\n\u003cp\u003eAlong with inflammation, the ageing of the immune system, called\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eimmunosenescence\u003c\/i\u003e, is also an age-related decline of the immune system that leads to an increased frequency and severity of infectious diseases and certain cancers (Solana \u0026amp; Pawelec, 2004; Clements \u0026amp; Carding, 2016; Bauer \u0026amp; Fuente, 2014). Immunosenescence is brought about by a continuous chronic antigenic - toxins inducing immune response – which then overload the ability of the immune system to keep up with the demands for naïve cells, the components of cells that enable the body to fight off new, unrecognized infections or diseases (Candore et al., 2006; Calder et al., 2018).*\u003c\/p\u003e\n\u003cp\u003eOnce low grade chronic inflammation is activated, it becomes a system-wide condition that leads to higher mortality rates from different illnesses (e.g., Bozzetto et al., 2018; AHA, 2017; Clements \u0026amp; Carding, 2016; Morrisette-Thomas et al., 2014). A study on 1018 Italian old persons demonstrated that higher levels of certain inflammation-related mediators such as IL- 6, IL-1ra ,TNA-a, TNF- a receptor II (TNFAR2) were associated with higher number of chronic illnesses, such as hypertension, diabetes, ischemic heart disease, stroke, cancer, Parkinson’s, hip fractures, joint diseases, anemia, kidney disease, and cognitive impairment (Fabbri et al., 2015).*\u003c\/p\u003e\n\u003cp\u003eLongevity is a balanced state of pro- and anti-inflammatory mediators. By protecting the body against the harmful effects of inflammation with high levels of anti-inflammatory molecules, long-life with better health is attainable. For example, Le Couteur et al. (2016) explain the profound effects nutrition has on ageing and longevity, with animal studies showing longevity is achieved with a specific diet that is similar to the dietary traditions of the long-lived people on the island of Okinawa – a predominantly plant based diet.*\u003c\/p\u003e\n\u003cp\u003eIn fact, major advances in science show we have nutrient-sensing cellular pathways that link diet and ageing (Le Couteur et al., 2016, Figure 2). Balancing the gut microbiome, avoiding foods that lead to obesity, getting enough sleep, upping whole plant carbohydrates and fibers (from vegetables, fruits, grains, seeds, and nuts), and reducing animal based protein intake, all are shown in research as interventions for extended lifespan and longevity (Vaiseman et al., 2017; Le Couteur et al., 2016; Mirzaei et al., 2014, respectively).*\u003c\/p\u003e\n\u003cp\u003eCandore et al. (2006) found that when we neutralize infectious agents and live in healthy environments, we have a better chance of lowering chronic inflammatory markers in the body and protecting our immune system. Yet, in today’s toxic world, keeping inflammation down is not an easy task. In chapter 8 of\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eLiving Well, Dying Well\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e(2018), Dr. Dohrea Bardell discusses a field of medicine that has been established to handle these complex issues - Lifestyle Medicine. Our daily routines include habits that support or detract from our health. Dr. Bardell outlines important steps we can take to improve our health, such as creating better (toxic free) environments at home and at work, changing our dietary habits by eating more plant-based foods, using natural products for personal grooming, our homes and gardens, exercising a few times a week, and more. These steps aim to lower the triggers of chronic inflammation, boost our immune system, energy level, and even sleep better. (\u003ca href=\"https:\/\/www.amazon.com\/Living-Well-Dying-choices-consequences\/dp\/0986393061\/ref=sr_1_1?ie=UTF8\u0026amp;qid=1546027022\u0026amp;sr=8-1\u0026amp;keywords=living+well+dying+well\"\u003eLivingWell,DyingWell\u003c\/a\u003e).*\u003c\/p\u003e\n\u003cp\u003eA plant based dietary habits is essential (Seidelmann et al., 2018). Many scientists have come to realize that health, longevity, and anti-aging are fundamentally dependent upon the correct nutritional strategy that facilitates and educates the body’s defense, repair, adaptation, and renewal functions (Calder et al., 2017; Mykytyn, 2005; see Research tab for more articles on this topic). *\u003c\/p\u003e\n\u003cp\u003eIn fact, scientific research insists upon the daily consumption of plant-based foods, probiotics and their fermented metabolites, plenty of fiber, and particular nutriceuticals to achieve and sustain longevity: the healthy systemic functions of the body (Seidelmann et al., 2018; Devi \u0026amp; Sekhar, 2018; Filosa et al, 2018; Donoiu et al., 2018; Iskar \u0026amp; Antonyak, 2018; Smith \u0026amp; Hsu, 2018; Holscher, 2017).*\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eThe No 7 Systemic Booster: The New Longevity\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eis thoughtfully designed to provide a measured serving of high active nutrients from vegetables, greens, fruits, and berries, fiber, naturally whole probiotics with their metabolites, and full servings of important nutriceuticals. No 7 Systemic Booster has a definitive purpose: boosting the body’s different systems with excellent nutritious drink that is potent with ingredients shown in research to offer longevity.*\u003c\/p\u003e\n\u003cp\u003eLet’s take a look at how the different ingredients work in the body. For a good jumping point, click on the Research Tab to access the global research and references to further study longevity and better health.\u003c\/p\u003e\n\u003cp\u003eOne of the keys to the aging process is our intestinal microbiota (Vaiseman et al., 2017). The presence of micro-organisms is actually found in the placenta and amniotic fluid (Collado et al., Nagpal et al., 2017; 2016; Arboleya et al., 2016). Stressors such as bad dietary habits, lack of exercise, toxic environments, use of antibiotics, can change the microbiota into a “dysbiosis state” that may cause different chronic diseases from immune-mediated disorders to neuropsychiatric conditions. Researchers believe that a dysbiosis state is due to alteration in the crosstalk between “commensals bacteria and intestinal epithelium, including immune cells of the gut associated lymphoid tissue (Lepage et al., 2011; Calder et al., 2017). An unfavorable balance or change in the microbiota is believed to be one of the reasons for obesity worldwide (Gao et al., 2015; Santacruz et al., 2010), an issue that affects people of all ages.\u003c\/p\u003e\n\u003cp\u003eScientists believe that dysbiosis of the gut is generated when lower diversity in the microbiota and inflammation of the gut are combined. Dysbiosis can lead to frailty (van Tongeren et al., 2005), Crohn’s (De Cruz et al., 2012), obesity and metabolic illnesses (Le Chatelier et al., 2013), colorectal cancer (Chen et al., 2012), among other conditions.\u003c\/p\u003e\n\u003cp\u003eThe No 7 super blend collection of naturally occurring probiotics with their supernatant and ORNs works together with plants polyphenols and fibers (as prebiotics). Probiotic microorganisms belong mostly to the following geni:\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eLactobacillu\u003c\/i\u003es,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eBifidobacterium\u003c\/i\u003e, and \u003ci\u003eLactococus\u003c\/i\u003e, \u003ci\u003eStreptococcus\u003c\/i\u003e, \u003ci\u003eEnterococcus\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e(Markowiak \u0026amp; Śliżewska, 2017). These foundational organisms form strong communities (ecosystems) that perform many health benefits (Nagpal et al., 2018).\u003c\/p\u003e\n\u003cp\u003eFor example, the Bifidobacterium have been identified as the most global inhabitants of the human host (Biavati \u0026amp; Mattarelli, 2006). From infancy (and even as a fetus), to adulthood and old age, health is associated with the Bifidobacterial family (Arboleya et al., 2016). In animal studies, Bifidobacterium is shown to support brain\/gut axis and prevent certain types of cancers (Savignac et al., 2014, Sivan et al., 2015).\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eLactobacillus casei\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003ehas shown in research to lower the formation of colorectal tumors (Ishikawa et al., 2005). Aging and pro-inflammation are linked ‘reduced transepithelial electric resistance’ or gut-permeability (Nicolettie, 2015). Probiotics organisms such as lactobacillus and Bifidobacterium both help to maintain a healthy microbiota which in turn halt or reverse detrimental effects of aging, strengthening intestinal barrier and the innate immune response (Nicoletti, 2015).\u003c\/p\u003e\n\u003cp\u003eResearch literature on age and longevity shows prolific evidence that links nutrition and gut microbiota to systemic inflammation, and suggests that dietary interventions can influence microbiota composition and diversity (Nagpal et al., 2017; Claesson et al., 2012). In fact, lower inflammation is strongly associated with vegetarian diets (or the Mediterranean diet), rich in fruits, vegetables, nuts, seeds, legumes, and whole grains, with fats from plant oils, e.g., olive oil (Calder et al., 2011; Sarubbo et al., 2018).\u003c\/p\u003e\n\u003cp\u003eWhat about brain aging?  Inflamm-aging is due in part to the increase of oxidative stress in the body and brain. Inflamm-aging is caused by a continuous antigenic load (a toxin inducing immune response) and stress which activates subclinical, chronic low-grade inflammation (Franceschi et al., 2017; 2006; Minciullo et al., 2015; Sarubbo et al., 2018).  Neuro-inflammation is part of the inflamm-aging process, and is linked with decreased brain functionality, e.g., memory, learning, and coordination (Sarubbo et al., 2018). Combination of vegetables, greens, fruits, and plant fiber provide a host of rich polyphenols, shown to lower a variety of pro-inflammatory markers (Spencer et al., 2012; Hermsdorff et al., 2010; Bhupathiraju \u0026amp; Tucker, 2010; Holt et al., 2009). Effects of polyphenols on the body and brain include complex interaction, mediation, and activation of a variety of important biomolecules, exerting influence over cell senescence, inflammation, apoptosis, stress resistance, and metabolism (Queen \u0026amp; Tollefsbol, 2010)  have been studied extensively for reducing oxidative stress and as anti-inflammatory and repair agents (Joseph et al., 2007; Sheridan et al., 2013; Pandey et al., 2009; Sheridan et al., 2013; Lau et al, 2005).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eNo 7 Longevity\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eoffers many phytonutrients from organic fruits, vegetables, greens, and plant fiber: Organic strawberry, raspberry, blueberry, tart cherry, elderberry, cranberry, apple extract, pineapple, beet, kale leaves, spinach leaves, broccoli florets.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGreen leafy vegetables\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cb\u003evegetables\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003esuch as beetroot contain dietary nitrates that mitigate many functions, such as increase energy for exercise, supplying blood and oxygen to working tissues (Kenjale et al., 2011; Lidder \u0026amp; Webb, 2013), blood pressure lowering (Kapil et al., 2015), and both decreasing blood pressure and improving exercise (Berry et al., 2015). Each additional serving of vegetable and fruits protect against erectile dysfunction among men with diabetes (Wang et al., 2013). Nitrates from food helps maintain brain health and function (Presley et al., 2010), and show an overall beneficial health effects, the more – the better (Hord, Tang, \u0026amp; Bryan, 2009).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBroccoli\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003ehas high levels of glucosinolates and sulforaphanes, a potent mix of phyto-nutrient shown in research to provide phase II enzyme inducer to boost the liver’s ability to detoxify. Broccoli is also shown in research as a protective agent, offering anti-carcinogenic properties and mechanisms (Zhang et al., 1994; Zhang et al., 2015; Leon et al., 2017).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFruits and berries\u003c\/b\u003e: Anthocyanins from berry fruits with red, blue, or purple, enhance cognitive functions and extend neuroprotective properties (Joseph et al., 2009; Poulose \u0026amp; Carey, 2012). Moreover, anthocyanins can be used for inflammation-mediated conditions such as atherosclerosis (Aboonabi \u0026amp; Singh, 2015; Lee et al., 2014). Proanthocyanidins found in berries have also neuroprotective effects (Joseph et al., 2010).\u003c\/p\u003e\n\u003cp\u003eSupplementation with dietary phytochemicals have direct and hormetic effects, balancing the pro and anti-inflammatory responses (Davinelli et al., 2015; Karlsen et al., 2007). Blueberries in particular have shown in research to improve memory in older adults (Krikorian et al., 2010; see research tab of our\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/bioimmersion.com\/products\/blueberry-extract\"\u003eBlueberry-Extract\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003efor more information). Cherries and cherry juice are shown to improve memory and cognition in older adult (Kent et al., 2015). For more research on berries, see our High-ORAC as well as\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/bioimmersion.com\/products\/phyto-power\"\u003ePhyto-Power\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eresearch tabs.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eThe Hormetic Response\u003c\/b\u003e:\u003c\/p\u003e\n\u003cp\u003eA teaspoon of the No 7 longevity can be thought of as one veggie\/fruit serving. And it can also work in small dosages called the hormetic effect or ‘preconditioning\/Hormesis.’ Food phytochemicals play an emerging role as hormetic inducers of neuroprotective pathways relevant for brain aging. For example, in small portions, dietary phytochemicals from vegetables and fruits offer a stimuli that trigger adaptive stress-response mediated by NF-kB to provide neuroprotection (Davinelli et al., 2016).\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSelective Nutriceuticals\u003c\/b\u003e: The No 7 Longevity also includes patented nutriceuticals such as the Fructo Borate (125mg) and Chromium (500mcg), B12 (250mcg; as Methylcobalamin), Folate (400mcg; as 5-methyltetrahydrofolate or Quatrefolic), and Vitamin D (1000IU).\u003c\/p\u003e\n\u003cp\u003eFructo Borate is a patented natural plant-derived molecule that works effectively on systemic inflammation (and pain) for people with osteoarthritis (Scorei et al., 2011). Together with polyphenols from the vegetables, greens, fruits, and berries, Fructo Borate is potentiated for a greater bone protection (Horcjada \u0026amp; Offord, 2012; Shen et al., 2012). As a systemic anti-inflammation, Boron and Fructo Borate show a great potential for longevity (Nielsen, 2018).\u003c\/p\u003e\n\u003cp\u003eChromium has also been researched extensively for blood sugar regulation, weight management, and longevity (, Smith \u0026amp; Hsu, 2018; Iskra \u0026amp; Antonyak, 2018).\u003c\/p\u003e\n\u003cp\u003eVitamins B12, Folate, and D have shown in research to support many different systems in the body, from cardiovascular and metabolic diseases, brain aging, arterial function, energy, and Longevity (Ford et al., 2014; Lee et al., 2014; Fenech, 2017; Kwok et al., 2012; Thomas \u0026amp; Fenech, 2015; Watson et al., 2018, respectively). Check out these and more references at the Research tab of\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/bioimmersion.com\/products\/no-7-systemic-booster\"\u003eNo-7-Longevity\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eThe No 7 Longevity\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eencompasses a great deal of research into better health. The scientific community has much more to discover, yet many of the findings do show a clear path toward health that is not riddled by chronic conditions that can be supported by a plant-based diet of whole foods, a cleaner home and office environments, exercise, toxic free personal and home cleaning products, organic or pesticides \u0026amp; herbicides free foods, and clean, researched based supplementations (see Living Well – Dying Well, Chapter 8).\u003c\/p\u003e\n\u003cp\u003eReferences\u003c\/p\u003e\n\u003cp\u003eAmerican Heart Association. (2017, March 09). 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Improving brain signaling in aging: could berries e the answer?. \u003ci\u003eExpert review of neurotherapeutics\u003c\/i\u003e, \u003ci\u003e12\u003c\/i\u003e(8), 887-889.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1586\/ern.12.86\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePresley, T. D., Morgan, A. R., Bechtold, E., Clodfelter, W., Dove, R. W., Jennings, J. M., ... \u0026amp; Burdette, J. H. (2011). Acute effect of a high nitrate diet on brain perfusion in older adults. \u003ci\u003eNitric Oxide\u003c\/i\u003e, \u003ci\u003e24\u003c\/i\u003e(1), 34-42.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3018552\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eQueen, B. L., \u0026amp; Tollefsbol, T. O. (2010). 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Polyphenols-What's Behind their Antiaging Brain Reputation. \u003ci\u003eAnn Nutr Food Sci. 2018; 1 (2)\u003c\/i\u003e, \u003ci\u003e1009\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/7a4f\/f3510573116c121683eabd75c4f35a0abb48.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSavignac, H. M., Kiely, B., Dinan, T. G., \u0026amp; Cryan, J. F. (2014). B ifidobacteria exert strain‐specific effects on stress‐related behavior and physiology in BALB\/c mice. \u003ci\u003eNeurogastroenterology \u0026amp; Motility\u003c\/i\u003e, \u003ci\u003e26\u003c\/i\u003e(11), 1615-1627.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12427\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSeidelmann, S. B., Claggett, B., Cheng, S., Henglin, M., Shah, A., Steffen, L. M., ... \u0026amp; Solomon, S. D. (2018). 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Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy. \u003ci\u003eScience\u003c\/i\u003e, aac4255.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/science.sciencemag.org\/content\/350\/6264\/1084\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSolana R. \u0026amp; Pawelec, G. (2004). Immunosenescence.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eNeuroImmune Biology, 4\u003c\/i\u003e, 9-21.\u003c\/p\u003e\n\u003cp\u003eSpencer, J. P., Vafeiadou, K., Williams, R. J., \u0026amp; Vauzour, D. (2012). Neuroinflammation: modulation by flavonoids and mechanisms of action. \u003ci\u003eMolecular aspects of medicine\u003c\/i\u003e, \u003ci\u003e33\u003c\/i\u003e(1), 83-97.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0098299711000732\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eStevens-Long, J. \u0026amp; Bardell, D. (2018).\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eLiving well, dying well\u003c\/i\u003e. Santa Barbara, CA: Fielding University Academic Press\u003c\/p\u003e\n\u003cp\u003e United Nation. (2017). Ageing.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.un.org\/en\/sections\/issues-depth\/ageing\/\"\u003ehttp:\/\/www.un.org\/en\/sections\/issues-depth\/ageing\/\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVaiserman, A. M., Koliada, A. K., \u0026amp; Marotta, F. (2017). Gut microbiota: A player in aging and a target for anti-aging ervention. \u003ci\u003eAgeing research reviews\u003c\/i\u003e, \u003ci\u003e35\u003c\/i\u003e, 36-45.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.arr.2017.01.001\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.arr.2017.01.001\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003evan Tongeren, S. P., Slaets, J. P., Harmsen, H. J. M., \u0026amp; Welling, G. W. (2005). Fecal microbiota composition and frailty. \u003ci\u003eApplied and environmental microbiology\u003c\/i\u003e, \u003ci\u003e71\u003c\/i\u003e(10), 6438-6442.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/aem.asm.org\/content\/71\/10\/6438.full\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWang, F., Dai, S., Wang, M., \u0026amp; Morrison, H. (2013). Erectile dysfunction and fruit\/vegetable consumption among diabetic Canadian men. \u003ci\u003eUrology\u003c\/i\u003e, \u003ci\u003e82\u003c\/i\u003e(6), 1330-1335.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24295250\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWorld Health Organization [WHO]. (2014). Twelfth general programme of work: Not merely the absence of disease.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/112792\/GPW_2014-2019_eng.pdf;jsessionid=0CB4A67AA7C6A75C958EE0B97B814151?sequence=1\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZamora-Ros, R., Rabassa, M., Cherubini, A., Urpí-Sardà, M., Bandinelli, S., Ferrucci, L., \u0026amp; Andres-Lacueva, C. (2013). High Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated with Decreased Mortality in Older Adults, 2. \u003ci\u003eThe Journal of nutrition\u003c\/i\u003e, \u003ci\u003e143\u003c\/i\u003e(9), 1445-1450.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/jn\/article\/143\/9\/1445\/4615208\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZhang, X., Shu, X. O., Xiang, Y. B., Yang, G., Li, H., Gao, J., ... \u0026amp; Zheng, W. (2011). Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality–. The American journal of clinical nutrition, 94(1), 240-246.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/ajcn\/article\/94\/1\/240\/4597862?ncid=txtlnkusaolp00000619\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZhang, Y., Kensler, T. W., Cho, C. G., Posner, G. H., \u0026amp; Talalay, P. (1994). Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proceedings of the National Academy of Sciences, 91(8), 3147-3150.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.pnas.org\/content\/pnas\/91\/8\/3147.full.pdf\"\u003eArticle\u003c\/a\u003e \u003c\/p\u003e\n\u003ch6\u003eResearch \u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003eFOOD SCIENCE: THE APPLICATION AND USE OF:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePhytonutrients\u003c\/strong\u003e- Organic strawberry, raspberry, blueberry, tart cherry, elderberry, cranberry, apple extract, pineapple, beet, kale leaves, spinach leaves, broccoli florets.\u003cbr\u003e\u003cstrong\u003eBioImmersion Super Blend:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eProbiotics\u003c\/strong\u003e- Bifidobacterium longum, Lactobacillus casei, lactobacillus acidophilus, Lactobacillus bulgaricus, and Steprococcus thermophilus.\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eSupernatant-\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eprobiotic metabolites, and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eORNs\u003c\/strong\u003e.\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003ePrebiotics-\u003c\/strong\u003eInulin from Chicory Root along with fiber from organic veggies, greens, fruits, and berries.\u003cbr\u003e\u003cstrong\u003eNutriceuticals\u003c\/strong\u003e- Fructo Borate, Vitamin B12, Vitamin D3, Folate, Chromium.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003ePhytonutrients \u0026amp; Microbiota: Markers for Longevity and Anti-Aging\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eArboleya, S., Watkins, C., Stanton, C., \u0026amp; Ross, R. P. (2016). Gut bifidobacteria populations in human health and aging. \u003ci\u003eFrontiers in microbiology\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e, 1204.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2016.01204\/full\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBasu A. Lyons TJ. (2012). Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eJ Agric Food Chem\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e60\u003c\/i\u003e, 5687-92.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf203488k\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBelščak-Cvitanović, A., Durgo, K., Huđek, A., Bačun-Družina, V., \u0026amp; Komes, D. (2018). Overview of polyphenols and their properties. In \u003ci\u003ePolyphenols: Properties, Recovery, and Applications\u003c\/i\u003e (pp. 3-44).\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/B978-0-12-813572-3.00001-4\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/B978-0-12-813572-3.00001-4\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBellavia, A., Larsson, S. C., Bottai, M., Wolk, A., \u0026amp; Orsini, N. (2013). Fruit and vegetable consumption and all-cause mortality: a dose-response analysis–. \u003ci\u003eThe American journal of clinical nutrition\u003c\/i\u003e, \u003ci\u003e98\u003c\/i\u003e(2), 454-459. DOI:\u003ca href=\"https:\/\/doi.org\/10.3945\/ajcn.112.056119\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.3945\/ajcn.112.056119\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBiagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., \u0026amp; Brigidi, P. (2013). Ageing and gut microbes: perspectives for health maintenance and longevity. \u003ci\u003ePharmacological Research\u003c\/i\u003e, \u003ci\u003e69\u003c\/i\u003e(1), 11-20.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.phrs.2012.10.005\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.phrs.2012.10.005\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCalder, P. C., Bosco, N., Bourdet-Sicard, R., Capuron, L., Delzenne, N., Doré, J., ... \u0026amp; Visioli, F. (2017). Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. \u003ci\u003eAgeing research reviews\u003c\/i\u003e, \u003ci\u003e40\u003c\/i\u003e, 95-119.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S156816371730003X\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ede la Luz Cádiz-Gurrea, M., Micol, V., Joven, J., Segura-Carretero, A., \u0026amp; Fernández-Arroyo, S. (2018). Different behavior of polyphenols in energy metabolism of lipopolysaccharide-stimulated cells. \u003ci\u003eFood Research International\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.foodres.2018.02.027\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.foodres.2018.02.027\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDevi, S. A., \u0026amp; Sekhar, S. R. (2018). Antiaging Interventions: An Insight into Polyphenols and Brain Aging. In \u003ci\u003eMolecular Basis and Emerging Strategies for Anti-aging Interventions\u003c\/i\u003e(pp. 281-295). Springer, Singapore.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-1699-9_18\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDing, S., Jiang, H., \u0026amp; Fang, J. (2018). Regulation of Immune Function by Polyphenols. \u003ci\u003eJournal of immunology research\u003c\/i\u003e, \u003ci\u003e2018\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1155\/2018\/1264074\"\u003ehttps:\/\/doi.org\/10.1155\/2018\/1264074\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eElmann, A., Wang, C. K., \u0026amp; Vauzour, D. (2018). Polyphenols Targeting Brain Cells Longevity, Brain’s Redox Status, and Neurodegenerative Diseases. \u003ci\u003eOxidative medicine and cellular longevity\u003c\/i\u003e, \u003ci\u003e2018\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6109470\/\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFilosa, S., Di Meo, F., \u0026amp; Crispi, S. (2018). Polyphenols-gut microbiota interplay and brain neuromodulation. \u003ci\u003eNeural regeneration research\u003c\/i\u003e, \u003ci\u003e13\u003c\/i\u003e(12), 2055.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6199944\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFlavel, M., Yang, X., \u0026amp; Kitchen, B. (2018). Benefits of plant polyphenols in food. \u003ci\u003eFood Australia\u003c\/i\u003e, \u003ci\u003e70\u003c\/i\u003e(3), 34.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/search.informit.com.au\/documentSummary;dn=838047905849863;res=IELHSS;type=pdf\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGalanakis, C. M. (Ed.). (2018). \u003ci\u003ePolyphenols: Properties, Recovery, and Applications\u003c\/i\u003e. Woodhead Publishing.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=Nm89DwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PP1\u0026amp;dq=polyphenols+and+longevity\u0026amp;ots=X5sVHWoj5Z\u0026amp;sig=p2UGkY8rOTqxSEYDcytNxGgiOEA#v=onepage\u0026amp;q=polyphenols%20and%20longevity\u0026amp;f=false\"\u003eBook\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHarman D. (2006). Free radical theory of aging: an update. Ann N Y Acad Sci,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e1067\u003c\/i\u003e,1–12.\u003c\/p\u003e\n\u003cp\u003eJoseph, J. A., Shukitt-Hale, B., \u0026amp; Casadesus, G. (2005). Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds–. \u003ci\u003eThe American Journal of Clinical Nutrition\u003c\/i\u003e, \u003ci\u003e81\u003c\/i\u003e(1), 313S-316S.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/ajcn\/article\/81\/1\/313S\/4607635\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKumar, R., Chauhan, S. K., Vijayalakshmi, S., \u0026amp; Nadanasabapathi, S. (2018). Phytonutrients: Their Relevance to Human Health. In \u003ci\u003eMedicinal Plants\u003c\/i\u003e (pp. 17-46). CRC Press.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.taylorfrancis.com\/books\/e\/9781351046503\/chapters\/10.1201\/9781351046510-2\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLi, Y. R., Li, S., \u0026amp; Lin, C. C. (2018). Effect of resveratrol and pterostilbene on aging and longevity. Biofactors, 44(1), 69-82.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/biof.1400\"\u003ehttps:\/\/doi.org\/10.1002\/biof.1400\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLink, A., Balaguer, F., \u0026amp; Goel, A. (2010). Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. \u003ci\u003eBiochemical pharmacology\u003c\/i\u003e, \u003ci\u003e80\u003c\/i\u003e(12), 1771-1792.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006295210004703\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLorand, A. (1913). \u003ci\u003eHealth and longevity through rational diet\u003c\/i\u003e. Davis. Philadelphia, PA: F.A. Davis Company, Publishers.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMattioli, R., Mosca, L., Sánchez-Lamar, A., Tempera, I., \u0026amp; Hausmann, R. (2018). Natural Bioactive Compounds Acting against Oxidative Stress in Chronic, Degenerative, and Infectious Diseases. \u003ci\u003eOxidative Medicine and Cellular Longevity\u003c\/i\u003e, \u003ci\u003e2018\u003c\/i\u003e. \u003ca href=\"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/3894381.pdf\"\u003eAbstract\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eMarkus, M. A., \u0026amp; Morris, B. J. (2008). Resveratrol in prevention and treatment of common clinical conditions of aging. \u003ci\u003eClinical interventions in aging\u003c\/i\u003e, \u003ci\u003e3\u003c\/i\u003e(2), 331.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2546476\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMaurya, P. K., \u0026amp; Rizvi, S. I. (2009). Protective role of tea catechins on erythrocytes subjected to oxidative stress during human aging. \u003ci\u003eNatural product research\u003c\/i\u003e, \u003ci\u003e23\u003c\/i\u003e(12), 1072-1079.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/14786410802267643\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMileo, A. M., \u0026amp; Miccadei, S. (2016). Polyphenols as modulator of oxidative stress in cancer disease: new therapeutic strategies. \u003ci\u003eOxidative medicine and cellular longevity\u003c\/i\u003e, \u003ci\u003e2016\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.1155\/2016\/6475624\"\u003ehttp:\/\/dx.doi.org\/10.1155\/2016\/6475624\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMinciullo, P. L., Catalano, A., Mandraffino, G., Casciaro, M., Crucitti, A., Maltese, G., ... \u0026amp; Basile, G. (2016). Inflammaging and anti-inflammaging: the role of cytokines in extreme longevity. \u003ci\u003eArchivum immunologiae et therapiae experimentalis\u003c\/i\u003e, \u003ci\u003e64\u003c\/i\u003e(2), 111-126.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/cmb.i-learn.unito.it\/pluginfile.php\/5044\/mod_resource\/content\/1\/Minciullo_et_al.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNagpal, R., Mainali, R., Ahmadi, S., Wang, S., Singh, R., Kavanagh, K., ... \u0026amp; Yadav, H. (2018). Gut microbiome and aging: Physiological and mechanistic insights. \u003ci\u003eNutrition and healthy aging\u003c\/i\u003e, \u003ci\u003e4\u003c\/i\u003e(4), 267-285.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6004897\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eO’Toole, P. W., \u0026amp; Jeffery, I. B. (2015). Gut microbiota and aging. \u003ci\u003eScience\u003c\/i\u003e, \u003ci\u003e350\u003c\/i\u003e(6265), 1214-1215.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/science.sciencemag.org\/content\/350\/6265\/1214\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eParedes-López, O., Cervantes-Ceja, M. L., Vigna-Pérez, M., \u0026amp; Hernández-Pérez, T. (2010). Berries: improving human health and healthy aging, and promoting quality life—a review. \u003ci\u003ePlant foods for human nutrition\u003c\/i\u003e, \u003ci\u003e65\u003c\/i\u003e(3), 299-308.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s11130-010-0177-1\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePeriandavan, K., \u0026amp; Velusamy, P. (2018). Role of Phytochemicals in Eliciting Longevity Genes. In \u003ci\u003eMolecular Basis and Emerging Strategies for Anti-aging Interventions\u003c\/i\u003e(pp. 267-279). Springer, Singapore.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-1699-9_17\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRafiei, H., Omidian, K., \u0026amp; Bandy, B. (2018). Protection by different classes of dietary polyphenols against palmitic acid-induced steatosis, nitro-oxidative stress and endoplasmic reticulum stress in HepG2 hepatocytes. \u003ci\u003eJournal of Functional Foods\u003c\/i\u003e, \u003ci\u003e44\u003c\/i\u003e, 173-182.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.jff.2018.02.033\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.jff.2018.02.033\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRahnasto-Rilla, M., Tyni, J., Huovinen, M., Jarho, E., Kulikowicz, T., Ravichandran, S., ... \u0026amp; Moaddel, R. (2018). Natural polyphenols as sirtuin 6 modulators. \u003ci\u003eScientific reports\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(1), 4163.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.nature.com\/articles\/s41598-018-22388-5\"\u003ehttps:\/\/www.nature.com\/articles\/s41598-018-22388-5\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eRamana, K. V., Reddy, A., Majeti, N. V., \u0026amp; Singhal, S. S. (2018). Therapeutic Potential of Natural Antioxidants. Oxidative medicine and cellular longevity, 2018. \u003ca href=\"http:\/\/downloads.hindawi.com\/journals\/omcl\/2018\/9471051.pdf\"\u003eAbstract\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eRizvi, S. I., \u0026amp; Maurya, P. K. (2007). Alterations in antioxidant enzymes during aging in humans. \u003ci\u003eMolecular biotechnology\u003c\/i\u003e, \u003ci\u003e37\u003c\/i\u003e(1), 58-61.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs12033-007-0048-7?LI=true\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRizvi, S. I., \u0026amp; Maurya, P. K. (2007). Markers of oxidative stress in erythrocytes during aging in humans. \u003ci\u003eAnnals of the New York academy of sciences\u003c\/i\u003e, \u003ci\u003e1100\u003c\/i\u003e(1), 373-382.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/abs\/10.1196\/annals.1395.041\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSarubbo, F., Esteban, S., Miralles, A., \u0026amp; Moranta, D. (2018). Effects of resveratrol and other polyphenols on Sirt1: relevance to brain function during aging. \u003ci\u003eCurrent Neuropharmacology\u003c\/i\u003e, \u003ci\u003e16\u003c\/i\u003e(2), 126-136.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ingentaconnect.com\/contentone\/ben\/cn\/2018\/00000016\/00000002\/art00004\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSarubbo, F., Moranta, D., Miralles, A., \u0026amp; Esteban, S. Polyphenols-What's Behind their Antiaging Brain Reputation. \u003ci\u003eAnn Nutr Food Sci. 2018; 1 (2)\u003c\/i\u003e, \u003ci\u003e1009\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/7a4f\/f3510573116c121683eabd75c4f35a0abb48.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShukitt-Hale, B., Lau, F. C., \u0026amp; Joseph, J. A. (2008). Berry fruit supplementation and the aging brain. \u003ci\u003eJournal of Agricultural and Food Chemistry\u003c\/i\u003e, \u003ci\u003e56\u003c\/i\u003e(3), 636-641.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf072505f\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSivakanesan, R. (2018). Antioxidants for Health and Longevity. In \u003ci\u003eMolecular Basis and Emerging Strategies for Anti-aging Interventions\u003c\/i\u003e (pp. 323-341). Springer, Singapore.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-981-13-1699-9_21\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSlemmer, J. E., Shacka, J. J., Sweeney, M. I., \u0026amp; Weber, J. T. (2008). Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. \u003ci\u003eCurrent medicinal chemistry\u003c\/i\u003e, \u003ci\u003e15\u003c\/i\u003e(4), 404-414.\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eDOI:\u003c\/strong\u003e \u003ca href=\"https:\/\/doi.org\/10.2174\/092986708783497337\"\u003ehttps:\/\/doi.org\/10.2174\/092986708783497337\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSpencer, J. P., Vafeiadou, K., Williams, R. J., \u0026amp; Vauzour, D. (2012). Neuroinflammation: modulation by flavonoids and mechanisms of action. \u003ci\u003eMolecular aspects of medicine\u003c\/i\u003e, \u003ci\u003e33\u003c\/i\u003e(1), 83-97.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0098299711000732\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eStork, B., \u0026amp; Ventura, N. (2018). Targeting the BECN1-BCL2 autophagy regulatory complex to promote longevity. \u003ci\u003eBiotarget\u003c\/i\u003e, \u003ci\u003e2\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/biotarget.amegroups.com\/article\/view\/4584\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTeplova, V. V., Isakova, E. P., Klein, O. I., Dergachova, D. I., Gessler, N. N., \u0026amp; Deryabina, Y. I. (2018). Natural Polyphenols: Biological Activity, Pharmacological Potential, Means of Metabolic Engineering. \u003ci\u003eApplied Biochemistry and Microbiology\u003c\/i\u003e, \u003ci\u003e54\u003c\/i\u003e(3), 221-237.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1134\/S0003683818030146\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTiihonen, K., Ouwehand, A. C., \u0026amp; Rautonen, N. (2010). Human intestinal microbiota and healthy ageing. \u003ci\u003eAgeing research reviews\u003c\/i\u003e, \u003ci\u003e9\u003c\/i\u003e(2), 107-116.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.arr.2009.10.004\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.arr.2009.10.004\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVitetta, L., Briskey, D., Alford, H., Hall, S., \u0026amp; Coulson S. (2014). Probiotics, prebiotics and the gastrointestinal tract in health and disease. Inflammopharmacology, DOI: 10.1007\/s10787-014-0201-4.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Luis_Vitetta\/publication\/260842062_Probiotics_prebiotics_and_the_gastrointestinal_tract_in_health_and_disease\/links\/0a85e53b47e7f81075000000.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWang, H., Liu, J., Li, T., \u0026amp; Liu, R. H. (2018). Blueberry extract promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans. \u003ci\u003eFood \u0026amp; function\u003c\/i\u003e, \u003ci\u003e9\u003c\/i\u003e(10), 5273-5282.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2018\/fo\/c8fo01680a\/unauth#!divAbstract\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZamora-Ros, R., Rabassa, M., Cherubini, A., Urpí-Sardà, M., Bandinelli, S., Ferrucci, L., \u0026amp; Andres-Lacueva, C. (2013). High Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated with Decreased Mortality in Older Adults, 2. \u003ci\u003eThe Journal of nutrition\u003c\/i\u003e, \u003ci\u003e143\u003c\/i\u003e(9), 1445-1450.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/jn\/article\/143\/9\/1445\/4615208\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eLongevity: Polyphenols, Probiotics and Nutriceuticals\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAn, R., Wilms, E., Masclee, A. A., Smidt, H., Zoetendal, E. G., \u0026amp; Jonkers, D. (2018). Age-dependent changes in GI physiology and microbiota: time to reconsider?. \u003ci\u003eGut\u003c\/i\u003e, \u003ci\u003e67\u003c\/i\u003e(12), 2213-2222.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/gut.bmj.com\/content\/67\/12\/2213\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBuford, T. W. (2017). 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Flavonoids and the gastrointestinal tract: local and systemic effects. \u003ci\u003eMolecular aspects of medicine\u003c\/i\u003e.\u003c\/p\u003e\n\u003cp\u003e \u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.mam.2018.01.001\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.mam.2018.01.001\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eParvez, S., Malik, K.A., Kang, S., \u0026amp; Kim, H.Y. (2006). Probiotics and their fermented food products are beneficial for health. J Appl Microbiol.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e100\u003c\/i\u003e, 1171–85.\u003c\/p\u003e\n\u003cp\u003ePasinetti, G. M., Singh, R., Westfall, S., Herman, F., Faith, J., \u0026amp; Ho, L. (2018). The role of the gut microbiota in the metabolism of polyphenols as characterized by gnotobiotic mice. \u003ci\u003eJournal of Alzheimer's Disease\u003c\/i\u003e, (Preprint), 1-13.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/content.iospress.com\/articles\/journal-of-alzheimers-disease\/jad171151\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRoberfroid, M.B. (2000). Prebiotics and probiotics: Are they functional foods? Am J Clin Nutr,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e71\u003c\/i\u003e, 1682S–7S.\u003c\/p\u003e\n\u003cp\u003eSaini, R., Saini, S., Sugandha. (2009). Probiotics: The health boosters. J Cutan Aesthet Surg,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e2\u003c\/i\u003e, 112.\u003c\/p\u003e\n\u003cp\u003eRizvi, S. I., \u0026amp; Çakatay, U. (2018). Molecular Basis and Emerging Strategies for Anti-aging Interventions. \u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/book\/10.1007%2F978-981-13-1699-9#about\"\u003eIntroduction\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAzcarate-Peril, M.A., Sikes, M., Bruno-Barcena, J.M. (2011). The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer?\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eAm J Physiol Gastrointest Liver Physiol\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e301\u003c\/i\u003e, G401-G424. doi:10.1152\/ajpgi.00110.2011.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eBoron and Chromium: Healthy Longevity\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eDonoiu, I., Militaru, C., Obleagă, O., Hunter, J. M., Neamţu, J., Biţă, A., ... \u0026amp; Rogoveanu, O. C. (2018). Effects of Boron-Containing Compounds on Cardiovascular Disease Risk Factors–A Review. \u003ci\u003eJournal of Trace Elements in Medicine and Biology\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0946672X18301561\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eIskra, R., \u0026amp; Antonyak, H. (2018). Chromium in Health and Longevity. In \u003ci\u003eTrace Elements and Minerals in Health and Longevity\u003c\/i\u003e (pp. 133-162). Springer, Cham.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-030-03742-0_5\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMalavolta, M., \u0026amp; Mocchegiani, E. Trace Elements and Minerals in Health and Longevity.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=_qN5DwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PR5\u0026amp;ots=_NhCR-TtqI\u0026amp;sig=lFpPWEztO90z1z_xVUXG4NMjG98#v=onepage\u0026amp;q\u0026amp;f=false\"\u003ePreface\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNielsen, F. H. (2018). Boron in Aging and Longevity. In \u003ci\u003eTrace Elements and Minerals in Health and Longevity\u003c\/i\u003e (pp. 163-177). Springer, Cham.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-030-03742-0_6\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSmith Jr, J. C., \u0026amp; Hsu, J. M. (2018). ZINC, COPPER, CHROMIUM, AND SELENIUM. \u003ci\u003eNutritional Approaches To Aging Research\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=kLxHDwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=RA1-PA52\u0026amp;dq=Chromium+mineral+and+longevity\u0026amp;ots=_xR2B6Aw3L\u0026amp;sig=upge-F9iZctfqAdObnLx2ug73Hs#v=onepage\u0026amp;q\u0026amp;f=false\"\u003eBook\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eFructo Borate and Polyphenols: Joint \u0026amp; Bone Health\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eHorcajada, M. N., \u0026amp; Offord, E. (2012). Naturally plant-derived compounds: role in bone anabolism. \u003ci\u003eCurrent molecular pharmacology\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e(2), 205-218.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ingentaconnect.com\/content\/ben\/cmp\/2012\/00000005\/00000002\/art00011\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSacco, S. M., Horcajada, M. N., \u0026amp; Offord, E. (2013). Phytonutrients for bone health during ageing. \u003ci\u003eBritish journal of clinical pharmacology\u003c\/i\u003e, \u003ci\u003e75\u003c\/i\u003e(3), 697-707.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full\/10.1111\/bcp.12033\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eScorei et al. (2011). A double-blind, Placebo-Controlled Polot Study to Evaluate the Effect of Calcium Fructoborate on Systemic Inflammation and Dyslipidemia Markers for Middle-Aged People with Ordinary Osteoarthritis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBiol Trace Elem Res\u003c\/em\u003e;144:253-263.\u003c\/p\u003e\n\u003cp\u003eShen, C.L., von Bergen, V., Chyu, M.C., Jenkins, M.R., Mo, H., Chen, C..H, \u0026amp; Kwun, I.S. (2012). Fruits and dietary phytochemicals in bone protection. Nutr Res, 32(12), 897-910. DOI:\u003ca href=\"https:\/\/doi.org\/10.1016\/j.nutres.2012.09.018\"\u003e10.1016\/j.nutres.2012.09.018\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWeaver, C. M., Alekel, D. L., Ward, W. E., \u0026amp; Ronis, M. J. (2012). Flavonoid intake and bone health. \u003ci\u003eJournal of nutrition in gerontology and geriatrics\u003c\/i\u003e, \u003ci\u003e31\u003c\/i\u003e(3), 239-253.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/21551197.2012.698220\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZhang, Y. B., Zhong, Z. M., Hou, G., Jiang, H., \u0026amp; Chen, J. T. (2011). Involvement of oxidative stress in age-related bone loss. \u003ci\u003eJournal of Surgical Research\u003c\/i\u003e, \u003ci\u003e169\u003c\/i\u003e(1), e37-e42.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.jss.2011.02.033\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.jss.2011.02.033\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eVitamin D, B12, \u0026amp; Folate: Systemic Longevity Boosters\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAutier, P., Boniol, M., Pizot, C., \u0026amp; Mullie, P. (2014). Vitamin D status and ill health: a systematic review. \u003ci\u003eThe lancet Diabetes \u0026amp; endocrinology\u003c\/i\u003e, \u003ci\u003e2\u003c\/i\u003e(1), 76-89. DOI:\u003ca href=\"https:\/\/doi.org\/10.1016\/S2213-8587(13)70165-7\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.1016\/S2213-8587(13)70165-\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFenech, M. (2017). Vitamins Associated with Brain Aging, Mild Cognitive Impairment, and Alzheimer Disease: Biomarkers, Epidemiological and Experimental Evidence, Plausible Mechanisms, and Knowledge Gaps. \u003ci\u003eAdvances in Nutrition\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(6), 958-970.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/an.117.015610\"\u003ehttps:\/\/doi.org\/10.3945\/an.117.015610\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFord, J. A., MacLennan, G. S., Avenell, A., Bolland, M., Grey, A., Witham, M., \u0026amp; RECORD Trial Group. (2014). Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis–. \u003ci\u003eThe American journal of clinical nutrition\u003c\/i\u003e, \u003ci\u003e100\u003c\/i\u003e(3), 746-755.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/ajcn\/article\/100\/3\/746\/4576427\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGrant, W. B. (2011). An estimate of the global reduction in mortality rates through doubling vitamin D levels. \u003ci\u003eEuropean Journal of Clinical Nutrition\u003c\/i\u003e, \u003ci\u003e65\u003c\/i\u003e(9), 1016. DOI:\u003ca href=\"https:\/\/doi.org\/10.1038\/ejcn.2011.68\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.1038\/ejcn.2011.68\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGoulão, B., Stewart, F., Ford, J. A., MacLennan, G., \u0026amp; Avenell, A. (2018). Cancer and vitamin D supplementation: a systematic review and meta-analysis. \u003ci\u003eThe American journal of clinical nutrition\u003c\/i\u003e, \u003ci\u003e107\u003c\/i\u003e(4), 652-663.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.cct.2017.11.015\"\u003ehttps:\/\/doi.org\/10.1016\/j.cct.2017.11.015\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLee, J.H., O’Keefe, J.H., Bell, D., Hensrud, D.D., Holick, M.F. (2008). Vitamin D deficiency: An important, common, and easily treatable\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ecardiovascular risk factor? J Am Coll Cardio,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003ci\u003e52\u003c\/i\u003e(24), 1949-1956.\u003c\/p\u003e\n\u003cp\u003eKwok, T., Chook, P., Qiao, M., Tam, L., Poon, Y. K. P., Ahuja, A. T., ... \u0026amp; Woo, K. S. (2012). Vitamin B-12 supplementation improves arterial function in vegetarians with subnormal vitamin B-12 status. \u003ci\u003eThe journal of nutrition, health \u0026amp; aging\u003c\/i\u003e, \u003ci\u003e16\u003c\/i\u003e(6), 569-573.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s12603-012-0036-x\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePannérec, A., Migliavacca, E., De Castro, A., Michaud, J., Karaz, S., Goulet, L., ... \u0026amp; Feige, J. N. (2018). Vitamin B12 deficiency and impaired expression of amnionless during aging. \u003ci\u003eJournal of cachexia, sarcopenia and muscle\u003c\/i\u003e, \u003ci\u003e9\u003c\/i\u003e(1), 41-52.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/jcsm.12260\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSae‐Lee, C., Corsi, S., Barrow, T. M., Kuhnle, G. G., Bollati, V., Mathers, J. C., \u0026amp; Byun, H. M. (2018). Dietary intervention modifies DNA methylation age assessed by the epigenetic clock. \u003ci\u003eMolecular Nutrition \u0026amp; Food Research,\u003c\/i\u003e\u003ci\u003e \u003c\/i\u003e\u003ci\u003e62\u003c\/i\u003e(23), 1800092.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/mnfr.201800092\"\u003ehttps:\/\/doi.org\/10.1002\/mnfr.201800092\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eThomas, P., \u0026amp; Fenech, M. (2015). Buccal Cytome Biomarkers and Their Association with Plasma Folate, Vitamin B12 and Homocysteine in Alzheimer's Disease. \u003ci\u003eLifestyle Genomics\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(2), 57-69.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1159\/000435784\"\u003ehttps:\/\/doi.org\/10.1159\/000435784\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eUday, S., \u0026amp; Högler, W. (2018). Prevention of rickets and osteomalacia in the UK: political action overdue. \u003ci\u003eArchives of disease in childhood\u003c\/i\u003e, \u003ci\u003e103\u003c\/i\u003e(9), 901-906.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/adc.bmj.com\/content\/103\/9\/901\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWalsh, S. P. K. (2018). Why foods derived from animals are not necessary for human health. Ethical Vegetarianism and Veganism, 19-33.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=xDZyDwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PT38\u0026amp;dq=vitamin+B12+and+longevity\u0026amp;ots=i_QN-76IA6\u0026amp;sig=owPmepniqIvTA8wk9-ReXgfOr3E#v=onepage\u0026amp;q=vitamin%20B12%20and%20longevity\u0026amp;f=false\"\u003eChapter11\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWatson, J., Lee, M., \u0026amp; Garcia-Casal, M. N. (2018). Consequences of Inadequate Intakes of Vitamin A, Vitamin B 12, Vitamin D, Calcium, Iron, and Folate in Older Persons. \u003ci\u003eCurrent geriatrics reports\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(2), 103-113.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s13670-018-0241-5\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eGreens and Red Beet Root: Dietary Nitrate (blood flow, heart, brain, and strong exercise)\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAquilano, K., Baldelli, S., Rotilio, G., \u0026amp; Ciriolo, M. R. (2008). Role of nitric oxide synthases in Parkinson’s disease: a review on the antioxidant and anti-inflammatory activity of polyphenols. \u003ci\u003eNeurochemical research\u003c\/i\u003e, \u003ci\u003e33\u003c\/i\u003e(12), 2416-2426.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s11064-008-9697-6\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAshton, N., Lind, E., Fiddler, J., \u0026amp; Fiddler, R. (2018). Beetroot Juice Supplementation Lowers Oxygen Cost of Vigorous Intensity Aerobic Exercise in Trained Endurance Athletes. In \u003ci\u003eInternational Journal of Exercise Science: Conference Proceedings\u003c\/i\u003e (Vol. 9, No. 6, p. 3).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/digitalcommons.wku.edu\/cgi\/viewcontent.cgi?article=3495\u0026amp;amp=\u0026amp;context=ijesab\u0026amp;amp=\u0026amp;sei-redir=1\u0026amp;referer=https%253A%252F%252Fscholar.google.com%252Fscholar%253Fhl%253Den%2526as_sdt%253D0%252C48%2526as_ylo%253D2018%2526q%253Dbeetroot%252Band%252Bexercise#search=%22beetroot%20exercise%22\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAvoort, C. M., Loon, L. J., Hopman, M. T., \u0026amp; Verdijk, L. B. (2018). Increasing vegetable intake to obtain the health promoting and ergogenic effects of dietary nitrate. \u003ci\u003eEuropean journal of clinical nutrition\u003c\/i\u003e, 1.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.nature.com\/articles\/s41430-018-0140-z\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBalsalobre-Fernández, C., Romero-Moraleda, B., Cupeiro, R., Peinado, A. B., Butragueño, J., \u0026amp; Benito, P. J. (2018). The effects of beetroot juice supplementation on exercise economy, rating of perceived exertion and running mechanics in elite distance runners: A double-blinded, randomized study. \u003ci\u003ePloS one\u003c\/i\u003e, \u003ci\u003e13\u003c\/i\u003e(7), e0200517.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0200517\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBlekkenhorst, L., Sim, M., Bondonno, C., Bondonno, N., Ward, N., Prince, R., ... \u0026amp; Hodgson, J. (2018). Cardiovascular health benefits of specific vegetable types: A narrative review. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e10\u003c\/i\u003e(5), 595.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/10\/5\/595\/htm\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCatsicas, R. (2018). Fabulous vegetables!. \u003ci\u003eDiabetes Lifestyle\u003c\/i\u003e, \u003ci\u003e2018\u003c\/i\u003e(2), 18-23.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/journals.co.za\/content\/journal\/10520\/EJC-fcd2be5c9\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCuenca, E., Jodra, P., Pérez-López, A., González-Rodríguez, L., Fernandes da Silva, S., Veiga-Herreros, P., \u0026amp; Domínguez, R. (2018). Effects of Beetroot Juice Supplementation on Performance and Fatigue in a 30-s All-Out Sprint Exercise: A Randomized, Double-Blind Cross-Over Study. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e10\u003c\/i\u003e(9), 1222.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/10\/9\/1222\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChen, G. C., Koh, W. P., Yuan, J. M., Qin, L. Q., \u0026amp; van Dam, R. M. (2018). Green leafy and cruciferous vegetable consumption and risk of type 2 diabetes: results from the Singapore Chinese Health Study and meta-analysis. \u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e, \u003ci\u003e119\u003c\/i\u003e(9), 1057-1067.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.cambridge.org\/core\/journals\/british-journal-of-nutrition\/article\/green-leafy-and-cruciferous-vegetable-consumption-and-risk-of-type-2-diabetes-results-from-the-singapore-chinese-health-study-and-metaanalysis\/B07200AD04BC0AC8963F3AAFFFBD94DA\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDai, Q., Borenstein, A. R., Wu, Y., Jackson, J. C., \u0026amp; Larson, E. B. (2006). Fruit and vegetable juices and Alzheimer’s disease: the Kame Project. \u003ci\u003eThe American journal of medicine\u003c\/i\u003e, \u003ci\u003e119\u003c\/i\u003e(9), 751-759.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.amjmed.2006.03.045\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.amjmed.2006.03.045\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJonvik, K. L., Nyakayiru, J., Van Dijk, J. W., Maase, K., Ballak, S. B., Senden, J. M. G., ... \u0026amp; Verdijk, L. B. (2018). Repeated-sprint performance and plasma responses following beetroot juice supplementation do not differ between recreational, competitive and elite sprint athletes. \u003ci\u003eEuropean journal of sport science\u003c\/i\u003e, \u003ci\u003e18\u003c\/i\u003e(4), 524-533.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/17461391.2018.1433722\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLetenneur, L., Proust-Lima, C., Le Gouge, A., Dartigues, J. F., \u0026amp; Barberger-Gateau, P. (2007). Flavonoid intake and cognitive decline over a 10-year period. \u003ci\u003eAmerican journal of epidemiology\u003c\/i\u003e, \u003ci\u003e165\u003c\/i\u003e(12), 1364-1371.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1093\/aje\/kwm036\"\u003ehttps:\/\/doi.org\/10.1093\/aje\/kwm036\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLidder, S., \u0026amp; Webb, A. J. (2013). Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate‐nitrite‐nitric oxide pathway. \u003ci\u003eBritish journal of clinical pharmacology\u003c\/i\u003e, \u003ci\u003e75\u003c\/i\u003e(3), 677-696. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1111\/j.1365-2125.2012.04420.x\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.1111\/j.1365-2125.2012.04420.x\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMorris, M. C., Wang, Y., Barnes, L. L., Bennett, D. A., Dawson-Hughes, B., \u0026amp; Booth, S. L. (2018). Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study. \u003ci\u003eNeurology\u003c\/i\u003e, \u003ci\u003e90\u003c\/i\u003e(3), e214-e222.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/n.neurology.org\/content\/90\/3\/e214\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMurphy, M., Eliot, K., Heuertz, R. M., \u0026amp; Weiss, E. (2012). Whole beetroot consumption acutely improves running performance. \u003ci\u003eJournal of the Academy of Nutrition and Dietetics\u003c\/i\u003e, \u003ci\u003e112\u003c\/i\u003e(4), 548-552. DOI:\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jand.2011.12.002\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.1016\/j.jand.2011.12.002\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSobko, T., Marcus, C., Govoni, M., \u0026amp; Kamiya, S. (2010). Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers. \u003ci\u003eNitric Oxide\u003c\/i\u003e, \u003ci\u003e22\u003c\/i\u003e(2), 136-140. DOI:\u003c\/p\u003e\n\u003cp\u003e \u003ca href=\"https:\/\/doi.org\/10.1016\/j.niox.2009.10.007\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.1016\/j.niox.2009.10.007\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLiu, A. H., Bondonno, C. P., Croft, K. D., Puddey, I. B., Woodman, R. J., Rich, L., ... \u0026amp; Hodgson, J. M. (2013). Effects of a nitrate-rich meal on arterial stiffness and blood pressure in healthy volunteers. \u003ci\u003eNitric Oxide\u003c\/i\u003e, \u003ci\u003e35\u003c\/i\u003e, 123-130. DOI:\u003ca href=\"https:\/\/doi.org\/10.1016\/j.niox.2013.10.001\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.1016\/j.niox.2013.10.001\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShahidi, F., \u0026amp; Yeo, J. (2018). Bioactivities of phenolics by focusing on suppression of chronic diseases: A review. International journal of molecular sciences, 19(6), 1573.\u003c\/p\u003e\n\u003cp\u003e \u003ca href=\"https:\/\/www.mdpi.com\/1422-0067\/19\/6\/1573\"\u003ehttps:\/\/www.mdpi.com\/1422-0067\/19\/6\/1573\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTan, R., Wylie, L. J., Thompson, C., Blackwell, J. R., Bailey, S. J., Vanhatalo, A., \u0026amp; Jones, A. M. (2018). Beetroot juice ingestion during prolonged moderate-intensity exercise attenuates progressive rise in O2 uptake. \u003ci\u003eJournal of Applied Physiology\u003c\/i\u003e, \u003ci\u003e124\u003c\/i\u003e(5), 1254-1263.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.physiology.org\/doi\/abs\/10.1152\/japplphysiol.01006.2017\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVyas, M. (2017). Nutritional profile of spinach and its antioxidant \u0026amp; antidiabetic evaluation. \u003ci\u003eInternational Journal of Green Pharmacy (IJGP)\u003c\/i\u003e, \u003ci\u003e11\u003c\/i\u003e(03).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/greenpharmacy.info\/index.php\/ijgp\/article\/view\/1125\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eCranberry: Heart, liver, and Oral Health\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eLapshina, E.A., Zamaraeva, M., Cheshchevik, V.T., Olchowik-Grabarek, E., Sekowski, S., Zukowska, I., … Zavodnik, I.B. (2015).Cranberry flavonoids prevent toxic rat liver mitochondrial damage in vivo and scavenge free radicals in vitro.\u003cem\u003eCell Miochem Funct\u003c\/em\u003e\u003ci\u003e, 33\u003c\/i\u003e(4), 202-210.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNovotny, J., Baer, D.J., Khoo, C., Gebauer, S.K., \u0026amp; Charron, C.S. (2015). Cranberry juice consumption lowers markers of cardiometabliolic risk, including blood pressure and circulating C-reactive protein, triglyceride, and glucose concentrations in adults. \u003cem\u003eJ Nutr\u003c\/em\u003e, \u003ci\u003e145\u003c\/i\u003e(6), 1185-93.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eCranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eFeldman M, Tanabe S, Howell A, Grenier D. BMC Complement Altern Med. 2012 Jan 16; 12:6. Epub 2012 Jan 16.\u003cspan\u003e \u003c\/span\u003e\u003c\/i\u003eDOI:\u003ca href=\"https:\/\/doi.org\/10.1186\/1472-6882-12-6\"\u003e10.1186\/1472-6882-12-6\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003ePolyphenols and Metabolic Syndrome Support\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBasu A. Lyons TJ. (2012). Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eJ Agric Food Chem\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e60\u003c\/i\u003e, 5687-92.\u003c\/p\u003e\n\u003cp\u003eLi, S., Tan, H. Y., Wang, N., Cheung, F., Hong, M., \u0026amp; Feng, Y. (2018). The potential and action mechanism of polyphenols in the treatment of liver diseases. \u003ci\u003eOxidative medicine and cellular longevity\u003c\/i\u003e, \u003ci\u003e2018\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1155\/2018\/8394818\"\u003ehttps:\/\/doi.org\/10.1155\/2018\/8394818\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRaustadottir, T., Davies, S.S., Stock, A.A., Su, Y., Heward, C.B., Roberts, L.J. 2\u003csup\u003end\u003c\/sup\u003e, Hrman, S.M. (2009). Tart cherry juice decreases oxidative stress in healthy older men and women.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eJ Nutr\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e139\u003c\/i\u003e, 1896-1900.\u003c\/p\u003e\n\u003cp\u003eTörrönen, R., Kolehmainen, M., Sarkkinen, E., Poutanen, K., Mykkänen, H., \u0026amp; Niskanen, L. (2013). Berries Reduce Postprandial Insulin Responses to Wheat and Rye Breads in Healthy Women1–4. \u003ci\u003eThe Journal of nutrition\u003c\/i\u003e, \u003ci\u003e143\u003c\/i\u003e(4), 430-436. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/jn.112.169771\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.3945\/jn.112.169771\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSievenpiper, J.L., Chiavaroli, L., de Souza, R.J., Mirrahimi, A., Cozma, A.I., Ha, V., … Jenkins, D.J. (2012). 'Catalytic' doses of fructose may benefit glycaemic control without harming cardiometabolic risk factors: a small meta-analysis of randomised controlled feeding trials. \u003ci\u003eBr J Nutr, 108\u003c\/i\u003e(3), 418-23.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eZulet, M. A. Fruit Fiber Consumption Specifically Improves Liver Health Status in Obese Subjects under Energy Restriction. \u003ci\u003ePrecision Nutrition and Metabolic Syndrome Management\u003c\/i\u003e, 55.\u003cspan\u003e\u003ca href=\"https:\/\/www.mdpi.com\/books\/pdfdownload\/book\/681#page=64\"\u003eBooklet\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eSuper Blend: Probiotics, Supernatant, ORNs, \u0026amp; Fiber\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBozzetto, L., Costabile, G., Della Pepa, G., Ciciola, P., Vetrani, C., Vitale, M., ... \u0026amp; Annuzzi, G. (2018). Dietary fibre as a unifying remedy for the whole spectrum of obesity-associated cardiovascular risk. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e10\u003c\/i\u003e(7), 943. DOI:\u003ca href=\"https:\/\/doi.org\/10.3390\/nu10070943\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.3390\/nu10070943\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGonzález-Herrera, S. M., Herrera, R. R., López, M. G., Rutiaga, O. M., Aguilar, C. N., Esquivel, J. C. C., \u0026amp; Martínez, L. A. O. (2015). Inulin in food products: prebiotic and functional ingredient. \u003ci\u003eBritish Food Journal\u003c\/i\u003e, \u003ci\u003e117\u003c\/i\u003e(1), 371-387.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.emeraldinsight.com\/doi\/abs\/10.1108\/BFJ-09-2013-0238\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"dx-doi\"\u003eHolscher, H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. \u003ci\u003eGut Microbes\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(2), 172-184.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/19490976.2017.1290756\"\u003ehttps:\/\/doi.org\/10.1080\/19490976.2017.1290756\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMcRae, M. P. (2018). The Benefits of Dietary Fiber Intake on Reducing the Risk of Cancer: An Umbrella Review of Meta-analyses. \u003ci\u003eJournal of Chiropractic Medicine\u003c\/i\u003e, \u003ci\u003e17\u003c\/i\u003e(2), 90-96.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.jcm.2017.12.001\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.jcm.2017.12.001\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMuir, J. G., Yao, C. K., \u0026amp; Gibson, P. G. (2015). Functional short-chain carbohydrates (prebiotics) in the diet to improve the microbiome and health of the gastrointestinal tract. \u003ci\u003eAnimal Production Science\u003c\/i\u003e, \u003ci\u003e55\u003c\/i\u003e(12), 1376-1380.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.publish.csiro.au\/AN\/AN15277\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePost, R. E., Mainous, A. G., King, D. E., \u0026amp; Simpson, K. N. (2012). Dietary fiber for the treatment of type 2 diabetes mellitus: a meta-analysis. \u003ci\u003eThe Journal of the American Board of Family Medicine\u003c\/i\u003e, \u003ci\u003e25\u003c\/i\u003e(1), 16-23. DOI:\u003ca href=\"https:\/\/doi.org\/10.3122\/jabfm.2012.01.110148\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.3122\/jabfm.2012.01.110148\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRoberfroid, M., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R., Rowland, I., ... \u0026amp; Guarner, F. (2010). Prebiotic effects: metabolic and health benefits.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e104\u003c\/i\u003e(S2), S1-S63. DOI:\u003ca href=\"https:\/\/doi.org\/10.1017\/S0007114510003363\"\u003e10.1017\/S0007114510003363\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTiihonen, K., Ouwehand, A. C., \u0026amp; Rautonen, N. (2010). Human intestinal microbiota and healthy ageing. \u003ci\u003eAgeing research reviews\u003c\/i\u003e, \u003ci\u003e9\u003c\/i\u003e(2), 107-116.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.arr.2009.10.004\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.arr.2009.10.004\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eLongevity and Plant-Based Diet\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAmerican Heart Association. (2017, March 09). Unhealthy diets linked to more than 400,000 cardiovascular deaths [AHA\/ASA Newsroom]. Retrieved from\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/newsroom.heart.org\/news\/unhealthy-diets-linked-to-more-than-400-000-cardiovascular-deaths?preview=f6bd\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBiagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., \u0026amp; Brigidi, P. (2013). Ageing and gut microbes: perspectives for health maintenance and longevity. \u003ci\u003ePharmacological Research\u003c\/i\u003e, \u003ci\u003e69\u003c\/i\u003e(1), 11-20.\u003cspan\u003e \u003c\/span\u003e\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.phrs.2012.10.005\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.phrs.2012.10.005\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBozzetto, L., Costabile, G., Della Pepa, G., Ciciola, P., Vetrani, C., Vitale, M., ... \u0026amp; Annuzzi, G. (2018). Dietary fibre as a unifying remedy for the whole spectrum of obesity-associated cardiovascular risk. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e10\u003c\/i\u003e(7), 943. DOI:\u003ca href=\"https:\/\/doi.org\/10.3390\/nu10070943\" target=\"_blank\" rel=\"noopener noreferrer\"\u003e10.3390\/nu10070943\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCalder, P. C., Bosco, N., Bourdet-Sicard, R., Capuron, L., Delzenne, N., Doré, J., ... \u0026amp; Visioli, F. (2017). Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. \u003ci\u003eAgeing research reviews\u003c\/i\u003e, \u003ci\u003e40\u003c\/i\u003e, 95-119.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S156816371730003X\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCaprara, G. (2018). Diet and longevity: The effects of traditional eating habits on human lifespan extension. \u003ci\u003eMediterranean Journal of Nutrition and Metabolism\u003c\/i\u003e, (Preprint), 1-34.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/content.iospress.com\/articles\/mediterranean-journal-of-nutrition-and-metabolism\/mnm180225\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDesmond, M. A., Sobiecki, J., Fewtrell, M., \u0026amp; Wells, J. C. (2018). Plant-based diets for children as a means of improving adult cardiometabolic health. \u003ci\u003eNutrition reviews\u003c\/i\u003e, \u003ci\u003e76\u003c\/i\u003e(4), 260-273.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1093\/nutrit\/nux079\"\u003ehttps:\/\/doi.org\/10.1093\/nutrit\/nux079\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDonoiu, I., Militaru, C., Obleagă, O., Hunter, J. M., Neamţu, J., Biţă, A., ... \u0026amp; Rogoveanu, O. C. (2018). Effects of Boron-Containing Compounds on Cardiovascular Disease Risk Factors–A Review. \u003ci\u003eJournal of Trace Elements in Medicine and Biology\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0946672X18301561\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFilosa, S., Di Meo, F., \u0026amp; Crispi, S. (2018). Polyphenols-gut microbiota interplay and brain neuromodulation. \u003ci\u003eNeural regeneration research\u003c\/i\u003e, \u003ci\u003e13\u003c\/i\u003e(12), 2055.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6199944\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"dx-doi\"\u003eHolscher, H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. \u003ci\u003eGut Microbes\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(2), 172-184.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/19490976.2017.1290756\"\u003ehttps:\/\/doi.org\/10.1080\/19490976.2017.1290756\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLe Couteur, D. G., Solon-Biet, S., Wahl, D., Cogger, V. C., Willcox, B. J., Willcox, D. C., ... \u0026amp; Simpson, S. J. (2016). New Horizons: Dietary protein, ageing and the Okinawan ratio. \u003ci\u003eAge and ageing\u003c\/i\u003e, \u003ci\u003e45\u003c\/i\u003e(4), 443-447.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/ageing\/article\/45\/4\/443\/1680839\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMcMacken, M., \u0026amp; Shah, S. (2017). A plant-based diet for the prevention and treatment of type 2 diabetes. \u003ci\u003eJournal of geriatric cardiology: JGC\u003c\/i\u003e, \u003ci\u003e14\u003c\/i\u003e(5), 342.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5466941\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSeidelmann, S. B., Claggett, B., Cheng, S., Henglin, M., Shah, A., Steffen, L. M., ... \u0026amp; Solomon, S. D. (2018). Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis. \u003ci\u003eThe Lancet Public Health\u003c\/i\u003e, \u003ci\u003e3\u003c\/i\u003e(9), e419-e428.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.thelancet.com\/journals\/lanpub\/article\/PIIS2468-2667(18)30135-X\/fulltext\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTuso, P. J., Ismail, M. H., Ha, B. P., \u0026amp; Bartolotto, C. (2013). Nutritional update for physicians: plant-based diets. \u003ci\u003eThe Permanente Journal\u003c\/i\u003e, \u003ci\u003e17\u003c\/i\u003e(2), 61.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3662288\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZamora-Ros, R., Rabassa, M., Cherubini, A., Urpí-Sardà, M., Bandinelli, S., Ferrucci, L., \u0026amp; Andres-Lacueva, C. (2013). High Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated with Decreased Mortality in Older Adults, 2. \u003ci\u003eThe Journal of nutrition\u003c\/i\u003e, \u003ci\u003e143\u003c\/i\u003e(9), 1445-1450.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/jn\/article\/143\/9\/1445\/4615208\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003e Ingredients\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eNo. 7 Systemic Booster:  The New Longevity\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eA Proprietary blend of-\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003e5 grams per tsp.\u003cb\u003e\u003cspan\u003e \u003c\/span\u003e                                            \u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePhytonutrients-\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003eOrganic fruits, berries, vegetables \u0026amp; greens: Strawberry, Raspberry, Blueberry, Tart Cherry, Elderberry, Cranberry, Apple Extract, Pineapple, Beet, Kale Leaves, Spinach Leaves, Broccoli Floret.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBioImmersion Probiotic Master Blend\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e–\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eProbiotics\u003c\/b\u003e-\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eLactobacillus plantarum, Lactobacillus paracasei, Lactobacillus reuteri, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium lactic, Bifidobacterium longum, Streptococcus thermophilus and Lactobacillus bulgaricus\u003c\/em\u003e;\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ePrebiotic\u003c\/b\u003e- Inulin from chicory Root;\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eSupernatant\u003c\/b\u003e- probiotic metabolites, and\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eORNs\u003c\/b\u003e. 30 billion CFU.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFiber-\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003eOrganic Inulin\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eNutriceuticals-\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003eFructo Borate 125mg, Vit. B-12 (\u003ci\u003emethyl cobalamin\u003c\/i\u003e) 250mcg, Vit. D3 1000IU, Folate 400mg, Chromium polynicotinate (trivalent with nicotimic acid) 250mcg.                                                                                       \u003c\/p\u003e\n\u003cp\u003eContainer- 150 grams\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003ch6\u003e\n\u003cspan\u003eProtocol\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eNO. 7 SYSTEMIC BOOSTER:\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003e\u003cb\u003eTHE NEW LONGEVITY\u003c\/b\u003e— The No 7 is designed to renew and revitalize, turning on the longevity genes.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eThe new longevity\u003c\/i\u003e: In research, aging is linked to a variety of chronic illnesses occur due to a continual inflammatory state in the body, which accelerates stem cells’ deterioration and ultimately lessens our ability to regenerate. The No 7 mix of polyphenols (berries, fruits, veggies, and greens), fibers, bio available nutraceuticals, prebiotic, and whole, naturally occurring probiotics with their supernatant and ORNs – all offer potent calming nutrients. Remember, we only have a limited number of stem cells.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eSystem boost\u003c\/i\u003e: The No 7 provides a boost of nutrients for many systems in the body: The GI Tract, Urogenital, Osteo-skeletal, Cardiovascular, Brain and Neurological, Detoxification, Metabolic, Digestive, and Energy. Take 1-2 teaspoons a day, mix with water or dissolve in the mouth. Add to Beta Glucan and Be Regular in your morning smoothie for added energy.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eImmunity\u003c\/i\u003e: The No 7 offers extra support during the cold and flu season, and especially helpful taken with\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eGarlic\u003c\/b\u003e. For a sore throat, open up 1-2 capsules of garlic into a cup of water, add 1 teaspoon of No 7, mix and drink.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eEnergy\u003c\/i\u003e: Add\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eEnergy\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e(Ultra Minerals \u0026amp; Apple Extract) and\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eWeight-Less\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003efor added vitality. 1-2 capsules each.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eWeight-Loss\u003c\/i\u003e: Add\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eWeight-Less\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e(1-2 capsules twice daily).*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eDetoxification\u003c\/i\u003e: The No 7 is foundational for a detox program. Our detox protocol: 4-8 caps of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eChlorella\u003c\/b\u003e, 1-2 caps of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eGlucosamine \u0026amp; Sulforaphanes\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e(broccoli cruciferous sprouts) for phase II liver detox,\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ePhyto Power\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eto regenerate brain and nerves, flush kidneys, an detox the liver, and\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eEnergy\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003efor added ultra-minerals.* \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eGut Health\u003c\/i\u003e: The No 7 is a calming and restorative formula for the whole GI Tract.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eTravel\u003c\/i\u003e: Take 1 teaspoon a day during travel along with\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eCranberry Pomegranate\u003c\/b\u003e, and\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eChlorella\u003c\/b\u003e.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOur Favorite:\u003cspan\u003e \u003c\/span\u003e\u003c\/i\u003eThe No 7 is so versatile and powerful. This is Dr. Dohrea Bardell’s second favorite product alongside the\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eBlueberry Extract\u003c\/b\u003e. It has all her favorite nutrients!*\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712314605612,"sku":"TF017","price":99.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/No-7-Systemic-Booster---Front.jpg?v=1723214786"},{"product_id":"high-orac-synbiotic-formula","title":"High ORAC Synbiotic","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eThe High ORAC Synbiotic formula is renowned as a comprehensive post-antibiotic care.*\u003c\/p\u003e\n\u003cp\u003eAntibiotics manage a variety of infections, but in the process, antibiotics change the balance of the microbiota community in the GI tract, which can cause yeast and fungal overgrowth, and allow a host of other pathogenic organisms to flourish. Constipation, diarrhea, yeast infections, bloating, itching and burning are just some of the uncomfortable effects.\u003c\/p\u003e\n\u003cp\u003eThe High ORAC Synbiotic offers a perfect combination of our Super Blend of naturally occurring whole probiotics with a rich complex of concentrated plant polyphenols that serve as a potent post-antibiotic care with anti-microbial, anti-oxidant, as well as exquisite anti-inflammatory and calming properties.\u003c\/p\u003e\n\u003cp\u003eORAC: 40,000ppm of Total ORAC (Oxygen Radical Absorbent Capacity), the highest on the market. Super Blend Probiotic: 30 billions CFU per gram of our pedigreed probiotics with their Supernatant metabolites and ORNs (microRNAs).*\u003c\/p\u003e\n\u003cp\u003eThe Research tab below presents a small fraction of the science. For further reading, see also the research tab of the No 7 Booster.\u003c\/p\u003e\n\u003cp\u003eThe High ORAC Synbiotic is Vegan, Kosher, Non GMO, and Gluten Free.\u003c\/p\u003e\n\u003ch6\u003eDescription \u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003eProbiotic\u003c\/strong\u003e-  Certified strains of\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eStreptococcus thermophilus\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e(30 billion CFU per gram);\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003ePrebiotic\u003c\/strong\u003e- Inulin from chicory Root;\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eSupernatant\u003c\/strong\u003e- probiotic metabolites, and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eORNs\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e(Oligoribonucleotides.  Also called MicroRNAs);\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003ePhytonutrients\u003c\/strong\u003e- Grape Seed Extract, Wild Blueberry, Quercetin, Resveratrol, Wild Bilberry, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry (Total ORAC assay 40,000 per capsule)\u003c\/p\u003e\n\u003cp\u003eAdvanced freeze-drying technology with 60 caps\/bottle. 500 mg\/ cap.\u003c\/p\u003e\n\u003cp\u003eNo excipients.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCombination of Green Technology for highest phytonutrient potential and Microbiome Technology for pure cultures of pedigreed strains of standardized referenced material with Original molecular identity confirmed routinely by DNA sequencing.\u003c\/li\u003e\n\u003cli\u003eBerry extracts and Fruit- 250mg of pure freeze dried Wild Blueberry, Grape Seed Extract, Raspberry Seed, Wild Bilberry, Cranberry, Tart Cherry, Prune, Strawberry, Quercetin, and Resveratrol.\u003c\/li\u003e\n\u003cli\u003e250mg of inulin from chicory fiber.\u003c\/li\u003e\n\u003cli\u003e30 billion of the Super Blend  of certified strains of\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eStreptococcus thermophilus.\u003c\/em\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe High ORAC Synbiotic is designed for calming and rejuvenating inflammatory conditions in the GI tract. In particular, it was formulated to offer a perfect first step after antibiotic therapy.\u003c\/li\u003e\n\u003cli\u003eA new generation Synbiotic formula: The selected probiotic organisms are shown in research to be excellent colonizers of the GI Tract. They inhibit pathogens, strengthen the mucus membrane, protect from yeast and other pathogens, and create a balanced environment that bolster the health of the microbiome (GI Tract). Phenols are shown in research to have powerful anti-microbial and anti-inflammatory properties. With the extensive variety of our potent berries and fruit concentrates, the formula is brought up to a new level of regenerating the GI Tract. Their phenolic profile and fibers work synergistically with probiotic organisms to form the next generation of symbiotic formulas. The High ORAC can be utilized as a comprehensive post antibiotic care, and as a daily booster.\u003c\/li\u003e\n\u003cli\u003eThe extensive variety of berries, fruits, and fiber from organic chicory root aligns with the recommended anti-oxidant score of 9-12 fruits and vegetables, with the phytonutrients and high ORAC values.\u003c\/li\u003e\n\u003cli\u003ePotent antioxidant with Total ORAC of 40,000 units per capsule (as compared to: 5-9 fruits and vegetables a day provide 1800 to 2500 ORAC units).\u003c\/li\u003e\n\u003cli\u003eSuper Blend Probiotics with their supernatant and microRNA selected to protect, counteract and neutralize dietary toxins, mutagens, carcinogens and infectious organisms.\u003c\/li\u003e\n\u003cli\u003eDetoxifies dietary mycotoxins, enterotoxins, exotoxins and carcinogens.\u003c\/li\u003e\n\u003cli\u003eReduces inflammation systemically and throughout the gastrointestinal system: Original strains in conjunction with Wild Blueberry, Wild Bilberry, Grape Seed Extract, Raspberry Seed Extract, Tart Cherry, Prune Quercetin, Resveratrol,.\n\u003cul\u003e\n\u003cli\u003ePreservation of stem cells.\u003c\/li\u003e\n\u003cli\u003eCardiovascular health\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003eRegeneration of the enteric nervous system: Wild Blueberry, Wild Bilberry.\u003c\/li\u003e\n\u003cli\u003eBroad spectrum antimicrobial: Original strains in conjunction with Raspberry Seed extract, Wild Blueberry Extract, Grape Seed extract, Cranberry.\u003c\/li\u003e\n\u003cli\u003eVision: Wild Blueberry, Wild Bilberry extt\u003c\/li\u003e\n\u003cli\u003eNo fillers, flowing agents or excipients of any kind.\u003c\/li\u003e\n\u003cli\u003eRead monograph in the web library.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch6\u003eResearch\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003ch4\u003e\u003cb\u003eFOOD SCIENCE: THE APPLICATION AND USE OF:\u003c\/b\u003e\u003c\/h4\u003e\n\u003ch4\u003e\n\u003cb\u003ePROBIOTIC SUPER BLEND:\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003e\u003cem\u003eL. ACIDOPHILUS\u003c\/em\u003e, \u003cem\u003eB. LONGUM\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eL. CASEI, L. BULGARICUS, AND STREPTOCOCCUS THERMOPHILUS\u003c\/em\u003e\u003cem\u003e,\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eSUPERNATANT, AND ORNS (MICRORNA). 30 BILLON CFU.\u003c\/h4\u003e\n\u003ch4\u003e\n\u003cb\u003ePHYTONUTRIENTS:\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003eGRAPE SEED EXTRACT, WILD BLUEBERRY, QUERCETIN, RESVERATROL, WILD BILBERRY, CRANBERRY, TART CHERRY, PRUNE, RASPBERRY SEED, STRAWBERRY, AND INULIN FROM CHICORY ROOT.*\u003c\/h4\u003e\n\u003ch4\u003e\n\u003cb\u003eHIGH ACTIVE POLYPHENOL: TOTAL ORAC 40,000\u003c\/b\u003e\u003cb\u003ePPM\u003c\/b\u003e\u003cb\u003e.\u003c\/b\u003e\n\u003c\/h4\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003ePost Antibiotic Care\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAguilar, C., Mano, M., \u0026amp; Eulalio, A. (2018). MicroRNAs at the Host–Bacteria Interface: Host Defense or Bacterial Offense. \u003ci\u003eTrends in microbiology\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0966842X18302348\"\u003eAbstrac\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAlbarracin, L., Kobayashi, H., Iida, H., Sato, N., Nochi, T., Aso, H., ... \u0026amp; Villena, J. (2017). Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells: influence of immunobiotic lactobacilli. \u003ci\u003eFrontiers in immunology\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e, 57.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2017.00057\/full\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAlvarez-Sieiro, P., Montalbán-López, M., Mu, D., \u0026amp; Kuipers, O. P. (2016). 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Gut bifidobacteria populations in human health and aging.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eFrontiers in microbiology\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e7\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2016.01204\/full\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eArena, M. P., Capozzi, V., Russo, P., Drider, D., Spano, G., \u0026amp; Fiocco, D. (2018). Immunobiosis and probiosis: antimicrobial activity of lactic acid bacteria with a focus on their antiviral and antifungal properties. \u003ci\u003eApplied microbiology and biotechnology\u003c\/i\u003e, \u003ci\u003e102\u003c\/i\u003e(23), 9949-9958.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00253-018-9403-9\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBarba-Vidal, E., Castillejos, L., López-Colom, P., Urgell, M. R., Muñoz, J. A. 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The Probiotic Combination of Bifidobacterium longum subsp. infantis CECT 7210 and Bifidobacterium animalis subsp. lactis BPL6 Reduces Pathogen Loads and Improves Gut Health of Weaned Piglets Orally Challenged with Salmonella Typhimurium.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eFrontiers in Microbiology\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e8\u003c\/i\u003e, 1570.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2017.01570\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBhat, M. I., Kumari, A., Kapila, S., \u0026amp; Kapila, R. (2019). Probiotic lactobacilli mediated changes in global epigenetic signatures of human intestinal epithelial cells during Escherichia coli challenge. \u003ci\u003eAnnals of Microbiology\u003c\/i\u003e, 1-10.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s13213-019-01451-0\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBhat, M. I., \u0026amp; Kapila, R. (2017). Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. \u003ci\u003eNutrition reviews\u003c\/i\u003e, \u003ci\u003e75\u003c\/i\u003e(5), 374-389.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28444216\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBarker, A., Duster, M., Valentine, S., Archbald-Pannone, L., Guerrant, R., \u0026amp; Safdar, N. (2015). Probiotics for Clostridium difficile infection in adults (PICO): Study protocol for a double-blind, randomized controlled trial. \u003ci\u003eContemporary clinical trials, 44, \u003c\/i\u003e26-32.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4723294\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBlaabjerg, S., Artzi, D. M., \u0026amp; Aabenhus, R. (2017). Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis. \u003ci\u003eAntibiotics\u003c\/i\u003e, \u003ci\u003e6\u003c\/i\u003e(4), 21.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2079-6382\/6\/4\/21\/pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBlackwood, B. P., Yuan, C. Y., Wood, D. R., Nicolas, J. D., Grothaus, J. S., \u0026amp; Hunter, C. J. (2017). Probiotic Lactobacillus Species Strengthen Intestinal Barrier Function and Tight Junction Integrity in Experimental Necrotizing Enterocolitis.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eJournal of probiotics \u0026amp; health\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e5\u003c\/i\u003e(1).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5475283\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBron, P. A., Kleerebezem, M., Brummer, R. J., Cani, P. D., Mercenier, A., MacDonald, T. T., ... \u0026amp; Wells, J. M. (2017). 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Antibacterial activity of berry fruits used for culinary purposes. \u003ci\u003eJournal of medicinal food\u003c\/i\u003e, \u003ci\u003e6\u003c\/i\u003e(1), 57-61.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12804021\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCribby, S., Taylor, M., \u0026amp; Reid, G. (2009). Vaginal microbiota and the use of probiotics. Interdisciplinary perspectives on infectious diseases, 2008: 256490.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/downloads.hindawi.com\/journals\/ipid\/2008\/256490.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDruart, C., Alligier, M., Salazar, N., Neyrinck, A.M., Delzenne, N.M. 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Probiotics for the prevention of pediatric antibiotic-associated diarrhea. \u003ci\u003eCochrane Database Syst Rev\u003c\/i\u003e, \u003ci\u003e11\u003c\/i\u003e(11).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/14651858.CD004827.pub3\/full\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKasubuchi, M., Hasegawa, S., Hiramatsu, T., Ichimura, A., \u0026amp; Kimura, I. (2015). Dietary gut microbial metabolites, short-chain fatty acids, and host metabolic regulation. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(4), 2839-2849.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/7\/4\/2839\/html\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKawabata, K., Yoshioka, Y., \u0026amp; Terao, J. (2019). 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The roles of inflammation, nutrient availability and the commensal microbiota in enteric pathogen infection. In\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eMetabolism and Bacterial Pathogenesis\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e(pp. 297-320). American Society of Microbiology.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26185088\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eThomas, L. V., Suzuki, K., \u0026amp; Zhao, J. (2015). Probiotics: a proactive approach to health. 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Benefits of polyphenols on gut microbiota and implications in human health.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eThe Journal of nutritional biochemistry\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e24\u003c\/i\u003e(8), 1415-1422.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0955286313000946\" target=\"_blank\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDuda-Chodak, A., Tarko, T., Satora, P., \u0026amp; Sroka, P. 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Cranberry proanthocyanidins inhibit the adherence properties of Candida albicans and cytokine secretion by oral epithelial cells.  BMC Comp and Alt Med, 12 (6):1-12.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/1472-6882-12-6\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGupta, A., Dwivedi, M., Mahdi, A. A., Gowda, G. N., Khetrapal, C. L., \u0026amp; Bhandari, M. (2012). Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eUrological research\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e40\u003c\/i\u003e(2), 143-150.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00240-011-0398-2\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHeinonen, M. (2007). Antioxidant activity and antimicrobial effect of berry phenolics–a Finnish perspective.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eMolecular nutrition \u0026amp; food research\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e51\u003c\/i\u003e(6), 684-691.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.200700006\/full\" target=\"_blank\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHossen, I., Hua, W., Ting, L., Mehmood, A., Jingyi, S., Duoxia, X., ... \u0026amp; Fang, Y. (2019). Phytochemicals and inflammatory bowel disease: a review. \u003ci\u003eCritical reviews in food science and nutrition\u003c\/i\u003e, 1-25.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30729797\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJABEHDAR, S. K., AGHJEHGHESHLAGH, F. M., Navidshad, B., Mahdavi, A., \u0026amp; Staji, H. (2019). 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Cranberry-derived proanthocyanidins impair virulence and inhibit quorum sensing of Pseudomonas aeruginosa. \u003ci\u003eScientific reports\u003c\/i\u003e, \u003ci\u003e6\u003c\/i\u003e, 30169.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.nature.com\/articles\/srep30169\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMafra, D., Borges, N., Alvarenga, L., Esgalhado, M., Cardozo, L., Lindholm, B., \u0026amp; Stenvinkel, P. (2019). Dietary Components That May Influence the Disturbed Gut Microbiota in Chronic Kidney Disease. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e11\u003c\/i\u003e(3), 496.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/11\/3\/496\/pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMileo, A. M., Nisticò, P., \u0026amp; Miccadei, S. (2019). 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Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans. \u003ci\u003eJournal of agricultural and food chemistry\u003c\/i\u003e, \u003ci\u003e59\u003c\/i\u003e(24), 12864-12873.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf2035466\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePuupponen‐Pimiä, R., Nohynek, L., Hartmann‐Schmidlin, S., Kähkönen, M., Heinonen, M., Määttä‐Riihinen, K., \u0026amp; Oksman‐Caldentey, K. M. (2005). Berry phenolics selectively inhibit the growth of intestinal pathogens.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eJournal of applied microbiology\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e98\u003c\/i\u003e(4), 991-1000.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2672.2005.02547.x\/full\" target=\"_blank\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePuupponen-Pimia, R., Nohynek, L., Alakomi, H.L., \u0026amp; Oksman-Caldentey, K.M. (2005). The action of berry phenolics against human intestinal pathogens. Biofactors, 23(4), 243-51.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16498212\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePuupponen‐Pimiä, R., Nohynek, L., Meier, C., Kähkönen, M., Heinonen, M., Hopia, A., \u0026amp; Oksman‐Caldentey, K. M. (2001). Antimicrobial properties of phenolic compounds from berries.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eJournal of applied microbiology\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e90\u003c\/i\u003e(4), 494-507.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2672.2005.02547.x\/full\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eOzdal, T., Sela, D. A., Xiao, J., Boyacioglu, D., Chen, F., \u0026amp; Capanoglu, E. (2016). The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(2), 78.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/8\/2\/78\/pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSkrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., \u0026amp; Sochor, J. (2015). Bioactive compounds and antioxidant activity in different types of berries. \u003ci\u003eInternational journal of molecular sciences\u003c\/i\u003e, \u003ci\u003e16\u003c\/i\u003e(10), 24673-24706.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/1422-0067\/16\/10\/24673\/pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShmuely, H., Ofek, I., Weiss, E. I., Rones, Z., \u0026amp; Houri-Haddad, Y. (2012). Cranberry components for the therapy of infectious disease. \u003ci\u003eCurrent opinion in biotechnology\u003c\/i\u003e, \u003ci\u003e23\u003c\/i\u003e(2), 148-152.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.muwellness.com\/sites\/default\/files\/Los%20ar%C3%A1ndanos%20rojos%20inhiben%20la%20adherencia%20de%20la%20bacteria%20H.%20Pylori%20a%20la%20pared%20estomacal.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTeodoro, G. R., Ellepola, K., Seneviratne, C. J., \u0026amp; Koga-Ito, C. Y. (2015). Potential use of phenolic acids as anti-Candida agents: a review. \u003ci\u003eFrontiers in microbiology\u003c\/i\u003e, \u003ci\u003e6\u003c\/i\u003e, 1420.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2015.01420\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eTomás-Barberán FA, Selma MV, Espín JC. (2016).\u003c\/em\u003e\u003ci\u003e \u003c\/i\u003eInteractions of gut microbiota with dietary polyphenols and consequences to human health.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCurr Opin Clin Nutr Metab Care, 19(6), 471-476.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27490306\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eValdez, J. C., \u0026amp; Bolling, B. W. (2019). Anthocyanins and intestinal barrier function: a review. \u003ci\u003eJournal of Food Bioactives\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e, 18-30.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.isnff-jfb.com\/index.php\/JFB\/article\/download\/64\/130\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eValdés, L., Cuervo, A., Salazar, N., Ruas-Madiedo, P., Gueimonde, M., \u0026amp; González, S. (2015). The relationship between phenolic compounds from diet and microbiota: impact on human health.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eFood \u0026amp; function\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e6\u003c\/i\u003e(8), 2424-2439.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/pubs.rsc.org\/-\/content\/articlelanding\/2015\/fo\/c5fo00322a\/unauth#!divAbstract\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVendrame, S., \u0026amp; Klimis-Zacas, D. (2015). Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-κB and mitogen-activated protein kinase signaling cascades.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eNutr Rev, 73\u003c\/i\u003e(6), 348-58.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26011910\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003ci\u003eBerries and Metabolic Syndrome: Heart, Obesity, and Cancer Support\u003c\/i\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBaby, B., Antony, P., Al Halabi, W., Al Homedi, Z., \u0026amp; Vijayan, R. (2016). 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Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial. \u003ci\u003eBr J Nutr\u003c\/i\u003e, \u003ci\u003e115\u003c\/i\u003e(2), 226-38.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Eunyoung_Park3\/publication\/284022696_Effects_of_grape_seed_extract_beverage_on_blood_pressure_and_metabolic_indices_in_individuals_with_pre-hypertension_A_randomised_double-blinded_two-arm_parallel_placebo-controlled_trial\/links\/588a0bbba6fdcc9a35c3be3b\/Effects-of-grape-seed-extract-beverage-on-blood-pressure-and-metabolic-indices-in-individuals-with-pre-hypertension-A-randomised-double-blinded-two-arm-parallel-placebo-controlled-trial.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePark.E., Edirisinghe, I., Wei, H., Vijayakumar, L.P., Banaszewski, K., \u0026amp; Burton-Freeman, B. (2016). A dose-response evaluation of freeze-dried strawberries independent of fiber content on metabolic indices in abdominally obese individuals with insulin resistance in a randomized, single-blinded, diet-controlled crossover trial. \u003ci\u003eMol Nutr Food Res\u003c\/i\u003e , \u003ci\u003e60\u003c\/i\u003e(5), 1099-109.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Eunyoung_Park3\/publication\/292990453_A_dose-response_evaluation_of_freeze-dried_strawberries_independent_of_fiber_content_on_metabolic_indices_in_abdominally_obese_individuals_with_insulin-resistance_in_a_randomized_single-blinded_diet-c\/links\/5c004b1245851523d153b0db\/A-dose-response-evaluation-of-freeze-dried-strawberries-independent-of-fiber-content-on-metabolic-indices-in-abdominally-obese-individuals-with-insulin-resistance-in-a-randomized-single-blinded-diet.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePanickar, K.S., \u0026amp; Anderson, R.A. (2010). Role of dietary polyphenols in attenuating brain edema and cell swelling in cerebral ischemia.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eRecent Pat CNS Drug Discov, 5\u003c\/i\u003e(2), 99-108.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20030622\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJenkins, D.J., Nguyen, T.H., Kendall, C.W., Faulkner, D.A., Bashyam, B, Kim, I.J., … Singer, W. (2008). The effect of strawberries in a cholesterol-lowering dietary portfolio. \u003ci\u003eMetabolism, 57\u003c\/i\u003e(12), 1636-44.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.academia.edu\/download\/44559956\/The_effect_of_strawberries_in_a_choleste20160408-12914-1xine52.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSkrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., \u0026amp; Sochor, J. (2015). Bioactive compounds and antioxidant activity in different types of berries. \u003ci\u003eInternational journal of molecular sciences\u003c\/i\u003e, \u003ci\u003e16\u003c\/i\u003e(10), 24673-24706.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.mdpi.com\/1422-0067\/16\/10\/24673\/htm\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSomasagara, R. R., Hegde, M., Chiruvella, K. K., Musini, A., Choudhary, B., \u0026amp; Raghavan, S. C. (2012). Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice. \u003ci\u003ePloS one\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(10), e47021.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0047021\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWeaver, J., Briscoe, T., Hou, M., Goodman, C., Kata, S., Ross, H., ... \u0026amp; Riches, A. (2009). Strawberry polyphenols are equally cytotoxic to tumourigenic and normal human breast and prostate cell lines. \u003ci\u003eInternational journal of oncology\u003c\/i\u003e, \u003ci\u003e34\u003c\/i\u003e(3), 777-786.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.spandidos-publications.com\/ijo\/34\/3\/777\/download\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWichansawakun, S., \u0026amp; Buttar, H. S. (2019). Antioxidant Diets and Functional Foods Promote Healthy Aging and Longevity Through Diverse Mechanisms of Action. In \u003ci\u003eThe Role of Functional Food Security in Global Health\u003c\/i\u003e (pp. 541-563). Academic Press.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128131480000323\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e* See Supernatant research \u0026amp; description tabs for more on the Probiotic Super Blend.\u003c\/b\u003e\u003c\/p\u003e\n\u003ch6\u003e\u003cb\u003eIngredients\u003c\/b\u003e\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eHigh ORAC Synbiotic: Post Antibiotic Care\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eA Proprietary blend of:                                        500mg\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePhytonutrients-\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003eGrape Seed Extract, Wild Blueberry, Quercetin, Resveratrol, Wild Bilberry, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry, and Inulin from Chicory Root. ORAC 40,000.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBioImmersion Probiotic Super Blend\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e–\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eProbiotics\u003c\/b\u003e-\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eBifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus and streptococcus thermophilus\u003c\/i\u003e;\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ePrebiotic\u003c\/b\u003e- Inulin from chicory Root;\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eSupernatant\u003c\/b\u003e- probiotic metabolites, and\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eORNs\u003c\/b\u003e. 30 billion CFU.\u003c\/p\u003e\n\u003cp\u003eCapsule- Cellulose \u0026amp; Water\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003ch6\u003e\n\u003cspan\u003eProtocol\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003eHIGH ORAC SYNBIOTIC\u003c\/strong\u003e—- The High ORAC is designed as a powerful post antibiotic care, with 40,000ppm Total ORAC.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003ePost Antibiotic Care\u003c\/em\u003e: The High ORAC is the most powerful anti-oxidant product on the market, with 40,000ppm of total ORAC, and a broad-spectrum plant polyphenol that boosts nitric oxide levels in the blood, stimulates antioxidant activity, and supports efficient cellular oxygen consumption. The mix restores and renews the GI Tract, re-colonizes the gut with strong organisms, and re-energizes every cell in the body. Take 1-2 capsules daily.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eYeast infection\u003c\/em\u003e: Antibiotics often unbalance the microbiome (GI Tract) resulting in overgrowth of yeast in the gut and vagina. Plant extracts have antimicrobial properties, and together with the probiotic, reduce pathogenic populations. Take 1-2 caps High ORAC. Add\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eGarlic\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e(2-3 capsules daily) for its antimicrobial ability for 7-10 days.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eSports, exercise, and reduction of oxidation\u003c\/em\u003e: The High ORAC’s total 40,000ppm Oxygen Radical Absorbent Capacity means that it has a high ability to neutralize free radicals in the body. Take 1 capsules before exercise to reduce muscle soreness. Add\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eEnergy\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e(1-2 caps) for added strength.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eOur favorite\u003c\/em\u003e: The High ORAC has such a calmative effect that even a very sensitive gut (intestines and colon) can benefit and thrive. The intense total ORAC has a powerful anti-inflammatory quality. For very sensitive guts: Start with 1 capsule every other day and increase to 1 cap a day.*\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712314998828,"sku":"TF010","price":79.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/High-Orac-Synbiotic---Front.jpg?v=1723214796"},{"product_id":"glucosinolates-sulforaphanes-organic-broccoli-sprouts","title":"Glucosinolates \u0026 Sulforaphanes","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eBroccoli sprouts are the richest source of glucoraphanin which is the direct precursor to sulforaphane.  Broccoli sulforaphane is one of the most potent inducers of phase II enzymes.  Our\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eGlucosinolates \u0026amp; Sulforaphanes \u003c\/b\u003eis a powerhouse, providing a four fold increase in the phase 2 enzyme potential.\u003c\/p\u003e\n\u003cp\u003eLearn more about the research and benefits of this power packed product. A daily must.\u003c\/p\u003e\n\u003cp\u003eThe broccoli sprout  concentrate is organic, vegan, kosher, Non GMO, gluten and yeast free\u003c\/p\u003e\n\u003ch6\u003eDescription\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eThe new Cruciferous Sprouts has 100% concentration of organic broccoli sprouts and is named, \u003cb\u003eGlucosinolates \u0026amp; Sulforaphanes\u003c\/b\u003e, since it offers a 4-6-fold increase of glucosinolates for a high sulforaphane potential. \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGlucosinolates \u0026amp; Sulforaphanes \u003c\/b\u003eis a potent mix of Glucosinolates with 15,000 ppm, Glucoraphanin with 10,000 ppm, and Sulforaphanes Potential of 4,000 ppm. Broccoli sprouts grow into their peak when they are three days old, and can contain from 10-100 times more glucoraphanin, the \u003ci\u003eglucosinolates of sulforaphane\u003c\/i\u003e, than a mature broccoli plant. Each of our vegan capsule has 500 mg of organic broccoli sprouts, harvested at the peak of their phytonutrient power. \u003c\/p\u003e\n\u003cp\u003eAccording to Leone et al. (2017), the vegetable broccoli accumulates a significant amount of the phyto-nutrient glucoraphanin (4-methylsulfinylbutyl \u003ci\u003eglucosinolates\u003c\/i\u003e) which is metabolized in our bodies into the biologically active Sulforaphane (SFN). The conversion requires the enzyme, myrosinase, which is also found in the broccoli plant as well as the bacterial myrosinases in the human colon. Once broccoli or broccoli sprouts are consumed and converted into SFN, this amazing phyto-nutrient is \u003ci\u003emetabolized via the mercapturic acid pathway to form cysteinylglycine-, cysteine-, and N-acetylcysteine (NAC) conjugates\u003c\/i\u003e. These metabolites are then excreted via the urine (Mennicke et al., 1988; Atwell et al., 2015). In fact, it has been shown in research that 70% of the ingested SFN was retrieved in urine (Egner et al., 2011), showing systemic benefits (Abbaoui et al., 2012).\u003c\/p\u003e\n\u003cp\u003eSulforaphanes (SFN) are found in high quantities in broccoli, and in higher quantities in broccoli sprouts. SFN is an isothiocyanate that occurs in a stored form as glucoraphanin in cruciferous vegetables (Vanduchova et al., 2018). Isothiocyanates are phyto-chemicals produced by cruciferous vegetables and sprouts.  They are derivatives of glucosinolates in the cells of cruciferous plants. The hydrolysis (chemical breakdown during digestion) of glucosinolates by the enzyme myrosinase creates this pungent compound as a defensive tool to protect against pathogens that want to eat the plant. This same defense mechanism is known to offer excellent health benefits, including a fungicidal affect (Parker, 2015; Troncoso-Rojas et al., 2014; for more on the mechanism of SFN, see Leon et al., 2017). \u003c\/p\u003e\n\u003cp\u003eSFN in Broccoli sprouts provide the most potent natural phase II enzyme inducer to boost the liver’s ability to detoxify. As a fun fact, broccoli sprouts are the most potent producers of Sulforaphanes, with broccoli plant as second, and then kohlrabi and cauliflower. But as we pointed out above, to activate the ability of broccoli, or SFN, the enzymes have to react: Two phytochemicals must react, or interact, to create SFN: Myrosinase (enzyme in the broccoli) and glucoraphanin (West et al., 2004). For this reason, we have chosen the most potent organic broccoli sprouts with high yield of Glucoraphanin of 10,000 ppm (a direct precursor to SFN).\u003c\/p\u003e\n\u003cp\u003eStandardizing the enzymes to produce a high potential SFN is important. Our organic broccoli sprouts are guaranteed for high sulforaphane potential of 4,000 ppm to ensure consistent daily intake of SFN. The history and ongoing research on the health benefits of cruciferous vegetables and in particular, broccoli and broccoli sprouts are impressive. Take a look at our Research tab and read some of the articles on SFN in broccoli sprouts.\u003c\/p\u003e\n\u003cp\u003eIn 1992, Zhang et al. have isolated sulforaphane and shown that it is potent and effective anti-carcinogenic agent (Zhang et al., 1992; Leon et al., 2017). Since then, Sulforaphanes (SFN) derived from cruciferous broccoli sprouts have shown numerous bioactivities (Su et al., 2018) that offer different kinds anti-carcinogenic properties (Mokhtari et al., 2018; Suresh et al., 2018; Su et al., 2018), phase II detoxifying enzymes (Thangapandiyan et al., 2018; James et al., 2012), including phase II antioxidant enzymes in the human upper airways (Riedl et al., 2009; Heber et al., 2014).\u003c\/p\u003e\n\u003cp\u003eMoreover, SFN has also been researched as an effective agent for cardiovascular health (Gray, 2018; Angeloni et al., 2009), anti-inflammation (López-Chillón et al., 2018), detoxification of airborne pollutants (Egner et al., 2014), H-pylori antimicrobial with a general benefit for gut health (Yanaka, 2017, and 2018) and brain health (Sedlak et al., 2017), including support for autism (Singh et al, 2014). \u003c\/p\u003e\n\u003cp\u003eTo understand how SFN works in our body, turn to researchers such as Xin Jiang et al. (2018), for a thorough review. In \u003ci\u003eChemopreventive activity of sulforaphane\u003c\/i\u003e, Jiang et al. explain the many bioactive dietary compounds in vegetables and fruits that have been demonstrated to be effective in cancer prevention and even intervention. Cruciferous vegetables, and in particular, sulforaphanes have been shown to have chemopreventive activity - in vitro and in vivo. Several mechanisms are outlined such as: regulation of Phase I and Phase II drug-metabolizing enzymes, cell cycle arrest, and induction of apoptosis, especially via regulation of signaling pathways as NrFe-Keap 1 and NF-k. Jiang et al. (2018) includes the research on SFN’s effect on epigenetic control of key genes involved in initiation and progression of cancer, showing a promise for using SFN as cancer chemopreventive strategy. In fact, there are many different kinds of phyto-nutrients that are found to be effective agents in the prevention of cancer, including favorable mediation of epigenetic changes (Pandey et al., 2017; Jiang et al., 2018). \u003c\/p\u003e\n\u003cp\u003eSulforaphanes are also known to have anti-inflammatory properties, significantly reducing DNA-binding activity of NF-kB, a transcription factor that regulates the expression of several pro-inflammatory genes (Jiang et al., 2018; Kamakar et al., 2006). \u003c\/p\u003e\n\u003cp\u003eSFN in broccoli sprouts is found to be safe (Shapiro et al., 2006) and well tolerated, even when it is used for advanced pancreatic cancer treatments (Lozanovski et al, 2014). Since SFN operates through several different mechanisms in the body, including regulations of Phase I and II, anti-inflammatory process, and more, it is well worth the inclusion of this dietary food into a daily routine. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAtwell, L. L., Hsu, A., Wong, C. P., Stevens, J. F., Bella, D., Yu, T. W., ... \u0026amp; Williams, D. E. (2015). Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase‐treated broccoli sprout extract. \u003ci\u003eMolecular nutrition \u0026amp; food research\u003c\/i\u003e, \u003ci\u003e59\u003c\/i\u003e(3), 424-433.\u003ca href=\"https:\/\/doi.org\/10.1002\/mnfr.201400674\"\u003ehttps:\/\/doi.org\/10.1002\/mnfr.201400674\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAbbaoui, B., Riedl, K. M., Ralston, R. A., Thomas‐Ahner, J. M., Schwartz, S. J., Clinton, S. K., \u0026amp; Mortazavi, A. (2012). Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion. \u003ci\u003eMolecular nutrition \u0026amp; food research\u003c\/i\u003e, \u003ci\u003e56\u003c\/i\u003e(11), 1675-1687. \u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/mnfr.201200276\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAngeloni, C., Leoncini, E., Malaguti, M., Angelini, S., Hrelia, P., \u0026amp; Hrelia, S. (2009). Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential. \u003ci\u003eJournal of agricultural and food chemistry\u003c\/i\u003e, \u003ci\u003e57\u003c\/i\u003e(12), 5615-5622.\u003ca href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf900549c\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEgner, P. A., Chen, J. G., Wang, J. B., Wu, Y., Sun, Y., Lu, J. H., ... \u0026amp; Jacobson, L. P. (2011). Bioavailability of sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. \u003ci\u003eCancer prevention research\u003c\/i\u003e, \u003ci\u003e4\u003c\/i\u003e(3), 384-395.\u003ca href=\"http:\/\/cancerpreventionresearch.aacrjournals.org\/content\/4\/3\/384.short\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEgner, P. A., Chen, J. G., Zarth, A. T., Ng, D., Wang, J., Kensler, K. H., ... \u0026amp; Fahey, J. W. (2014). Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. \u003ci\u003eCancer prevention research\u003c\/i\u003e, canprevres-0103.\u003ca href=\"http:\/\/cancerpreventionresearch.aacrjournals.org\/content\/early\/2014\/06\/07\/1940-6207.CAPR-14-0103.short\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGray, S. G. (2018). The Potential of Epigenetic Compounds in Treating Diabetes. In \u003ci\u003eEpigenetics in Human Disease (Second Edition)\u003c\/i\u003e (pp. 489-547).\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/B978-0-12-812215-0.00017-0\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/B978-0-12-812215-0.00017-0\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHeber, D., Li, Z., Garcia-Lloret, M., Wong, A. M., Lee, T. Y. A., Thames, G., ... \u0026amp; Nel, A. (2014). Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. \u003ci\u003eFood \u0026amp; function\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e(1), 35-41.\u003ca href=\"https:\/\/pubs.rsc.org\/en\/content\/articlehtml\/2014\/fo\/c3fo60277j\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJames, D., Devaraj, S., Bellur, P., Lakkanna, S., Vicini, J., \u0026amp; Boddupalli, S. (2012). Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. \u003ci\u003eNutrition reviews\u003c\/i\u003e, \u003ci\u003e70\u003c\/i\u003e(11), 654-665.\u003ca href=\"https:\/\/doi.org\/10.1111\/j.1753-4887.2012.00532.x\"\u003ehttps:\/\/doi.org\/10.1111\/j.1753-4887.2012.00532.x\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJiang, X., Liu, Y., Ma, L., Ji, R., Qu, Y., Xin, Y., \u0026amp; Lv, G. (2018). Chemopreventive activity of sulforaphane. \u003ci\u003eDrug design, development and therapy\u003c\/i\u003e, \u003ci\u003e12\u003c\/i\u003e, 2905.\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6141106\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKarmakar, S., Weinberg, M. S., Banik, N. L., Patel, S. J., \u0026amp; Ray, S. K. (2006). Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane. \u003ci\u003eNeuroscience\u003c\/i\u003e, \u003ci\u003e141\u003c\/i\u003e(3), 1265-1280.\u003ca title=\"Persistent link using digital object identifier\" href=\"https:\/\/doi.org\/10.1016\/j.neuroscience.2006.04.075\" target=\"_blank\" rel=\"noopener noreferrer\"\u003ehttps:\/\/doi.org\/10.1016\/j.neuroscience.2006.04.075\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLópez-Chillón, M. T., Carazo-Díaz, C., Prieto-Merino, D., Zafrilla, P., Moreno, D. A., \u0026amp; Villaño, D. (2018). Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects. \u003ci\u003eClinical Nutrition\u003c\/i\u003e.\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0261561418301183\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp class=\"dx-doi\"\u003eMennicke, W. 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Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proceedings of the National Academy of Sciences, 91(8), 3147-3150. Article\u003c\/p\u003e\n\u003cp\u003eZhang, Y., Talalay, P., Cho, C. G., \u0026amp; Posner, G. H. (1992). A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proceedings of the national academy of sciences, 89(6), 2399-2403. https:\/\/doi.org\/10.1073\/pnas.89.6.2399\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCardiovascular \u0026amp; Diabetes Support\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAngeloni, C., Leoncini, E., Malaguti, M., Angelini, S., Hrelia, P., \u0026amp; Hrelia, S. (2009). Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential. Journal of agricultural and food chemistry, 57(12), 5615-5622. Article\u003c\/p\u003e\n\u003cp\u003eBahadoran, Z., Mirmiran, P., Hosseinpanah, F., Hedayati, M., Hosseinpour-Niazi, S., \u0026amp; Azizi, F. (2011). Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial. European journal of clinical nutrition, 65(8), 972. Article\u003c\/p\u003e\n\u003cp\u003eBahadoran, Z., Tohidi, M., Nazeri, P., Mehran, M., Azizi, F., \u0026amp; Mirmiran, P. (2012). Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. International journal of food sciences and nutrition, 63(7), 767-771. Abstract\u003c\/p\u003e\n\u003cp\u003eBahadoran, Z., Tohidi, M., Nazeri, P., Mehran, M., Azizi, F., \u0026amp; Mirmiran, P. (2012). Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. International journal of food sciences and nutrition, 63(7), 767-771. https:\/\/doi.org\/10.3109\/09637486.2012.665043\u003c\/p\u003e\n\u003cp\u003eGray, S. G. (2018). The Potential of Epigenetic Compounds in Treating Diabetes. In Epigenetics in Human Disease (Second Edition) (pp. 489-547). https:\/\/doi.org\/10.1016\/B978-0-12-812215-0.00017-0\u003c\/p\u003e\n\u003cp\u003eLópez-Chillón, M. T., Carazo-Díaz, C., Prieto-Merino, D., Zafrilla, P., Moreno, D. A., \u0026amp; Villaño, D. (2018). Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects. Clinical Nutrition. Abstract\u003c\/p\u003e\n\u003cp\u003eMirmiran, P., Bahadoran, Z., Hosseinpanah, F., Keyzad, A., \u0026amp; Azizi, F. (2012). Effects of broccoli sprout with high sulforaphane concentration on inflammatory markers in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. Journal of Functional Foods, 4(4), 837-841. 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Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food \u0026amp; function, 5(1), 35-41. Article\u003c\/p\u003e\n\u003cp\u003eJiang, Y., Wu, S. H., Shu, X. O., Xiang, Y. B., Ji, B. T., Milne, G. L., ... \u0026amp; Yang, G. (2014). Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women. Journal of the Academy of Nutrition and Dietetics, 114(5), 700-708. DOI:10.1016\/j.jand.2013.12.019\u003c\/p\u003e\n\u003cp\u003eNoah, T. L., Zhang, H., Zhou, H., Glista-Baker, E., Müller, L., Bauer, R. N., ... \u0026amp; Robinette, C. (2014). Effect of broccoli sprouts on nasal response to live attenuated influenza virus in smokers: a randomized, double-blind study. PloS one, 9(6), e98671. Article\u003c\/p\u003e\n\u003cp\u003ePark, J. H., Kim, J. W., Lee, C. M., Kim, Y. D., Chung, S. W., Jung, I. D., ... \u0026amp; Seo, J. K. (2012). Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma. BMB reports, 45(5), 311-316. Abstract\u003c\/p\u003e\n\u003cp\u003eRiedl, M. A., Saxon, A., \u0026amp; Diaz-Sanchez, D. (2009). Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clinical immunology, 130(3), 244-251. Abstract\u003c\/p\u003e\n\u003cp\u003eRiso, P., Vendrame, S., Del Bo', C., Martini, D., Martinetti, A., Seregni, E., ... \u0026amp; Porrini, M. (2014). Effect of 10-day broccoli consumption on inflammatory status of young healthy smokers. International journal of food sciences and nutrition, 65(1), 106-111. DOI: 10.3109\/09637486.2013.830084\u003c\/p\u003e\n\u003cp\u003eRiso, P., Vendrame, S., Del Bo', C., Martini, D., Martinetti, A., Seregni, E., ... \u0026amp; Porrini, M. (2014). Effect of 10-day broccoli consumption on inflammatory status of young healthy smokers. International journal of food sciences and nutrition, 65(1), 106-111. DOI:10.3109\/09637486.2013.830084\u003c\/p\u003e\n\u003cp\u003eRitz, S. A., Wan, J., \u0026amp; Diaz-Sanchez, D. (2007). Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract. American Journal of Physiology-Lung Cellular and Molecular Physiology, 292(1), L33-L39. Article\u003c\/p\u003e\n\u003cp\u003e\\Wang, A. S., Xu, Y., Zhang, Z. W., Lu, B. B., Yin, X., Yao, A. J., ... \u0026amp; Zhang, X. H. (2017). Sulforaphane protects MLE-12 lung epithelial cells against oxidative damage caused by ambient air particulate matter. Food \u0026amp; function, 8(12), 4555-4562. Abstract\u003c\/p\u003e\n\u003cp\u003eWu, X., Zhu, Y., Yan, H., Liu, B., Li, Y., Zhou, Q., \u0026amp; Xu, K. (2010). Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells. 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Molecular neuropsychiatry, 3(4), 214-222. https:\/\/www.karger.com\/Article\/Abstract\/487639\u003c\/p\u003e\n\u003cp\u003eSingh, K., Connors, S. L., Macklin, E. A., Smith, K. D., Fahey, J. W., Talalay, P., \u0026amp; Zimmerman, A. W. (2014). Sulforaphane treatment of autism spectrum disorder (ASD). Proceedings of the National Academy of Sciences, 111(43), 15550-15555. DOI: 10.1073\/pnas.1416940111\u003c\/p\u003e\n\u003ch6\u003eIngredients\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eOne Capsule Contains: 700mg\u003cbr\u003eBroccoli Sprout Powder (\u003cem\u003eBrassica oleracea italica\u003c\/em\u003e)\u003cbr\u003eQAI Certified Organic\u003cbr\u003eGlucosinolates 15,000ppm\u003cbr\u003eGlucoraphanins 10,000ppm\u003cbr\u003eSulforaphane Potention 4,000ppm\u003c\/p\u003e\n\u003cp\u003eOther ingredients: \u003cbr\u003ecellulose \u0026amp; water (capsule shell)\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003ch6\u003e\n\u003cspan\u003eProtocol\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eGLUCOSINOLATES \u0026amp; SULFORAPHANES\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e(Broccoli\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eCruciferous Sprouts)\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— Glucosinolates \u0026amp; Sulforaphanes is designed to support the integrity of cellular DNA and enact Phase II liver detox.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003ePhase II liver detox\u003c\/i\u003e: High levels of glucosinolates (15,000ppm) and sulforaphanes (4,000ppm potential) from broccoli spouts support every cell’s elimination and protection mechanism.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eSupport during cancer treatment\u003c\/i\u003e: Take 2 capsules twice a day. Add\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eBlueberry Extract\u003c\/b\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eHigh ORAC\u003c\/b\u003e, and the\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eOriginal\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eor\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eSupernatant\u003c\/b\u003e. Consult your health care provider.*\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003ci\u003eSupport during toxic overload\u003c\/i\u003e: Take 2 capsules twice a day. This will help to protect the body and to help support the body’s detox mechanism. Add  4 tabs of \u003cb\u003eChlorella\u003c\/b\u003e and 2 capsules of \u003cb\u003ePhyto Power\u003c\/b\u003e.*\u003c\/span\u003e\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712315097132,"sku":"TF021","price":61.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Glucosinolates-_-Sulforaphanes---Front.jpg?v=1723214806"},{"product_id":"garlic-organic","title":"Garlic, Organic","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eThis exceptionally potent supplement boasts four to five cloves of organic garlic in every capsule. Known as the Russian Penicillin, garlic has been used for centuries therapeutically as an antimicrobial and over the last thirty years this has been our focus as well.\u003c\/p\u003e\n\u003cp\u003eSourcing garlic cloves with exceptional antimicrobial potential, along with utilizing the most advanced air\/belt drying and manufacturing technologies enable us to provide the most therapeutically potent garlic in the market.\u003c\/p\u003e\n\u003cp\u003eIt is a must have product to have on your shelf. Learn more about its many usages.\u003c\/p\u003e\n\u003ch6\u003eDescription \u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003ePure High Actives organic garlic. QAI Certified. Exceptionally potent 26,800 ppm alliin (the industry standard for high potency is 10,000 ppm alliin). Advanced air\/belt dying technology. No excipients. 60 capsule per bottle. 500 mg per vegetarian capsule.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eGreen Technology and Patented Technology for highest phytonutrient potential.\u003c\/li\u003e\n\u003cli\u003eQAI certified raw organic garlic, Advanced Sublimation Technology. 26,800 ppm alliin content (industry standard for high potency is 10,000 ppm).\u003c\/li\u003e\n\u003cli\u003eHistorical data:\n\u003cul\u003e\n\u003cli\u003eFirst recorded 5000 BC - Sumerians of Mesopotamia.\u003c\/li\u003e\n\u003cli\u003eHippocrates 400 BC - infections, digestive problems and cancer.\u003c\/li\u003e\n\u003cli\u003eDioscorides 100 BC - infections, clearing arteries and Leprosy.\u003c\/li\u003e\n\u003cli\u003eLouis Pasteur 1858 - scientific proof that garlic kills germs.\u003c\/li\u003e\n\u003cli\u003eKnown in WWII as the \"Russian Penicillin\".\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003eAllicin in garlic is a broad-spectrum antimicrobial: anti bacterial, viral, fungal and protozoal.\u003c\/li\u003e\n\u003cli\u003eGarlic in low doses stimulates the immune system by increasing numbers of lymphocytes, phagocytosis and natural killer cell activity.\u003c\/li\u003e\n\u003cli\u003eReduces elevated serum lipid levels- triglycerides and cholesterol.\u003c\/li\u003e\n\u003cli\u003eReduces platelet aggregation and thrombus formation.\u003c\/li\u003e\n\u003cli\u003eIncreases blood flow of erythrocytes through capillaries and decreases plasma viscosity.\u003c\/li\u003e\n\u003cli\u003eExerts a mild hypotensive effect.\u003c\/li\u003e\n\u003cli\u003eDecreases incidences of gastrointestinal cancers.\u003c\/li\u003e\n\u003cli\u003eClinically is used to chelate mercury interstitially.\u003c\/li\u003e\n\u003cli\u003eNo fillers, flowing agents or excipients of any kind.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch6\u003eResearch\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eFOOD SCIENCE: THE APPLICATION AND USE OF Garlic.*\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eAntimicrobial\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAbbas, H. M. K., Kong, X., Wu, J., Ali, M., \u0026amp; Dong, W. (2019). Antimicrobial Potential of Genes from Garlic (Allium sativum L.). In \u003ci\u003eStudies on Garlic\u003c\/i\u003e. IntechOpen.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.intechopen.com\/online-first\/antimicrobial-potential-of-genes-from-garlic-allium-sativum-l\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAnkri, S., \u0026amp; Mirelman, D. (1999). Antimicrobial properties of allicin from garlic. \u003ci\u003eMicrobes and infection\u003c\/i\u003e, \u003ci\u003e1\u003c\/i\u003e(2), 125-129. \u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/s3.amazonaws.com\/academia.edu.documents\/31180275\/5389.pdf?AWSAccessKeyId=AKIAIWOWYYGZ2Y53UL3A\u0026amp;Expires=1554422083\u0026amp;Signature=EFbGC43P5%2BDTRgc7LfKq4zkZLhY%3D\u0026amp;response-content-disposition=inline%3B%20filename%3DAntimicrobial_properties_of_allicin_from.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBakri, I. M., \u0026amp; Douglas, C. W. I. (2005). Inhibitory effect of garlic extract on oral bacteria. \u003ci\u003eArchives of oral biology\u003c\/i\u003e, \u003ci\u003e50\u003c\/i\u003e(7), 645-651.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003996905000038\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBenkeblia, N. (2004). Antimicrobial activity of essential oil extracts of various onions (Allium cepa) and garlic (Allium sativum). \u003ci\u003eLWT-food science and technology\u003c\/i\u003e, \u003ci\u003e37\u003c\/i\u003e(2), 263-268.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mona.uwi.edu\/lifesciences\/hortlab\/papers\/LWT.2004.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDarwis, M. Z., Yuniati, L., \u0026amp; Arifin, A. F. (2019). Effectiveness of Garlic (Allium sativum) as Antimicrobial Agent against Bacteria Causing Urinary Tract Infection. \u003ci\u003eJournal of Pharmacy and Pharmacology\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e, 278-281.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.davidpublisher.org\/Public\/uploads\/Contribute\/5ca409cad1696.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDelaha, E. C., \u0026amp; Garagusi, V. F. (1985). Inhibition of mycobacteria by garlic extract (Allium sativum). \u003ci\u003eAntimicrobial agents and chemotherapy\u003c\/i\u003e, \u003ci\u003e27\u003c\/i\u003e(4), 485-486.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/aac.asm.org\/content\/aac\/27\/4\/485.full.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGhrairi, T., Jaraud, S., Alves, A., Fleury, Y., El Salabi, A., \u0026amp; Chouchani, C. (2019). New Insights into and Updates on Antimicrobial Agents from Natural Products. \u003ci\u003eBioMed research international\u003c\/i\u003e, \u003ci\u003e2019\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/downloads.hindawi.com\/journals\/bmri\/2019\/7079864.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHarris, J. C., Cottrell, S., Plummer, S., \u0026amp; Lloyd, D. (2001). Antimicrobial properties of Allium sativum (garlic). \u003ci\u003eApplied microbiology and biotechnology\u003c\/i\u003e, \u003ci\u003e57\u003c\/i\u003e(3), 282-286.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s002530100722\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHughes, B. G., \u0026amp; Lawson, L. D. (1991). Antimicrobial effects of Allium sativum L.(garlic), Allium ampeloprasum L.(elephant garlic), and Allium cepa L.(onion), garlic compounds and commercial garlic supplement products. \u003ci\u003ePhytotherapy Research\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e(4), 154-158.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/ptr.2650050403\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eElnima, E. I., Ahmed, S. A., Mekkawi, A. G., \u0026amp; Mossa, J. S. (1983). The antimicrobial activity of garlic and onion extracts. \u003ci\u003eDie Pharmazie\u003c\/i\u003e, \u003ci\u003e38\u003c\/i\u003e(11), 747-748.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Dr_Daljit_Singh_Arora\/publication\/12837814_Antimicrobial_activity_of_spices_Int_J_Antimicrob_Agents\/links\/5a1551dd0f7e9b925cd539e7\/Antimicrobial-activity-of-spices-Int-J-Antimicrob-Agents.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eIwalokun, B. A., Ogunledun, A., Ogbolu, D. O., Bamiro, S. B., \u0026amp; Jimi-Omojola, J. (2004). In vitro antimicrobial properties of aqueous garlic extract against multidrug-resistant bacteria and Candida species from Nigeria. \u003ci\u003eJournal of medicinal food\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(3), 327-333.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/3be7\/da9c87bbad719ff34344c0516168f27777da.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKoch, H. P., \u0026amp; Lawson, L. D. (1996). \u003ci\u003eGarlic: the science and therapeutic application of Allium sativum L. and related species\u003c\/i\u003e. Lippincott Williams \u0026amp; Wilkins.\u003c\/p\u003e\n\u003cp\u003eKannar, D., Wattanapenpaiboon, N., Savige, G. S., \u0026amp; Wahlqvist, M. L. (2001). Hypocholesterolemic effect of an enteric-coated garlic supplement. \u003ci\u003eJournal of the American College of Nutrition\u003c\/i\u003e, \u003ci\u003e20\u003c\/i\u003e(3), 225-231.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/apjcn.nhri.org.tw\/server\/markwpapers\/Papers\/Papers%202001\/P302.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKyung, K. H. (2012). Antimicrobial properties of allium species. \u003ci\u003eCurrent opinion in biotechnology\u003c\/i\u003e, \u003ci\u003e23\u003c\/i\u003e(2), 142-147.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0958166911006720\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLawson, L. D., \u0026amp; Gardner, C. D. (2005). Composition, stability, and bioavailability of garlic products used in a clinical trial. \u003ci\u003eJournal of agricultural and food chemistry\u003c\/i\u003e, \u003ci\u003e53\u003c\/i\u003e(16), 6254-6261.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2584604\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLawson, L. D. (1998). Garlic: a review of its medicinal effects and indicated active compounds. In \u003ci\u003eACS Symposium Series\u003c\/i\u003e(Vol. 691, pp. 176-209). American Chemical Society.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/bk-1998-0691.ch014\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLawson, L. D., \u0026amp; Hughes, B. G. (1992). Characterization of the formation of allicin and other thiosulfinates from garlic. \u003ci\u003ePlanta Medica\u003c\/i\u003e, \u003ci\u003e58\u003c\/i\u003e(04), 345-350.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17226483\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLawson, L. D., Wood, S. G., \u0026amp; Hughes, B. G. (1991). HPLC analysis of allicin and other thiosulfinates in garlic clove homogenates. \u003ci\u003ePlanta medica\u003c\/i\u003e, \u003ci\u003e57\u003c\/i\u003e(3), 263.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17226157\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePai, S. T., \u0026amp; Platt, M. W. (1995). Antifungal effects of Allium sativum (garlic) extract against the Aspergillus species involved in otomycosis [ear infection]. \u003ci\u003eLetters in applied microbiology\u003c\/i\u003e, \u003ci\u003e20\u003c\/i\u003e(1), 14-18.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7765862\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRees, L. P., Minney, S. F., Plummer, N. T., Slater, J. H., \u0026amp; Skyrme, D. A. (1993). A quantitative assessment of the antimicrobial activity of garlic (Allium sativum). \u003ci\u003eWorld journal of microbiology and biotechnology\u003c\/i\u003e, \u003ci\u003e9\u003c\/i\u003e(3), 303-307.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/BF00383068\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRios, J. L., \u0026amp; Recio, M. C. (2005). Medicinal plants and antimicrobial activity. \u003ci\u003eJournal of ethnopharmacology\u003c\/i\u003e, \u003ci\u003e100\u003c\/i\u003e(1-2), 80-84.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/s3.amazonaws.com\/academia.edu.documents\/30556795\/ref15.pdf?AWSAccessKeyId=AKIAIWOWYYGZ2Y53UL3A\u0026amp;Expires=1554422709\u0026amp;Signature=cowfN9vqLolC9DkMYh%2B2L8s6otA%3D\u0026amp;response-content-disposition=inline%3B%20filename%3DMedicinal_plants_and_antimicrobial_activ.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRoss, Z. M., O'Gara, E. A., Hill, D. J., Sleightholme, H. V., \u0026amp; Maslin, D. J. (2001). Antimicrobial properties of garlic oil against human enteric bacteria: evaluation of methodologies and comparisons with garlic oil sulfides and garlic powder. \u003ci\u003eAppl. Environ. Microbiol.\u003c\/i\u003e, \u003ci\u003e67\u003c\/i\u003e(1), 475-480.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/aem.asm.org\/content\/aem\/67\/1\/475.full.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSalehi, B., Zucca, P., Orhan, I. E., Azzini, E., Adetunji, C. O., Mohammed, S. A., ... \u0026amp; Armstrong, L. (2019). Allicin and health: A comprehensive review. \u003ci\u003eTrends in Food Science \u0026amp; Technology\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Radha_Singh6\/publication\/330934709_Garlic_A_spice_with_wide_medicinal_actions\/links\/5c5c576292851c48a9c17046\/Garlic-A-spice-with-wide-medicinal-actions.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSiddiqui, M. F., \u0026amp; Bano, B. (2019). Probing the binding effects of zinc and cadmium with garlic phytocystatin: Implication of the abiotic stress on garlic phytocystatin. \u003ci\u003eInternational journal of biological macromolecules\u003c\/i\u003e, \u003ci\u003e133\u003c\/i\u003e, 945-956.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S014181301837199X\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSivam, G. P., Lampe, J. W., Ulness, B., Swanzy, S. R., \u0026amp; Potter, J. D. (1997). Helicobacter pylori—in vitro susceptibility to garlic (Allium sativum) extract.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9121937\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWatson, C. J., Grando, D., Fairley, C. K., Chondros, P., Garland, S. M., Myers, S. P., \u0026amp; Pirotta, M. (2014). The effects of oral garlic on vaginal candida colony counts: A randomised placebo controlled double‐blind trial. \u003ci\u003eBJOG: An International Journal of Obstetrics \u0026amp; Gynaecology\u003c\/i\u003e, \u003ci\u003e121\u003c\/i\u003e(4), 498-506.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1471-0528.12518\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWeber, N. D., Andersen, D. O., North, J. A., Murray, B. K., Lawson, L. D., \u0026amp; Hughes, B. G. (1992). In vitro virucidal effects of Allium sativum (garlic) extract and compounds. \u003ci\u003ePlanta medica\u003c\/i\u003e, \u003ci\u003e58\u003c\/i\u003e(05), 417-423.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1470664\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWilson, E. A., \u0026amp; Demmig-Adams, B. (2007). Antioxidant, anti-inflammatory, and antimicrobial properties of garlic and onions. \u003ci\u003eNutrition \u0026amp; food science\u003c\/i\u003e, \u003ci\u003e37\u003c\/i\u003e(3), 178-183.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.emeraldinsight.com\/doi\/abs\/10.1108\/00346650710749071?journalCode=nfs\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYee, M. M. (2019). Investigation of Chemical Composition, Antimicrobial and Antioxidant Activities of Allium Wallichii Kunth (Garlic) Bulb. \u003ci\u003eAmerican Scientific Research Journal for Engineering, Technology, and Sciences (ASRJETS)\u003c\/i\u003e, \u003ci\u003e54\u003c\/i\u003e(1), 30-41.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.asrjetsjournal.org\/index.php\/American_Scientific_Journal\/article\/download\/4750\/1673\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eCardiovascular Health\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAbebe, W. (2019). Review of herbal medications with the potential to cause bleeding: dental implications, and risk prediction and prevention avenues. \u003ci\u003eEPMA Journal\u003c\/i\u003e, 1-14.\u003c\/p\u003e\n\u003cp\u003eAckermann, R. T., Mulrow, C. D., Ramirez, G., Gardner, C. D., Morbidoni, L., \u0026amp; Lawrence, V. A. (2001). Garlic shows promise for improving some cardiovascular risk factors. \u003ci\u003eArchives of Internal Medicine\u003c\/i\u003e, \u003ci\u003e161\u003c\/i\u003e(6), 813-824.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/articlepdf\/647744\/ira00067.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBhagyalakshmi, N., Thimmaraju, R., Venkatachalam, L., Murthy, K. C., \u0026amp; Sreedhar, R. V. (2005). Nutraceutical applications of garlic and the intervention of biotechnology. \u003ci\u003eCritical reviews in food science and nutrition\u003c\/i\u003e, \u003ci\u003e45\u003c\/i\u003e(7-8), 607-621.\u003c\/p\u003e\n\u003cp\u003eBlock, E. (2010).\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eGarlic and other alliums: The lore and the science\u003c\/i\u003e. Cambridge, UK: The Royal Society of Chemistry.\u003c\/p\u003e\n\u003cp\u003eBlock, E., Naganathan, S., Putman, D., \u0026amp; Zhao, S. H. (1992). 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Trends in the Use of Plant Non-Starch Polysaccharides within Food, Dietary Supplements, and Pharmaceuticals: Beneficial Effects on Regulation and Wellbeing of the Intestinal Tract. \u003ci\u003eScientia Pharmaceutica\u003c\/i\u003e, \u003ci\u003e86\u003c\/i\u003e(4), 49.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2218-0532\/86\/4\/49\"\u003eAbstra\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDutta, S., Ali, K. M., Dash, S. K., \u0026amp; Giri, B. (2018). ROLE OF NUTRACEUTICALS ON HEALTH PROMOTION AND DISEASE PREVENTION: A REVIEW. \u003ci\u003eJournal of Drug Delivery and Therapeutics\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(4), 42-47. \u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Biplab_Giri2\/publication\/326669894_ROLE_OF_NUTRACEUTICALS_ON_HEALTH_PROMOTION_AND_DISEASE_PREVENTION_A_REVIEW\/links\/5b5f6b1eaca272a2d6755d88\/ROLE-OF-NUTRACEUTICALS-ON-HEALTH-PROMOTION-AND-DISEASE-PREVENTION-A-REVIEW.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEl Sabban, F. \u0026amp; Abouazra, H. (‎2008)‎. Effect of garlic on atherosclerosis and its factors. \u003ci\u003eEMHJ - Eastern Mediterranean Health Journal, 14 (‎1)‎, 195-205, 2008\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/117426\/14_1_2008_195_205.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGardner, C. D., Lawson, L. 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Soy, garlic, and ginkgo biloba: their potential role in cardiovascular disease prevention and treatment. \u003ci\u003eCurrent atherosclerosis reports\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e(6), 468-475.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/John_Farquhar2\/publication\/5593550_Soy_garlic_and_ginkgo_biloba_Their_potential_role_in_cardiovascular_disease_prevention_and_treatment\/links\/56896dad08ae1975839aaae7.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKemper, K. J. (2000). Garlic (Allium sativum). \u003ci\u003eThe Longwood Herbal Task Force and the Center for Holistic Pediatric Education and Research\u003c\/i\u003e, \u003ci\u003e49\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.longwoodherbal.org\/garlic\/garlic.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKumar, R., \u0026amp; Rizvi, S. I. (2019). The Protective Role of Nutraceuticals and Functional Food in Hyperlipidemia. In \u003ci\u003eNutraceutical and Functional Foods in Disease Prevention\u003c\/i\u003e (pp. 233-254). IGI Global.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.igi-global.com\/chapter\/the-protective-role-of-nutraceuticals-and-functional-food-in-hyperlipidemia\/207976\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLawson, L. D. (1998). Effect of garlic on serum lipids. \u003ci\u003eJama\u003c\/i\u003e, \u003ci\u003e280\u003c\/i\u003e(18), 1568-1568.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/jamanetwork.com\/journals\/jama\/article-abstract\/1152390\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLawson, L. D., Ransom, D. K., \u0026amp; Hughes, B. G. (1992). Inhibition of whole blood platelet-aggregation by compounds in garlic clove extracts and commercial garlic products. \u003ci\u003eThrombosis research\u003c\/i\u003e, \u003ci\u003e65\u003c\/i\u003e(2), 141-156.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1579891\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePadiya, R., \u0026amp; K Banerjee, S. (2013). Garlic as an anti-diabetic agent: recent progress andpatent reviews. \u003ci\u003eRecent patents on food, nutrition \u0026amp; agriculture\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e(2), 105-127.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ingentaconnect.com\/content\/ben\/pfna\/2013\/00000005\/00000002\/art00002\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePinilla, C. M. B., Thys, R. C. S., \u0026amp; Brandelli, A. (2019). Antifungal properties of phosphatidylcholine-oleic acid liposomes encapsulating garlic against environmental fungal in wheat bread. \u003ci\u003eInternational journal of food microbiology\u003c\/i\u003e, \u003ci\u003e293\u003c\/i\u003e, 72-78.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0168160518304379\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRied, K. (2016). Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: an updated meta-analysis and review. \u003ci\u003eThe Journal of nutrition\u003c\/i\u003e, \u003ci\u003e146\u003c\/i\u003e(2), 389S-396S.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/jn\/article\/146\/2\/389S\/4584698\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTattelman, E. (2005). Health effects of garlic. \u003ci\u003eAm Fam Physician\u003c\/i\u003e, \u003ci\u003e72\u003c\/i\u003e(1), 103-6.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/citeseerx.ist.psu.edu\/viewdoc\/download?doi=10.1.1.490.3111\u0026amp;rep=rep1\u0026amp;type=pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWoodbury, A., \u0026amp; Sniecinski, R. (2016). Garlic-induced surgical bleeding: how much is too much?. \u003ci\u003eA\u0026amp;A Practice\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(12), 266-269.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/journals.lww.com\/aacr\/Fulltext\/2016\/12150\/Garlic_Induced_Surgical_Bleeding___How_Much_Is_Too.5.aspx\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZhang, Y., Xu, L., Ding, M., Su, G., \u0026amp; Zhao, Y. (2019). Anti-obesity effect of garlic oil on obese rats via Shenque point administration. \u003ci\u003eJournal of ethnopharmacology\u003c\/i\u003e, \u003ci\u003e231\u003c\/i\u003e, 486-493.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874118313540\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eHeavy Metal Detox Agent\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAbdalla, F. H., Bellé, L. P., De Bona, K. S., Bitencourt, P. E. R., Pigatto, A. S., \u0026amp; Moretto, M. B. (2010). Allium sativum L. extract prevents methyl mercury-induced cytotoxicity in peripheral blood leukocytes (LS\u003c\/p\u003e\n\u003cp\u003eAmadi, C. N., Offor, S. J., Frazzoli, C., \u0026amp; Orisakwe, O. E. (2019). Natural antidotes and management of metal toxicity. \u003ci\u003eEnvironmental Science and Pollution Research\u003c\/i\u003e, 1-21.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s11356-019-05104-2\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBellé, L. P., De Bona, K. S., Abdalla, F. H., Pimentel, V. C., Pigatto, A. S., \u0026amp; Moretto, M. B. (2009). Comparative evaluation of adenosine deaminase activity in cerebral cortex and hippocampus of young and adult rats: effect of garlic extract (Allium sativum L.) on their susceptibility to heavy metal exposure. \u003ci\u003eBasic \u0026amp; clinical pharmacology \u0026amp; toxicology\u003c\/i\u003e, \u003ci\u003e104\u003c\/i\u003e(5), 408-413.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-7843.2009.00390.x\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChung, R. T. M. (2017). Detoxification effects of phytonutrients against environmental toxicants and sharing of clinical experience on practical applications. \u003ci\u003eEnvironmental Science and Pollution Research\u003c\/i\u003e, \u003ci\u003e24\u003c\/i\u003e(10), 8946-8956.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs11356-015-5263-3\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHanafy, M. S., Shalaby, S. M., El-Fouly, M. A., Abd, M. E. A., \u0026amp; Soliman, F. A. (1994). Effect of garlic on lead contents in chicken tissues. \u003ci\u003eDTW. Deutsche tierarztliche Wochenschrift\u003c\/i\u003e, \u003ci\u003e101\u003c\/i\u003e(4), 157-158.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/europepmc.org\/abstract\/med\/8205968\"\u003eAbtract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEl-Sebaey, A. M., Abdelhamid, F. M., \u0026amp; Abdalla, O. A. (2019). Protective effects of garlic extract against hematological alterations, immunosuppression, hepatic oxidative stress, and renal damage induced by cyclophosphamide in rats. \u003ci\u003eEnvironmental Science and Pollution Research\u003c\/i\u003e, 1-14.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s11356-019-04993-7\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eIsaac Eliaz, M. D. (2013). MINDING Your MERCURY: Solutions to Mercury Toxicity. \u003ci\u003eAlternative Medicine\u003c\/i\u003e, (13), 44.\u003c\/p\u003e\n\u003cp\u003eKianoush, S., Balali‐Mood, M., Mousavi, S. R., Moradi, V., Sadeghi, M., Dadpour, B., ... \u0026amp; Shakeri, M. T. (2012). Comparison of Therapeutic Effects of Garlic and d‐Penicillamine in Patients with Chronic Occupational Lead Poisoning. \u003ci\u003eBasic \u0026amp; clinical pharmacology \u0026amp; toxicology\u003c\/i\u003e, \u003ci\u003e110\u003c\/i\u003e(5), 476-481.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-7843.2011.00841.x\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMelino, S., Sabelli, R., \u0026amp; Paci, M. (2011). Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy. \u003ci\u003eAmino acids\u003c\/i\u003e, \u003ci\u003e41\u003c\/i\u003e(1), 103-112.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/art.torvergata.it\/bitstream\/2108\/13110\/2\/paci.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMassadeh, A. M., Al-Safi, S. A., Momani, I. F., Alomary, A. A., Jaradat, Q. M., \u0026amp; AlKofahi, A. S. (2007). Garlic (Allium sativum L.) as a potential antidote for cadmium and lead intoxication: cadmium and lead distribution and analysis in different mice organs. \u003ci\u003eBiological trace element research\u003c\/i\u003e, \u003ci\u003e120\u003c\/i\u003e(1-3), 227-234.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Idrees_Al-Momani\/publication\/289528007_Garlic_Allium_sativum_L_as_a_Potential_Antdote_for_Cadmium_and_lead_intoxication_Cadmium_and_Lad_Distribution_and_Analysis_in_Different_Mice_Organs\/links\/5840821108ae2d21755f3755\/Garlic-Allium-sativum-L-as-a-Potential-Antdote-for-Cadmium-and-lead-intoxication-Cadmium-and-Lad-Distribution-and-Analysis-in-Different-Mice-Organs.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNepravishta, R., Sabelli, R., Iorio, E., Micheli, L., Paci, M., \u0026amp; Melino, S. (2012). Oxidative species and S‐glutathionyl conjugates in the apoptosis induction by allyl thiosulfate. \u003ci\u003eThe FEBS journal\u003c\/i\u003e, \u003ci\u003e279\u003c\/i\u003e(1), 154-167.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-4658.2011.08407.x\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePercival, M. (1997). Phytonutrients and detoxification. \u003ci\u003eClinical nutrition insights\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e(2), 1-4.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.acudoc.com\/phytonutrients%20and%20detoxification.PDF\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSenapati, S. K., Dey, S., Dwivedi, S. K., \u0026amp; Swarup, D. (2001). Effect of garlic (Allium sativum L.) extract on tissue lead level in rats. \u003ci\u003eJournal of Ethnopharmacology\u003c\/i\u003e, \u003ci\u003e76\u003c\/i\u003e(3), 229-232.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11448543\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSuru, S. M. (2008). Onion and garlic extracts lessen cadmium-induced nephrotoxicity in rats. \u003ci\u003eBiometals\u003c\/i\u003e, \u003ci\u003e21\u003c\/i\u003e(6), 623-633.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s10534-008-9148-5\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSusan, A., Rajendran, K., Sathyasivam, K., \u0026amp; Krishnan, U. M. (2019). An overview of plant-based interventions to ameliorate arsenic toxicity. \u003ci\u003eBiomedicine \u0026amp; Pharmacotherapy\u003c\/i\u003e, \u003ci\u003e109\u003c\/i\u003e, 838-852.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332218350571\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eSupport During Cancer Therapy\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAjami, M., \u0026amp; Vazirijavid, R. (2019). Garlic (Allium sativum L.). In \u003ci\u003eNonvitamin and Nonmineral Nutritional Supplements\u003c\/i\u003e (pp. 227-234). Academic Press.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128124918000333\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eArbach, M., Santana, T. M., Moxham, H., Tinson, R., Anwar, A., Groom, M., \u0026amp; Hamilton, C. J. (2019). Antimicrobial garlic-derived diallyl polysulfanes: Interactions with biological thiols in Bacillus subtilis. \u003ci\u003eBiochimica et Biophysica Acta (BBA)-General Subjects\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0304416519300625\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eArya, R., \u0026amp; Saldanha, S. N. (2019). Dietary Phytochemicals, Epigenetics, and Colon Cancer Chemoprevention. In \u003ci\u003eEpigenetics of Cancer Prevention\u003c\/i\u003e (pp. 205-229). Academic Press.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B978012812494900010X\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCao, H. X., Zhu, K. X., Fan, J. G., \u0026amp; Qiao, L. (2014). Garlic-derived allyl sulfides in cancer therapy. \u003ci\u003eAnti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents)\u003c\/i\u003e, \u003ci\u003e14\u003c\/i\u003e(6), 793-799.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24851880\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGioia, M. L. (2019). Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides. \u003ci\u003eMedChemComm\u003c\/i\u003e, \u003ci\u003e10\u003c\/i\u003e(1), 116-119.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6350762\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGruhlke, M. C., Antelmann, H., Bernhardt, J., Kloubert, V., Rink, L., \u0026amp; Slusarenko, A. J. (2019). The human allicin-proteome: S-thin and its biological effects. \u003ci\u003eFree Radical Biology and Medicine\u003c\/i\u003e, \u003ci\u003e131\u003c\/i\u003e, 144-153.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584918315375\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHashemi, S. A., Ghorbanoghli, S., Manouchehri, A. A., \u0026amp; Hatkehlouei, M. B. (2019). Pharmacological effect of Allium sativum on oagulation, blood pressure, diabetic nephropathy, neurological disorders, spermatogenesis, antibacterial effects.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.aimspress.com\/article\/10.3934\/agrfood.2019.2.386\/fulltext.html\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLau, B. H., Tadi, P. P., \u0026amp; Tosk, J. M. (1990). Allium sativum (garlic) and cancer prevention. \u003ci\u003eNutrition research\u003c\/i\u003e, \u003ci\u003e10\u003c\/i\u003e(8), 937-948.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Padma_Tadi_Uppala\/publication\/223827582_Allium_sativum_Garlic_and_cancer_prevention\/links\/5afba49a458515c00b6e564b\/Allium-sativum-Garlic-and-cancer-prevention.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMelino, S., Sabelli, R., \u0026amp; Paci, M. (2011). Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy. \u003ci\u003eAmino acids\u003c\/i\u003e, \u003ci\u003e41\u003c\/i\u003e(1), 103-112.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/art.torvergata.it\/bitstream\/2108\/13110\/2\/paci.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNepravishta, R., Sabelli, R., Iorio, E., Micheli, L., Paci, M., \u0026amp; Melino, S. (2012). Oxidative species and S‐glutathionyl conjugates in the apoptosis induction by allyl thiosulfate. \u003ci\u003eThe FEBS journal\u003c\/i\u003e, \u003ci\u003e279\u003c\/i\u003e(1), 154-167.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1742-4658.2011.08407.x\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRomagnolo, D. F., Davis, C. D., \u0026amp; Milner, J. A. (2012). Phytoalexins in cancer prevention. \u003ci\u003eFrontiers in bioscience (Landmark edition)\u003c\/i\u003e, \u003ci\u003e17\u003c\/i\u003e, 2035-2058.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/europepmc.org\/abstract\/med\/22652763\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShastri, A. A., \u0026amp; Spallholz, J. E. (2019). Catalytic Generation of Superoxide by Different Alcohols. \u003ci\u003eFree Radicals \u0026amp; Antioxidants\u003c\/i\u003e, \u003ci\u003e9\u003c\/i\u003e(1).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.antiox.org\/sites\/default\/files\/FreeRadAntiox-9-1-43.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSINGH, A., MASOODI, M., NABI, N., \u0026amp; ASHRAF, I. (2019). MEDICINAL PLANTS AS COMBATING STRATEGY AGAINST CANCER: A REVIEW. \u003ci\u003eCancer\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(04).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.ijsrr.co.in\/images\/full_pdf\/1555241885_SB5.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSingh, R., \u0026amp; Singh, K. (2019). Garlic: A spice with wide medicinal actions. \u003ci\u003eJournal of Pharmacognosy and Phytochemistry\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(1), 1349-1355.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Radha_Singh6\/publication\/330934709_Garlic_A_spice_with_wide_medicinal_actions\/links\/5c5c576292851c48a9c17046\/Garlic-A-spice-with-wide-medicinal-actions.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWaly, M. I., \u0026amp; Rahman, M. S. (2018). Garlic Preventive Effect on Cancer Development. In \u003ci\u003eBioactive Components, Diet and Medical Treatment in Cancer Prevention\u003c\/i\u003e (pp. 89-95). Springer, Cham.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-319-75693-6_6\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWu, D. D., Wang, D. Y., Li, H. M., Guo, J. C., Duan, S. F., \u0026amp; Ji, X. Y. (2019). Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease. \u003ci\u003eOxidative medicine and cellular longevity\u003c\/i\u003e, \u003ci\u003e2019\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/downloads.hindawi.com\/journals\/omcl\/2019\/3831713.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYi, L. V., Kwok-Fai, S. O., Nai-Kei, W. O. N. G., \u0026amp; Jia, X. I. A. O. (2019). Anti-cancer activities of S-allylmercaptocysteine from aged garlic. \u003ci\u003eChinese journal of natural medicines\u003c\/i\u003e, \u003ci\u003e17\u003c\/i\u003e(1), 43-49.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/europepmc.org\/abstract\/med\/30704623\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003eIngredients\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cspan\u003eOne Vegetarian Capsule Contains:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eGarlic Bulb 400mg Freeze-dried, organic \u003c\/span\u003e\u003cem\u003eAllium sativum L.\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eAlliin 11mg (Allicin potential 5mg) \u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eOther ingredients: cellulose \u0026amp; water (capsule shell)\u003c\/span\u003e\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003ch6\u003e\n\u003cspan\u003eProtocol\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eGARLIC, ORGANIC\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— The Garlic is designed to offer a potent antimicrobial support.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eAntimicrobial\u003c\/i\u003e: Garlic offers a broad-spectrum antimicrobial for GI pathogenic infections from bacteria to viruses to yeast\/mold and Protozoa (i.e., giardia, Cryptosporidium, amoebae, H. pylori, and more). Take 1-2 capsules once or twice a day. Each capsule has five garlic cloves.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eCold\/Flu\u003c\/i\u003e: Take 1-2 garlic capsules at the onset of a cold or flu, twice a day. For sore throat, open 1-2 capsule in a cup of water, mix and let it ‘react’ to create the antimicrobial allicin. Drink slowly. Add to the water 1 teaspoon of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eOriginal\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003efor added immune boosting nutrients.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eImmune support\u003c\/i\u003e: Take 1 capsule of garlic a day. Add 1 teaspoon of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eOriginal\u003c\/b\u003e, dissolve in mouth.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eHeart health\u003c\/i\u003e: take 1 capsule a day to boost heart health.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eDNA integrity\u003c\/i\u003e: Garlic is shown to support DNA integrity against carcinogens. Take also during cancer treatment to support cells and DNA integrity. *\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOur Favorite\u003c\/i\u003e: As a powerful antimicrobial, the Garlic is so useful. We find that one capsule added to our salad dressings, sprinkled on our veggies, and added to soups (after taken off the heat) helps keep our immune system happy.*\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712315293740,"sku":"TF007","price":46.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Garlic---Barcode.jpg?v=1723214816"},{"product_id":"fructo-borate-complex","title":"Fructo Borate Complex","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eThe Fructo Borate Complex is a new form of boron based on the organic mineral structure found in whole foods.\u003c\/p\u003e\n\u003cp\u003eExceptionally bio-available, Fructo Borate is highly effective for joint and bone health. This organic form of boron is able to cross the gastrointestinal barrier into the systemic circulation intact with its carbohydrate linkage.\u003c\/p\u003e\n\u003cp\u003eAs a master mineral, boron is responsible for the support of many metabolic pathways: the osteo-skeletal system, endocrine system, and immune system. Boron supplementation is important due to faulty farming practices that have depleted boron from the soil.\u003c\/p\u003e\n\u003cp\u003eThe Fructo Borate is Vegan, Kosher, Non GMO, and Gluten Free.\u003c\/p\u003e\n\u003ch6\u003eDescription \u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cspan\u003eNew form of boron supplementation that is the exact molecular structure of dietary boron found in fruits, vegetables and nuts. US Patent #US 5962049 A. Fructo Borate 240 mg with calcium ascorbate 260 mg provides 6 mg of elemental boron. No excipients. 60 capsules per bottle. 500 mg per vegetarian capsule.\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePatented Technology creates a highly effective Fructo Borate molecule.\u003c\/li\u003e\n\u003cli\u003e240mg fructoborate and 260mg calcium ascorbate per vegetarian capsule.\u003c\/li\u003e\n\u003cli\u003eEach capsule supplies 6mg of elemental boron.\u003c\/li\u003e\n\u003cli\u003eNew form of boron supplementation: US patented carbohydrate bound boron.\u003c\/li\u003e\n\u003cli\u003eExact duplicate of dietary boron found in fruits, vegetables and nuts.\u003c\/li\u003e\n\u003cli\u003eAssociation Constant high: Receptor sites receive entire molecule.\u003c\/li\u003e\n\u003cli\u003eOsteoporosis: Reduces excretion of Mg and Ca, re-mineralizes bone.\u003c\/li\u003e\n\u003cli\u003eUse therapeutically against osteoarthritis: Reduces pain and swelling and increases mobility.\u003c\/li\u003e\n\u003cli\u003eDown-regulates immune system: Reduces over-reactive neutrophil levels.\u003c\/li\u003e\n\u003cli\u003eAnti-oxidant: Increases SOD and Catalase production.\u003c\/li\u003e\n\u003cli\u003eAnti-aging: Increases Vitamin D and Steroid hormone levels in the blood.\u003c\/li\u003e\n\u003cli\u003eAnti-cancer: Reduces PSA marker for prostate cancer.\u003c\/li\u003e\n\u003cli\u003eClinical trial: 1 to 2 capsules BID to reduce pain and regenerate bone; 1 capsule daily for maintenance. Observed results period is from 2-8 weeks.\u003c\/li\u003e\n\u003cli\u003eNo filler, flowing agents or excipients of any kind.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch6\u003eResearch\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eFOOD SCIENCE: THE APPLICATION AND USE OF\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eFructo Borate\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e[plant-based Dietary boron].*\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eArthritis and Osteoporosis: Bone and Joint Health\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBaldivia, A. S. (2016). 10. Will boron be essential for human nutrition?. \u003ci\u003eArchivos Latinoamericanos de Nutrición\u003c\/i\u003e, \u003ci\u003e66\u003c\/i\u003e(1).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/alanjournal.com\/index.php\/path\/article\/download\/59\/61\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBartl, R., \u0026amp; Bartl, C. (2019). A Step-by-Step Programme for Healthy Bones. In \u003ci\u003eThe Osteoporosis Manual\u003c\/i\u003e (pp. 137-150). Springer, Cham.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s12011-018-1583-8\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBeattie, J. H., \u0026amp; Peace, H. S. (1993). The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. \u003ci\u003eBritish journal of nutrition\u003c\/i\u003e, \u003ci\u003e69\u003c\/i\u003e(3), 871-884.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/John_Beattie\/publication\/14870661_The_influence_of_a_low-boron_diet_and_boron_supplementation_on_bone_major_mineral_and_sex_steroid_metabolism_in_postmenopausal_women\/links\/0046352de89dceb343000000.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBoyacioglu, O., Orenay-Boyacioglu, S., Yildirim, H., \u0026amp; Korkmaz, M. (2018). Boron intake, osteocalcin polymorphism and serum level in postmenopausal osteoporosis. \u003ci\u003eJournal of Trace Elements in Medicine and Biology\u003c\/i\u003e, \u003ci\u003e48\u003c\/i\u003e, 52-56.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0946672X17308611\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBunker, V. W. (1994). The role of nutrition in osteoporosis. \u003ci\u003eBritish journal of biomedical science\u003c\/i\u003e, \u003ci\u003e51\u003c\/i\u003e(3), 228-240.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/europepmc.org\/abstract\/med\/7881322\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDevirian, T. A., \u0026amp; Volpe, S. L. (2003). The physiological effects of dietary boron.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/ec1f\/4e3a7bb5c292affd19a04b5d5edff6d78089.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGaby, A. R. (1999). Natural treatments for osteoarthritis. \u003ci\u003eAlternative Medicine Review\u003c\/i\u003e, \u003ci\u003e4\u003c\/i\u003e, 330-341.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.anaturalhealingcenter.com\/documents\/Thorne\/articles\/Osteoarthritis4-5.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGoldstein, M. C., \u0026amp; Goldstein, M. A. (2018). \u003ci\u003eVitamins and Minerals: Fact Versus Fiction\u003c\/i\u003e. ABC-CLIO.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=3yJWDwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PP1\u0026amp;dq=A+double-blind,+placebo-controlled+pilot+study+to+evaluate+the+effect+of+calcium+fructoborate+on+systemic+inflammation+and+dyslipidemia+markers+for+middle-aged+people+with+primary+osteoarthritis\u0026amp;ots=wx7dsIFUYU\u0026amp;sig=4cK7_tR1tzu3Osv2GUCZ3bUgHzA#v=onepage\u0026amp;q=%20calcium%20fructoborate%20\u0026amp;f=false\"\u003eBookP.4-5\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHelliwell, T. R., Kelly, S. A., Walsh, H. P. J., Klenerman, L., Haines, J., Clark, R., \u0026amp; Roberts, N. B. (1996). Elemental analysis of femoral bone from patients with fractured neck of femur or osteoarthrosis. \u003ci\u003eBone\u003c\/i\u003e, \u003ci\u003e18\u003c\/i\u003e(2), 151-157.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/8756328295004408\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHunter, J. M., Nemzer, B. V., Rangavajla, N., Biţă, A., Rogoveanu, O. C., Neamţu, J., ... \u0026amp; Mogoşanu, G. D. (2019). The Fructoborates: Part of a Family of Naturally Occurring Sugar–Borate Complexes—Biochemistry, Physiology, and Impact on Human Health: a Review. \u003ci\u003eBiological trace element research\u003c\/i\u003e, \u003ci\u003e188\u003c\/i\u003e(1), 11-25.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s12011-018-1550-4\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJain, R., \u0026amp; Tiwari, A. (2019). Boron: A dietary mineral for human health. \u003ci\u003eApollo Medicine\u003c\/i\u003e, \u003ci\u003e16\u003c\/i\u003e(1), 66.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.apollomedicine.org\/article.asp?issn=0976-0016;year=2019;volume=16;issue=1;spage=66;epage=67;aulast=Jain\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKhaliq, H., Juming, Z., \u0026amp; Ke-Mei, P. (2018). The physiological role of boron on health. \u003ci\u003eBiological trace element research\u003c\/i\u003e, \u003ci\u003e186\u003c\/i\u003e(1), 31-51.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Haseeb_Khaliq3\/publication\/323792821_The_Physiological_Role_of_Boron_on_Health\/links\/5b708af7299bf14c6d9ad27d\/The-Physiological-Role-of-Boron-on-Health.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLewiecki, E. M., Bilezikian, J. P., Carey, J. J., Dell, R. M., Gordon, C. M., Harris, S. T., ... \u0026amp; Rosenblatt, M. (2018). 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Calcium fructoborate: plant-based dietary boron as potential medicine for cancer therapy. \u003ci\u003eFront Biosci (Schol Ed)\u003c\/i\u003e, \u003ci\u003e3\u003c\/i\u003e, 205-215.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/4a1f\/4db22fdde6e2d0345b8f08ca879ca3cde2bb.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eScorei, R., Ciubar, R., Ciofrangeanu, C. M., Mitran, V., Cimpean, A., \u0026amp; Iordachescu, D. (2008). Comparative effects of boric acid and calcium fructoborate on breast cancer cells. \u003ci\u003eBiological trace element research\u003c\/i\u003e, \u003ci\u003e122\u003c\/i\u003e(3), 197-205.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s12011-007-8081-8\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSimsek, F., Inan, S., \u0026amp; Korkmaz, M. (2019). An in Vitro Study in Which New Boron Derivatives Maybe an Option for Breast Cancer Treatment. \u003ci\u003ebreast cancer\u003c\/i\u003e, \u003ci\u003e13\u003c\/i\u003e, 14.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ejmo.org\/pdf\/An%20in%20Vitro%20Study%20in%20Which%20New%20Boron%20Derivatives%20Maybe%20an%20Option%20for%20Breast%20Cancer%20Treatment-0020.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVijay Bhasker, T., Gowda, N. K. S., Krishnamoorthy, P., Pal, D. T., Sejian, V., Awachat, V. B., \u0026amp; Verma, A. K. (2017). Boron supplementation provides hepato-protective effect and improves performance in Wistar rats fed calcium deficit diet. \u003ci\u003eIndian J Anim Sci\u003c\/i\u003e, \u003ci\u003e87\u003c\/i\u003e(10), 1213-1218.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Veerasamy_Sejian\/publication\/320857136_Boron_supplementation_provides_hepato-protective_effect_and_improves_performance_in_Wistar_rats_fed_calcium_deficit_diet\/links\/5a156145a6fdccd697bc2207\/Boron-supplementation-provides-hepato-protective-effect-and-improves-performance-in-Wistar-rats-fed-calcium-deficit-diet.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eAnti-inflammatory \u0026amp; Longevity\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAcaroz, U., Ince, S., Arslan-Acaroz, D., Gurler, Z., Kucukkurt, I., Demirel, H. H., ... \u0026amp; Zhu, K. (2018). The ameliorative effects of boron against acrylamide-induced oxidative stress, inflammatory response, and metabolic changes in rats. \u003ci\u003eFood and chemical toxicology\u003c\/i\u003e, \u003ci\u003e118\u003c\/i\u003e, 745-752.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0278691518304034\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNielsen, F. H. (2018). Boron in Aging and Longevity. In \u003ci\u003eTrace Elements and Minerals in Health and Longevity\u003c\/i\u003e (pp. 163-177). Springer, Cham.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-030-03742-0_6\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eScorei, R. I., \u0026amp; Rotaru, P. (2011). Calcium fructoborate—potential anti-inflammatory agent. \u003ci\u003eBiological trace element research\u003c\/i\u003e, \u003ci\u003e143\u003c\/i\u003e(3), 1223-1238.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Petre_Rotaru\/publication\/49792303_Calcium_Fructoborate-Potential_Anti-inflammatory_Agent\/links\/09e4150ed51c0f0da9000000.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eScorei, R. I., Ciofrangeanu, C., Ion, R., Cimpean, A., Galateanu, B., Mitran, V., \u0026amp; Iordachescu, D. (2010). In vitro effects of calcium fructoborate upon poduction of inflammatory mediators by LPS-stimulated RAW 264.7 macrophages. \u003ci\u003eBiological trace element research\u003c\/i\u003e, \u003ci\u003e135\u003c\/i\u003e(1-3), 334-344.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Anisoara_Cimpean\/publication\/26731275_In_Vitro_Effects_of_Calcium_Fructoborate_upon_Production_of_Inflammatory_Mediators_by_LPS-stimulated_RAW_2647_Macrophages\/links\/54c8bd0c0cf289f0ced0c628.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eScorei, R., Ciubar, R., Iancu, C., Mitran, V., Cimpean, A., \u0026amp; Iordachescu, D. (2007). In vitro effects of calcium fructoborate on fMLP-stimulated human neutrophil granulocytes. \u003ci\u003eBiological trace element research\u003c\/i\u003e, \u003ci\u003e118\u003c\/i\u003e(1), 27-37.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Anisoara_Cimpean\/publication\/5991262_In_Vitro_Effects_of_Calcium_Fructoborate_on_fMLP-stimulated_Human_Neutrophil_Granulocytes\/links\/54c8bcb00cf289f0ced0c597.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eScorei, R., Cimpoiasu, V. M., \u0026amp; Iordachescu, D. (2005). In vitro evaluation of the antioxidant activity of calcium fructoborate. \u003ci\u003eBiological trace element research\u003c\/i\u003e, \u003ci\u003e107\u003c\/i\u003e(2), 127-134.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1385\/BTER:107:2:127\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eBoron and Polyphenols: Fructo Borate in No 7 Systemic Booster (or with High ORAC)\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eArjmandi, B. H., Johnson, C. D., Campbell, S. C., Hooshmand, S., Chai, S. C., \u0026amp; Akhter, M. P. (2010). Combining fructooligosaccharide and dried plum has the greatest effect on restoring bone mineral density among select functional foods and bioactive compounds. \u003ci\u003eJournal of medicinal food\u003c\/i\u003e, \u003ci\u003e13\u003c\/i\u003e(2), 312-319.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.liebertpub.com\/doi\/abs\/10.1089\/jmf.2009.0068\"\u003eAbstract\u003c\/a\u003e  [High ORAC]\u003c\/p\u003e\n\u003cp\u003eAustermann, K., Baecker, N., Stehle, P., \u0026amp; Heer, M. (2019). Putative Effects of Nutritive Polyphenols on Bone Metabolism In Vivo—Evidence from Human Studies. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e11\u003c\/i\u003e(4), 871.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/11\/4\/871\/pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBasu, S., Michaëlsson, K., Olofsson, H., Johansson, S., \u0026amp; Melhus, H. (2001). Association between oxidative stress and bone mineral density. \u003ci\u003eBiochemical and biophysical research communications\u003c\/i\u003e, \u003ci\u003e288\u003c\/i\u003e(1), 275-279.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X0195747X\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBrondani, J. E., Comim, F. V., Flores, L. M., Martini, L. A., \u0026amp; Premaor, M. O. (2019). Fruit and vegetable intake and bones: A systematic review and meta-analysis. \u003ci\u003ePloS one\u003c\/i\u003e, \u003ci\u003e14\u003c\/i\u003e(5), e0217223.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0217223\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDomazetovic, V., Marcucci, G., Pierucci, F., Bruno, G., Di Cesare Mannelli, L., Ghelardini, C., ... \u0026amp; Vincenzini, M. T. (2019). Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT 1. \u003ci\u003eFEBS open bio\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/2211-5463.12634\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGarrett, I. R., Boyce, B. F., Oreffo, R. O., Bonewald, L., Poser, J., \u0026amp; Mundy, G. R. (1990). Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. \u003ci\u003eThe Journal of clinical investigation\u003c\/i\u003e, \u003ci\u003e85\u003c\/i\u003e(3), 632-639.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.jci.org\/articles\/view\/114485\/files\/pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHardcastle, A. C., Aucott, L., Reid, D. M., \u0026amp; Macdonald, H. M. (2011). Associations between dietary flavonoid intakes and bone health in a Scottish population. \u003ci\u003eJournal of Bone and Mineral Research\u003c\/i\u003e, \u003ci\u003e26\u003c\/i\u003e(5), 941-947.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.285\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHubert, P., Lee, S., Lee, S. K., \u0026amp; Chun, O. (2014). Dietary polyphenols, berries, and age-related bone loss: A review based on human, animal, and cell studies. \u003ci\u003eAntioxidants\u003c\/i\u003e, \u003ci\u003e3\u003c\/i\u003e(1), 144-158.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2076-3921\/3\/1\/144\/pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKoch, W. (2019). Dietary Polyphenols—Important Non-Nutrients in the Prevention of Chronic Noncommunicable Diseases. A Systematic Review. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e11\u003c\/i\u003e(5), 1039.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/11\/5\/1039\/pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLobene, A. J., McCabe, L. D., Stone, M. S., Kindler, J. M., Bailey, R. L., Moshfegh, A. J., ... \u0026amp; Weaver, C. M. (2019). Dietary Mineral Intake Ratios and Bone Health in Adults. In \u003ci\u003eNutritional Influences on Bone Health\u003c\/i\u003e (pp. 53-67). Springer, Cham.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-319-98464-3_6\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNew, S. A., Robins, S. P., Campbell, M. K., Martin, J. C., Garton, M. J., Bolton-Smith, C., ... \u0026amp; Reid, D. M. (2000). Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?. \u003ci\u003eThe American journal of clinical nutrition\u003c\/i\u003e, \u003ci\u003e71\u003c\/i\u003e(1), 142-151.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/ajcn\/article\/71\/1\/142\/4729315\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWelch, A., MacGregor, A., Jennings, A., Fairweather‐Tait, S., Spector, T., \u0026amp; Cassidy, A. (2012). Habitual flavonoid intakes are positively associated with bone mineral density in women. \u003ci\u003eJournal of Bone and Mineral Research\u003c\/i\u003e, \u003ci\u003e27\u003c\/i\u003e(9), 1872-1878.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/efsa.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.1649\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWelch, A. A., \u0026amp; Hardcastle, A. C. (2014). The effects of flavonoids on bone. \u003ci\u003eCurrent osteoporosis reports\u003c\/i\u003e, \u003ci\u003e12\u003c\/i\u003e(2), 205-210.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s11914-014-0212-5\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWelch, A., MacGregor, A., Jennings, A., Fairweather‐Tait, S., Spector, T., \u0026amp; Cassidy, A. (2012). Habitual flavonoid intakes are positively associated with bone mineral density in women. \u003ci\u003eJournal of Bone and Mineral Research\u003c\/i\u003e, \u003ci\u003e27\u003c\/i\u003e(9), 1872-1878.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/efsa.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.1649\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWeitzmann, M. N. (2013). The role of inflammatory cytokines, the RANKL\/OPG axis, and the immunoskeletal interface in physiological bone turnover and osteoporosis. \u003ci\u003eScientifica\u003c\/i\u003e, \u003ci\u003e2013\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/downloads.hindawi.com\/journals\/scientifica\/2013\/125705.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYahia, E. M., García-Solís, P., \u0026amp; Celis, M. E. M. (2019). Contribution of Fruits and Vegetables to Human Nutrition and Health. In \u003ci\u003ePostharvest Physiology and Biochemistry of Fruits and Vegetables\u003c\/i\u003e (pp. 19-45). Woodhead Publishing.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128132784000026\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZhang, Z. Q., He, L. P., Liu, Y. H., Liu, J., Su, Y. X., \u0026amp; Chen, Y. M. (2014). Association between dietary intake of flavonoid and bone mineral density in middle aged and elderly Chinese women and men. \u003ci\u003eOsteoporosis International\u003c\/i\u003e, \u003ci\u003e25\u003c\/i\u003e(10), 2417-2425.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s00198-014-2763-9\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003eIngredients\u003c\/h6\u003e\n\u003cp\u003eOne capsule contains:\u003cbr\u003eVitamin C (from Calcium Ascorbate)  234mg    400%DV\u003cbr\u003eCalcium (from Calcium Ascorbate)  26mg     3%DV\u003cbr\u003eFructo Borate Complex (yields 6mg elemental Boron)  240mg \u003c\/p\u003e\n\u003cp\u003eOther Ingredients:  Cellulose \u0026amp;water (capsule shell).\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e \u003cmeta charset=\"utf-8\"\u003e\u003c\/p\u003e\n\u003ch6\u003eProtocol\u003c\/h6\u003e\n\u003cp\u003e\u003cstrong\u003eFRUCTO BORATE\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e— The Fructo Borate is designed to reduce osteoarthritis’ joint pain and swelling, and increase joint mobility.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAnti-inflammation and reduction of joint pain\u003c\/em\u003e: Clinical trials suggest 1-2 capsules twice a day.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eBone health\u003c\/em\u003e: Fructo Borate helps to re-mineralize and strengthen bones, increases absorption of vitamin D, calcium, and magnesium. Take 1-2 caps a day.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eHeart health\u003c\/em\u003e: Boron is shown to lower C-reactive proteins (marker for cardiovascular disease). Take 1-2 caps a day.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eLung \u0026amp; immune support\u003c\/em\u003e: Take 1-2 caps a day as anti-inflammatory for lung congestion (can take up to 6 a day for 2 days, reduce to 2-4 caps a day). Take 1-2 caps at the onset of a cold or flu.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eOur favorite\u003c\/em\u003e: The master mineral, boron, in the Fructo Borate is in command of so many functions in the body. We add it to many of our protocols to enhance healing. Since Frcuto Borate mimics the boron in foods, it is exceptionally available.*\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712315326508,"sku":"TF009","price":63.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Fructo-Borate---Front.jpg?v=1723214826"},{"product_id":"energy-ultra-minerals-with-apple-extract","title":"Energy","description":"\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eEnergy\u003c\/b\u003e is an intelligent healthy booster with a unique combination of plant-based Ultra Minerals and Apple Extracts.*\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eEnergy\u003c\/b\u003e increases our production of ATP, an important molecule that energizes and fuels every metabolic process in our body.* \u003c\/p\u003e\n\u003cp\u003eThe combination of Ultra Minerals and Apple Extracts deliver powerful polyphenols and a full spectrum of important plant-based elements and minerals, most of which are absent from foods and supplements currently on the market. One capsule a day for energy and endurance.*\u003c\/p\u003e\n\u003cp\u003eEnergy is plant-based (vegan) and has kosher, gluten free, organic, and Non-GMO ingredients.\u003c\/p\u003e\n\u003ch6\u003eDescription\u003c\/h6\u003e\n\u003cp\u003e\u003cb\u003eEnergy\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eis an intelligent healthy booster. With a unique combination of 72 plant-based Ultra Minerals and Apple Extracts,\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eEnergy\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eincreases our production of ATP, an important molecule that energizes and fuels every metabolic process in our body.*\u003c\/p\u003e\n\u003cp\u003eWhat is ATP? Adenosine-5’-triphosphate or ATP is known as a primary intracellular energy source in our body (Wilson et al., 2013). ATP and its metabolites are also involved in various important functions in the body, such as cardiac function, neurotransmission, blood flow, and muscle contraction and strength (Joy et al., 2015; Rathmacher et al., 2012; Jordan et al., 2004). In essence, having adequate ATP levels in the blood is correlated with improved health and performance (Herda et al., 2008). ATP is a vital molecule for good health, yet clinical results with\u003cspan\u003e \u003c\/span\u003e\u003ci\u003esynthetic ATP\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003esupplementation were mixed (Jordan et al., 2004).\u003c\/p\u003e\n\u003cp\u003eReyes-Izquirdo et al. (2013; 2014; Joy et al., 2016) set out to examine a food-based source that can indirectly increase endogenous ATP levels: they used a combination mix of apple extracts and plant ultra-minerals from Mesozoic Vegetate (see more below on Ultra Minerals). In both clinical trials, Reyes-Izquirdo et al. found a considerable increase in ATP levels and overall energy and strength in the body, compared with placebo (2013; 2014).*\u003c\/p\u003e\n\u003cp\u003eMoreover, the combination of ultra-minerals and apple extracts significantly boosted the body’s ability\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eto exercise longer and harder\u003c\/i\u003e. The trials utilized a 150mg dosage of the mix and showed blood ATP increased by 40% at 60 minutes following ingestion and dropped 28% at 120 minutes following ingestion. Muscle biopsy was also performed to show an 281% increase of ATP levels in muscle tissue at 60 minutes, and 433% at 120 minutes following ingestion (Reyes-Izquirdo et al., 2014). Even more promising, the natural food-based mix of apple extracts and ultra-minerals were shown to\u003cspan\u003e \u003c\/span\u003e\u003ci\u003edecrease\u003cspan\u003e \u003c\/span\u003e\u003c\/i\u003ereactive oxygen species (Reyes-Izquirdo et al., 2013). Typically, ATP production increases the levels of reactive oxygen species which is pro-inflammatory (Chang et al., 2010), but the plant-based mix of ultra minerals and apple extracts’ phenols serve as anti-inflammatory agents, reducing inflammation markers in the blood. This clinical finding is important as Energy can be used to enhance exercise and endurance performance and at the same time to reduce inflammation that is common when exercising, and more so when over-exercising (Joy et al., 2016; Swamy et al., 2011).*\u003c\/p\u003e\n\u003cp\u003eUltra-Minerals is a unique blend of 72 cold-water extracted plant-based minerals. Derived from deeply buried flora and plants dated back to the ancient Mesozoic Era, the ultra-minerals deliver\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ea full spectrum\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003eof important elements and trace minerals, most of which are absent from foods and supplements currently on the market.*\u003c\/p\u003e\n\u003cp\u003eMinerals and ultra (or trace) minerals are essential nutrients for human health (Davidson, 2017), playing a central role in regulating cardiovascular function (Mohammadifard et al., 2017), metabolic functions, internal antioxidant defense mechanism, bone formation, immune function, and much more (Pappas et al., 2018). The soil lacks many nutrients, in particular minerals and trace minerals, all due to ongoing poor farming methods, overuse of herbicides and pesticides, mono crops, inadequate fertilizers, and other shortsighted agricultural practices.*\u003c\/p\u003e\n\u003cp\u003eFinding rich sources of nutrients has become difficult as our oceans, lakes and rivers are also polluted. Rock sourced minerals can also present some toxicity issues as well as low absorption rates (Pappas et al., 2018). The ancient plant-based properties of our Ultra Minerals are unique: they are excavated from deep within the earth where lush plants belonging to tropical forests existed. These amazing deposits of Mesozoic Vegetate from nutrients-dense rain forests are full of nutrients that we extract with cold water and then dehydrated. The ultra-minerals are wholesome, readily available, and easily digested and absorbed.*\u003c\/p\u003e\n\u003cp\u003eApple and apple extracts are associated with numerous health benefits (Hyson, 2011), including longevity, cognition, and energy (Hodgson et al., 2016; Flanagan et al., 2016, respectively). As an energy booster, apple is found to be as energizing as coffee! In fact, apples offer equivalent energy as caffeinated drinks. More so, due to the different polyphenols in apples, athletes and sports players enjoy improved endurance during intense exercise while keeping their muscles flexible and pain free (Deley et al., 2017; Flanagan et al., 2016).*\u003c\/p\u003e\n\u003cp\u003eAntioxidants and polyphenols have shown in research to reduce oxidative stress created by exercise (Morillas-Ruiz et al., 2006). Over the years, clinical trials have focused on the ability of apples and apple extracts to reduce inflammation of joints and increase joint function for a greater range of motion (Jensen et al., 2014).*\u003c\/p\u003e\n\u003cp\u003eScientists view apple’s polyphenols as excellent anti-oxidants and anti-inflammatory properties in improving inflammatory bowel disease (Denis et al, 2016; Pastrelo et al., 2017). Moreover, apple is found to exhibit anti-microbial effect, reducing microbial growth in beef, pork, and turkey, and protecting against carcinogens during heat processing of beef (Jensen et al., 2016; Sabally et al., 2016). Apple’s many attributes are associated with beneficial effects on conditions from anti-carcinogenic (Tu et al., 2017), cardiovascular (Bondonno et al., 2017), to asthma (Sawyer et al., 2017), to cognition and of course, energy (Hyson, 2011).*\u003c\/p\u003e\n\u003cp\u003eTogether, the plant based Ultra Minerals and apple extracts offer an energy boost alongside a host of many health benefits. One capsule in the morning as a daily supplement, or one capsule before exercising to enhance strength and endurance.*\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBondonno, N. P., Bondonno, C. P., Ward, N. C., Hodgson, J. M., \u0026amp; Croft, K. D. (2017). The cardiovascular health benefits of apples: whole fruit vs. isolated compounds. \u003ci\u003eTrends in Food Science \u0026amp; Technology\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924224416305271\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChang, J. C., Kou, S. J., Lin, W. T., \u0026amp; Liu, C. S. (2010). Regulatory role of mitochondria in oxidative stress and atherosclerosis. \u003ci\u003eWorld journal of cardiology\u003c\/i\u003e, \u003ci\u003e2\u003c\/i\u003e(6), 150.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2999054\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDavison, K. M. (2017). Mineral Nutrients: From Macro-Level to Ultra Trace. In \u003ci\u003eNutrition Guide for Physicians and Related Healthcare Professionals\u003c\/i\u003e (pp. 261-272). Humana Press, Cham.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-319-49929-1_26\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDeley, G., Guillemet, D., Allaert, F. A., \u0026amp; Babault, N. (2017). An acute dose of specific grape and apple polyphenols improves endurance performance: a randomized, crossover, double-blind versus placebo controlled study. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e9\u003c\/i\u003e(8), 917.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/9\/8\/917\/htm\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDenis, M. C., Roy, D., Yeganeh, P. R., Desjardins, Y., Varin, T., Haddad, N., ... \u0026amp; Patey, N. (2016). Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease. \u003ci\u003eClinical Science\u003c\/i\u003e, CS20160524.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.clinsci.org\/content\/early\/2016\/09\/14\/CS20160524\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFlanagan, E. K., Jimenez, L. Q., Flanagan, C. P., Arwari, B., \u0026amp; Smith, W. N. (2016). Apple versus Caffeinated Beverages as Ergogenic Aids During Physical and Cognitive Performance: A Pilot Study. \u003ci\u003eMedicine \u0026amp; Science in Sports \u0026amp; Exercise\u003c\/i\u003e, \u003ci\u003e48\u003c\/i\u003e(5S), 63.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/journals.lww.com\/acsm-msse\/fulltext\/2016\/05001\/Apple_versus_Caffeinated_Beverages_as_Ergogenic.192.aspx\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHerda, T. J., Ryan, E. D., Stout, J. R., \u0026amp; Cramer, J. T. (2008). Effects of a supplement designed to increase ATP levels on muscle strength, power output, and endurance. \u003ci\u003eJournal of the International Society of Sports Nutrition\u003c\/i\u003e, \u003ci\u003e5\u003c\/i\u003e(1), 3.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1550-2783-5-3\"\u003ehttps:\/\/doi.org\/10.1186\/1550-2783-5-3\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHodgson, J. M., Prince, R. L., Woodman, R. J., Bondonno, C. P., Ivey, K. L., Bondonno, N., ... \u0026amp; Lewis, J. R. (2016). Apple intake is inversely associated with all-cause and disease-specific mortality in elderly women. \u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e, \u003ci\u003e115\u003c\/i\u003e(5), 860-867.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S0007114515005231\"\u003ehttps:\/\/doi.org\/10.1017\/S0007114515005231\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHyson, D. A. (2011). A comprehensive review of apples and apple components and their relationship to human health. \u003ci\u003eAdvances in nutrition\u003c\/i\u003e, \u003ci\u003e2\u003c\/i\u003e(5), 408-420.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/advances\/article\/2\/5\/408\/4557935\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJensen, G. S., Attridge, V. L., Bratton, D. V., Reed, R. L., \u0026amp; Stevens, J. F. (2016). Dried apple peel powder decreases microbial expansion during storage of beef, pork and turkey, and protects against carcinogen production during heat processing of ground beef. \u003ci\u003eJ. Anim. Feed Sci\u003c\/i\u003e, \u003ci\u003e25\u003c\/i\u003e(2), 167-173.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.jafs.com.pl\/Dried-apple-peel-powder-decreases-microbial-expansion-during-storage-of-beef-pork-and-turkey-and-protects-against-carcinogen-production-during-heat-processing-of-ground-beef,65577,0,2.html\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJensen, G. S., Attridge, V. L., Benson, K. F., Beaman, J. L., Carter, S. G., \u0026amp; Ager, D. (2014). Consumption of dried apple peel powder increases joint function and range of motion. \u003ci\u003eJournal of medicinal food\u003c\/i\u003e, \u003ci\u003e17\u003c\/i\u003e(11), 1204-1213.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.liebertpub.com\/doi\/abs\/10.1089\/jmf.2014.0037\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJordan, A. N., Jurca, R., Abraham, E. H., Salikhova, A., Mann, J. K., Morss, G. M., ... \u0026amp; Earnest, C. P. (2004). Effects of oral ATP supplementation on anaerobic power and muscular strength. \u003ci\u003eMedicine \u0026amp; Science in Sports \u0026amp; Exercise\u003c\/i\u003e, \u003ci\u003e36\u003c\/i\u003e(6), 983-990.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Conrad_Earnest\/publication\/8528047_Effects_of_Oral_ATP_Supplementation_on_Anaerobic_Power_and_Muscular_Strength\/links\/5a4a4580aca272d29462d1d5\/Effects-of-Oral-ATP-Supplementation-on-Anaerobic-Power-and-Muscular-Strength.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJoy, J. M., Vogel, R. M., Moon, J. R., Falcone, P. H., Mosman, M. M., Pietrzkowski, Z., … \u0026amp; Kim, M. P. (2016). Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men. \u003cem\u003eBMC complementary and alternative medicine\u003c\/em\u003e, \u003cem\u003e16\u003c\/em\u003e(1), 224.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4950767\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJoy, J. M., Falcone, P. H., Vogel, R. M., Mosman, M. M., Kim, M. P., \u0026amp; Moon, J. R. (2015). Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men. \u003cem\u003eApplied Physiology, Nutrition, and Metabolism\u003c\/em\u003e, \u003cem\u003e40\u003c\/em\u003e(11), 1171-1177.\u003c\/p\u003e\n\u003cp\u003eMohammadifard, N., Humphries, K. H., Gotay, C., Mena-Sánchez, G., Salas-Salvadó, J., Esmaillzadeh, A., ... \u0026amp; Sarrafzadegan, N. (2017). Trace minerals intake: risks and benefits for cardiovascular health. \u003ci\u003eCritical reviews in food science and nutrition\u003c\/i\u003e, 1-13.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/10408398.2017.1406332\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMorillas-Ruiz, J. M., García, J. V., López, F. J., Vidal-Guevara, M. L., \u0026amp; Zafrilla, P. (2006). Effects of polyphenolic antioxidants on exercise-induced oxidative stress. \u003ci\u003eClinical Nutrition\u003c\/i\u003e, \u003ci\u003e25\u003c\/i\u003e(3), 444-453.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0261561405002141\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePappas, A. C., Godlewska, K., \u0026amp; Surai, P. F. (2018). Dietary Food and Feed Supplements with Trace Elements. \u003ci\u003eRecent Advances in Trace Elements\u003c\/i\u003e, 421-441.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=AWxODwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PA421\u0026amp;dq=trace-minerals+and+human+health\u0026amp;ots=SSfRNUDo8R\u0026amp;sig=5dmZgNMWPcyNYtgNlsxb0EzOU0Y#v=onepage\u0026amp;q=trace-minerals%20and%20human%20health\u0026amp;f=false\"\u003eChapter20\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePastrelo, M. M., Ribeiro, C. C. D., Duarte, J. W., Gollücke, A. P. B., Artigiani-Neto, R., Ribeiro, D. A., ... \u0026amp; Paiotti, A. P. R. (2017). Effect of concentrated apple extract on experimental colitis induced by acetic acid. \u003ci\u003eInternational journal of molecular and cellular medicine\u003c\/i\u003e, \u003ci\u003e6\u003c\/i\u003e(1), 38.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5568191\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRathmacher, J. A., Fuller, J. C., Baier, S. M., Abumrad, N. N., Angus, H. F., \u0026amp; Sharp, R. L. (2012). Adenosine-5'-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets. \u003ci\u003eJournal of the International Society of Sports Nutrition\u003c\/i\u003e, \u003ci\u003e9\u003c\/i\u003e(1), 48.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1550-2783-9-48\"\u003ehttps:\/\/doi.org\/10.1186\/1550-2783-9-48\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eReyes-Izquierdo, T., Shu, C., Argumedo, R., Nemzer, B., \u0026amp; Pietrzkowski, Z. (2014). The effect of elevATP™ on whole blood ATP levels: a single dose, crossover clinical study. \u003ci\u003eJ Aging Res Clin Practice\u003c\/i\u003e, \u003ci\u003e3\u003c\/i\u003e, 56-60.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Tania_Reyes3\/publication\/260944047_The_effect_of_ElevATPon_whole_blood_ATP_levels_a_single_dose_cross_over_clinical_study\/links\/540741a80cf2c48563b29dc5.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eReyes-Izquierdo, T., Nemzer, B., Argumedo, R., Shu, C., Huynh, L., \u0026amp; Pietrzkowski, Z. (2013). Effect of the dietary supplement ElevATP on blood ATP level: An acute pilot clinical study. \u003cem\u003eJ Aging Res Clin Practice\u003c\/em\u003e, \u003cem\u003e2\u003c\/em\u003e, 178-84.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/d38d\/a55d69a6dc8a49309820a6506295c58a737d.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSabally, K., Sleno, L., Jauffrit, J. A., Iskandar, M. M., \u0026amp; Kubow, S. (2016). Inhibitory effects of apple peel polyphenol extract on the formation of heterocyclic amines in pan fried beef patties. \u003ci\u003eMeat science\u003c\/i\u003e, \u003ci\u003e117\u003c\/i\u003e, 57-62.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0309174016300572?via%3Dihub\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSawyer, G. M., Stevenson, D. E., McGhie, T. K., \u0026amp; Hurst, R. D. (2017). Suppression of CCL26 and CCL11 generation in human alveolar epithelial cells by apple extracts containing procyanidins. \u003ci\u003eJournal of Functional Foods\u003c\/i\u003e, \u003ci\u003e31\u003c\/i\u003e, 141-151.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1756464617300488\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTu, S. H., Chen, L. C., \u0026amp; Ho, Y. S. (2017). An apple a day to prevent cancer formation: Reducing cancer risk with flavonoids. \u003ci\u003eJournal of food and drug analysis\u003c\/i\u003e, \u003ci\u003e25\u003c\/i\u003e(1), 119-124.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1021949816301788\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSwamy, M. S., Sivanna, N., Tamatam, A., \u0026amp; Khanum, F. (2011). Effect of poly phenols in enhancing the swimming capacity of rats. \u003ci\u003eFunctional Foods in Health and disease\u003c\/i\u003e, \u003ci\u003e1\u003c\/i\u003e(11), 482-491.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/ffhdj.com\/index.php\/ffhd\/article\/view\/115\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWilson, J. M., Joy, J. M., Lowery, R. P., Roberts, M. D., Lockwood, C. M., Manninen, A. H., ... \u0026amp; Rathmacher, J. A. (2013). Effects of oral adenosine-5′-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men. \u003ci\u003eNutrition \u0026amp; metabolism\u003c\/i\u003e, \u003ci\u003e10\u003c\/i\u003e(1), 57.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/nutritionandmetabolism.biomedcentral.com\/articles\/10.1186\/1743-7075-10-57\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003eResearch \u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFOOD SCIENCE: THE APPLICATION AND USE OF ULTRA MINERALS AND APPLE EXTRACTS.*\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUltra Minerals \u0026amp; Apple Extracts: ATP Production for Energy and Strength\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFlanagan, E. K., Jimenez, L. Q., Flanagan, C. P., Arwari, B., \u0026amp; Smith, W. N. (2016). Apple versus Caffeinated Beverages as Ergogenic Aids During Physical and Cognitive Performance: A Pilot Study. \u003ci\u003eMedicine \u0026amp; Science in Sports \u0026amp; Exercise\u003c\/i\u003e, \u003ci\u003e48\u003c\/i\u003e(5S), 63.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/journals.lww.com\/acsm-msse\/fulltext\/2016\/05001\/Apple_versus_Caffeinated_Beverages_as_Ergogenic.192.aspx\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJoy, J. M., Vogel, R. M., Moon, J. R., Falcone, P. H., Mosman, M. M., Pietrzkowski, Z., … \u0026amp; Kim, M. P. (2016). Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men. \u003cem\u003eBMC complementary and alternative medicine\u003c\/em\u003e, \u003cem\u003e16\u003c\/em\u003e(1), 224.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-016-1222-x\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJoy, J. M., Falcone, P. H., Vogel, R. M., Mosman, M. M., Kim, M. P., \u0026amp; Moon, J. R. (2015). Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men. \u003cem\u003eApplied Physiology, Nutrition, and Metabolism\u003c\/em\u003e, \u003cem\u003e40\u003c\/em\u003e(11), 1171-1177.\u003c\/p\u003e\n\u003cp\u003eMorillas-Ruiz, J. M., García, J. V., López, F. J., Vidal-Guevara, M. L., \u0026amp; Zafrilla, P. (2006). Effects of polyphenolic antioxidants on exercise-induced oxidative stress. \u003ci\u003eClinical Nutrition\u003c\/i\u003e, \u003ci\u003e25\u003c\/i\u003e(3), 444-453.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0261561405002141\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePappas, A. C., Godlewska, K., \u0026amp; Surai, P. F. (2018). Dietary Food and Feed Supplements with Trace Elements. \u003ci\u003eRecent Advances in Trace Elements\u003c\/i\u003e, 421-441.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=AWxODwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PA421\u0026amp;dq=trace-minerals+and+human+health\u0026amp;ots=SSfRNUDo8R\u0026amp;sig=5dmZgNMWPcyNYtgNlsxb0EzOU0Y#v=onepage\u0026amp;q=trace-minerals%20and%20human%20health\u0026amp;f=false\"\u003eChapter20\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRathmacher, J. A., Fuller, J. C., Baier, S. M., Abumrad, N. N., Angus, H. F., \u0026amp; Sharp, R. L. (2012). Adenosine-5'-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets. \u003ci\u003eJournal of the International Society of Sports Nutrition\u003c\/i\u003e, \u003ci\u003e9\u003c\/i\u003e(1), 48.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1550-2783-9-48\"\u003ehttps:\/\/doi.org\/10.1186\/1550-2783-9-48\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eReyes-Izquierdo, T., Shu, C., Argumedo, R., Nemzer, B., \u0026amp; Pietrzkowski, Z. (2014). The effect of elevATP™ on whole blood ATP levels: a single dose, crossover clinical study. \u003ci\u003eJ Aging Res Clin Practice\u003c\/i\u003e, \u003ci\u003e3\u003c\/i\u003e, 56-60.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Tania_Reyes3\/publication\/260944047_The_effect_of_ElevATPon_whole_blood_ATP_levels_a_single_dose_cross_over_clinical_study\/links\/540741a80cf2c48563b29dc5.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eReyes-Izquierdo, T., Nemzer, B., Argumedo, R., Shu, C., Huynh, L., \u0026amp; Pietrzkowski, Z. (2013). Effect of the dietary supplement ElevATP on blood ATP level: An acute pilot clinical study. \u003cem\u003eJ Aging Res Clin Practice\u003c\/em\u003e, \u003cem\u003e2\u003c\/em\u003e, 178-84.\u003c\/p\u003e\n\u003cp\u003eSwamy, M. S., Sivanna, N., Tamatam, A., \u0026amp; Khanum, F. (2011). Effect of poly phenols in enhancing the swimming capacity of rats. \u003ci\u003eFunctional Foods in Health and disease\u003c\/i\u003e, \u003ci\u003e1\u003c\/i\u003e(11), 482-491.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/ffhdj.com\/index.php\/ffhd\/article\/view\/115\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eApple A Day\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBondonno, N. P., Bondonno, C. P., Ward, N. C., Hodgson, J. M., \u0026amp; Croft, K. D. (2017). The cardiovascular health benefits of apples: whole fruit vs. isolated compounds. \u003ci\u003eTrends in Food Science \u0026amp; Technology\u003c\/i\u003e.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924224416305271\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDeley, G., Guillemet, D., Allaert, F. A., \u0026amp; Babault, N. (2017). An acute dose of specific grape and apple polyphenols improves endurance performance: a randomized, crossover, double-blind versus placebo controlled study. \u003ci\u003eNutrients\u003c\/i\u003e, \u003ci\u003e9\u003c\/i\u003e(8), 917.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/9\/8\/917\/htm\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDenis, M. C., Roy, D., Yeganeh, P. R., Desjardins, Y., Varin, T., Haddad, N., ... \u0026amp; Patey, N. (2016). Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease. \u003ci\u003eClinical Science\u003c\/i\u003e, CS20160524.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.clinsci.org\/content\/early\/2016\/09\/14\/CS20160524\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHodgson, J. M., Prince, R. L., Woodman, R. J., Bondonno, C. P., Ivey, K. L., Bondonno, N., ... \u0026amp; Lewis, J. R. (2016). Apple intake is inversely associated with all-cause and disease-specific mortality in elderly women. \u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e, \u003ci\u003e115\u003c\/i\u003e(5), 860-867.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S0007114515005231\"\u003ehttps:\/\/doi.org\/10.1017\/S0007114515005231\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHyson, D. A. (2011). A comprehensive review of apples and apple components and their relationship to human health. \u003ci\u003eAdvances in nutrition\u003c\/i\u003e, \u003ci\u003e2\u003c\/i\u003e(5), 408-420.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/advances\/article\/2\/5\/408\/4557935\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePastrelo, M. M., Ribeiro, C. C. D., Duarte, J. W., Gollücke, A. P. B., Artigiani-Neto, R., Ribeiro, D. A., ... \u0026amp; Paiotti, A. P. R. (2017). Effect of concentrated apple extract on experimental colitis induced by acetic acid. \u003ci\u003eInternational journal of molecular and cellular medicine\u003c\/i\u003e, \u003ci\u003e6\u003c\/i\u003e(1), 38.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5568191\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSawyer, G. M., Stevenson, D. E., McGhie, T. K., \u0026amp; Hurst, R. D. (2017). Suppression of CCL26 and CCL11 generation in human alveolar epithelial cells by apple extracts containing procyanidins. \u003ci\u003eJournal of Functional Foods\u003c\/i\u003e, \u003ci\u003e31\u003c\/i\u003e, 141-151.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1756464617300488\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSwamy, M. S., Sivanna, N., Tamatam, A., \u0026amp; Khanum, F. (2011). Effect of poly phenols in enhancing the swimming capacity of rats. \u003ci\u003eFunctional Foods in Health and disease\u003c\/i\u003e, \u003ci\u003e1\u003c\/i\u003e(11), 482-491.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/ffhdj.com\/index.php\/ffhd\/article\/view\/115\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTu, S. H., Chen, L. C., \u0026amp; Ho, Y. S. (2017). An apple a day to prevent cancer formation: Reducing cancer risk with flavonoids. \u003ci\u003eJournal of food and drug analysis\u003c\/i\u003e, \u003ci\u003e25\u003c\/i\u003e(1), 119-124.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1021949816301788\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eMinerals, Ultra Minerals, Energy and Well-Being\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eGeissler, C., \u0026amp; Powers, H. J. (Eds.). (2017). \u003ci\u003eHuman nutrition\u003c\/i\u003e. Oxford University Press.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=YQapDgAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PP1\u0026amp;dq=minerals+in+human+nutrition\u0026amp;ots=yBjGHN2qi0\u0026amp;sig=Qdzl-37Z01uvWpwPFBRp5kg4R8E#v=onepage\u0026amp;q=minerals%20in%20human%20nutrition\u0026amp;f=false\"\u003eBookReview\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGharibzahedi, S. M. T., \u0026amp; Jafari, S. M. (2017). The importance of minerals in human nutrition: Bioavailability, food fortification, processing effects and nanoencapsulation. \u003ci\u003eTrends in Food Science \u0026amp; Technology\u003c\/i\u003e, \u003ci\u003e62\u003c\/i\u003e, 119-132.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924224416306203\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHuskisson, E., Maggini, S., \u0026amp; Ruf, M. (2007). The role of vitamins and minerals in energy metabolism and well-being. \u003ci\u003eJournal of international medical research\u003c\/i\u003e, \u003ci\u003e35\u003c\/i\u003e(3), 277-289.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/147323000703500301\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMann, J., \u0026amp; Truswell, S. (Eds.). (2017). \u003ci\u003eEssentials of human nutrition\u003c\/i\u003e. Oxford University Press.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=a6t0DgAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PP1\u0026amp;dq=minerals+in+human+nutrition\u0026amp;ots=cr3lB5BPvU\u0026amp;sig=TqRD10yAKeH-s6r0aonIF7az9Jo#v=onepage\u0026amp;q=minerals%20in%20human%20nutrition\u0026amp;f=false\"\u003eBookReview\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMohammad, S., Gharibzahedi, T., \u0026amp; Mahdi, S. (2017). Trends in Food Science \u0026amp; Technology The importance of minerals in human nutrition: Bioavailability, food fortification, processing effects and nanoencapsulation. \u003ci\u003eTrends in Food Science \u0026amp; Technology\u003c\/i\u003e, \u003ci\u003e62\u003c\/i\u003e, 119-132.\u003c\/p\u003e\n\u003cp\u003eSaltman, P. D., \u0026amp; Strause, L. G. (1993). The role of trace minerals in osteoporosis. \u003ci\u003eJournal of the American College of Nutrition\u003c\/i\u003e, \u003ci\u003e12\u003c\/i\u003e(4), 384-389.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/07315724.1993.10718327\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTuormaa, T. E. (2000). Chromium, selenium and copper and other trace minerals in health and reproduction. \u003ci\u003eJournal of orthomolecular medicine\u003c\/i\u003e, \u003ci\u003e15\u003c\/i\u003e(3), 145-156.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/7ae1\/9bf625034a5cb3624c87ccb4e7b8a3949446.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVan Soest, P. J. (2018). \u003ci\u003eNutritional ecology of the ruminant\u003c\/i\u003e. Cornell university press.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=TlluDwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PP1\u0026amp;dq=minerals+in+human+nutrition\u0026amp;ots=lnycDimWey\u0026amp;sig=jktGPfJLqJVTrC6wCKeTpzzxVxU#v=onepage\u0026amp;q=minerals%20\u0026amp;f=false\"\u003eChapter9\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003eIngredients \u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eEnergy: Plant Ultra Minerals with Apple Extract\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e72 Mesozoic Plant Trace Mineral                     150mg\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWith Apple Extract.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eA proprietary blend of Ultra Minerals derived from Mesozoic Vegetate (plant minerals from a tropical rainforest in the late dinosaur period), blended with Apple Extract.\u003c\/p\u003e\n\u003cp\u003eCapsule- Cellulose \u0026amp; Water\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch6\u003e\n\u003cspan\u003eProtocol\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eENERGY\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e(Ultra Minerals with Apple Extract)— Energy is designed with plant minerals and apple extract to increase energy levels and vitality in the body.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eEnergy\u003c\/i\u003e: Clinical trials show 1-2 capsules before exercise increases endurance strength and stamina. Take in the morning and if needed, repeat in the afternoon. For an energy boost, take 1 capsule of each\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eHigh ORAC\u003c\/b\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eFructo Borate\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ePhyto Power\u003c\/b\u003e.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eMinerals\u003c\/i\u003e: Energy is a great nutritional product filled with 72 plant-based ultra minerals that are no longer available in our soil and therefore missing in our foods.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOur Favorite\u003c\/i\u003e: Energy is one of Seann’s favorite products, along with the\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eFructo Borate\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eChromium\u003c\/b\u003e. He strongly advocates for more mineral supplementation due to our depleted soil. His morning routine includes all three products taken along with 1 capsule each of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eCranberry Pomegranate\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e(for prostate health),\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eBlueberry Extract\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e(brain),\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eGlucosinolates \u0026amp; Sulforaphanes\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003e(for DNA cellular integrity – protection), and 1 teaspoon of the\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eNo 7\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003emixed with water. He then goes for his early morning jog! *\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712315719724,"sku":"TF024","price":63.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Energy---Front.jpg?v=1723214835"},{"product_id":"cranberry-pomegranate-synbiotic-formula","title":"Cranberry Pomegranate Synbiotic","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eThe advanced Cranberry Pomegranate Synbiotic formula is a marvel for UTI care.*\u003c\/p\u003e\n\u003cp\u003eHigher potency concentrates of organic cranberries and extracts of pomegranates are combined with BioImmersion’s renowned Super Blend of naturally occurring whole probiotic organism, expertly grown to retain their Supernatant and ORNs (oligoribonucleotides). The advanced formula is a powerhouse of goodness for urinary tract infections, and an effective agent for bladder, prostate, and kidney health.*\u003c\/p\u003e\n\u003cp\u003eThe Super Blend in the Cranberry Pomegranate formula has 30 billion CFU per gram.\u003c\/p\u003e\n\u003cp\u003eThe formula is organic, vegan, Kosher, Non GMO, and Gluten free.\u003c\/p\u003e\n\u003ch6\u003eDescription\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eUrinary tract infection (UTI) is one of the most common bacterial infections (Foxman, 2014), often caused by Gram-negative bacteria, enterobacteriaceae (Bader, Loeb \u0026amp; Brooks, 2017), and more specifically within this large bacterial family, the familiar Escherichia coli (Jensen et al., 2017). In recent years, more women suffer from chronic UTIs due to the climbing rise of antibiotic resistant bacteria. As a natural alternative or a supportive adjunct treatment with antibiotics, the Cranberry Pomegranate Synbiotic Formula offers well-researched phyto nutrients, probiotics, prebiotics, and D- mannose. Studies and clinical trials find cranberries (Bader et al., 2017; Jensen et al., 2017; de Llano et al., 2015), Pomegranates (Pagliarulo et al., 2016; Heber, 2011; Duman et al., 2009), along with probiotics, prebiotics, and D- mannose (Spaulding et al., 2017; 2017a; Domenici et al., 2016), to offer effective management and support for UTI.*\u003c\/p\u003e\n\u003cp\u003eHistorically, cranberries and cranberry juice have long been used to alleviate urinary tract infections, with research linking the ability of cranberries’ proanthocyanidins (Krueger et al., 2013) to inhibit adhesion of E. coli bacteria (Neto, 2007). As early as 1933, research by Fellers et al. has shown cranberries to positively effect urinary health. Cowan’s (1999) seminal work on plant products as antimicrobial agents, which includes cranberries, has been cited in approximately 7,500 research articles. Studies on cranberries show not only an alternative to antibiotic but also as a daily supplement for a steady prevention of UTIs.*\u003c\/p\u003e\n\u003cp\u003eRecent studies continue to observe and explain cranberries’ excellent antimicrobial properties, especially the phenol elements and mechanism that are beneficial for the management and prevention of UTI (Jensen et al., 2017; Rodríguez-Pérez et al., 2017; Baranowska \u0026amp; Bartoszek, 2016; Sagdic et al, 2006; Lee, 2000). As stated above, proanthocyanidins in cranberries are found to prevent the adherence of Escherichia coli to uroepithelial cells in the urinary tract (Sun et al., 2015; Rowley, 2012; Burger et al., 2000), and disrupt hard to treat biofilm-mediated infections caused by Pseudomonas aeruginosa (Ulrey et al., 2014).*\u003c\/p\u003e\n\u003cp\u003eCranberries also pack other antimicrobial, antioxidant and anti-inflammatory benefits. With their powerful anti-adhesion properties, cranberries are found to inhibit growth of Helicobacter Pylori (Shmuely et al., 2007; Zhang et al., 2005; Burger et al., 2002), suppress tumor cell proliferation and offer support during cancer treatment (Bshayee et al., 2016; Kresty et al., 2015), as well as lower markers of cardio-metabolic risk (Novotny et al., 2015), and enhance the GI’s microbiota (Blumberg et al., 2016). Cranberries are shown to be effective agents for health.*\u003c\/p\u003e\n\u003cp\u003ePomegranate has enjoyed an exalted status since ancient times, and no wonder (Parseh et al., 2012). Studies show pomegranates contain 124 different phyto-nutrients with curative and preventative qualities. The pomegranate fruit is actually considered a berry, or more accurately, each pomegranate contains 600 seeds, each surrounded by fleshy white to dark red pulp (Rahimi et al., 2012).*\u003c\/p\u003e\n\u003cp\u003eWith their potent polyphenolic flavonoids, pomegranates show higher concentrations of antioxidants than green tea (Noda et al., 2002; Nori-Okamoto et al., 2004), cranberries, apples, grapes, or pears (Hmid et al., 2017; Heber, 2011; Heber et al., 2006). The pomegranate’s high concentration of polyphenols wields an inhibitory effect on pathogenic Staphylococcus aureus and Escherichia coli, serving as natural antimicrobial agents (Pagliarulo et al., 2016; Naz et al., 2007; Voravuthikunchai et al., 2005). Other microbial organisms are shown to be sensitive to the pomegranate phenolic flavonoids. Nascimento et al. (2000) tested extracts from a variety of plants in search of a natural support against antibiotic resistant microorganisms and found the pomegranate to be especially effective against Pseudomonas aeruginosa. Machado et al. (2002) identified antimicrobial ellagitannin of the pomegranate to be valuable to treat methicillin-resistant Staphylococcus aureus (MRSA) strains.*\u003c\/p\u003e\n\u003cp\u003eSimilarly, the pomegranate’s antioxidants work as scavengers and metal chelators (Kulkarni et al., 2007). The antioxidant, antimalarial, and antimicrobial activities of the tannin-rich fractions, ellagitannins and phenolic acids from pomegranates offer excellent daily dietary food supplement to enhance the immune system (Reddy et al., 2007).*\u003c\/p\u003e\n\u003cp\u003eProbiotics and Supernatant are important to the health of our urogenital system. The genus Lactobacillus has been studied for their promising preventative and\/or treatment potential against UTIs (de Llano et al., 2017). Three strains of lactobacillus were tested for their capabilities to inhibit pathogenic adherence of E. coli, E. faecalis, and Staphylococcus epidermidis to T24 epithelial bladder cells. L. salivarious, L. acidophilus showed a significantly inhibited the adherence of pathogens (de Llano et al., 2017; see also Shim et al., 2016). Lactobacillus species were also studies with infants experiencing acute pyelonephritis [kidney infection], and found effective in the prevention of urinary tract infections (Lee et al., 2016).*\u003c\/p\u003e\n\u003cp\u003eThe “anti-infective activities” of lactobacillus strains are exhibiting a great promise as innovative anti-infectious agents (Liévin-Le Moal et al., 2014), and especially for recurrent UTIs (Manzoor et al., 2016).*\u003c\/p\u003e\n\u003cp\u003eDepletion of vaginal Lactobacilli has also found in research to be linked with UTI risk, which suggests that repletion (re-colonization of Lactobacilli) might be beneficial (Syngai et al., 2016; Fontana et al., 2013; Maurya et al., 2014).*\u003c\/p\u003e\n\u003cp\u003eSupernatant is the fermented medium crated during the culturing process of probiotics. Supernatant is the fermented “soup” that contains important probiotic metabolites which is comprised of enzymes, peptides, proteins, vitamins, and other nutrients and factors, including antimicrobials such as bacitracins. Supernatant is shown in research to have powerful antimicrobial properties with the potential to block adhesion, invasion and translocation of E. coli, yet it is gentle enough to be used to ‘enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense’ (He et al., 2017). In fact, Lazar et al. (2009) in vitro study concluded that the soluble probiotic metabolites, or supernatant, might actually interfere with the beginning stages of adherence and colonization of selected E. coli. This means that the supernatant itself exudes protective effects (Lazar et al., 2009), as well as work synergistically with probiotics organism to stimulate the immune system against pathogenic invasion (Ditu et al., 2014).*\u003c\/p\u003e\n\u003cp\u003eD-mannose has long shown an ability to support acute UTIs, inhibiting bacterial adhesion to the urothelium (Domenici et al., 2016; Kranjčec et al., 2014). Testing more sensitive populations, such as people with multiple sclerosis (MS) who suffer from recurrent UTIs, showed that D-mannose effected a reduction in the number of UTIs as well as reduction for the need of antibiotics (Panicker et al., 2016).*\u003c\/p\u003e\n\u003cp\u003eSince 150 million people suffer from UTIs annually, using natural foods and nutriceutical agents to combat recurrence of UTI infections is advisable (Spaulding et al., 2017). The use of cranberries, pomegranates, probiotics, supernatant, and D-mannose form a potent synergistic effect that is shown in research to be very effective (Vicarotto, 2014).*\u003c\/p\u003e\n\u003cp\u003eThere are many more health functions that cranberries and pomegranates perform. For many years cranberries and pomegranates were studied to understand their anti-tumorigenic elements (e.g., Castonguay et al., 1997). More recent studies continue to reveal and explain the bioactivity of pomegranate (Panth et al., 2017; Bishayee et al., 2016; Faria \u0026amp; Calhau, 2011) and cranberries (Kresty et al., 2015; Hochman et al., 2008; Ferguson et al., 2006) as promising suppressants and inhibitors of different kinds of cancer cells (Weh et al., 2016; Liberty et al., 2009; Adams et al., 2006).*\u003c\/p\u003e\n\u003cp\u003eAnd there is more: Research studies find pomegranate and cranberries phenolics to contribute to heart health (Taheri et al., 2017; Novotny et al., 2015; Aviram et al., 2008, 2002), to balance the gut microbiota (Blumberg et al., 2016), and to offer liver support (Bishayee et al., 2013, 2011). Check the Research Tab for more in depth studies.*\u003c\/p\u003e\n\u003cp\u003eThe Cranberry Pomegranate Synbiotic Formula is an excellent choice for UTIs. Cranberries, Pomegranates, Probiotics, supernatant, and D-mannose have all shown in research to provide a potent effect against UTIs. The combination of these ingredients offers a promising natural supplement to prevent and maintain a healthy balance of the urogenital system. We suggest 2-4 capsules twice daily for UTI management, and 1-2 capsules daily for preventative support.*\u003c\/p\u003e\n\u003ch5\u003e\u003cstrong\u003eREFERENCES\u003c\/strong\u003e\u003c\/h5\u003e\n\u003cp\u003eBader, M. S., Loeb, M., \u0026amp; Brooks, A. A. (2017). An update on the management of urinary tract infections in the era of antimicrobial resistance. Postgraduate medicine, 129(2), 242-258. http:\/\/dx.doi.org\/10.1080\/00325481.2017.1246055\u003c\/p\u003e\n\u003cp\u003eBaranowska, M., \u0026amp; Bartoszek, A. (2016). Antioxidant and antimicrobial properties of bioactive phytochemicals from cranberry. Postepy higieny i medycyny doswiadczalnej (Online), 70, 1460-1468. DOI: 10.5604\/17322693.1227896\u003c\/p\u003e\n\u003cp\u003eBishayee, A., Mandal, A., Bhattacharyya, P., Bhatia, D. (2016). Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. Nutr Cancer, 68(1), 120-30. DOI: 10.1080\/01635581.2016.1115094\u003c\/p\u003e\n\u003cp\u003eBlumberg, J.B., Basu, A., Krueger, C.G., Lila, M.A., Neto, C.C., Novotny, JA… Toner, C.D. (2016). Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015. Adv Nutr, 7(4), 759S-70S. DOI:10.3945\/an.116.012583\u003c\/p\u003e\n\u003cp\u003eBurger, O., Weiss, E., Sharon, N., Tabak, M., Neeman, I., Ofek, I. (2002). Inhibition of Helicobacter pylori adhesion to human gastric mucus by a high-molecular-weight constituent of cranberry juice. Crit Rev Food Sci Nutr, 42(3), 279-84. DOI: 10.1080\/10408390209351916\u003c\/p\u003e\n\u003cp\u003eCowan, M. M. (1999). Plant products as antimicrobial agents. Clinical microbiology reviews, 12(4), 564-582. Abstract\u003c\/p\u003e\n\u003cp\u003ede Llano, D. G., Arroyo, A., Cárdenas, N., Rodríguez, J. M., Moreno-Arribas, M., \u0026amp; Bartolomé, B. (2017). Strain-specific inhibition of the adherence of uropathogenic bacteria to bladder cells by probiotic Lactobacillus spp. Pathogens and Disease, 75(4). DOI:10.1093\/femspd\/ftx043\u003c\/p\u003e\n\u003cp\u003ede Llano, D.G., Esteban-Fernández, A., Sánchez-Patán, F., Martínlvarez, P.J., Moreno-Arribas, M.V., Bartolomé, B. (2015). Anti-Adhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Escherichia coli in Bladder Epithelial Cell Cultures. Int J Mol Sci, 16(6), 12119-30. DOI:10.3390\/ijms160612119\u003c\/p\u003e\n\u003cp\u003eDitu, L.M., Chifiriuc, M.C., Bezirtzoglou, E., Marutescu, L., Bleotu, C., Pelinescu, D., Mihaescu, G., Lazar, V. (2014). Immunomodulatory effect of non-viable components of probiotic culture stimulated with heat-inactivated Escherichia coli and Bacillus cereus on holoxenic mice. Microb Ecol Health Dis, 25. DOI:10.3402\/mehd.v25.23239\u003c\/p\u003e\n\u003cp\u003eDomenici, L., Monti, M., Bracchi, C., Giorgini, M., Colagiovanni, V., Muzii, L., \u0026amp; Panici, P. B. (2016). D-mannose: a promising support for acute urinary tract infections in women. A pilot study. Eur Rev Med Pharmacol Sci, 20(13), 2920-5. Article\u003c\/p\u003e\n\u003cp\u003eErmel, G., Georgeault, S., Inisan, C., Besnard, M. (2012). Inhibition of adhesion of uropathogenic Escherichia coli bacteria to uroepithelial cells by extracts from cranberry. J Med Food, 15(2):126-34. DOI: 10.1089\/jmf.2010.0312\u003c\/p\u003e\n\u003cp\u003eFellers, C. R., Redmon, B. C., \u0026amp; Parrott, E. M. (1933). Effect of cranberries on urinary acidity and blood alkali reserve. Journal of Nutrition, 6, 455-463. Abstract\u003c\/p\u003e\n\u003cp\u003eFontana, L., Bermudez-Brito, M., Plaza-Diaz, J., Munoz-Quezada, S., \u0026amp; Gil, A. (2013). Sources, isolation, characterisation and evaluation of probiotics. British journal of nutrition, 109(S2), S35-S50. DOI:10.1017\/S0007114512004011\u003c\/p\u003e\n\u003cp\u003eFoxman B. (2014). Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden. Infect. Dis. Clin. North. Am. 28, 1–13. DOI:10.1016\/j.idc.2013.09.003\u003c\/p\u003e\n\u003cp\u003eHe, X., Zeng, Q., Puthiyakunnon, S., Zeng, Z., Yang, W., Qiu, J… Cao H...(2017). Lactobacillus rhamnosus GG [ATCC 53103] supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense. Sci Rep, 7, 43305. DOI: 10.1038\/srep43305\u003c\/p\u003e\n\u003cp\u003eHeber, D. (2011). Pomegranate Ellagitannins. In I.F.F., Benzie, \u0026amp; S. Wachtel-Galor (Eds.), Herbal medicine: Biomolecular and clinical aspects. 2nd edition. Boca Raton, FL: CRC Press\/Taylor \u0026amp; Francis. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92772\/\u003c\/p\u003e\n\u003cp\u003eHeber, D., Schulman, R. N., \u0026amp; Seeram, N. P. (Eds.). (2006). Pomegranates: ancient roots to modern medicine. CRC press. Summary\u003c\/p\u003e\n\u003cp\u003eHmid, I., Elothmani, D., Hanine, H., Oukabli, A., \u0026amp; Mehinagic, E. (2017). Comparative study of phenolic compounds and their antioxidant attributes of eighteen pomegranate (Punica granatum L.) cultivars grown in Morocco. Arabian Journal of Chemistry, 10, S2675-S2684. https:\/\/doi.org\/10.1016\/j.arabjc.2013.10.011\u003c\/p\u003e\n\u003cp\u003eHochman, N., Houri-Haddad, Y., Koblinski, J., Wahl, L., Roniger, M., Bar-Sinai, A. …Hochman, J. (2008). Cranberry juice constituents impair lymphoma growth and augment the generation of antilymphoma antibodies in syngeneic mice. Nutr Cancer, 60, 511–7. DOI:10.1080\/01635580801956493\u003c\/p\u003e\n\u003cp\u003eJensen, H.D., Carsten, S., Christensen, S.B., \u0026amp; Krogfelt, K.A. (2017). Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection. Front Microbiol, 8, 542. doi: 10.3389\/fmicb.2017.00542\u003c\/p\u003e\n\u003cp\u003eKresty, L.A., Weh, K.M., Zeyzus-Johns, B., Perez, L.N., Howell, A.B. (2015). Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K\/AKT\/mTOR inactivation. Oncotarget, 6, 33438–33455. DOI:10.18632\/oncotarget.5586\u003c\/p\u003e\n\u003cp\u003eKrueger, C. G., Reed, J. D., Feliciano, R. P., \u0026amp; Howell, A. B. (2013). Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health. Analytical and bioanalytical chemistry, 405(13), 4385-4395. DOI: 10.1007\/s00216-013-6750-3\u003c\/p\u003e\n\u003cp\u003eKulkarni, A. P., Mahal, H. S., Kapoor, S., \u0026amp; Aradhya, S. M. (2007). In vitro studies on the binding, antioxidant, and cytotoxic actions of punicalagin. Journal of agricultural and food chemistry, 55(4), 1491-1500. DOI:10.1021\/jf0626720\u003c\/p\u003e\n\u003cp\u003eLazar, V., Miyazaki, Y., Hanawa, T., Chifiriuc, M. C., Ditu, L. M., Marutescu, L., ... \u0026amp; Kamiya, S. (2009). The influence of some probiotic supernatants on the growth and virulence features expression of several selected enteroaggregative E. coli clinical strains. Roum Arch Microbiol Immunol, 68(4), 207-214. Abstract\u003c\/p\u003e\n\u003cp\u003eLee, S. J., Cha, J., \u0026amp; Lee, J. W. (2016). Probiotics prophylaxis in pyelonephritis infants with normal urinary tracts. World Journal of Pediatrics, 12(4), 425-429. DOI: 10.1007\/s12519-016-0013-2\u003c\/p\u003e\n\u003cp\u003eLee, Y. L., Owens, J., Thrupp, L., \u0026amp; Cesario, T. C. (2000). Does cranberry juice have antibacterial activity?. Jama, 283(13), 1691-1691.\u003c\/p\u003e\n\u003cp\u003eLiberty, A.M., Amoroso, J.W., Hart, P.E., Neto, C.C. (2009). Cranberry PACs and triterpenoids: anti-cancer activities in colon tumor cell lines. Proceedings of the Second International Symposium on Human Health Effects of Fruits and Vegetables. Acta Horticulturae, 841, 61–66. DOI: 10.17660\/ActaHortic.2009.841.4\u003c\/p\u003e\n\u003cp\u003eLiévin-Le Moal, V., \u0026amp; Servin, A. L. (2014). Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents. Clinical microbiology reviews, 27(2), 167-199. DOI: 10.1128\/CMR.00080-13\u003c\/p\u003e\n\u003cp\u003eMachado, T. D. B., Leal, I. C., Amaral, A. C. F., Santos, K., Silva, M. G. D., \u0026amp; Kuster, R. M. (2002). Antimicrobial ellagitannin of Punica granatum fruits. Journal of the Brazilian Chemical Society, 13(5), 606-610. Article\u003c\/p\u003e\n\u003cp\u003eManzoor, A., Ul-Haq, I., Baig, S., Qazi, J. I., \u0026amp; Seratlic, S. (2016). Efficacy of locally isolated lactic acid bacteria against antibiotic-resistant uropathogens. Jundishapur journal of microbiology, 9(1). DOI:10.5812\/jjm.18952\u003c\/p\u003e\n\u003cp\u003eMaurya, P., Mogra, R., \u0026amp; Bajpai, P. (2014). Probiotics: an approach towards health and disease. Trends in Biosciences, 7(20), 3107-3113. Abstract\u003c\/p\u003e\n\u003cp\u003eNoda, Y., Kaneyuki, T., Mori, A., Packer, L. (2002). Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin. J Agric Food Chem, 50(1), 166-71. DOI: 10.1021\/jf0108765\u003c\/p\u003e\n\u003cp\u003eMori-Okamoto J, Otawara-Hamamoto Y, Yamato H, Yoshimura H. (2004). Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice. J Ethnopharmacol, 92(1), 93-101. https:\/\/doi.org\/10.1016\/j.jep.2004.02.006\u003c\/p\u003e\n\u003cp\u003eNovotny, J. A., Baer, D. J., Khoo, C., Gebauer, S. K., \u0026amp; Charron, C. S. (2015). Cranberry juice consumption lowers markers of cardiometabolic risk, including blood pressure and circulating C-reactive protein, triglyceride, and glucose concentrations in adults. The Journal of nutrition, 145(6), 1185-1193. DOI:10.3945\/jn.114.203190\u003c\/p\u003e\n\u003cp\u003ePagliarulo, C., De Vito, V., Picariello, G., Colicchio, R., Pastore, G., Salvatore, P., \u0026amp; Volpe, M. G. (2016). Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food chemistry, 190, 824-831. DOI: 10.1016\/j.foodchem.2015.06.028\u003c\/p\u003e\n\u003cp\u003ePanth, N., Manandhar, B., Paudel, K.R. (2017). Anticancer Activity of Punica granatum (Pomegranate): A Review. Phytother Res, 31(4), 568-578. DOI:10.1002\/ptr.5784\u003c\/p\u003e\n\u003cp\u003eParseh, H., Hassanpour, S., Emam-Djome, Z., Lavasani, A. S., Mahmoodabady, H. Z., CHabok, M., ... \u0026amp; Ghahsareh, A. M. (2012, April). Antimicrobial properties of Pomegranate (Punica granatum L.) as a Tannin rich Fruit: a review. In The 1st International and The 4th National Congress on Recycling of Organic Waste in Agriculture. Iran.\u003c\/p\u003e\n\u003cp\u003eQuinlan, J. D., \u0026amp; Jorgensen, S. K. (2017). Recurrent UTIs in women: how you can refine your care. Journal of Family Practice, 66(2), 94-100. Article\u003c\/p\u003e\n\u003cp\u003eReddy, M. K., Gupta, S. K., Jacob, M. R., Khan, S. I., \u0026amp; Ferreira, D. (2007). Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum L. Planta medica, 53(05), 461-467. DOI: 10.1055\/s-2007-967167\u003c\/p\u003e\n\u003cp\u003eRodríguez-Pérez, C., Quirantes-Piné, R., Uberos, J., Jiménez-Sánchez, C., Peña, A., \u0026amp; Segura-Carretero, A. (2016). Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli. Food \u0026amp; function, 7(3), 1564-1573. DOI:10.1039\/c5fo01441g\u003c\/p\u003e\n\u003cp\u003eSagdic, O., Aksoy, A., \u0026amp; Ozkan, G. (2006). Evaluation of the antibacterial and antioxidant potentials of cranberry (gilaburu, Viburnum opulus L.) fruit extract. Acta Alimentaria, 35(4), 487-492. https:\/\/doi.org\/10.1556\/AAlim.35.2006.4.12\u003c\/p\u003e\n\u003cp\u003eShmuely, H., Burger, O., Neeman, I., Yahav, J., Samra, Z., Niv, Y…. Ofek, I. (2004). Susceptibility of Helicobacter pylori isolates to the antiadhesion activity of a high-molecular-weight constituent of cranberry. Diagn Microbiol Infect Dis, 50(4), 231-5. DOI:10.1016\/j.diagmicrobio.2004.08.011\u003c\/p\u003e\n\u003cp\u003eSpaulding, C. N., Klein, R. D., Ruer, S., Kau, A. L., Schreiber, H. L., Cusumano, Z. T., ... \u0026amp; Remaut, H. (2017). Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist. Nature, 546(7659), 528-532. DOI:10.1038\/nature22972\u003c\/p\u003e\n\u003cp\u003eSpaulding, C. N., Kau, A. L., Klein, R. D., Janetka, J. W., Gordon, J. I., \u0026amp; Hultgren, S. J. (2017a). Small-molecule inhibitors against type 1 pili selectively target uropathogenic E. coli in the gut and bladder. The FASEB Journal, 31(1 Supplement), 939-9. Abstract\u003c\/p\u003e\n\u003cp\u003eSun, J., Marais, J. P., Khoo, C., LaPlante, K., Vejborg, R. M., Givskov, M., ... \u0026amp; Rowley, D. C. (2015). Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli. Journal of functional foods, 17, 235-242. DOI:10.1016\/j.jff.2015.05.016\u003c\/p\u003e\n\u003cp\u003eSyngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., \u0026amp; Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of food science and technology, 53(2), 921-933. DOI: 10.1007\/s13197-015-2011-0\u003c\/p\u003e\n\u003cp\u003eVicariotto, F. (2014). Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study. Journal of clinical gastroenterology, 48, S96-S101. DOI:10.1097\/MCG.0000000000000224\u003c\/p\u003e\n\u003cp\u003eVoravuthikunchai, S. P., Sririrak, T., Limsuwan, S., Supawita, T., Iida, T., \u0026amp; Honda, T. (2005). Inhibitory effects of active compounds from Punica granatum pericarp on verocytotoxin production by enterohemorrhagic Escherichia coli O157: H7. Journal of health science, 51(5), 590-596. DOI:10.1016\/j.foodchem.2015.06.028\u003c\/p\u003e\n\u003ch6\u003eResearch\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003ch4\u003eFOOD SCIENCE: THE APPLICATION AND USE OF CRANBERRY, POMEGRANATE, PROBIOTICS (BULGARIAN ORIGIN), SUPERNATANT, D-MANNOSE, AND CHICORY SOLUBLE FIBER.*\u003c\/h4\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eHistorical and Clinical Reviews of Cranberries and Pomegranate\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHeber, D. (2011). Pomegranate Ellagitannins. In I.F.F., Benzie, \u0026amp; S. Wachtel-Galor (Eds.), Herbal medicine: Biomolecular and clinical aspects. 2\u003csup\u003end\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eedition. Boca Raton, FL: CRC Press\/Taylor \u0026amp; Francis.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92772\/\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92772\/\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNeto, C.C., \u0026amp; Vinson, J.A. (2011). Cranberry. In I.F.F., Benzie, \u0026amp; S. Wachtel-Galor (Eds.),\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eHerbal medicine: Biomolecular and clinical aspects\u003c\/em\u003e. 2\u003csup\u003end\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eedition. Boca Raton, FL: CRC Press\/Taylor \u0026amp; Francis.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92771\/\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92771\/\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eUsta, C., Ozdemir, S., Schiariti, M., \u0026amp; Puddu, P. E. (2013). The pharmacological use of ellagic acid-rich pomegranate fruit.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eInternational journal of food sciences and nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e64\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(7), 907-913. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3109\/09637486.2013.798268\"\u003e10.3109\/09637486.2013.798268\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eCranberries\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e:\u003cem\u003e\u003cspan\u003e \u003c\/span\u003eUTI Support and Management\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAvorn, J., Monane, M., Gurwitz. J.H., Glynn. R.J., Choodnovskiy, I., Lipsitz, L.A. (1994). Reduction ofbacteriuria and pyuria after ingestion of cranberry juice.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Am Med Assoc,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e271\u003c\/em\u003e, 751–4.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/jamanetwork.com\/journals\/jama\/article-abstract\/366888\"\u003edoi:10.1001\/jama.1995.03510340041031\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBailey, D.T., Dalton, C., Daugherty, F.J., \u0026amp; Tempesta, M.S. (2007). Can a concentrated cranberry extract prevent recurrent urinary tract infections in women? A pilot study.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePhytomed\u003c\/em\u003e, 14, 237–41. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.phymed.2007.01.004\"\u003e10.1016\/j.phymed.2007.01.004\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBader, M. S., Loeb, M., \u0026amp; Brooks, A. A. (2017). 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A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCan J Urol,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e9\u003c\/em\u003e, 1558–62.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12121581\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSun, J., Marais, J.P.J., Khoo, C., LaPlante, K., Vejborg, R.M., Givskov, M., Tolker-Nielsen, T.,Seeram, N.P., Rowley, D.C. (2015). Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ. Funct. 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Inhibitory activity of cranberry extract on the bacterial adhesiveness in the urine of women: an ex-vivo study.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eInt J Immunopathol Pharmacol, 23\u003c\/em\u003e(2), 611-8. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1177\/039463201002300223\"\u003e10.1177\/039463201002300223\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eUlrey, R.K., Barksdale, S.M., Zhou, W., van Hoek, M.L. (2014). Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBMC Complement Altern Med, 14\u003c\/em\u003e, 499. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1472-6882-14-499\"\u003e10.1186\/1472-6882-14-499\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVasileiou, I., Katsargyris, A., Theocharis, S., \u0026amp; Giaginis, C. (2013). Current clinical status on the preventive effects of cranberry consumption against urinary tract infections. Nutr Res, 33(8), 595-607. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.nutres.2013.05.018\"\u003e10.1016\/j.nutres.2013.05.018\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWang, C. H., Fang, C. C., Chen, N. C., Liu, S. S., Yu, P. H … Chen, S.C. (2012). Cranberry-containing products for prevention of urinary tract infections in susceptible populations: a systematic review and meta-analysis of randomized controlled trials. Arch. Intern. Med, 172, 988–996. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1001\/archinternmed.2012.3004\"\u003e10.1001\/archinternmed.2012.3004\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWing, D.A., Rumney, P.J., Preslicka, C.W., \u0026amp; Chung, J.H. (2008). 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Inhibitory activity of cranberry juice on adherence of type 1 and type P-fimbriated Escherichia coli to eucaryotic cells.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAntimicrob Agents Chemother\u003c\/em\u003e, 33, 92–8.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC171427\/\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003ePomegranate: Antimicrobial Effect\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eAl-Zoreky, N. S. (2009). 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Antimicrobial effect of the Tunisian Nana variety Punica granatum L. extracts against Salmonella enterica (serovars Kentucky and Enteritidis) isolated from chicken meat and phenolic composition of its peel extract.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eInternational journal of food microbiology\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e241\u003c\/em\u003e, 123-131. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.ijfoodmicro.2016.10.007\"\u003e10.1016\/j.ijfoodmicro.2016.10.007\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eProbiotics and Supernatant: UTI Support and Management\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003ede Llano, D. G., Arroyo, A., Cárdenas, N., Rodríguez, J. M., Moreno-Arribas, M., \u0026amp; Bartolomé, B. (2017). Strain-specific inhibition of the adherence of uropathogenic bacteria to bladder cells by probiotic Lactobacillus spp.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePathogens and Disease\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e75\u003c\/em\u003e(4). DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1093\/femspd\/ftx043\"\u003e10.1093\/femspd\/ftx043\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDitu, L.M., Chifiriuc, M.C., Bezirtzoglou, E., Marutescu, L., Bleotu, C., Pelinescu, D., Mihaescu, G., Lazar, V. (2014). Immunomodulatory effect of non-viable components of probiotic culture stimulated with heat-inactivated Escherichia coli and Bacillus cereus on holoxenic mice.\u003cem\u003eMicrob Ecol Health Dis, 25.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3402\/mehd.v25.23239\"\u003e10.3402\/mehd.v25.23239\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFontana, L., Bermudez-Brito, M., Plaza-Diaz, J., Munoz-Quezada, S., \u0026amp; Gil, A. (2013). Sources, isolation, characterisation and evaluation of probiotics.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBritish journal of nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e109\u003c\/em\u003e(S2), S35-S50. 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The influence of some probiotic supernatants on the growth and virulence features expression of several selected enteroaggregative E. coli clinical strains.\u003cem\u003eRoum Arch Microbiol Immunol\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e68\u003c\/em\u003e(4), 207-214.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20583474\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLee, S. J., Cha, J., \u0026amp; Lee, J. W. (2016). Probiotics prophylaxis in pyelonephritis infants with normal urinary tracts.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eWorld Journal of Pediatrics\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e12\u003c\/em\u003e(4), 425-429. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s12519-016-0013-2\"\u003e10.1007\/s12519-016-0013-2\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLiévin-Le Moal, V., \u0026amp; Servin, A. L. (2014). Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eClinical microbiology reviews\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e27\u003c\/em\u003e(2), 167-199. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1128%2FCMR.00080-13\"\u003e10.1128\/CMR.00080-13\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eManzoor, A., Ul-Haq, I., Baig, S., Qazi, J. I., \u0026amp; Seratlic, S. (2016). Efficacy of locally isolated lactic acid bacteria against antibiotic-resistant uropathogens.\u003cem\u003eJundishapur journal of microbiology\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e9\u003c\/em\u003e(1). 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D-mannose: a promising support for acute urinary tract infections in women. A pilot study.\u003cem\u003eEur Rev Med Pharmacol Sci\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e20\u003c\/em\u003e(13), 2920-5.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.europeanreview.org\/article\/11121\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKranjčec, B., Papeš, D., Altarac, S.(2014). D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eWorld J Urol, 32\u003c\/em\u003e(1), 79-84.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s00345-013-1091-6\"\u003e10.1007\/s00345-013-1091-6\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePalleschi, G., Carbone, A., Zanello, P. P., Mele, R., Leto, A., Fuschi, A., ... \u0026amp; Maurizi, A. (2017). Prospective study to compare antibiosis versus the association of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract in preventing urinary tract infections in patients submitted to urodynamic investigation.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eArchivio Italiano di Urologia e Andrologia\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e89\u003c\/em\u003e(1), 45-50. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.4081\/aiua.2017.1.45\"\u003e10.4081\/aiua.2017.1.45\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePanicker, J., Phé, V., Pakzad, M., Haslam, C., Gonzales, G., Curtis, C., ... \u0026amp; Chataway, J. (2016). D-MANNOSE TO PREVENT URINARY TRACT INFECTIONS IN MULTIPLE SCLEROSIS.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.1136\/jnnp-2016-315106.151\"\u003ehttp:\/\/dx.doi.org\/10.1136\/jnnp-2016-315106.151\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSpaulding, C. N., Klein, R. D., Ruer, S., Kau, A. L., Schreiber, H. L., Cusumano, Z. T., ... \u0026amp; Remaut, H. (2017). Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNature\u003c\/em\u003e, 546(7659), 528-532. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1038\/nature22972\"\u003e10.1038\/nature22972\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSpaulding, C. N., Kau, A. L., Klein, R. D., Janetka, J. W., Gordon, J. I., \u0026amp; Hultgren, S. J. (2017a). Small-molecule inhibitors against type 1 pili selectively target uropathogenic E. coli in the gut and bladder.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe FASEB Journal\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e31\u003c\/em\u003e(1 Supplement), 939-9.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.fasebj.org\/content\/31\/1_Supplement\/939.9.short\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVicariotto, F. (2014). Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of clinical gastroenterology\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e48\u003c\/em\u003e, S96-S101. 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A high molecular mass constituent of cranberry juice inhibits\u003cem\u003eHelicobacter pylori\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eadhesion to human gastric mucus.\u003cem\u003eFEMS Immunol Med Microbiol,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e29\u003c\/em\u003e, 295–301.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11118911\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMatsushima, M., Suzuki, T., Masui, A., (Edss). (2008). Growth inhibitory action of cranberry on\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eHelicobacter pylori\u003c\/em\u003e.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Gastroenterol Hepatol\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e2\u003c\/em\u003e, S175–80. 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Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K\/AKT\/mTOR inactivation.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eOncotarget\u003c\/em\u003e\u003cem\u003e,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e6\u003c\/em\u003e, 33438–33455. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.18632\/oncotarget.5586\"\u003e10.18632\/oncotarget.5586\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKresty, L.A., Clarke, J., Ezell, K., Exum, A., Howell, A.B., Guettouche, T. (2011). MicroRNA alterations in Barrett's esophagus, esophageal adenocarcinoma, and esophageal adenocarcinoma cell lines following cranberry extract treatment: Insights for chemoprevention.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ. Carcinog\u003c\/em\u003e\u003cem\u003e,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e10\u003c\/em\u003e, 34. 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Food Chem\u003c\/em\u003e\u003cem\u003e,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e50\u003c\/em\u003e, 5844–5849.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf0202234\"\u003eDOI:10.1021\/jf0202234\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003ePomegranate and Cranberries: Prostate Cancer Support\u003c\/em\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBonetta, A., \u0026amp; Di Pierro, F. (2012). Enteric-coated, highly standardized cranberry extract reduces risk of UTIs and urinary symptoms during radiotherapy for prostate carcinoma. \u003cem\u003eCancer Manag Res, 4\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e, 281-6. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.2147\/CMAR.S35342\"\u003e10.2147\/CMAR.S35342\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDeziel, B., MacPhee, J., Patel, K. Catalli, A., Kulka, M., Neto, C., … Hurta, R. (2012). American cranberry (Vaccinium macrocarpon) extract affects human prostate cancer cell growth via cell cycle arrest by modulating expression of cell cycle regulators. Food Funct, 3(5), 556-64. DOI:\u003ca href=\"https:\/\/doi.org\/10.1039\/c2fo10145a\"\u003e10.1039\/c2fo10145a\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHong, M.Y., Seeram, N.P., \u0026amp; Heber, D. (2008). Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Nutr Biochem\u003c\/em\u003e, 19(12), 848-55. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jnutbio.2007.11.006\"\u003e10.1016\/j.jnutbio.2007.11.006\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKoyama, S., Cobb, L.J., Mehta, H.H., Seeram, N.P., Heber, D., Pantuck, A.J., \u0026amp; Cohen, P. (2010). Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eGrowth Horm IGF Res\u003c\/em\u003e, 20(1), 55-62. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.ghir.2009.09.003\"\u003e10.1016\/j.ghir.2009.09.003\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMalik, A., Afaq, F., Sarfaraz, S., Adhami, V.M., Syed, D.N., Mukhtar, H. (2005). Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNatl Acad Sci USA,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e102\u003c\/em\u003e, 14813–8. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1073\/pnas.0505870102\"\u003e10.1073\/pnas.0505870102\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePantuck, A.J., Leppert, J.T., Zomorodian, N., Aronson, W., Hong, J., Barnard, R.J., … Belldegrun, A. (2006). Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eClin Cancer Res\u003c\/em\u003e, 12(13), 4018-26. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1158\/1078-0432.CCR-05-2290\"\u003e10.1158\/1078-0432.CCR-05-2290\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRetting, M.B., Heber, D., An, J. Seeram, N.P., Rao, J.Y., Rao, J.Y., Liu, H., … Pantuck, A. (2008). Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMol Cancer ther, 7\u003c\/em\u003e(9), 2662-71. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1158\/1535-7163.MCT-08-0136\"\u003e10.1158\/1535-7163.MCT-08-0136\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSeeram, N.P., Aronson, W.J., Zhang, Y., Henning, S.M., Moro, A., Lee, R.P., … Heber, D. (2007). Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland.\u003cem\u003eJ Agric Food Chem\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e55\u003c\/em\u003e(19), 7732-7. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf071303g\"\u003e10.1021\/jf071303g\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSeeram, N.P., Henning, S.M., Zhang, Y., Suchard, M., Li, Z., \u0026amp; Heber, D. (2006). Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours.\u003cem\u003eJ Agric Food Chem\u003c\/em\u003e, 136(10), 2481-5.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/jn.nutrition.org\/content\/136\/10\/2481.long\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSeeram, N.P., Adams, L.S., Hardy, M.L., \u0026amp; Heber, D. (2004). Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines.\u003cem\u003eJ Agric Food Chem, 52\u003c\/em\u003e(9), 2512-7. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf0352778\"\u003e10.1021\/jf0352778\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eCranberries \u0026amp; Pomegranate: Heart Health, Gut Microbiota, Liver Support\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eAviram, M., Volkova, N., Coleman, R., Dreher, M., Reddy, M.K., Ferreira D., Rosenblat, M. (2008). Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein e-deficient (E 0) mice and in vitro in cultured macrophages and lipoproteins. J Agric Food Chem, 56(3),1148-57. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf071811q\"\u003e10.1021\/jf071811q\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAviram, M., Dornfeld, L., Kaplan, M., Coleman, R., Gaitini, D., Nitecki, S…. Fuhrman, B. (2002). Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans. Drugs Exp Clin Res, 28(2-3), 49-62.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12224378\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAviram, M., Dornfeld, L., Rosenblat, M., Volkova, N., Kaplan, M., Coleman, R., Hayek, T., Presser, D., \u0026amp; Fuhrman, B. (2000). Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: Studies in humans and in atherosclerotic apolipoprotein E-deficient mice.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAm J Clin Nutr,\u003c\/em\u003e\u003cem\u003e71\u003c\/em\u003e, 1062–1076.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/ajcn.nutrition.org\/content\/71\/5\/1062.long\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBlumberg, J.B., Basu, A., Krueger, C.G., Lila, M.A., Neto, C.C., Novotny, JA… Toner, C.D. (2016). Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015. Adv Nutr, 7(4), 759S-70S. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/an.116.012583\"\u003e10.3945\/an.116.012583\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBishayee, A., Thoppil, R.J., Darvesh, A.S., Ohanyan, V., Meszaros, J.G., Bhatia, D. (2013). Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis. J.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr. Biochem\u003c\/em\u003e\u003cem\u003e,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e24\u003c\/em\u003e, 178–187. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jnutbio.2012.04.009\"\u003e10.1016\/j.jnutbio.2012.04.009\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBishayee, A., Bhatia, D., Thoppil, R.J., Darvesh, A.S., Nevo, E. \u0026amp; Lansky, E.P. (2011). Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms.\u003cem\u003eCarcinogenesis, 32\u003c\/em\u003e(6), 688-96. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1093\/carcin\/bgr045\"\u003e10.1093\/carcin\/bgr045\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChu, Y.F., \u0026amp; Liu, R.H. (2005). Cranberries inhibit LDL oxidation and induce LDL receptor expression in hepatocytes.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eLife Sci,\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e77\u003c\/em\u003e, 1892–1901. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.lfs.2005.04.002\"\u003e10.1016\/j.lfs.2005.04.002\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGil, M.I., Tomàs-Barberàn, F.A., Hess-Pierce, B., Holcroft, D.M., Kader, A.A. (2000). Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e48\u003c\/em\u003e, 4581–9.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11052704\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKaplan, M., Hayek, T., Raz, A., Coleman, R., Dornfeld, L., Vaya, J., \u0026amp; Aviram, M. (2001). Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis.\u003cem\u003eThe Journal of nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e131\u003c\/em\u003e(8), 2082-2089.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/jn.nutrition.org\/content\/131\/8\/2082.short\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNovotny, J. A., Baer, D. J., Khoo, C., Gebauer, S. K., \u0026amp; Charron, C. S. (2015). Cranberry juice consumption lowers markers of cardiometabolic risk, including blood pressure and circulating C-reactive protein, triglyceride, and glucose concentrations in adults.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe Journal of nutrition\u003c\/em\u003e,\u003cem\u003e145\u003c\/em\u003e(6), 1185-1193. 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The effect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers, and the histopathology of pancreatic islets of Langerhans in streptozotocin-nicotinamide induced type 2 diabetic Sprague-Dawley rats.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBMC Complement Altern Med, 17\u003c\/em\u003e(1):156. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/s12906-017-1667-6\"\u003e10.1186\/s12906-017-1667-6\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVinson, J.A., Bose, P., Proch, J. AI Kharrant, H., \u0026amp; Samman, N. (2008). Cranberries and cranberry products: powerful in vitro, ex vivo, and in vivo sources of antioxidants.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem, 56\u003c\/em\u003e(14), 5884-91. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf073309b\"\u003e10.1021\/jf073309b\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDuthie, S. J., Jenkinson, A. M., Crozier, A., Mullen, W., Pirie, L., Kyle, J., ... \u0026amp; Duthie, G. G. (2006). The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEuropean journal of nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e45\u003c\/em\u003e(2), 113-122. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s00394-005-0572-9\"\u003e10.1007\/s00394-005-0572-9\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003ePomegranate: Neuro-regeneration and Cognitive Support\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eBraidy, N., Essa, M. M., Poljak, A., Selvaraju, S., Al-Adawi, S., Manivasagm, T., ... \u0026amp; Guillemin, G. J. (2016). Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer's disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eOncotarget\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e7\u003c\/em\u003e(40), 64589. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.18632%2Foncotarget.10905\"\u003e10.18632\/oncotarget.10905\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBraidy, N., Selvaraju, S., Essa, M.M., Vishnav, R., Al-Adawi, S., Al-Senawi, H., … Guillemin, G.J. (2013). Neuroprotective effects of a variety of pomegranate juice extracts against MPTP-induced cytotoxicity and oxidative stress in human primary neurons.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eOxid Med Cell Longev\u003c\/em\u003e. DOI:\u003ca href=\"https:\/\/doi.org\/10.1155\/2013\/685909\"\u003e10.1155\/2013\/685909\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEssa, M.M., Subash, S., Akbar, M., Al-Adawi, S., \u0026amp; Guillemin, G.J. (2015). Long-term dietary supplementation of pomegranates, figs and dates alleviate neuroinflammation in a transgenic mouse model of Alzheimer's disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePLoS One, 10\u003c\/em\u003e(3). DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1371\/journal.pone.0120964\"\u003e10.1371\/journal.pone.0120964\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSubash, S., Braidy, N., Essa, M.M., Al-Buraiki, Z., Vaishnav, R., Al-Adawi, S., Al-Asmi, A., Guillemin, G.J. (2014). Long Term (15 Months) Dietary Supplementation with Pomegranates from Oman Attenuates Cognitive and Behavioural Deficts in a Transgenic Mice Model of Alzheimer's Disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrition, 31\u003c\/em\u003e223-9.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.nut.2014.06.004\"\u003e10.1016\/j.nut.2014.06.004\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYan, T., Ma, H., Liu, W., Niesen, D.B., Shah, N., Crews, R., … Seeram, N.P. (2016). Pomegranate's Neuroprotective Effects against Alzheimer's Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eACS Chem Neurosci\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e7\u003c\/em\u003e(1), 26-33. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/acschemneuro.5b00260\"\u003e10.1021\/acschemneuro.5b00260\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eThe Bioavailability of Cranberry and Pomegranate\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eCarlsen, M.H., Halvorsen, B.L., Holte, K., Bohn, S.K., Dragland, S., Sampson, L., … Blomhoff, R. (2010). The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J, 9,3. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1186%2F1475-2891-9-3\"\u003e10.1186\/1475-2891-9-3\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDuthie, G.G., Kyle, J.A., Jenkinson, A.M., Duthie, S.J., Baxter, G.J., Paterson, J.R. (2005). Increased salicylate concentrations in urine of human volunteers after consumption of cranberry juice.\u003cem\u003eJ Agric Food Chem,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e53\u003c\/em\u003e, 2897–9000. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf040393b\"\u003e10.1021\/jf040393b\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGrace, M.H., Massey, A.R., Mbeunkui. F., Yousef, G.G., \u0026amp; Lila, M.A. (2012). Comparison of health-relevant flavonoids in commonly consumed cranberry products.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Food Sci, 77\u003c\/em\u003e(8), H176-83. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1111\/j.1750-3841.2012.02788.x\"\u003e10.1111\/j.1750-3841.2012.02788.x\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLila, M.A., Burton-Freeman, B., Grace, M., \u0026amp; Kalt, W. (2016). Unraveling Anthocyanin Bioavailability for Human Health.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAnnu Rev Food Sci Technol,7\u003c\/em\u003e, 375-93. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1146\/annurev-food-041715-033346\"\u003e10.1146\/annurev-food-041715-033346\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eOhnishi R, Ito H, Kasajima N, editors. (2006). Urinary excretion of anthocyanins in humans after cranberry juice ingestion.\u003cem\u003eBiosci Biotechnol Biochem,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e70\u003c\/em\u003e, 1681–7. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1271\/bbb.60023\"\u003e10.1271\/bbb.60023\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSandhu, A.K., Huang, Y., Xiao, D., Par, E., Edirisinghe, I., \u0026amp; Burton-Freeman, B. (2016). Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem, 64\u003c\/em\u003e(24), 4891-9. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/acs.jafc.6b00805\"\u003e10.1021\/acs.jafc.6b00805\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSeeram, N. P., Zhang, Y., McKeever, R., Henning, S. M., Lee, R. P., Suchard, M. A., ... \u0026amp; Nguyen, M. (2008). Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of medicinal food\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e11\u003c\/em\u003e(2), 390-394. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1089\/jmf.2007.650\"\u003e10.1089\/jmf.2007.650\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZhang, K., Zuo, Y. (2004). GC-MS Determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice. J Agric Food Chem, 52:222–7. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf035073r\"\u003e10.1021\/jf035073r\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003eIngredients\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eCranberry Pomegranate Synbiotic: UTI Support\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eA Proprietary blend of:                                        500mg\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePhytonutrients-\u003cspan\u003e \u003c\/span\u003e\u003c\/b\u003eOrganic Cranberry 6%, Pomegranate Extract with 40% Punicalagins, D-Mannose.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBioImmersion Probiotic Master Blend\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e–\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eProbiotics\u003c\/b\u003e-\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eBifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus and streptococcus thermophilus\u003c\/i\u003e;\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ePrebiotic\u003c\/b\u003e- Inulin from chicory Root;\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eSupernatant\u003c\/b\u003e- probiotic metabolites, and\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eORNs\u003c\/b\u003e. 30 billion CFU.\u003c\/p\u003e\n\u003cp\u003eCapsule- Cellulose \u0026amp; Water\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003ch6\u003e\n\u003cspan\u003eProtocol\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eCRANBERRY POMEGRANATE\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— The Cranberry Pomegranate is designed to care for the bladder, kidneys, and prostate. *\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eUTI (urinary tract infection) support\u003c\/i\u003e: Take 2-4 capsules every 3 hours till the bladder relaxes and urine flow improves, then reduce to 2 caps X 3 daily for several days. For maintenance, take 1-2 a day. Add\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eGarlic\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eas an antimicrobial agent, 1-2 capsules, and\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eOriginal\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003efor added probiotics and fiber.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eProstate support\u003c\/i\u003e: Take 1-2 a day.  If it is difficult to urinate, take 2-4 every 3 hours till inflammation subsides and urine flows. Add 1 capsule of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ePhyto Power, Fructo Borate\u003c\/b\u003e, and 1 teaspoon of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eNo 7\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eto reduce swelling, and along with 1 capsule of\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eGlucosamine \u0026amp; Sulforaphanes\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e(broccoli cruciferous sprouts) to support DNA cellular integrity.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eBloating and\u003cspan\u003e \u003c\/span\u003e\u003c\/i\u003eswelling: Excellent to help the kidneys and bladder flush. Take 2 capsules with extra water till swelling or bloating subsides (every 3 hours).*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOur favorite\u003c\/i\u003e: The Cran\/Pom is Dr. Dohrea Bardell’s third favorite product (yes, she has a list:\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eBlueberry Extract\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eand\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eNo 7\u003c\/b\u003e, respectively). During travel or stressful times, the microbiome (GI Tract), along with the bladder and prostate, can easily become unbalanced (bloating, swelling, aching). The Cranberry Pomegranate is an exceptionally potent anti-inflammatory for the whole GI Tract, bladder, prostate, and even helps that achy low back pain. Take up to 4-6 when very uncomfortable, and drink plenty of water. *\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712315818028,"sku":"TF019","price":67.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Cranberry-Pomegranate-Synbiotic---Front.jpg?v=1723214846"},{"product_id":"chromium-bio-organic-with-beet","title":"Chromium, with Beet","description":"\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eNew Chromium with High Active Red Beet Root is 9 time stronger, with 50mcg of elemental trivalent chromium (whole molecule is 500mcg). The ligand on each of the new trivalent chromium is a molecule of nicotinic acid – Niacin.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eChromium is well represented in scientific literature with findings on cardiovascular health, including blood sugar metabolism and weight loss support (Hua et al., 2012; Wright \u0026amp; Hunter, 2014; Kim, 2018; Nair, 2019).*\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eHigh Active beet root offers a standardized 10,000ppm plant nitrate, which the body converts to nitric oxides (McDonagh et al., 2018). Beets promote nitric oxide bioavailability, which is shown in research to relax blood vessel muscles and open up circulation. Beets are reputed to be heart healthy, enhancing phase II liver enzyme (our body detoxification pathway), weight loss, and energizing the body with more oxygen (Hobbs et al., 2012; Beals et al., 2017; Krajka-Kuźniak et al., 2013; Clifford et al., 2015).\u003c\/p\u003e\n\u003ch6\u003eDescription \u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eA potent form of trivalent chromium presented in a food-derived organic carrier of Niacin. Each capsule provides 500 micrograms of trivalent chromium polynicotinate (50mcg of elemental chromium) and 250 mg of High Active red beet root with a standardized 10,000ppm plant nitrate, which the body converts to nitric oxides (McDonagh et al., 2018).\u003c\/p\u003e\n\u003cp\u003ePatented Technology creates a potent new form of trivalent Chromium (US patent) presented in a food-derived organic carrier.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSuperior activity to other forms of Chromium: safe, stable, and water-soluble.\u003c\/li\u003e\n\u003cli\u003eGlucose metabolism: Chromium with High Active Beet Root improves insulin efficiency by decreasing insulin resistance, increase glucose uptake in the absence of insulin, lowers glycosolated hemoglobin levels, reduce both fasting and postprandial hyperglycemia (Abdollahi et al., 2013; Abraham et al., 1992; Aghdassi et al., 2010; Anderson, 1998; Balk et al., 2007; Cefalu \u0026amp; Hu, 2004; 2013; Maret, 2019).\u003c\/li\u003e\n\u003cli\u003eCardiovascular health: Chromium with High Active Beet Root improve metabolic syndrome, moderate hypertension and hypercholesterolemia, prevent lipid peroxidation, and support insulin sensitivity (Balk et al., 2007; Boyd, 2013; Hobbs et al., 2013; 2012; Jajja et al., 2014; Orhan et al., 2019; Panchal et al., 2017),\u003c\/li\u003e\n\u003cli\u003eAntioxidant, anti-carcinogenic, and anti-inflammatory activity (Nifali (2017).  \u003c\/li\u003e\n\u003cli\u003eWeight management, Energy, and Stamina: Chromium with High Active Beet Root stimulates muscle growth, improves sports performance, aids in loss of body fat while helping maintain lean muscle mass, increase energy production and ability to exercise longer (Beals et al., 2017; Nifali, 2017; Crawford et al., 1999; Onakpoya et al., 2013.\u003c\/li\u003e\n\u003cli\u003eBeetroot protects against toxicity in liver, and initiates phase II enzyme detox (Krajka-Kuźniak et al., 2013; 2012; Lee et al., 2005)\u003c\/li\u003e\n\u003cli\u003eBeet also contain betalains, which research shows reduce isoprostanes by 30% in humans. Betalains neutralize highly oxidative hypochlorous acid generated in bloodstream, betalains are bioavailable and 3-4 times more potent antioxidants than Vitamin C, betalains induce phase 2 proteins (P2P function as internal defense system again toxins and free radicals).\u003c\/li\u003e\n\u003cli\u003eAdvanced drying technology. No excipients, fillers, or flowing agents. 60 capsules per bottle. 500 mg per vegetarian capsule. Vegan, Gluten Free, Kosher.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch6\u003eResearch \u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFOOD SCIENCE: THE APPLICATION AND USE OF trivalent Chromium with Niacin as ligans, and Red Beet Root.*\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eMetabolic Syndrome: Insulin Sensitivity \u0026amp; Cardiovascular Health\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eAbdollahi, M., Farshchi, A., Nikfar, S., \u0026amp; Seyedifar, M. (2013). Effect of chromium on glucose and lipid profiles in patients with type 2 diabetes; a meta-analysis review of randomized trials. \u003ci\u003eJournal of Pharmacy \u0026amp; Pharmaceutical Sciences\u003c\/i\u003e, \u003ci\u003e16\u003c\/i\u003e(1), 99-114.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/journals.library.ualberta.ca\/jpps\/index.php\/JPPS\/article\/download\/18858\/15149\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAbraham, A. S., Brooks, B. A., \u0026amp; Eylath, U. (1992). The effects of chromium supplementation on serum glucose and lipids in patients with and without non-insulin-dependent diabetes. \u003ci\u003eMetabolism\u003c\/i\u003e, \u003ci\u003e41\u003c\/i\u003e(7), 768-771.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/0026049592903185\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAghdassi, E., Arendt, B. M., Salit, I. E., Mohammed, S. S., Jalali, P., Bondar, H., \u0026amp; Allard, J. P. (2010). In patients with HIV-infection, chromium supplementation improves insulin resistance and other metabolic abnormalities: a randomized, double-blind, placebo controlled trial. \u003ci\u003eCurrent HIV Research\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(2), 113-120.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20163347\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAgustini, R., \u0026amp; Sanjaya, I. G. M. (2018, July). Determination of chromium content in various foodstuffs. In \u003ci\u003eProceedings\u003c\/i\u003e (Vol. 1, No. 1, pp. 474-479).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/ojs.pnb.ac.id\/index.php\/Proceedings\/article\/download\/929\/745\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAnderson, R. A. (1998). Chromium, glucose intolerance and diabetes. \u003ci\u003eJournal of the American College of Nutrition\u003c\/i\u003e, \u003ci\u003e17\u003c\/i\u003e(6), 548-555.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9853533\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAnderson, R. A., Cheng, N., Bryden, N. A., Polansky, M. M., Cheng, N., Chi, J., \u0026amp; Feng, J. (1997). Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. \u003ci\u003eDiabetes\u003c\/i\u003e, \u003ci\u003e46\u003c\/i\u003e(11), 1786-1791.\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed?Db=pubmed\u0026amp;Cmd=ShowDetailView\u0026amp;TermToSearch=9356027\u0026amp;ordinalpos=3\u0026amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBalk, E. M., Tatsioni, A., Lichtenstein, A. H., Lau, J., \u0026amp; Pittas, A. G. (2007). Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. \u003ci\u003eDiabetes care\u003c\/i\u003e, \u003ci\u003e30\u003c\/i\u003e(8), 2154-2163.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/care.diabetesjournals.org\/content\/diacare\/30\/8\/2154.full.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBoyd, M. (2013). The role of supplemental chromium on glucose intolerance and insulin resistance. \u003ci\u003eTopics in Clinical Nutrition\u003c\/i\u003e, \u003ci\u003e28\u003c\/i\u003e(2), 171-180.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/journals.lww.com\/topicsinclinicalnutrition\/Abstract\/2013\/04000\/The_Role_of_Supplemental_Chromium_on_Glucose.8.aspx\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCefalu, W. T., \u0026amp; Hu, F. B. (2013). Role of chromium in human health and in diabetes. Diabetes Care 2004; 27: 2741–2751. \u003ci\u003eDiabetes care\u003c\/i\u003e, \u003ci\u003e36\u003c\/i\u003e(9), 2872.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3747905\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCrawford, V., Scheckenbach, R., \u0026amp; Preuss, H. G. (1999). Effects of niacin‐bound chromium supplementation on body composition in overweight African‐American women.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eDiabetes, Obesity and Metabolism\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e1\u003c\/i\u003e(6), 331-337.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1046\/j.1463-1326.1999.00055.x\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDeshmukh, N. S., Bagchi, M., Lau, F. C., \u0026amp; Bagchi, D. (2009). Safety of an oxygen-coordinated niacin-bound chromium (III) complex (NBC): II. Developmental toxicity study in rats. \u003ci\u003eJournal of inorganic biochemistry\u003c\/i\u003e, \u003ci\u003e103\u003c\/i\u003e(12), 1755-1760.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.academia.edu\/download\/46898486\/j.jinorgbio.2009.03.00820160629-30498-1wyzn0o.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). (2010). Scientific Opinion on the safety of trivalent chromium as a nutrient added for nutritional purposes to foodstuffs for particular nutritional uses and foods intended for the general population (including food supplements). \u003ci\u003eEFSA Journal\u003c\/i\u003e, \u003ci\u003e8\u003c\/i\u003e(12), 1882.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/efsa.onlinelibrary.wiley.com\/doi\/pdf\/10.2903\/j.efsa.2010.1882\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGrant, K. E., Chandler, R. M., Castle, A. L., \u0026amp; Ivy, J. L. (1997). Chromium and exercise training: effect on obese women.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eMedicine and science in sports and exercise\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e29\u003c\/i\u003e(8), 992-998.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.burn-ts.com\/wp-content\/uploads\/2015\/05\/chromium-clinical-study.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHua, Y., Clark, S., Ren, J., \u0026amp; Sreejayan, N. (2012). Molecular mechanisms of chromium in alleviating insulin resistance.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eThe Journal of Nutritional Biochemistry\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e23\u003c\/i\u003e(4), 313-319.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3308119\/\"\u003eArticle\u003c\/a\u003e \u003c\/p\u003e\n\u003cp\u003eIrmak, M., ŞAHİN, N., Orhan, C., Tuzcu, M., Deeh, P. B. D., Yardim, M., ... \u0026amp; ŞAHİN, K. (2019). Combination of amylopectin and chromium form improves energy storage and reduces muscle fatigue in rats during exhaustive exercise. \u003ci\u003eTurkish Journal of Veterinary and Animal Sciences\u003c\/i\u003e, \u003ci\u003e43\u003c\/i\u003e(1), 44-53.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/journals.tubitak.gov.tr\/veterinary\/issues\/vet-19-43-1\/vet-43-1-6-1810-24.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJeejeebhoy, K. N., Chu, R. C., Marliss, E. B., Greenberg, G. R., \u0026amp; Bruce-Robertson, A. (1977). Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long-term total parenteral nutrition. \u003ci\u003eThe American Journal of Clinical Nutrition\u003c\/i\u003e, \u003ci\u003e30\u003c\/i\u003e(4), 531-538.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/ajcn\/article-abstract\/30\/4\/531\/4650242\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKhan, J. A. (2019). Modulation of Hormonal, Oxidative Stress and Fatty Acids Profiling in Response to Glutamine and Chromium in Diabetic Rats. \u003ci\u003eJournal of Pharmaceutical Research International\u003c\/i\u003e, 1-8.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/journaljpri.com\/index.php\/JPRI\/article\/view\/30156\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKim, H. N., Kim, S. H., Eun, Y. M., \u0026amp; Song, S. W. (2018). Effects of zinc, magnesium, and chromium supplementation on cardiometabolic risk in adults with metabolic syndrome: A double-blind, placebo-controlled randomised trial. \u003ci\u003eJournal of Trace Elements in Medicine and Biology\u003c\/i\u003e, \u003ci\u003e48\u003c\/i\u003e, 166-171.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0946672X18300695\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLau, F. C., Bagchi, M., Sen, C. K., \u0026amp; Bagchi, D. (2008). Nutrigenomic basis of beneficial effects of chromium (III) on obesity and diabetes. \u003ci\u003eMolecular and cellular biochemistry\u003c\/i\u003e, \u003ci\u003e317\u003c\/i\u003e(1-2), 1-10.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/citeseerx.ist.psu.edu\/viewdoc\/download?doi=10.1.1.626.409\u0026amp;rep=rep1\u0026amp;type=pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLee, N. A., \u0026amp; Reasner, C. A. (1994). Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. \u003ci\u003eDiabetes care\u003c\/i\u003e, \u003ci\u003e17\u003c\/i\u003e(12), 1449-1452.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/care.diabetesjournals.org\/content\/17\/12\/1449.short\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLefavi, R. G., Anderson, R. A., Keith, R. E., Wilson, G. D., McMillan, J. L., \u0026amp; Stone, M. H. (1992). Efficacy of chromium supplementation in athletes; emphasis on anabolism. \u003ci\u003eInternational journal of sport nutrition\u003c\/i\u003e, \u003ci\u003e2\u003c\/i\u003e(2), 111-122.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/journals.humankinetics.com\/doi\/pdf\/10.1123\/ijsn.2.2.111\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLin, C. C., \u0026amp; Huang, Y. L. (2015). Chromium, zinc and magnesium status in type 1 diabetes. \u003ci\u003eCurrent Opinion in Clinical Nutrition \u0026amp; Metabolic Care\u003c\/i\u003e, \u003ci\u003e18\u003c\/i\u003e(6), 588-592.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26406393\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMaret, W. (2019). Chromium Supplementation in Human Health, Metabolic Syndrome, and Diabetes. \u003ci\u003eEssential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic\u003c\/i\u003e, \u003ci\u003e19\u003c\/i\u003e, 231.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=-y-GDwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PA231\u0026amp;dq=Chromium+and+diabetes\u0026amp;ots=fU6qmYycN1\u0026amp;sig=Hc1iQUv8ZrgdX5C9TXFWxlW-NDg#v=onepage\u0026amp;q=Chromium%20and%20diabetes\u0026amp;f=false\"\u003eBook\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMasironi, R. (1969). Trace elements and cardiovascular diseases. \u003ci\u003eBulletin of the World Health Organization\u003c\/i\u003e, \u003ci\u003e40\u003c\/i\u003e(2), 305.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2554609\/pdf\/bullwho00223-0127.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMorris, B. W., Kouta, S., Robinson, R., MacNeil, S., \u0026amp; Heller, S. (2000). Chromium supplementation improves insulin resistance in patients with Type 2 diabetes mellitus. \u003ci\u003eDiabetic Medicine\u003c\/i\u003e, \u003ci\u003e17\u003c\/i\u003e(9), 684-685.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1046\/j.1464-5491.2000.00342.x\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNussbaumerova, B., Rosolova, H., Krizek, M., Sefrna, F., Racek, J., Müller, L., \u0026amp; Sindberg, C. (2018). Chromium Supplementation Reduces Resting Heart Rate in Patients with Metabolic Syndrome and Impaired Glucose Tolerance. \u003ci\u003eBiological trace element research\u003c\/i\u003e, 1-8.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs12011-017-1128-6\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNair, S. (2019). Metabolic effects of chromium—Potential molecular mechanisms. In \u003ci\u003eThe Nutritional Biochemistry of Chromium (III)\u003c\/i\u003e (pp. 175-191). Elsevier.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780444641212000052\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNgala, R. A., Awe, M. A., \u0026amp; Nsiah, P. (2018). The effects of plasma chromium on lipid profile, glucose metabolism and cardiovascular risk in type 2 diabetes mellitus. A case-control study. \u003ci\u003ePloS one\u003c\/i\u003e, \u003ci\u003e13\u003c\/i\u003e(7), e0197977.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0197977\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eOlin, K. L., Stearns, D. M., Armstrong, W. H., \u0026amp; Keen, C. L. (1994). Comparative retention\/absorption of 51chromium (51Cr) from 51Cr chloride, 51Cr nicotinate and 51Cr picolinate in a rat model. \u003ci\u003eTrace Elements and Electrocytes\u003c\/i\u003e, \u003ci\u003e11\u003c\/i\u003e(4), 182-186.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/ucdavis.pure.elsevier.com\/en\/publications\/comparative-retentionabsorption-of-sup51supchromium-sup51supcr-fr\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eOnakpoya, I., Posadzki, P., \u0026amp; Ernst, E. (2013). Chromium supplementation in overweight and obesity: a systematic review and meta‐analysis of randomized clinical trials. \u003ci\u003eObesity reviews\u003c\/i\u003e, \u003ci\u003e14\u003c\/i\u003e(6), 496-507.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/obr.12026\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eOrhan, C., Kucuk, O., Tuzcu, M., Sahin, N., Komorowski, J. R., \u0026amp; Sahin, K. (2019). Effect of supplementing chromium histidinate and picolinate complexes along with biotin on insulin sensitivity and related metabolic indices in rats fed a high‐fat diet. \u003ci\u003eFood science \u0026amp; nutrition\u003c\/i\u003e, \u003ci\u003e7\u003c\/i\u003e(1), 183-194.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/fsn3.851\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePanchal, S. K., Wanyonyi, S., \u0026amp; Brown, L. (2017). Selenium, vanadium, and chromium as micronutrients to improve metabolic syndrome. \u003ci\u003eCurrent hypertension reports\u003c\/i\u003e, \u003ci\u003e19\u003c\/i\u003e(3), 10.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s11906-017-0701-x\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePrasad, A. (2016). Role of chromium compounds in diabetes. \u003ci\u003eIndian Journal of Pharmacy and Pharmacology\u003c\/i\u003e, \u003ci\u003e3\u003c\/i\u003e(1), 17-23.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.academia.edu\/download\/44647611\/IJPP_31_17-23.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePreuss, H. G., Echard, B., Clouatre, D., Bagchi, D., \u0026amp; Perricone, N. V. (2011). Niacin-bound chromium increases life span in Zucker Fatty Rats. \u003ci\u003eJournal of inorganic biochemistry\u003c\/i\u003e, \u003ci\u003e105\u003c\/i\u003e(10), 1344-1349.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0162013411000158\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePreuss, H. G., Bagchi, D., \u0026amp; Bagchi, M. (2002). Protective effects of a novel niacin‐bound chromium complex and a grape seed proanthocyanidin extract on advancing age and various aspects of syndrome X. \u003ci\u003eAnnals of the New York Academy of Sciences\u003c\/i\u003e, \u003ci\u003e957\u003c\/i\u003e(1), 250-259.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.academia.edu\/download\/46898447\/j.1749-6632.2002.tb02921.x20160629-7302-kvgg5j.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePolansky, M. M., Bryden, N. A., \u0026amp; Anderson, R. A. (1993, February). Effects of form of chromium on chromium absorption. In \u003ci\u003eFASEB JOURNAL\u003c\/i\u003e (Vol. 7, No. 3, pp. A77-A77).\u003c\/p\u003e\n\u003cp\u003eSahin, K., Tuzcu, M., Orhan, C., Sahin, N., Kucuk, O., Ozercan, I. H., ... \u0026amp; Komorowski, J. R. (2013). Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin. \u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e, \u003ci\u003e110\u003c\/i\u003e(2), 197-205.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/1744\/57140833cfd0c68229463e480f193b1a2bec.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSeif, A. A. (2015). Chromium picolinate inhibits cholesterol-induced stimulation of platelet aggregation in hypercholesterolemic rats. \u003ci\u003eIrish Journal of Medical Science (1971-)\u003c\/i\u003e, \u003ci\u003e184\u003c\/i\u003e(2), 291-296.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s11845-014-1102-7\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShara, M., Kincaid, A. E., Limpach, A. L., Sandstrom, R., Barrett, L., Norton, N., ... \u0026amp; Bagchi, M. (2007). Long-term safety evaluation of a novel oxygen-coordinated niacin-bound chromium (III) complex. \u003ci\u003eJournal of inorganic biochemistry\u003c\/i\u003e, \u003ci\u003e101\u003c\/i\u003e(7), 1059-1069.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.academia.edu\/download\/46898485\/j.jinorgbio.2007.03.01520160629-4925-1tlysd9.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShrivastava, R., Upreti, R. K., Seth, P. K., \u0026amp; Chaturvedi, U. C. (2002). Effects of chromium on the immune system. \u003ci\u003eFEMS Immunology \u0026amp; Medical Microbiology\u003c\/i\u003e, \u003ci\u003e34\u003c\/i\u003e(1), 1-7.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/femspd\/article-pdf\/34\/1\/1\/19165618\/34-1-1.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSuksomboon, N., Poolsup, N., \u0026amp; Yuwanakorn, A. (2014). Systematic review and meta‐analysis of the efficacy and safety of chromium supplementation in diabetes. \u003ci\u003eJournal of clinical pharmacy and therapeutics\u003c\/i\u003e, \u003ci\u003e39\u003c\/i\u003e(3), 292-306.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24635480\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSwaroop, A., Bagchi, M., Preuss, H. G., Zafra-Stone, S., Ahmad, T., \u0026amp; Bagchi, D. (2019). Benefits of chromium (III) complexes in animal and human health. In \u003ci\u003eThe Nutritional Biochemistry of Chromium (III)\u003c\/i\u003e (pp. 251-278). Elsevier.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780444641212000088\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eThomas, V. L., \u0026amp; Gropper, S. S. (1996). Effect of chromium nicotinic acid supplementation on selected cardiovascular disease risk factors. \u003ci\u003eBiological trace element research\u003c\/i\u003e, \u003ci\u003e55\u003c\/i\u003e(3), 297-305.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/BF02785287\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTsang, C., Taghizadeh, M., Aghabagheri, E., Asemi, Z., \u0026amp; Jafarnejad, S. (2019). A meta‐analysis of the effect of chromium supplementation on anthropometric indices of subjects with overweight or obesity. \u003ci\u003eClinical obesity\u003c\/i\u003e, e12313.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/cob.12313\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWilson, B. E., \u0026amp; Gondy, A. (1995). Effects of chromium supplementation on fasting insulin levels and lipid parameters in healthy, non-obese young subjects. \u003ci\u003eDiabetes research and clinical practice\u003c\/i\u003e, \u003ci\u003e28\u003c\/i\u003e(3), 179-184.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/016882279501097W\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWorld Health Organization. (1996). Trace elements in human nutrition and health.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/37931\/9241561734_eng.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWright, N.J.D., Hunter, T. (2014). Evidence for use of chromium in treatement of pre-diabetes. Journal of Pharmaceutical and Scientific Innovation, p. 298-305.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/084d\/5a97092bc47a7d24558d21a1b3a9b0295b7c.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVincent, J.B. (2019).\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eThe nutritional biochemistry of Chromium (III)\u003c\/i\u003e. Amsterdam, Netherlands: Elsevier.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/books.google.com\/books?hl=en\u0026amp;lr=\u0026amp;id=n0FvDwAAQBAJ\u0026amp;oi=fnd\u0026amp;pg=PP1\u0026amp;dq=Aghdassi+et+al.,+2010+chromium\u0026amp;ots=QTH1t-wirz\u0026amp;sig=Z-J0mLhb10Gq0E8JTEDQrkYeKVY#v=onepage\u0026amp;q=Aghdassi%20et%20al.%2C%202010%20chromium\u0026amp;f=false\"\u003eBook\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVincent, J. B. (2018). Beneficial effects of chromium (III) and vanadium supplements in diabetes. In \u003ci\u003eNutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome (Second Edition)\u003c\/i\u003e (pp. 365-374).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128120194000295\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVincent, J. B. (2004). Recent advances in the nutritional biochemistry of trivalent chromium. \u003ci\u003eProceedings of the Nutrition Society\u003c\/i\u003e, \u003ci\u003e63\u003c\/i\u003e(1), 41-47.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/7614\/7b0df411badda6f7d9c1b641d1cab99c1c17.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWilson, B. E., \u0026amp; Gondy, A. (1995). Effects of chromium supplementation on fasting insulin levels and lipid parameters in healthy, non-obese young subjects. \u003ci\u003eDiabetes research and clinical practice\u003c\/i\u003e, \u003ci\u003e28\u003c\/i\u003e(3), 179-184.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8529496\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCardiovascular Health with High Nitrate Beet Root\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eBeals, J.W., Binns, S.E., Davis, J.L., Giordano, G.R., Klochak, A.L., Paris, H.L. … Bell, C. (2017). Concurrent Beet Juice and Carbohydrate Ingestion: Influence on Glucose Tolerance in Obese and Nonobese Adults. \u003cem\u003eJ Nutr Metab, 2017\u003c\/em\u003e:6436783. \u003ca href=\"http:\/\/downloads.hindawi.com\/journals\/jnme\/2017\/6436783.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBond Jr, V., Curry, B. H., Adams, R. G., Millis, R. M., \u0026amp; Haddad, G. E. (2013). Cardiorespiratory function associated with dietary nitrate supplementation.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eApplied physiology, nutrition, and metabolism\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e39\u003c\/i\u003e(2), 168-172.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3909870\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBuckley, J., Riley, M., Wood, L., Skeaff, S., \u0026amp; Noakes, M. (2018). Abstracts of the 10th Asia-Pacific Conference on Clinical Nutrition.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2504-3900\/2\/12\/573\/pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eClifford, T., Howatson, G., West, D.J., \u0026amp; Stevenson, E.J. (2015). The potential benefits of red beetroot supplementation in health and disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients\u003c\/em\u003e, 7(4), 2801-22.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/7\/4\/2801\/htm?__hstc=3584879.822a9c3981f04695664b9dc054b5f524.1523232001968.1523232001969.1523232001970.1\u0026amp;__hssc=3584879.1.1523232001971\u0026amp;__hsfp=1773666937\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDomínguez, R., Cuenca, E., Maté-Muñoz, J.L., García-Fernández, P., Serra-Paya, N., Estevan, M.C., Herreros, P.V., Garnacho-Castaño, M.V. (2017). Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review. \u003cem\u003eNutrients, 9\u003c\/em\u003e(1).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.mdpi.com\/2072-6643\/9\/1\/43\/pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEngan, H. K., Jones, A. M., Ehrenberg, F., \u0026amp; Schagatay, E. (2012). Acute dietary nitrate supplementation improves dry static apnea performance.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eRespiratory physiology \u0026amp; neurobiology\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e182\u003c\/i\u003e(2-3), 53-59.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1569904812001036\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHobbs, D. A., Goulding, M. G., Nguyen, A., Malaver, T., Walker, C. F., George, T. W., ... \u0026amp; Lovegrove, J. A. (2013). Acute Ingestion of Beetroot Bread Increases Endothelium-Independent Vasodilation and Lowers Diastolic Blood Pressure in Healthy Men: A Randomized Controlled Trial–4.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eThe Journal of nutrition\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e143\u003c\/i\u003e(9), 1399-1405.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/jn\/article\/143\/9\/1399\/4637675\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHobbs, D. A., Kaffa, N., George, T. W., Methven, L., \u0026amp; Lovegrove, J. A. (2012). Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eBritish Journal of Nutrition\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e108\u003c\/i\u003e(11), 2066-2074.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/nrl.northumbria.ac.uk\/6688\/1\/TWG_2012_Beetroot_epub.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJajja, A., Sutyarjoko, A., Lara, J., Rennie, K., Brandt, K., Qadir, O., Siervo, M. (2014). Beetroot supplementation lowers daily systolic blood pressure in older, overweight subjects. \u003cem\u003eNutr Res. 34\u003c\/em\u003e(10), 868-75.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/nrl.northumbria.ac.uk\/6688\/1\/TWG_2012_Beetroot_epub.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKrajka-Kuźniak, V., Paluszczak, J., Szaefer, H., \u0026amp; Baer-Dubowska, W. (2013). Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying\/antioxidant enzymes in human liver cell lines. \u003cem\u003eBritish Journal of Nutrition\u003c\/em\u003e, \u003cem\u003e110\u003c\/em\u003e(12), 2138-2149.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pdfs.semanticscholar.org\/7170\/b1495779b43c1e54c9371ea82b14d610963d.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKrajka-Kuźniak, V., Szaefer, H., Ignatowicz, E., Adamska, T., \u0026amp; Baer-Dubowska, W. (2012). Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats. \u003cem\u003eFood and chemical toxicology\u003c\/em\u003e, \u003cem\u003e50\u003c\/em\u003e(6), 2027-2033. \u003ca href=\"https:\/\/krachtsap.nl\/images\/pdf\/2012%20-%20rodebietensap%20tegen%20leverproblemen%20ratten%20(nitrosodiethylamine)%20-....pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLarsen, F. J., Schiffer, T. A., Borniquel, S., Sahlin, K., Ekblom, B., Lundberg, J. O., \u0026amp; Weitzberg, E. (2011). Dietary inorganic nitrate improves mitochondrial efficiency in humans.\u003cspan\u003e \u003c\/span\u003e\u003ci\u003eCell metabolism\u003c\/i\u003e,\u003cspan\u003e \u003c\/span\u003e\u003ci\u003e13\u003c\/i\u003e(2), 149-159.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1550413111000052\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLee, C.H., Wettasinghe, M., Bolling, B.W., Ji, L.L., Parkin, K.L. (2005). Betalains, phase II enzyme-inducing components from red beetroot (Beta vulgaris L.) extracts. \u003cem\u003eNutr Cancer,\u003c\/em\u003e \u003cem\u003e53\u003c\/em\u003e(1), 91-103.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.researchgate.net\/profile\/Kirk_Parkin\/publication\/7417524_Betalains_Phase_II_Enzyme-Inducing_Components_From_Red_Beetroot_Beta_vulgaris_L_Extracts\/links\/02e7e5399db02899da000000.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMcDonagh, S. T., Wylie, L. J., Thompson, C., Vanhatalo, A., \u0026amp; Jones, A. M. (2019). Potential benefits of dietary nitrate ingestion in healthy and clinical populations: A brief review. \u003ci\u003eEuropean journal of sport science\u003c\/i\u003e, \u003ci\u003e19\u003c\/i\u003e(1), 15-29.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17461391.2018.1445298\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNinfali P, Antonini E, Frati A, Scarpa ES. (2017). C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePhytother Res, 31\u003c\/em\u003e(6), 871-884.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28464411\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSiervo, M., Lara, J., Ogbonmwan, I., Mathers, J.C. (2013). Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. \u003cem\u003eJ Nutr, 143\u003c\/em\u003e(6), 818-26.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/academic.oup.com\/jn\/article\/143\/6\/818\/4571708\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWootton-Beard, P.C., Brandt, K., Fell, D., Warner, S., Ryan, L. (2014). Effects of a beetroot juice with high neobetanin content on the early-phase insulin response in healthy volunteers. J Nutr Sci, 3:e9.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/535AAA8B832FBE11FDD4692C968187B9\/S204867901400007Xa.pdf\/div-class-title-effects-of-a-beetroot-juice-with-high-neobetanin-content-on-the-early-phase-insulin-response-in-healthy-volunteers-div.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003e Ingredients \u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOne Vegetarian Capsule Contains: \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eTrivalent Chromium 500mcg nucleotides from Brewer's yeast as ligands. \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eRed Beet Root Powder 250mg organic, freeze-dried. \u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eOther Ingredients: cellulose \u0026amp; water (capsule shell).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch6\u003e\n\u003cspan\u003eProtocol\u003c\/span\u003e\u003cbr\u003e\n\u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCHROMIUM\u003c\/b\u003e— The Chromium with organic red beet root is designed to supports pre-diabetic and diabetic conditions.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003ePre-diabetic\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e\u0026amp;\u003cspan\u003e \u003c\/span\u003e\u003ci\u003ediabetic support\u003c\/i\u003e: Take 1 capsule twice a day to help improve blood sugar management. Chromium partners up with insulin to open up the cell door to receive glucose. Hence chromium helps overcome insulin resistance. An essential mineral for energy and circulation.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eEnergy \u0026amp; sports\u003c\/i\u003e: Chromium is an essential trace mineral for energy and circulation, and in combination with the red beetroot’s ability to increase nitric oxide, it is a perfect supplement for exercise. Take 1 capsule a day. Add\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eEnergy\u003c\/b\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eBeta Glucan\u003c\/b\u003e, and\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eBe Regular\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003efor a sustained energy boost.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eWeight-Loss and heart health\u003c\/i\u003e: Chromium is important mineral for fat and carbohydrate metabolism. Take 1 capsule a day. Add\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eWeight-Less\u003c\/b\u003e, 1-2 capsules twice daily for a smart weight loss.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOur favorite\u003c\/i\u003e: chromium is one of Seann’s favorite products, keeping his energy up for a long morning jog, along with\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eEnergy\u003c\/b\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eFructo Borate\u003c\/b\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eGlucosinolates \u0026amp; Sulforaphanes\u003c\/b\u003e, and\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eNo 7\u003c\/b\u003e. His routine has been established over 12 years ago when we started the potent therapeutic foods supplement range.*\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Chlorium","offer_id":43712315883564,"sku":"TF012","price":37.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Chromium---Front.jpg?v=1723214857"},{"product_id":"blueberry-extact","title":"Blueberry Extract","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eThe Brain is the center of our personal universe, controlling and effecting all the systems in the body, including motor functions (balance, strength or frailty), immunity, and of course, how we think. Foggy brain, memory lapses, and cognitive decline are effecting the old and young populations alike.\u003c\/p\u003e\n\u003cp\u003eScientists describe blueberries’ polyphenols as essential agents of neuro-regeneration and repair. Research studies show that a daily intake of at least 1 cup of blueberries offer important regenerative support for a healthy brain.*\u003c\/p\u003e\n\u003cp\u003eThe Blueberry Extract is potent: It takes 80 pounds of blueberries to get one pound of the pure purple extract. One capsule of the polyphenolic extract is equivalent to a cup and a quarter of whole blueberries!*\u003c\/p\u003e\n\u003cp\u003eOur Blueberry Extract stands alone. 100% North American blueberry extract (\u003cem\u003eVaccinium corymbosum\u003c\/em\u003e) provides a daily comprehensive profile of polyphenols to feed your brain.*\u003c\/p\u003e\n\u003cp\u003eThe Blueberry Extract is Pure, Vegan, Kosher, and Non GMO.\u003c\/p\u003e\n\u003ch6\u003eDescription \u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eThe\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eBlueberry Extract\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eoffers the highest concentration of the North American blueberry species,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eVaccinium corymbosum\u003c\/em\u003e, with a significant broad-spectrum phenolic profile.\u003c\/p\u003e\n\u003cp\u003eThe\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eBlueberry Extract\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eis a powerful concentration of anthocyanins: It takes eighty pounds of blueberries to get one pound of the pure purple extract. This means that one capsule of the extract is equivalent to a cup and a quarter of whole blueberries.\u003c\/p\u003e\n\u003cp\u003eEach vegan capsule has 500mg of the pure extract, without any excipients or fillers.\u003c\/p\u003e\n\u003cp\u003eTuft University’s James Joseph and Barbara Shukitt-Hale have researched the use and application of blueberries as a potential therapeutic agent for many years. Their studies along with their colleagues demonstrate that blueberries and blueberry extract reverse and prevent brain aging (Shukitt-Hale et al., 2008; 2007), improve memory and motor skills (Carey et al., 2014; Malin et al., 2011; Brewer et al., 2010), repair neuronal tissue and function (Joseph et al., 2003; Miller et al., 2012), and serve as a potent anti-aging food (Joseph et al., 1999; 2009; Shukitt-Hale et al., 2015; 2012).*\u003c\/p\u003e\n\u003cp\u003eThe\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eBlueberry Extract\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003ewas designed with Dr. Joseph’s assistance by converting some of the data from his research to human consumption.*\u003c\/p\u003e\n\u003cp\u003eSteward, Sridhar, and Meyer (2013) define regeneration of the nerves as a process of repairing or replacing nerve cells that have been damaged. Studies have hypothesized that an antioxidant-enriched diet may affect neuro-regeneration and inhibit inflammation due to their high anthocyanins (Szajdek \u0026amp; Borowska, 2008; Sweeney et al., 2002).*\u003c\/p\u003e\n\u003cp\u003eResearch studies and reviews by Latif (2015), Panickar \u0026amp; Anderson (2010), Subash et al. (2014), Panickar (2013), Schaffer et al. (2006), and Letenneur et al. (2007), demonstrate the great ability of flavonoids to offer a consistent neuro-protective nutriceutical.\u003c\/p\u003e\n\u003cp\u003eStratheam et al. (2014) demonstrate that anthocyanin rich extracts of blueberries and grape seed support the process of neuro re-generation by interfering with the neurotoxin, rotenone, and improving the mitochondrial function. Gao et al. (2012) find that a habitual intake of dietary flavonoids is associated with a lower risk of developing neurological issues, such as Parkinson, or lessening brain edema (Panickar \u0026amp; Anderson, 2010). Kovacsova et al. (2010) researched the biochemical pathways and molecular neuro-protective mechanisms of polyphenols in the brain. Antioxidant activity reduces neuro-inflammation and supports the prevention of neuro-degeneration (Stromberg et al., 2005). Williams \u0026amp; Spencer (2012) and Galli et al. (2006) show that a blueberry-supplemented diet reverses age-related declines with improved cognition and nerve regeneration.*\u003c\/p\u003e\n\u003cp\u003eThe process of neurological regenerative ability of blueberries is linked to their potent anti-inflammatory and antioxidant properties (Subash et al., 2014; Duffy et al., 2008; Shukitt-Hale et al., 2008), effecting the reduction of NF Kappa beta, Cox-2 and Isoprostane (Youdim et al., 2002). For this reason, studies emphasize the important dietary role of blueberries, as anthocyanins are able to reduce oxidative stress and anti-inflammatory cytokines (McAnulty et al., 2011).*\u003c\/p\u003e\n\u003cp\u003eDue to their high levels of anthocyanins, blueberries are also shown in research to contribute to heart health (McAnulty, 2014; Louis et al., 2014; Erlund et al., 2008; Youdim \u0026amp; Joseph, 2001).*\u003c\/p\u003e\n\u003cp\u003eHow available are these anthocyanins? Mazza et al. (2002) has demonstrated that consumption of blueberries raises blood serum ORAC (antioxidant capacity). Emerging evidence confirms the ability of the human body to absorb anthocyanins, demonstrating a greater bioavailability (Bell et al., 2015), prolonged circulation, and relatively high concentration of anthocyanins metabolites (Lila et al., 2016).*\u003c\/p\u003e\n\u003cp\u003eSee the Research tab for additional bibliography to further understand the application and use of blueberry and blueberry extract.\u003c\/p\u003e\n\u003cp\u003e*These statements have not been evaluated by the Food \u0026amp; Drug Administration. This products is not intended to diagnose, treat, cure or prevent any disease. The information and citations of research are for informational purposes only. Please be sure to consult your health care provider before taking this or any other product.\u003c\/p\u003e\n\u003ch5\u003e\u003cstrong\u003eREFERENCES\u003c\/strong\u003e\u003c\/h5\u003e\n\u003cp\u003eErlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P… Jula, A. (2008). Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAm J Clin Nutr 87\u003c\/em\u003e, 323-331.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/ajcn.nutrition.org\/content\/87\/2\/323.short\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGalli, R.L., Bielinski, D.F., Szprengiel, A., Shukitt-Hale, B., Joseph, J.A. (2006). Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNeurobio Aging, 27\u003c\/em\u003e, 344-350. DOI:\u003ca href=\"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2005.01.017\"\u003e10.1016\/j.neurobiolaging.2005.01.017\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGao, X., Cassidy, A., Schwarzschild, M.A., Rimm, E.B., \u0026amp; Ascherio, A. (2012). Habitual intake of dietary flavonoids and risk of Parkinson disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNeurology, 78\u003c\/em\u003e(10), 1138-45. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1212%2FWNL.0b013e31824f7fc4\"\u003e10.1212\/WNL.0b013e31824f7fc4\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJoseph, J., Cole, G., Head, E., Ingram, D. (2009). Nutrition, brain aging, and neurodegeneration.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ. Neurosci.\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e29(41), 12795–12801. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1523\/JNEUROSCI.3520-09.2009\"\u003e10.1523\/JNEUROSCI.3520-09.2009\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJoseph, J.A., Shukitt-Hale, B., \u0026amp; Lau, F.C. (2007). Fruit polyphenols and their effects on neuronal signaling and behavior in senescence\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003eAnn NY Acd Sci\u003c\/em\u003e\u003cem\u003e, 1100,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e470-85\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1196\/annals.1395.052\"\u003e10.1196\/annals.1395.052\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eJoseph, J.A., Denisova, N.A., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003). Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Neurosci, 6\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e(3), 153-162. 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Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Nutr Biochem, 21\u003c\/em\u003e, 991-998. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jnutbio.2009.08.005\"\u003e10.1016\/j.jnutbio.2009.08.005\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCarey, A.N., Gomes, S.M., \u0026amp; Shukitt-Hale, B. (2014). Blueberry supplementation improves memory in middle-aged mice fed a high-fat diet.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e62\u003c\/em\u003e, 3972-3978. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf404565s\"\u003e10.1021\/jf404565s\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCasadesus, G., Shukitt-Hale, B., Stellwagen, H.M., Zhu, X., Lee, H.G., Smith, M.A., Joseph, J.A. (2004). Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Neurosci, 7\u003c\/em\u003e, 309-316. DOI:\u003ca href=\"https:\/\/doi.org\/10.1080\/10284150400020482\"\u003e10.1080\/10284150400020482\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChemiack, E.P. (2012). A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorder.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBr J Nutr, 108\u003c\/em\u003e(5), 794-800. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S0007114512000669\"\u003e10.1017\/S0007114512000669\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDevore, E.E., Kang, J.H., Breteler, M.M., \u0026amp; Grodstein, F. (2012). 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Arch Biochem Biophys, 492(1-2):1-9 DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S0029665112000146\"\u003e10.1017\/S0029665112000146\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSteward, M.N., Sridhar, A., \u0026amp; Meyer, J.S. (2013). Neural regeneration. Curr Top Microbiol Immunol, 367, 163-91. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/82_2012_302\"\u003e10.1007\/82_2012_302\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eStrathearm, K.D., Yousef, G.G., Grace, M.H., Tambe, M.A., Ferruzzi, M.G., Wu, Q.L., Simon, J.E., Lila, M.A., \u0026amp; Rochet, J.C. (2014). Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson’s diseases.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBrain Res\u003c\/em\u003e, 1555, 60-77. . DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.brainres.2014.01.047\"\u003e10.1016\/j.brainres.2014.01.047\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eStromberg, I., Gemma, C., Vila, J., Bickford, P.C. (2005). Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eExp Neurol, 196\u003c\/em\u003e, 298-307. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2005.08.013\"\u003e10.1016\/j.expneurol.2005.08.013\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSubash, S., Essa, M.M., Al-Adwi, S., Memon, M.A., Manivasagan, T., \u0026amp; Akbar, M. (2014). Neuroprotective effects of berry fruits on neurodegenerative diseases.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNeural Regeneration Research\u003c\/em\u003e, 9(16), 1557-1566. .\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.nrronline.org\/article.asp?issn=1673-5374;year=2014;volume=9;issue=16;spage=1557;epage=1566;aulast=Subash\"\u003eDOI:10.4103\/1673-5374.139483\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSweeney, M.I., Kalt, W., MacKinnon, S.L., Ashby, J., Gottschall-Pass, K.T. (2002) Feeding rats diets enriched in lowbush blueberries for six weeks decreases ischemia-induced brain damage.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Neurosci 5\u003c\/em\u003e, 427- 431. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/1028415021000055970\"\u003e10.1080\/1028415021000055970\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSzajdek, A., Borowska, J.E. (2008). Bioactive compounds and health-promoting properties of berry fruits a review.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePlant Foods Hum Nutr, 63\u003c\/em\u003e,147-156. DOI:\u003ca href=\"https:\/\/doi.org\/10.1007\/s11130-008-0097-5\"\u003e10.1007\/s11130-008-0097-5\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWang, Y., Chang, C.F., Chou, J., Chen, H.L., Deng, X., Harvey, B.K., Cadet, J.L., Bickford, P.C. (2005). Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eExp Neurol, 193\u003c\/em\u003e, 75-84. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2004.12.014\"\u003e10.1016\/j.expneurol.2004.12.014\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWilliams, C.M., El Mohsen, M.A., Vauzour, D., Rendeiro, C., Butler, L.T., Ellis, J.A., Whiteman, M., Spencer, J.P. (2008). Blueberry induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFree Radical Biol Med, 45\u003c\/em\u003e, 295-305. DOI:\u003ca href=\"https:\/\/doi.org\/10.1016\/j.freeradbiomed.2008.04.008\"\u003e10.1016\/j.freeradbiomed.2008.04.008\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWilliams, R.J. \u0026amp; Spencer, J.P. (2012). Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFree Radic Biol Med, 52\u003c\/em\u003e(1), 35-45. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.freeradbiomed.2011.09.010\"\u003e10.1016\/j.freeradbiomed.2011.09.010\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYoudim, K.A., Joseph, J.A. (2001). A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFree Radic Biol Med, 30\u003c\/em\u003e, 583-594.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/doi.org\/10.1016\/S0891-5849%2800%2900510-4\"\u003ehttp:\/\/doi.org\/10.1016\/S0891-5849(00)00510-4\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYoudim, K.A., Shukitt-Hale, B., Martin, A., Wang, H., Denisova, N., Bickford, P.C., Joseph, J.A. (2000). Short-term dietary supplementation of blueberry polyphenolics: beneficial effects on aging brain performance and peripheral tissue function.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Neurosci, 3\u003c\/em\u003e, 383-397.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.1080\/1028415X.2000.11747338\"\u003ehttp:\/\/dx.doi.org\/10.1080\/1028415X.2000.11747338\u003c\/a\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cem\u003e\u003cstrong\u003eSYSTEMIC ANTI-INFLAMMATORY SUPPORT\u003c\/strong\u003e\u003c\/em\u003e\u003c\/h5\u003e\n\u003cp\u003eAkiyama et al. (2000). Inflammation and Alzheimer’s disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNeurobiol Aging\u003c\/em\u003e, 21(3), 383-421. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1101%2Fcshperspect.a006346\"\u003e10.1101\/cshperspect.a006346\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGrace, M.H., Esposito D., Dunlap K.L., \u0026amp; Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem\u003c\/em\u003e, 62(18), 4007-17. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1021%2Fjf403810y\"\u003e10.1021\/jf403810y\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003eMcAnulty, L.S. Nieman, D.C., Dumke, C.L., Shooter, L.A., Henson, D.A., Utter, A.C., … McAnulty, S.R. (2011). Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAppl Physio Nutr Metab\u003c\/em\u003e, 36(6), 976-84. DOI:\u003ca href=\"https:\/\/doi.org\/10.1139\/h11-120\"\u003e10.1139\/h11-120\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePanickar, K.S., \u0026amp; Anderson, R.A. (2010). Role of dietary polyphenols in attenuating brain edema and cell swelling in cerebral ischemia.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eRecent Pat CNS Drug Discov, 5\u003c\/em\u003e(2), 99-108. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.2174\/157488910791213149\"\u003ehttps:\/\/doi.org\/10.2174\/157488910791213149\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYoudim, K.A., McDonald, J., Kalt, W., Joseph, J.A. (2002). Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ. Nutr. Biochem,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e13\u003c\/em\u003e(5), 282-288.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/doi.org\/10.1016\/S0955-2863%2801%2900221-2\"\u003ehttp:\/\/doi.org\/10.1016\/S0955-2863(01)00221-2\u003c\/a\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cem\u003e\u003cstrong\u003eBLUEBERRY AND HEART HEALTH\u003c\/strong\u003e\u003c\/em\u003e\u003c\/h5\u003e\n\u003cp\u003eErlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P… Jula, A. (2008). Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAm J Clin Nutr 87\u003c\/em\u003e, 323-331.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/ajcn.nutrition.org\/content\/87\/2\/323.short\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLouis, X.L., Thandapilly, S.J., Kalt, W., Vinqvist-Tymchuk, M., Aloud, B.M, Raj, P., … Netticadan, T. (2014). Blueberry polyphenols prevent cardiomyocyte death by preventing calpain activation and oxidative stress.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFood Funct, 5\u003c\/em\u003e(8), 1785-94. DOI:\u003ca href=\"https:\/\/doi.org\/10.1039\/c3fo60588d\"\u003e10.1039\/c3fo60588d\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMcAnulty, L.S., Collier, S.R., Landram, M.J., Whittaker, D.S., Isaacs, S.E., Klemka, J.M… McAnulty, S.R. (2014). Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Res, 34\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(7), 577-84. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.nutres.2014.07.002\"\u003e10.1016\/j.nutres.2014.07.002\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMcAnulty, S.R., McAnulty, L.S., Morrow, J.D., Khardouni, D., Shooter, L., Monk, J., Gross, S., Brown, V. (2005). Effect of daily fruit ingestion on converting enzyme activity, blood pressure, and oxidative stress in chronic smokers.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFree Radic R\u003c\/em\u003ees,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e39\u003c\/em\u003e(11),1241-8. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/10715760500306836\"\u003e10.1080\/10715760500306836\u003c\/a\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cem\u003e\u003cstrong\u003eBIOAVAILABILITY OF ANTHOCYANIN FOR HEALTH\u003c\/strong\u003e\u003c\/em\u003e\u003c\/h5\u003e\n\u003cp\u003eBell, L., Lamport, D.J., Butler, L.T., \u0026amp; Williams, C.M. (2015).A Review of the Cognitive Effects Observed in Humans Following Acute Supplementation with Flavonoids, and Their Associated Mechanisms of Action.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients\u003c\/em\u003e\u003cem\u003e,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003e7\u003c\/em\u003e(12), 10290-10306. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.3390\/nu7125538\"\u003e10.3390\/nu7125538\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLila, M.A., Burton-Freeman, B., Grace, M., \u0026amp; Kalt, W. (2016). Unraveling Anthocyanin Bioavailability for Human Health.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAnnu Rev Food Sci Technol,7\u003c\/em\u003e, 375-93. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1146\/annurev-food-041715-033346\"\u003e10.1146\/annurev-food-041715-033346\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMazza, G., Kay, C.D., Cottrell, T., \u0026amp; Holub, B.J. (2002). Absorption of Anthocyanins from Blueberries and Serum Antioxidant Status in Human Subjects.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ. Agric. Food Chem, 50\u003c\/em\u003e(26), 7731-7737.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf020690l\"\u003ehttp:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf020690l\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSandhu, A.K., Huang, Y., Xiao, D., Par, E., Edirisinghe, I., \u0026amp; Burton-Freeman, B. (2016). Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem, 64\u003c\/em\u003e(24), 4891-9. DOI:\u003ca href=\"https:\/\/doi.org\/10.1021\/acs.jafc.6b00805\"\u003e10.1021\/acs.jafc.6b00805\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003eIngredients \u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cspan\u003eOne Vegetarian Capsule Contains: \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBlueberry (\u003cem\u003eVaccinium corymbosum\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e\u003cstrong\u003e) Freeze-dried Extract \u003c\/strong\u003e(80:1)  500mg \u003c\/span\u003e\u003cem\u003e\u003cbr\u003e\u003c\/em\u003e\u003cspan\u003e  Anthocyanins 12% Typical \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e  Polyphenos 40% Minimum \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e  Chlorogeninc Acid 5% Minimum \u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e  ORAC units per gram 6500 \u003c\/span\u003e\u003cbr\u003e\u003cbr\u003e\u003cspan\u003eTypical Other Ingredients cellulose \u0026amp; water (capsule shell)\u003c\/span\u003e\u003c\/p\u003e\n\u003ch6\u003e\u003cspan mce-data-marked=\"1\"\u003eProtocol\u003c\/span\u003e\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eBLUEBERRY EXTRACT\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— Designed to support the regeneration of the brain and nervous system\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eBrain health\u003c\/i\u003e: Take 1 capsule a day for regeneration of brain and nerve cells.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eCognitive and memory\u003c\/i\u003e: Take 1 capsule a day. Add 1 cap\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eHigh ORAC\u003c\/b\u003e.  Students: Take 1-2 caps of both the Blueberry Extract and the High ORAC a day.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eFoggy brain\u003c\/i\u003e: Take 2 capsules for a month then 1 cap a day as maintenance.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eNeural regeneration\u003c\/i\u003e: Take 1-2 capsules a day. Add\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ePhyto Power\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eand\/or\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eNo 7\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003efor broad-spectrum phenolic support.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eAnti-inflammation\u003c\/i\u003e: Due to the high concentration of anthocyanins (80 pounds produce 1 pound of the extract), the Blueberry Extract is excellent as anti-inflammatory agent. Reduces C-reactive protein (inflammatory marker), Isoprostane (marker for lipid oxidation), and NF-Kß (global inflammatory marker) for brain, heart, and DNA health.* \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOur Favorite\u003c\/i\u003e: When our president, Dr. Dohrea Bardell, went through her PhD program, for six years she took 2 capsules of the Blueberry Extract every day to keep her brain active and agile. She worked 12 hours days researching and writing. When she presented papers at conventions, she often added the\u003cspan\u003e \u003c\/span\u003e\u003cb\u003ePhyto Power\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003efor extra boost. The Blueberry Extract is one of her most favorite products.*\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Blueberry","offer_id":43712316112940,"sku":"TF008","price":141.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Blueberry-Extract---Front.jpg?v=1723214870"},{"product_id":"beta-glucan-high-potency-synbiotic","title":"Beta-Glucan Synbiotic","description":"\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe Beta Glucan Synbiotic Formula qualifies for the American Heart Association and Food and Drug Administration “Healthy Heart” seal of approval (FDA, 2002). The suggested daily guideline of two tablespoons contains high concentration of oat beta glucan (10%) for cardiovascular support. Oat beta glucan is also shown in research to reduce serum LDL cholesterol and improve liver function (see research tab).*\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eThe Beta Glucan offers heart, gut, and immune boosting healthy support. The formula contains an advanced combination of naturally occurring whole pedigreed probiotic organisms, with their supernatant and ORNs. Together, the super blend of organisms with special fibers from beta glucan, beetroot, and inulin, effectively building a robust, healthy ecosystem (microbiome) in the gastrointestinal tract. The whole organic red beetroot (15%) and inulin from organic chicory fiber (10%) are also found to confer many exciting health benefits: energy production, antioxidants, bowel regularity, liver support, a gentle detox, and more. The beta glucan from oats are 99.98% gluten free. US Patent # 6,060,519.*\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eThe Beta Glucan is Vegan, Kosher, Non GMO, and 99.98% Gluten Free.\u003c\/p\u003e\n\u003ch6\u003eDescription\u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eWe are proud to have the Beta Glucan qualifies for the American Heart Association and the FDA \"Heart Healthy\" seal of approval: improving lipid serum levels.*\u003c\/p\u003e\n\u003cp\u003eThe special heat-shearing technology used to liberate the beta-glucans from the oat is patented (US Patent # 6,060,519), and considered by the FDA as a gluten free ingredient (99.98% gluten free). For our gluten sensitive friends, please consult your doctor.*\u003c\/p\u003e\n\u003cp\u003eThe food ingredients in the Beta Glucan formula are chosen carefully for their highest phytonutrient potential. The proprietary mix contains: Organic matrix USDA patented hydrocolloidal beta glucan oat bran (75%), organic whole red beetroot (15%), and organic inulin from chicory fiber (10%). Advances in microbiome research and technology allow us to grow our hardy and viable pedigreed Original probiotic strains. Our high potency Original probiotics, along with the B-Glucans, Beetroot, and Inulin offer heart healthy properties, GI support with plant fibers and probiotics, weight-management, regularity, and a boost in energy.*\u003c\/p\u003e\n\u003cp\u003eOats and oat beta glucan have enjoyed a rich cultural historicity and extensive research on heart health (Andersson \u0026amp; Hellstrand, 2012). From Shaper \u0026amp; Jones (1959) analysis of healthy dietary habits, to the Cornell China study in 1998, and the NIH report in 2015, dietary fibers, whole plant-based foods, and exercise are shown in research to be essential for a healthy heart. Oats and oat beta glucan are found to reduce serum LDL cholesterol (Ho et al., 2016; Zhu et al., 2015; Whitehead et al., 2014; Wolever et al., 2010), improve liver function (Chang et al., 2013), and promote bowel regularity (Clemens, 2012; Mobley et al., 2014).*\u003c\/p\u003e\n\u003cp\u003eRed beetroot offer a rich source of phyto-nutrients, including ascorbic acid (vitamin C), carotenoids, phenolic acids, and flavonoids. Beets provide a source of dietary nitrate, shown in research to have important implication for heart health (Kapil et al., 2014). Beet’s nutrients are shown to prevent oxidation of LDLs, lower triglycerides, and balances blood pressure (Clifford et al., 2015; Eggenbeen et al., 2016; Hobbs et al., 2013). As a multifunctional food, beet also stimulate Phase II liver detox (Vulić et al., 2014), as well as perform a host of other health benefits, including the production of energy for exercise (Murphy et al., 2012), promotion of joint health (Pietrzkowski et al., 2010), Antioxidant (Georgiev et al., 2010), and support for individuals who undergo cancer treatments (Kapadia et al., 2013, 2011; Das et al., 2013).*\u003c\/p\u003e\n\u003cp\u003eThe Beta Glucan formula is comprised of our \u003cstrong\u003eBioImmersion Probiotic Master Blend\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e–\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eProbiotics\u003c\/strong\u003e-\u003cem\u003e\u003cspan\u003e \u003c\/span\u003eLactobacillus acidophilus, Lactobacillus casei rhamnosus, Lactobacillus plantarum, Streptococcus thermophilus, Bifidobacterium longum\u003c\/em\u003e;\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eSupernatant\u003c\/strong\u003e- probiotic metabolites, and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eORNs\u003c\/strong\u003e.  65 billion CFU.  The Beta Glucans strains of lactic acid bacteria are pedigreed and certified, based on ATCC prototypical strains and confirmed routinely by 16sRNA sequencing to provide highest quality probiotic material. Our strains are hardy, strong, and effective.*\u003c\/p\u003e\n\u003cp\u003eProbiotics are found in research to positively effect heart health (Kassaian et al., 2017; Sáez-Lara et al., 2016; DiRienzo, 2014; Delzenne et al., 2011; Saini et al., 2010), with many researchers positing the connection between heart and gut health (Serino et al., 2014; Huang et al., 2013). The Beta Glucan was formulated to nourish both heart and gut into health.*\u003c\/p\u003e\n\u003cp\u003eInulin from organic chicory root supplies food for the probiotic organisms. Probiotic organisms need fiber to grow and multiply. See Slavin (2013) on fiber as prebiotics, and Dehghan et al. (2013) on inulin and cardiovascular support.*\u003c\/p\u003e\n\u003cp\u003eTogether with probiotic, inulin is also found in research to help tighten cell junctions, which is thought to aid against leaky gut syndrome (Cani et al., 2007, 2007a, 2008, 2009).*\u003c\/p\u003e\n\u003cp\u003eThe Beta Glucan formula is utilized for bowel regulation. Plant fiber and gluten free whole oat fiber are shown to increase bowel regularity (Schmier et al., 2014).*\u003c\/p\u003e\n\u003cp\u003eThe Beta Glucan is multifunctional due to its oat beta glucans, red beetroot, inulin from chicory, and strong probiotic organism. Each ingredient is shown in research to offer heart healthy food, boost energy, and support the GI tract, liver and kidneys, promoting regularity and GI comfort. Take a look at the food science tab to see the bibliography and engage in learning more about the many health applications scientists have discovered over the years. The tab only shows a fraction of the research findings on oat beta glucan, probiotics, red beetroot, and inulin.*\u003c\/p\u003e\n\u003cp\u003eSee the Research tab for additional bibliography to further understand the application and use of beta glucan, red beetroot, inulin, and probiotics.\u003c\/p\u003e\n\u003cp\u003e*These statements have not been evaluated by the Food \u0026amp; Drug Administration. This products is not intended to diagnose, treat, cure or prevent any disease. The information and citations of research are for informational purposes only. Please be sure to consult your health care provider before taking this or any other product.\u003c\/p\u003e\n\u003ch5\u003e\u003cstrong\u003eREFERENCES\u003c\/strong\u003e\u003c\/h5\u003e\n\u003cp\u003eAnderson, K.E., \u0026amp; Hellstrand, P. (2012). Dietary oats and modulation of atherogenic pathways.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMol Nutr Food Res\u003c\/em\u003e, 56(7), 1003-13. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/mnfr.201100706\"\u003e10.1002\/mnfr.201100706\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P.D., Pssemiers, S., Van de Wiele, T., Guiot, Y., Everad, A., Rottier, O…. Delzenne, N.M. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eGut\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e58\u003c\/em\u003e(8), 1091-1103. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1136\/gut.2008.165886\"\u003e10.1136\/gut.2008.165886\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P.D., Bibiloni, R., Knauf, C., waget, A., Neyrinck, A.M., Delzenne, N.M., Burcelin, R. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eDiabetes\u003c\/em\u003e, 57, 1470-8. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.2337\/db07-1403\"\u003e10.2337\/db07-1403\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P.D., Amar, J., Iglesias, M.A., Poggi, M., Knauf, C., Bastelica, D. … Burelini, R. (2007). Metabolic endotoxemia initiates obesity and insulin resistance.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eDiabetes\u003c\/em\u003e, 56, 1761-72. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.2337\/db06-1491\"\u003e10.2337\/db06-1491\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P.D., Neyrinck, A.M., Fava, F., Knauf, C., Burcelin, R.G., Tuohy, K.M. … Delzenne, N.M. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eDiabetologia\u003c\/em\u003e, 50, 2374-83. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s00125-007-0791-0\"\u003e10.1007\/s00125-007-0791-0\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChang, H.C., Huang, C.N., Yeh, D.M., Wang, S.J., Peng, C.H., \u0026amp; Wang, C.J. (2013). Oat prevents obesity and abdominal fat distribution, and improves liver function in human.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePlant Foods Hum Nutr\u003c\/em\u003e, 68(1), 18-23. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s11130-013-0336-2\"\u003e10.1007\/s11130-013-0336-2\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eClemens, R., Kranz, S., Mobley, A.R., Nicklas, T.A., Raimondi, M.P., Rodriguez, J.C., … Warshaw, H. (2012). Filling American’s fiber intake gap: Summary of roundtable to probe realistic solutions with a focus on grain-based foods.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Nutr\u003c\/em\u003e, 142(7), 1390-1401. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/jn.112.160176\"\u003e10.3945\/jn.112.160176\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eClifford T, Howatson G, West DJ, Stevenson EJ. (2017). Beetroot Juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAppl Physiol Nutr Metab\u003c\/em\u003e. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1139\/apnm-2017-0238\"\u003e10.1139\/apnm-2017-0238\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eClifford, T., Howatson, G., West, D.J., Stevenson, E.J. (2015). The potential benefits of red beetroot supplementation in health and disease.\u003cem\u003eNutrients,7\u003c\/em\u003e(4):2801-22\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu7042801\"\u003e10.3390\/nu7042801\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDas, S., Fillippone, S.M., Williams, D.S., Das, A., Kukreja, R.C. (2016). Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMol Cell Biochem, 421\u003c\/em\u003e(1-2), 89-101. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s11010-016-2789-8\"\u003e10.1007\/s11010-016-2789-8\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDas, S., Williams, D.S., Das, A., Kukreja, R.C. (2013). Beet root juice promotes apoptosis in oncogenic MDA-MB-231 cells while protecting cardiomyocytes under doxorubicin treatment.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ. Exp. Second. Sci\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e2\u003c\/em\u003e, 1–6.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.semanticscholar.org\/paper\/Beet-Root-Juice-Promotes-Apoptosis-in-Oncogenic-MD-Das-Williams\/06075020ded1ab59c1c91ab595380fa6a93d0605\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDehghan, P., Pourghassem, G.B, \u0026amp; Asgharijafarabadi, M. (2013). Effects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes: a randomized, placebo-controlled clinical trial.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eHealth Promot Perspect\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e3\u003c\/em\u003e(1), 55-63. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.5681\/hpp.2013.007\"\u003e10.5681\/hpp.2013.007\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDelzenne, N.M., Neyrinck, A.M., Cani, P.D.(2011). Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMicrob Cell Fact, 10 Suppl 1, S10.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1475-2859-10-S1-S10\"\u003e10.1186\/1475-2859-10-S1-S10\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDiRienzo D.B. (2014). Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Rev\u003c\/em\u003e, 72(1), 18-29. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1111\/nure.12084\"\u003e10.1111\/nure.12084\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDomínguez R, Cuenca E, Maté-Muñoz JL, García-Fernández P, Serra-Paya N, Estevan MC, Herreros PV, Garnacho-Castaño MV.(2017). Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients, 9\u003c\/em\u003e(1).DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jand.2011.12.002\"\u003e10.1016\/j.jand.2011.12.002\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEggenbeen, J., Kim-Shapiro, D.B., Haykowsky, M., Morgan, T.M., Basu, S., Brubaker, P., … Kitzman, D.W. (2016). One week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction. JACC Heart Fail, 4(6), 428-37. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jchf.2015.12.013\"\u003e10.1016\/j.jchf.2015.12.013\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGeorgiev, V.G., Weber, J., Kneschke, E.M., Denev, P.N., Bley, T., Pavlov, A.I. (2010). Antioxidant activity and phenolic content of betalain extracts from intact plants and hairy root cultures of the red beetroot Beta vulgaris cv. Detroit dark red.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePlant Foods Hum Nutr, 65\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(2):105-11. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s11130-010-0156-6\"\u003e10.1007\/s11130-010-0156-6\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHo, H.V., Sievenpiper, J.L., Zurbau, A., Blanco Mejia, S., Jovanovski, E., Au-Yeung, F… Vuksan, V. (2016). The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBr J Nutr. 116\u003c\/em\u003e(8):1369-1382\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S000711451600341X\"\u003e10.1017\/S000711451600341X\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHobbs, D.A., George, T.W., Lovegrove, J.A. (2013). The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Res Rev\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e26\u003c\/em\u003e(2), 210-22. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S0954422413000188\"\u003e10.1017\/S0954422413000188\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHuang, Y., Wang, X., Wang, J., Wu, F., Sui, Y., Yang, L., Wang, Z. (2013). Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Dairy Sci, 96\u003c\/em\u003e(5), 2746-53.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3168\/jds.2012-6123\"\u003e10.3168\/jds.2012-6123\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKapadia, G.J., Rao, G.S., Ramachandran, C., Iida, A., Suzuki, N., \u0026amp; Tokuda, H. (2013). Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Complement Integr Med\u003c\/em\u003e., 1. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1515\/jcim-2013-0007\"\u003e10.1515\/jcim-2013-0007\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKapadia, G.J., Azuine, M.A., Rao, G.S, Arai, T., Lida, A., \u0026amp; Tokuda, H. (2011), Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAnticancer Agents Med Chem\u003c\/em\u003e, 11(3), 280-4.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21434853\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKapil, V., Weitzberg, E., Lundberg, J.O., Ahluwalia, A. (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNitric Oxide, 38\u003c\/em\u003e, 45-57. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.niox.2014.03.162\"\u003e10.1016\/j.niox.2014.03.162\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKassaian, N., Aminorroaya, A., Feizi, A., Jafari, P., Amini, M. (2017). The effects of probiotic and synbiotic supplementation on metabolic syndrome indices in adults at risk of type 2 diabetes: study protocol for a randomized controlled trial.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eTrial, 18\u003c\/em\u003e(1), 148. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1186%2Fs13063-017-1885-8\"\u003e10.1186\/s13063-017-1885-8\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMobley, A.R., Jones, J.M., Rodriguez, J., Slavin, J., \u0026amp; Zelman, K.M. (2014). Identifying practical solutions to meet American’s fiber needs: Proceedings from the Food \u0026amp; Fiber Summit.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients\u003c\/em\u003e, 8(7), 2540-51. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu6072540\"\u003e10.3390\/nu6072540\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMurphy, M., Eliot, K., Heuertz, R.M., Weiss, E. (2012). Whole beetroot consumption acutely improves running performance.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Acad Nutr Diet\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e, 112(4), 548-52. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jand.2011.12.002\"\u003e10.1016\/j.jand.2011.12.002\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSáez-Lara, M.J., Robles-Sanchez, C., Ruiz-Ojeda, F.J., Plaza-Diaz, J., Gil, A.(2016). Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eInt J Mol Sci, 17\u003c\/em\u003e(6).DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/ijms17060928\"\u003e10.3390\/ijms17060928\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSaini, R., Saini, S., \u0026amp; Sharma, S. (2010). Potential of probiotics in controlling cardiovascular diseases.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ.\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCardiovasc Dis Res\u003c\/em\u003e,1(4), 213-214. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.4103%2F0975-3583.74267\"\u003e10.4103\/0975-3583.74267\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSchmier, J.K., Miller, P.E., Levine, J.A., Perez, V., Maki, K.C., Rains, T.M., … Alexander, D.D. (2014). Cost savings reduced constipation rates attributed to increased dietary fiber intakes: A decision-analytic model.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBMC Public Health\u003c\/em\u003e, 14-374. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1471-2458-14-374\"\u003e10.1186\/1471-2458-14-374\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSerino, M., Blasco-Baque, V., Nicolas, S., \u0026amp; Burcelin, R. (2014). Far from the Eyes, Close to the Heart: Dysbiosis of Gut Microbiota and Cardiovasuclar Consequences.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCurr Cardiol Rep\u003c\/em\u003e, 16(11), 540. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s11886-014-0540-1\"\u003e10.1007\/s11886-014-0540-1\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShaper, A.G., \u0026amp; Jones, K.W. (1959). 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Whole grains and coronary heart disease: the whole kernel of truth.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAm J clin Nutr\u003c\/em\u003e, 80(6), 1459-60.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/ajcn.nutrition.org\/content\/80\/6\/1459.full\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAnderson, K.E., \u0026amp; Hellstrand, P. (2012). Dietary oats and modulation of atherogenic pathways.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMol Nutr Food Res\u003c\/em\u003e, 56(7), 1003-13. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/mnfr.201100706\"\u003e10.1002\/mnfr.201100706\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBenjamin M.M., \u0026amp; Roberts, W.C. (2013). Facts and principles learned at the 19\u003csup\u003eth\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eAnnual Williamsburg Conference on Heart Disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eProc\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(Bayl Univ Med Cent), 26(2), 124-36.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3603726\/\"\u003eArticles\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCampbell T.C., Parpia, B., \u0026amp; Chen, J. (1998). Diet, lifestyle, and the etiology of coronary artery disease: the Cornell China Study.\u003cem\u003eAm J Cardio\u003c\/em\u003e, 82(10B), 18T-21T.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9860369\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDe Biase, S.G., Fernandes, S.F., Gianini, R.J., \u0026amp; Duarte, J.L. (2007). Vegetarian diet and cholesterol and triglycerides levels.\u003cem\u003eArq. Bras Cardiol\u003c\/em\u003e, 88(1), 35-9.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17364116\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDiRienzo D.B. (2014). Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Rev\u003c\/em\u003e, 72(1), 18-29. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1111\/nure.12084\"\u003e10.1111\/nure.12084\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eErkkila, A.T., Herrington, D.M., Mozaffarian, D., \u0026amp; Lichtenstein, A.H. (2005). Cereal fiber and whole-grain intake are associated with reduced progression of coronary-artery atherosclerosis in postmenopausal women with coronary artery disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAm Heart J\u003c\/em\u003e, 150(1), 94-101. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.ahj.2004.08.013\"\u003e10.1016\/j.ahj.2004.08.013\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEsslestyn, C.B. (2010). Is the present therapy for coronary artery disease the radical mastectomy of the twenty-first century?\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAm J Card\u003c\/em\u003eiol, 106(6), 902-4. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.amjcard.2010.05.016\"\u003e10.1016\/j.amjcard.2010.05.016\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFood and Drug Administration. (2002). Food labeling: health claims; soluble dietary fiber from certain foods and coronary heart disease. Interim final rule.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFood and Drug Administration, HHS.. Fed Regist, 67(191), 61773-83.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12361061\"\u003eAbstract\u003c\/a\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eHartley, L., May, M.D., Loveman, E., Colquitt, J.L., Rees, K. (2016). Dietary fibre for the primary prevention of cardiovascular disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCochrane Database Syst Rev, (1),\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eCD011472\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/14651858.CD011472.pub2\"\u003e10.1002\/14651858.CD011472.pub2\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHo, H.V., Sievenpiper, J.L., Zurbau, A., Blanco Mejia, S., Jovanovski, E., Au-Yeung, F… Vuksan, V. (2016). The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBr J Nutr. 116\u003c\/em\u003e(8):1369-1382\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S000711451600341X\"\u003e10.1017\/S000711451600341X\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLambeau, K.V., McRorie, J.W. Jr. (2017).Fiber supplements and clinically proven health benefits: How to recognize and recommend an effective fiber therapy.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Am Assoc Nurse Pract, 29\u003c\/em\u003e(4),\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e216-223.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/2327-6924.12447\"\u003e10.1002\/2327-6924.12447\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMyerburg, R.J., \u0026amp; Junttila M.J. (2012). Sudden cardiac death cause by coronary heart disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCirculation 28\u003c\/em\u003e, 125 (8), 1043-52. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.111.023846\"\u003e10.1161\/CIRCULATIONAHA.111.023846\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNIH (2015). Coronary Heart Disease. 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Serum-cholesterol, diet, and coronary heart disease in Africans, and Asians in Uganda.\u003cem\u003eThe Lancet\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e275\u003c\/em\u003e(7102), 534-37. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1093\/ije\/dys137\"\u003e10.1093\/ije\/dys137\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSingh, R., De, S., \u0026amp; Belkheir, A. (2013) Avena sativa (oat), a potential neutraceutical and therapeutic agent: An Overview.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCriti rev Food sci Nutr\u003c\/em\u003e, 53(2), 126-44. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/10408398.2010.526725\"\u003e10.1080\/10408398.2010.526725\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eStreppel, M.T., Ocke, M.C., Boshuizen, H.C., Kok, F.J., \u0026amp; Kromhout, D. (2008). Dietary fiber intake in relation to coronary heart disease and all-cause mortality over 40 y: the Zutpehn study.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAm J Clin Nur\u003c\/em\u003e, 88, 1119-25. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/ajcn.2010.29417\"\u003e10.3945\/ajcn.2010.29417\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTiwari, U., \u0026amp; Cummins, E. (2011). Meta analysis of the effect of β-glucan [from oats] intake on blood cholesterol and glucose levels.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrition\u003c\/em\u003e, 27(10), 1008-16. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.nut.2010.11.006\"\u003e10.1016\/j.nut.2010.11.006\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eTighe, P., Duthie, G., Vaughan, N., Brittenden, J., Simpson, W.G., Duthie, S…. Thies, F. (2010). 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Concepts in functional foods: the case of inulin and oligofructose.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe Journal of Nutrition\u003c\/em\u003e, 129(7), 1398-1401.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10395606\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSlavin, J. (2013). Fiber and prebiotics: mechanism and health benefits.\u003cem\u003eNutrients\u003c\/em\u003e, 5(4), 1417-1435. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu5041417\"\u003e10.3390\/nu5041417\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eRed Beetroot: Cardiovascular support\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eClifford, T., Howatson, G., West, D.J., \u0026amp; Stevenson, E.J. (2015. The potential benefits of red beetroot supplementation in health and disease.\u003cem\u003eNutrients\u003c\/em\u003e, 7(4), 2801-22. 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Dietary nitrate supplementation improves reaction time in type 2 diabetes: development and application of a novel nitrate-depleted beetroot juice placebo.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNitric Oxide, 40\u003c\/em\u003e, 67-74. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.niox.2014.05.003\"\u003e10.1016\/j.niox.2014.05.003\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHobbs, D.A., George, T.W., Lovegrove, J.A. (2013). The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies. \u003cem\u003eNutr Res Rev\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e26\u003c\/em\u003e(2), 210-22. 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Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEur J Nutr, 55\u003c\/em\u003e(2):451-459\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s00394-015-0872-7\"\u003e10.1007\/s00394-015-0872-7\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKapil, V., Weitzberg, E., Lundberg, J.O., Ahluwalia, A. (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNitric Oxide, 38\u003c\/em\u003e, 45-57. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.niox.2014.03.162\"\u003e10.1016\/j.niox.2014.03.162\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNinfali P, Angelino D. (2013). Nutritional and functional potential of Beta vulgaris cicla and rubra. Fitoterapia, 89, 188-99. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.fitote.2013.06.004\"\u003e10.1016\/j.fitote.2013.06.004\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePresley, T.D., Morgan, A.R., Bechtold, E., Clodfelter, W., Dove, R.W., Jennings, J.M. …Miller, G.D. (2011). Acute effect of a high nitrate diet on brain perfusion in older adults. \u003cem\u003eNitric Oxide, 24\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(1), 34-42. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.niox.2010.10.002\"\u003e10.1016\/j.niox.2010.10.002\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSiervo, M., Lara, J., Ogbonmwan, I., Mathers, J.C. (2013). Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Nutr, 143\u003c\/em\u003e(6), 818-26.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/jn.112.170233\"\u003e10.3945\/jn.112.170233\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWebb, A.J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S.…. Ahluwalia, A. (2008). Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eHypertension, 51\u003c\/em\u003e(3), 784-90. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.107.103523\"\u003e10.1161\/HYPERTENSIONAHA.107.103523\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWootton-Beard, P.C., Brandt, K., Fell, D., Warner, S., Ryan, L. (2014). Effects of a beetroot juice with high neobetanin content on the early-phase insulin response in healthy volunteers. J Nutr Sci, 3:e9. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/jns.2014.7\"\u003e10.1017\/jns.2014.7\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eBeetroot and Liver Support\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eLee, C.H., Wettasinghe, M., Bolling, B.W., Ji, L.L., Parkin, K.L. (2005). Betalains, phase II enzyme-inducing components from red beetroot (Beta vulgaris L.) extracts.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Cancer,\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e53\u003c\/em\u003e(1), 91-103. 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Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFood and chemical toxicology\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e50\u003c\/em\u003e(6), 2027-2033.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.fct.2012.03.062\"\u003ehttps:\/\/doi.org\/10.1016\/j.fct.2012.03.062\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSzaefer, H., Krajka Kuźniak, V., Ignatowicz, E., Adamska, T., \u0026amp; Baer‐Dubowska, W. (2014). Evaluation of the Effect of Beetroot Juice on DMBA‐induced Damage in Liver and Mammary Gland of Female Sprague–Dawley Rats.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePhytotherapy Research\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e28\u003c\/em\u003e(1), 55-61. 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Foods. 2014;6:168–175.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jff.2013.10.003\"\u003ehttps:\/\/doi.org\/10.1016\/j.jff.2013.10.003\u003cspan\u003e \u003c\/span\u003e\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eBeetroot: Antioxidant, Anti-inflammatory, Antimicrobial Support\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eČanadanović-Brunet, J. M., Savatović, S. S., Ćetković, G. S., Vulić, J. J., Djilas, S. M., Markov, S. L., \u0026amp; Cvetković, D. D. (2011). Antioxidant and antimicrobial activities of beet root pomace extracts.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCzech Journal of Food Sciences\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e29\u003c\/em\u003e(6), 575-585.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/agris.fao.org\/agris-search\/search.do?recordID=CZ2012000215\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eClifford, T., Howatson, G., West, D.J., Stevenson, E.J. (2015). The potential benefits of red beetroot supplementation in health and disease.\u003cem\u003eNutrients,7\u003c\/em\u003e(4):2801-22\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu7042801\"\u003e10.3390\/nu7042801\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGeorgiev, V.G., Weber, J., Kneschke, E.M., Denev, P.N., Bley, T., Pavlov, A.I. (2010). Antioxidant activity and phenolic content of betalain extracts from intact plants and hairy root cultures of the red beetroot Beta vulgaris cv. Detroit dark red.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003ePlant Foods Hum Nutr, 65\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(2):105-11. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s11130-010-0156-6\"\u003e10.1007\/s11130-010-0156-6\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKujala, T. S., Vienola, M. S., Klika, K. D., Loponen, J. M., \u0026amp; Pihlaja, K. (2002). Betalain and phenolic compositions of four beetroot (Beta vulgaris) cultivars.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEuropean Food Research and Technology\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e214\u003c\/em\u003e(6), 505-510. 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(2011).The gut microbiome as therapeutic target. \u003cem\u003ePharmacol Ther, 130\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(2), 202-12.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.pharmthera.2011.01.012\"\u003e10.1016\/j.pharmthera.2011.01.012\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P.D., Pssemiers, S., Van de Wiele, T., Guiot, Y., Everad, A., Rottier, O…. Delzenne, N.M. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eGut\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e58\u003c\/em\u003e(8), 1091-1103. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1136\/gut.2008.165886\"\u003e10.1136\/gut.2008.165886\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P.D., Bibiloni, R., Knauf, C., waget, A., Neyrinck, A.M., Delzenne, N.M., Burcelin, R. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eDiabetes\u003c\/em\u003e, 57, 1470-8. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.2337\/db07-1403\"\u003e10.2337\/db07-1403\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P.D., Amar, J., Iglesias, M.A., Poggi, M., Knauf, C., Bastelica, D. … Burelini, R. (2007). Metabolic endotoxemia initiates obesity and insulin resistance.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eDiabetes\u003c\/em\u003e, 56, 1761-72. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.2337\/db06-1491\"\u003e10.2337\/db06-1491\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCani, P.D., Neyrinck, A.M., Fava, F., Knauf, C., Burcelin, R.G., Tuohy, K.M. … Delzenne, N.M. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eDiabetologia\u003c\/em\u003e, 50, 2374-83. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s00125-007-0791-0\"\u003e10.1007\/s00125-007-0791-0\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDelzenne, N.M., Neyrinck, A.M., Backhed, F., Cani P.D. (2011). Targeting gut microbiota in obesity: effects of prebiotics and probiotics.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNat Rev Endocrinol, 7\u003c\/em\u003e(11), 639-46. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1038\/nrendo.2011.126\"\u003e10.1038\/nrendo.2011.126\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDelzenne, N.M., Neyrinck, A.M., Cani, P.D.(2011). Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMicrob Cell Fact, 10 Suppl 1, S10.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1475-2859-10-S1-S10\"\u003e10.1186\/1475-2859-10-S1-S10\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEid, H.M., Wright, M.L., Anil Kumar, N.V., Qawasmeh, A., Hassan, S.T.S., Mocan, A. … Haddad, P.S. (2017).Significance of Microbiota in Obesity and Metabolic Diseases and the Modulatory Potential by Medicinal Plant and Food Ingredients.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFront Pharmacol, 8\u003c\/em\u003e, 387. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3389\/fphar.2017.00387\"\u003e10.3389\/fphar.2017.00387\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFrazier TH, DiBaise JK, McClain CJ. (2011).Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJPEN J Parenter Enteral Nutr, 35(5 Suppl),\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e14S-20S. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1177\/0148607111413772\"\u003e10.1177\/0148607111413772\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eFiber for Regularity*\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eClemens, R., Kranz, S., Mobley, A.R., Nicklas, T.A., Raimondi, M.P., Rodriguez, J.C., … Warshaw, H. (2012). Filling American’s fiber intake gap: Summary of roundtable to probe realistic solutions with a focus on grain-based foods.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Nutr\u003c\/em\u003e, 142(7), 1390-1401. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/jn.112.160176\"\u003e10.3945\/jn.112.160176\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCooper, D.N., Kable, M.E., Marco, M.L., De Leon, A., Rust, B., Baker, J.E. … Keim, N.L. (2017). The Effects of Moderate Whole Grain Consumption on Fasting Glucose and Lipids, Gastrointestinal Symptoms, and Microbiota.\u003cem\u003eNutrients, 9(2). ).\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu9020173\"\u003e10.3390\/nu9020173\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMobley, A.R., Jones, J.M., Rodriguez, J., Slavin, J., \u0026amp; Zelman, K.M. (2014). Identifying practical solutions to meet American’s fiber needs: Proceedings from the Food \u0026amp; Fiber Summit.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients\u003c\/em\u003e, 8(7), 2540-51. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu6072540\"\u003e10.3390\/nu6072540\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKranz, S., Dodd, K.W., Juan, W.Y., Johnson, L.K., Jahns, L. (2017). Whole Grains Contribute Only a Small Proportion of Dietary Fiber to the U.S. Diet.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients, 9\u003c\/em\u003e(2).DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu9020153\"\u003e10.3390\/nu9020153\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSchmier, J.K., Miller, P.E., Levine, J.A., Perez, V., Maki, K.C., Rains, T.M., … Alexander, D.D. (2014). Cost savings reduced constipation rates attributed to increased dietary fiber intakes: A decision-analytic model.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBMC Public Health\u003c\/em\u003e, 14-374. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1186\/1471-2458-14-374\"\u003e10.1186\/1471-2458-14-374\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSeal, C.J., Brownlee, I.A.(2015). Whole-grain foods and chronic disease: evidence from epidemiological and intervention studies.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eProc Nutr Soc, 74\u003c\/em\u003e(3), 313-9\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S0029665115002104\"\u003e10.1017\/S0029665115002104\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e*For more data on GI regularity see the research for Be Regular\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eB-Glucan:\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e\u003c\/em\u003e\u003cem\u003e\u003cstrong\u003eSupport During Oncological treatment\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eChoromanska, A., Kulbacka, J., Rembialkowska, N., Pilat, J., Oledzki, R., Harasym, J., Saczko, J. (2015). Anticancer properties of low molecular weight oat beta-glucan – An in vitro study.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eInt J Biol Macromol, 80\u003c\/em\u003e, 23-8. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.ijbiomac.2015.05.035\"\u003e10.1016\/j.ijbiomac.2015.05.035\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVetvicka, V. (2013). Synthetic oligossacharides: clinical application in cancer therapy.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAnticancer Agents Md Chem\u003c\/em\u003e, 13(5), 720-4.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23140354\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eYoon, T.J., Koppula, S., \u0026amp; Lee, K.H. (2013). The effects of B-glucans on cancer metastasis.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAnticancer Agents Med Chem\u003c\/em\u003e, 13(5), 699-708.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23140352\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eRed beetroot: Support During Oncological treatment\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eDas, S., Fillippone, S.M., Williams, D.S., Das, A., Kukreja, R.C. (2016). Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eMol Cell Biochem, 421\u003c\/em\u003e(1-2), 89-101. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s11010-016-2789-8\"\u003e10.1007\/s11010-016-2789-8\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDas, S., Williams, D.S., Das, A., Kukreja, R.C. (2013). Beet root juice promotes apoptosis in oncogenic MDA-MB-231 cells while protecting cardiomyocytes under doxorubicin treatment.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ. Exp. Second. Sci\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e2\u003c\/em\u003e, 1–6.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.semanticscholar.org\/paper\/Beet-Root-Juice-Promotes-Apoptosis-in-Oncogenic-MD-Das-Williams\/06075020ded1ab59c1c91ab595380fa6a93d0605\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKapadia, G.J., Rao, G.S., Ramachandran, C., Iida, A., Suzuki, N., \u0026amp; Tokuda, H. (2013). Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Complement Integr Med\u003c\/em\u003e., 1. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1515\/jcim-2013-0007\"\u003e10.1515\/jcim-2013-0007\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKapadia, G.J., Azuine, M.A., Rao, G.S, Arai, T., Lida, A., \u0026amp; Tokuda, H. (2011), Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAnticancer Agents Med Chem\u003c\/em\u003e, 11(3), 280-4.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21434853\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKapadia, G. J., Azuine, M. A., Sridhar, R., Okuda, Y., Tsuruta, A., Ichiishi, E., ... \u0026amp; Tokuda, H. (2003). Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePharmacological Research\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e47\u003c\/em\u003e(2), 141-148.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/S1043-6618%2802%2900285-2\"\u003ehttps:\/\/doi.org\/10.1016\/S1043-6618(02)00285-2\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKapadia, G.J., Tokuda, H., Konoshima, T., \u0026amp; Nishino, H. (1996). Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCancer Lett\u003c\/em\u003e, 100(1-2), 211-4.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8620443\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNinfali P, Antonini E, Frati A, Scarpa ES.(2017). C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review.\u003cem\u003ePhytother Res, 31\u003c\/em\u003e(6), 871-884. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/ptr.5819\"\u003e10.1002\/ptr.5819\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNinfali, P., \u0026amp; Angelino, D. (2013). Nutritional and functional potential of Beta vulgaris cicla and rubra.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFitoterapia\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e89\u003c\/em\u003e, 188-199.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.fitote.2013.06.004\"\u003ehttps:\/\/doi.org\/10.1016\/j.fitote.2013.06.004\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNowacki, L., Vigneron, P., Rotellini, L., Cazzola, H., Merlier, F., Prost, E. … Vayssade, M.(2015). Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePhytother Res, 29\u003c\/em\u003e(12), 1964-73. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/ptr.5491\"\u003e10.1002\/ptr.5491\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZielińska-Przyjemska, M., Olejnik, A., Dobrowolska-Zachwieja, A., Łuczak, M., Baer-Dubowska, W.(2016). DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin. \u003cem\u003ePostepy Hig Med Dosw (Online),\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e70, 265-71.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27117102\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eBeetroot: Energy \u0026amp; Weight Management\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eBailey, S.J., Winyard, P., Vanhatalo, A., Blackwell, J.R., Dimenna, F.J., Wilkerson, D.P. … Jones, A.M. (1985; 2009). Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans\u003cem\u003e. J Appl Physiol, 107\u003c\/em\u003e(4), 1144-55. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1152\/japplphysiol.00722.2009\"\u003e10.1152\/japplphysiol.00722.2009\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eBeals, J.W., Binns, S.E., Davis, J.L., Giordano, G.R., Klochak, A.L., Paris, H.L. … Bell, C.(2017). Concurrent Beet Juice and Carbohydrate Ingestion: Influence on Glucose Tolerance in Obese and Nonobese Adults.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Nutr Metab, 2017\u003c\/em\u003e:6436783.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1155\/2017\/6436783\"\u003ehttps:\/\/doi.org\/10.1155\/2017\/6436783\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eClifford, T., Howatson, G., West, D.J., Stevenson, E.J. (2017). Beetroot Juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAppl Physiol Nutr Metab\u003c\/em\u003e. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1139\/apnm-2017-0238\"\u003e10.1139\/apnm-2017-0238\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eClifford, T., Constantinou, C.M., Keane, K.M., West, D.J., Howatson, G., Stevenson, E.J. (2017). The plasma bioavailability of nitrate and betanin from Beta vulgaris rubra in humans.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEur J Nutr, 56\u003c\/em\u003e(3), 1245-54. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s00394-016-1173-5\"\u003e10.1007\/s00394-016-1173-5\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eClifford T, Berntzen B, Davison GW, West DJ, Howatson G, Stevenson EJ. (2016). Effects of Beetroot Juice on Recovery of Muscle Function and Performance between Bouts of Repeated Sprint Exercise.\u003cem\u003eNutrients, 8\u003c\/em\u003e(8). DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.3390%2Fnu8080506\"\u003e10.3390\/nu8080506\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eDomínguez, R., Cuenca, E., Maté-Muñoz, J.L., García-Fernández, P., Serra-Paya, N., Estevan, M.C., Herreros, P.V., Garnacho-Castaño, M.V. (2017). Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients, 9\u003c\/em\u003e(1).DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jand.2011.12.002\"\u003e10.1016\/j.jand.2011.12.002\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMurphy, M., Eliot, K., Heuertz, R.M., Weiss, E. (2012). Whole beetroot consumption acutely improves running performance.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Acad Nutr Diet\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e, 112(4), 548-52. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jand.2011.12.002\"\u003e10.1016\/j.jand.2011.12.002\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eVanhatalo, A., Bailey, S.J., Blackwell, J.R., DiMenna, F.J., Pavey, T.G., Wilkerson, D.P. … Jones, A.M. (2010). Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAm J Physiol Regul Integr Comp Physiol\u003c\/em\u003e, 299(4), R1121-31. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1152\/ajpregu.00206.2010\"\u003e10.1152\/ajpregu.00206.2010\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZielińska-Przyjemska, M., Olejnik, A., Dobrowolska-Zachwieja, A., Grajek, W. (2009). In vitro effects of beetroot juice and chips on oxidative metabolism and apoptosis in neutrophils from obese individuals.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePhytother Res\u003c\/em\u003e,\u003cem\u003e23\u003c\/em\u003e(1), 49-55. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/ptr.2535\"\u003e10.1002\/ptr.2535\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003eIngredients\u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBeta Glucan Synbiotic: High Potency Cardiovascular and Metabolic Support\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA Proprietary blend-\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e13grams (2 tablespoons)\u003cstrong\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrebiotic and Phytonutrients-\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eOat Bran (10% Beta Glucan fiber 850mg), Organic Red Beetroot, and Inulin from Organic Chicory Root. (99.98% gluten free)\u003cstrong\u003e\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioImmersion Probiotic Master Blend\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e–\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eProbiotics\u003c\/strong\u003e-\u003cem\u003e\u003cspan\u003e \u003c\/span\u003eLactobacillus acidophilus, Lactobacillus casei rhamnosus, Lactobacillus plantarum, Streptococcus thermophilus, Bifidobacterium longum\u003c\/em\u003e;\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eSupernatant\u003c\/strong\u003e- probiotic metabolites, and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eORNs\u003c\/strong\u003e.  65 billion CFU.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNutrients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCalories                                  45\u003cbr\u003eCalories from fat                     5\u003cbr\u003eTotal fat                                  1g\u003cbr\u003eTotal carbohydrate                 8g\u003cbr\u003eDietary fiber                           2g\u003cbr\u003eSoluble fiber       less than     1g\u003cbr\u003eProtein                                   2g\u003cbr\u003eIron                                  .70mg\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eContainer:\u003c\/strong\u003e  300 grams\u003c\/p\u003e\n\u003ch6\u003eProtocol\u003c\/h6\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBETA GLUCAN SYNBIOTIC\u003c\/strong\u003e—The Beta Glucan is designed as a daily food for heart health. The powerful probiotic mix together with the beta glucans offers one of the best combinations for a healthy microbiome (GI Tract).*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eHeart health\u003c\/em\u003e: Take 2 tablespoons a day to lower cholesterol, mix with water or diluted juice. The Beta Glucan has the American Heart Association seal of approval.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eMetabolic Syndrome\u003c\/em\u003e:  Includes issues related to the heart, obesity, diabetes, congestive liver, and cancer. The American Heart Association suggests 3.5 grams of oat beta glucans (2 heaping tablespoons) a day as a measure to prevent and reverse metabolic syndrome.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eLeaky gut \u0026amp; endotoxemia\u003c\/em\u003e: The probiotic mix produces short chained fatty acids which in turn tighten the junction (where cells join other cells on the gut wall), preventing large molecules from leaking into the systemic circulation, leading to endotoxemia. Take 1 teaspoon to 1 tablespoon a day.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eProtection\u003c\/em\u003e: The probiotics mix supports detox and help protect against foodborne pathogens (clostridium, E. coli, salmonella, campylobacter, etc.), Foodborne carcinogens (heterocyclic amines from grilled red meat, nitrosamines from sausage and cured meats, etc.), mycotoxins (mold toxins), and heavy metals. Take 1 teaspoon to 1 tablespoon a day.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWeight-Loss \u0026amp; Energy\u003c\/em\u003e: Take 1-2 caps\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eWeight-Less\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e15-20 minutes before meals. Add 1 cap\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eEnergy\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e(Ultra Minerals) and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eFructo Borate\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eto boost strength and endurance.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eOur favorite\u003c\/em\u003e: Create a smoothie combining Beta Glucan with\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eBe Regular\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003efor a more powerful fiber and nutrient boost and as a meal replacement with diluted juice, berries, Fruits (bananas), flax seeds and plant-based protein powder if needed. At times, for variety, add raw cocoa,\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eNo 7 Systemic Booster\u003c\/strong\u003e, and greens.*\u003c\/p\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Beta Glucan","offer_id":43712316407852,"sku":"TF011","price":100.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Beta-Glucan-Synbiotic---Front.jpg?v=1723214880"},{"product_id":"test","title":"Staff of Life","description":"\u003cp style=\"font-weight: 400;\"\u003eSeann and I have known for many years that there is something exceptional about the \u003cem\u003eStaff of Life\u003c\/em\u003e formula. These ancient seeds have a certain energizing and empowering properties that nourish us on a fundamental level.*\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eMaybe because these seeds have been used for thousands of years in healing ceremonies that we feel so deeply nourished and in such a fundamental way. \u003cspan\u003e \u003c\/span\u003eAnd maybe because these seeds were revered spiritually because they literally supplied life sustaining nutrients.* \u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eIt goes further than that.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eThere is a basic happy elevation of feelings and emotions that these seeds give us – that is the energy that you feel when you take the blend in the morning or before your run or exercise. It is truly magical what certain foods do to our body and mind.*\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eAnd yes, as usual, you will see in the description and research tabs, and the news blog, all the amazing scientific studies, with accurate description of each seed and the research of their different health effects, nourishment stats, and nutritional profiles. You know how thorough we are with research findings.\u003c\/p\u003e\n\u003cp style=\"font-weight: 400;\"\u003eBut do keep in mind the magic and power as well, after all, life is so much more pleasing when each cell in our body is buzzing with life's energy.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eStaff of Life\u003c\/em\u003e is Organic, Vegan, Kosher, Non GMO, and Gluten Free.\u003c\/p\u003e\n\u003ch6\u003eDescription\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eDaily fiber intake is shown in research as one of the most important health requirements. However, optimum levels are rarely achieved, most Americans only consume about 15 g of fiber instead of the recommended 25 g of fiber for adult women and 38 g fiber for adult men (American Dietetic Association, 2008; Kranz et al., 2017). Eating enough fiber is important to our physical health but also our financial health. A Canadian research team discovered that eating enough dietary fiber enhances health and reduces costs for health care (Abdula et al., 2015). This conclusion aligned with the research of Schmier et al. in 2014. The position of the American Dietetic is based on epidemiologic studies showing fiber offers protection against several chronic diseases such as cardiovascular, including blood pressure, lipid levels, and inflammation (p. 1719-20; Gabrial et al., 2016; Cooper et al., 2017). Data also show a correlating relationship between dietary fiber and cancer with studies supporting the theory that dietary fibers offer protection against cancer (ADA, 2008, p. 1723).*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eStaff of Life\u003c\/em\u003e is a global blend of powerful nutrients and dietary fiber that is comprised of indigenous organic whole seeds: Amaranth, Quinoa, Buckwheat, Chia and Millet (which some think of as also a grain). The Aztec people developed amaranth; the Incas raised Quinoa, while buckwheat was native in Asia, parts of Europe and the USA. Chia is a revered seed that is native to central and southern Mexico and Guatemala. Millets are a group of indigenous small-seeded grasses, especially known in Africa and Asia but are cultivated and enjoyed all over the world.\u003c\/p\u003e\n\u003cp\u003eThese ancient seeds have been with us for thousands of years. The \u003cem\u003eStaff of Life\u003c\/em\u003e's five seeds are grown organically in the USA, and through a patented high pressure, heat-shearing process, the soluble fiber and nutrients of the five seeds are released to offer an ideal amount of plant-based protein, complex carbohydrates with low glycemic index, gentle dietary fiber, vitamins and minerals, polyphenols, and so much more. All easily digested.\u003c\/p\u003e\n\u003cp\u003eAdding a tablespoon or two of \u003cem\u003eStaff of Life\u003c\/em\u003e to your morning shakes, cereals, baked goods, and even soups, adds dietary fiber and nutrients that contribute positively to a host of health benefits such as: cardiovascular health, reduction of fatty liver (van Gijssel et al., 2016; Georgoulis et al., 2014; Grooms et al., 2013, respectively), lasting energy, weight management (de Vries et al., 2016; Albertson et al., 2016; Lambeau et al., 2017), daily regular bowel movements (American Dietetic Association, 2008; Seal \u0026amp; Brownlee, 2015), the list of benefits is long.*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuinoa (Chenopodium quinoa)\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ewas revered as sacred by the Incas, and rightly so as it is considered to be a super food. The quinoa plant was cultivated along the Andes for the last 7000 in challenging environments developing into highly nutrient seed (Vega-Gálvez et al., 2010). Uniquely balanced in all nine essential amino acids needed for tissue development in humans, it is one of the best plant sources of proteins, with protein content of 15%, dietary fiber, vitamins, minerals, vitamin e, and omega oils (Abugoch, 2009; Graf et al., 2015; Nowak et al., 2016). Quinoa is higher in calcium, phosphorus, magnesium, potassium, iron, copper, manganese, and zinc than wheat, barley, or corn. Quinoa is one of nature's most complete foods. It's glycemic load is 18. Since Quinoa is gluten free, it is a healthy dietary fiber for those who suffer celiac disease (Filho et al., 2017; Alvarez-Jubete et al., 2009). Because of its low glycemic index, quinoa and buckwheat offer an important nutritious food and dietary fiber to improve insulin resistance and offer glycemic control for type 2-diabetes (Gabrial et al., 2016). Quinoa and amaranth are also shown to have high amounts of antioxidant activity, phenolic and flavonoids power, and hence believed to offer anti-inflammatory and antioxidant potential (Nsima et al., 2008; Tang et al., 2016, 2015).*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAmaranth (Amaranthus hypochondriacus)\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ewas used by the Aztecs both for food and in their religious ceremonies. It has 12% protein and is high in lycine and methionine (amino acids), fiber (three times the fiber of wheat), iron (five times that of wheat), K, P and Ca (two times more than milk), Vitamin A and C. It is 90% digestible. Amaranth's glycemic load is 21 (Mota et al., 2016; Nascimento et al., 2014). Amaranth is shown to have high dietary fiber for daily regularity (Lamothe et al., 2015), and is an excellent fiber for celiac disease (Ballabio et al., 2011). Amaranth confers many other health benefits, including decreasing plasma cholesterol levels and stimulating the immune system (Caselato-Sousa et al., 2015; Soares et al., 2015; Czerwiński et al., 2004), and antioxidants and phenols to protect and support the liver (López et al., 2011). Amaranth is also found in research to contain phytochemical compounds as rutin, nicotiflorin, and peptides that offer antihypertensive and anticarcinogenic activities (Maldonado-Cervantes et al., 2010; Silva-Sánchez et al., 2008).*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBuckwheat ( Fagopyrum esculentum)\u003c\/strong\u003e is over 8000 years old as a human staple. The Yi people of China consume a diet high in Buckwheat. When researchers tested blood lipids of 805 Yi Chinese, they found that buckwheat intake was associated with lower total serum cholesterol, lower LDL, and high HDL (Kumar et al., 2015). Buckwheat is an excellent source of lysine, threonine, tryptophan and sulfur amino acids. Buckwheat's glycemic load is 44, with high content of flavonoid (Quettier-Deleu et al., 2001), high rutin content in the bran (Gabrial et al., 2016; Bai et al., 2015, respectively), and even higher antioxidant activity of catechins (Watanabe, 1998). The buckwheat amino acid composition is contributed to its cholesterol lowering power, antihypertension effects, and dietary fiber for regularly (Li, 2001).*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChia (Salvia hispanica L.)\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eis a magical whole seed. It's use as energy, life sustaining food dates back 5, 500 years. It is 20% protein, 25% dietary fiber, has an unusually high level of omega-3 and omega-6, vitamins, minerals and high source of antioxidants (Marchinek \u0026amp; Kreipcio, 2017; Chicco et al., 2009; Ulah et al., 2016). Aztec warriors subsisted primarily on Chia. It is called the running food: Native Americans running from the Colorado to the California coast to trade turquoise for seas shells would only bring Chia seeds for their nourishment (Sreeremya, 2017; Kreiter, 2005). Chia's glycemic load is 1. Chia is shown in research to have good protein quality, improves lipid profiles and supports the liver (da Silva et al., 2016; Jin et al., 2012; Mohd Ali et al., 2012). The ancient seed of Chia is a great source of dietary fiber, a benefit for the whole digestive system (Ullah et al., 2016).*\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMillet (Panicum Miliaceum)\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eis an ancient seed that is over 10,000 old, a major source of food for energy (Habiyaremye et al., 2016; Saleh et al., 2013). A non-acid forming food, millet is easy to digest and considered to be one of the least allergenic seeds (Gupta et al., 2014). Proso Millet (panicum Miliaceum) contains significant amounts of amino acids, especially methionine and cysteine, demonstrating a protein quality of 51% higher than wheat. Millet is also found to contain dietary fiber, B Complex, vitamins (including niacin, thiamin, folic acid and riboflavin), minerals (Ca, Fe, K, Mg, Zn, P), and a significant amount of amino acids (especially methionine and cysteine), and lecithin (Amadou \u0026amp; Gounga, 2013; Gupta et al., 2014). Millet confers many health benefits due to its high nutrients quality and phytochemical profile (Pathak, 2013), including prevention of cancer (Zhang et al., 2014; Shahidi \u0026amp; Chandrasekara, 2013; Chandrasekara \u0026amp; Shahidi, 2011), diabetes (Kam et al., 2016), liver support (Nishizawa et al., 2002), and protection against degenerative diseases (Pathak, 2013). Millet is a staple food of the Hunzas, a society renowned for robust longevity. Millet's glycemic load is 21.*\u003c\/p\u003e\n\u003cp\u003eStaff of Life can be mixed with \u003cem\u003eBeta Glucan\u003c\/em\u003e for the added benefit of oat beta glucan (99.98% gluten free) and red beet root for added dietary fiber and probiotics or taken with the \u003cem\u003eOriginal Synbiotic\u003c\/em\u003e Formula (100% gluten free) to add inulin fiber fro chicory root and our excellent probiotics for daily regularity.\u003c\/p\u003e\n\u003ch3\u003eREFERENCES\u003c\/h3\u003e\n\u003cp\u003eAbdullah, M.M., Gyles, C.L., Marinangeli, C.P., Carlberg, J.G., Jones, P.J. (2015). Dietary fibre intakes and reduction in functional constipation rates among Canadian adults: a cost-of-illness analysis. \u003cem\u003eFood Nutr Res, 59\u003c\/em\u003e, 28646.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4677277\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAbugoch James, L.E. (2009). Quinoa (Chenopodium quinoa Willd.): composition, chemistry, nutritional, and functional properties.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAdv Food Nutr Res, 58\u003c\/em\u003e, 1-31.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/S1043-4526%2809%2958001-1\"\u003e10.1016\/S1043-4526(09)58001-1\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAlbertson, A.M., Reicks, M., Joshi, N., Gugger, C.K.(2016). Whole grain consumption trends and associations with body weight measures in the United States: results from the cross sectional National Health and Nutrition Examination Survey 2001-2012.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr J. 15\u003c\/em\u003e, 8\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jada.2006.06.003\"\u003e10.1016\/j.jada.2006.06.003\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAmerican Dietetic Association (2008). 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Biochemical and immunochemical characterization of different varieties of amaranth (Amaranthus L. ssp.) as a safe ingredient for gluten-free products.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Agric Food Chem. 59\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(24):12969-74.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf2041824\"\u003e10.1021\/jf2041824\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCaselato-Sousa VM, Amaya-Farfán J.(2012). State of knowledge on amaranth grain: a comprehensive review.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Food Sci, 77\u003c\/em\u003e(4), R93-104\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1111\/j.1750-3841.2012.02645.x\"\u003e10.1111\/j.1750-3841.2012.02645.x\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChicco, A.G., D'Alessandro, M.E., Hein, G.J., Oliva, M.E., Lombardo, Y.B. (2009).Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBr J Nutr, 101\u003c\/em\u003e(1), 41-50.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S000711450899053X\"\u003e10.1017\/S000711450899053X\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCooper, D.N., Kable, M.E., Marco, M.L., De Leon, A., Rust, B., Baker, J.E. … Keim, N.L. (2017). The Effects of Moderate Whole Grain Consumption on Fasting Glucose and Lipids, Gastrointestinal Symptoms, and Microbiota.\u003cem\u003eNutrients, 9(2).\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu9020173\"\u003e10.3390\/nu9020173\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCzerwiński, J., Bartnikowska, E., Leontowicz, H., Lange, E., Leontowicz, M., Katrich, E., ... \u0026amp; Gorinstein, S. (2004). Oat (Avena sativa L.) and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eamaranth\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e(Amaranthus hypochondriacus) meals positively affect plasma lipid profile in rats fed cholesterol-containing diets.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe Journal of nutritional biochemistry\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e15\u003c\/em\u003e(10), 622-629.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jnutbio.2004.06.002\"\u003ehttps:\/\/doi.org\/10.1016\/j.jnutbio.2004.06.002\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ede Vries, J., Birkett, A., Hulshof, T., Verbeke, K., Gibes, K. (2016). Effects of Cereal, Fruit and Vegetable Fibers on Human Fecal Weight and Transit Time: A Comprehensive Review of Intervention Trials.\u003cem\u003eNutrients, 8\u003c\/em\u003e(3), 130\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu8030130\"\u003e10.3390\/nu8030130\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eFilho, A.M., Pirozi, M.R., Borges, J.T., Pinheiro Sant'Ana, H.M., Chaves, J.B., Coimbra, J.S.(2017). Quinoa: Nutritional, functional, and antinutritional aspects.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCrit Rev Food Sci Nutr. 57\u003c\/em\u003e(8), 1618-1630. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/10408398.2014.1001811\"\u003e10.1080\/10408398.2014.1001811\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGabrial, S.G., Shakib, M.R., Gabrial, G.N.(2016). Effect of Pseudocereal-Based Breakfast Meals on the First and Second Meal Glucose Tolerance in Healthy and Diabetic Subjects.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eOpen Access Maced J Med Sci, 4\u003c\/em\u003e(4), 565-573 DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3889\/oamjms.2016.115\"\u003e10.3889\/oamjms.2016.115\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGeorgoulis, M., Kontogianni, M.D., Tileli, N., Margaritie, A., Fragopoulou, E., Tiniakos, D., Zafiropoulou, R., \u0026amp; Papatheodoridis, G. (2014). The impact of cereal grain consumption on the development and severity of non-alcoholic fatty liver disease.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEur J Nutr\u003c\/em\u003e, 53(8), 1727-35. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s00394-014-0679-y\"\u003e10.1007\/s00394-014-0679-y\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGraf, B.L., Rojas-Silva, P., Rojo, L.E., Delatorre-Herrera, J., Baldeón, M.E., Raskin, I. (2015). Innovations in Health Value and Functional Food Development of Quinoa (Chenopodium quinoa Willd.).\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCompr Rev Food Sci Food\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eSaf, 14(4), 431-445.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1541-4337.12135\/abstract\"\u003eDOI:10.1111\/1541-4337.12135\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKam, J., Puranik, S., Yadav, R., Manwaring, H. R., Pierre, S., Srivastava, R. K., \u0026amp; Yadav, R. S. (2016). Dietary interventions for type 2 diabetes: how millet comes to help.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFrontiers in plant science\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e7\u003c\/em\u003e. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3389\/fpls.2016.01454\"\u003e10.3389\/fpls.2016.01454\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKranz, S., Dodd, K.W., Juan, W.Y., Johnson, L.K., Jahns, L. (2017). Whole Grains Contribute Only a Small Proportion of Dietary Fiber to the U.S. Diet.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients, 9\u003c\/em\u003e(2).DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu9020153\"\u003e10.3390\/nu9020153\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKreiter, T. (2005). SEEDS OF WELLNESS: RETURN OF A SUPERCR\/lIN.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eSaturday Evening Post\u003c\/em\u003e.\u003c\/p\u003e\n\u003cp\u003eKUMAR, R., BHAYANA, S., \u0026amp; KAPOOR, S. (2015). THE ROLE OF FUNCTIONAL FOODS FOR HEALTHY LIFE: CURRENT PERSPECTIVES.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eInt J Pharm Bio Sci\u003c\/em\u003e,\u003cem\u003e6\u003c\/em\u003e, 429-443.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.ijpbs.net\/cms\/php\/upload\/4556_pdf.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLambeau, K.V., McRorie, J.W. Jr.(2017). Fiber supplements and clinically proven health benefits: How to recognize and recommend an effective fiber therapy.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Am Assoc Nurse Pract, 29\u003c\/em\u003e(4), 216-223. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1002\/2327-6924.12447\"\u003e10.1002\/2327-6924.12447\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLamothe, L.M., Srichuwong, S., Reuhs, B.L., Hamaker, B.R. (2015). Quinoa (Chenopodium quinoa W.) and amaranth (Amaranthus caudatus L.) provide dietary fibres high in pectic substances and xyloglucans.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFood Chem\u003c\/em\u003e\u003cem\u003e, 167\u003c\/em\u003e, 490-6. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.foodchem.2014.07.022\"\u003e10.1016\/j.foodchem.2014.07.022\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLópez, V. R. L., Razzeto, G. S., Giménez, M. S., \u0026amp; Escudero, N. L. (2011). Antioxidant properties of Amaranthus hypochondriacus seeds and their effect on the liver of alcohol-treated rats.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePlant foods for human nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e66\u003c\/em\u003e(2), 157-162. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s11130-011-0218-4\"\u003e10.1007\/s11130-011-0218-4\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMohd Ali, N., Yeap, S.K., Ho, W.Y, Beh, B.K., Tan, S.W., Tan, S.G. (2012).The promising future of chia, Salvia hispanica L. \u003cem\u003eJ Biomed Biotechnol. 2012, 171956.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1155\/2012\/171956\"\u003e10.1155\/2012\/171956\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMota, C., Santos, M., Mauro, R., Samman, N., Matos, A.S., Torres, D., Castanheira, I.(2016). Protein content and amino acids profile of pseudocereals.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFood Chem193\u003c\/em\u003e, 55-61.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.foodchem.2014.11.043\"\u003e10.1016\/j.foodchem.2014.11.043\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNascimento, A.C., Mota, C., Coelho, I., Gueifão, S., Santos, M., Matos, A.S. … Castanheira I. (2014). Characterisation of nutrient profile of quinoa (Chenopodium quinoa), amaranth (Amaranthus caudatus), and purple corn (Zea mays L.) consumed in the North of Argentina: proximates, minerals and trace elements.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFood Chem, 148\u003c\/em\u003e, 420-6.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.foodchem.2013.09.155\"\u003e10.1016\/j.foodchem.2013.09.155\u003c\/a\u003e\u003c\/p\u003e\n\u003ch6\u003eResearch\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eFood Science: The Application and Use of Whole Seeds for Dietary Fiber: Quinoa, Amaranth, Buckwheat, Chia, and Millet.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eDietary Fiber for Regularity\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eAbdullah, M.M., Gyles, C.L., Marinangeli, C.P., Carlberg, J.G., Jones, P.J. (2015). Dietary fibre intakes and reduction in functional constipation rates among Canadian adults: a cost-of-illness analysis. \u003cem\u003eFood Nutr Res, 59\u003c\/em\u003e, 28646.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4677277\/\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAlbertson, A.M., Reicks, M., Joshi, N., Gugger, C.K.(2016). Whole grain consumption trends and associations with body weight measures in the United States: results from the cross sectional National Health and Nutrition Examination Survey 2001-2012.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr J. 15\u003c\/em\u003e, 8\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jada.2006.06.003\"\u003e10.1016\/j.jada.2006.06.003\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eAmerican Dietetic Association (2008). Position of the American Dietetic Association: Health implications of Dietary Fiber. Journal of the American Dietetic Association, 108(10), 1716-1731.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jada.2008.08.007\"\u003ehttps:\/\/doi.org\/10.1016\/j.jada.2008.08.007\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eClemens, R., Kranz, S., Mobley, A.R., Nicklas, T.A., Raimondi, M.P., Rodriguez, J.C., … Warshaw, H. (2012). Filling American’s fiber intake gap: Summary of roundtable to probe realistic solutions with a focus on grain-based foods.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Nutr\u003c\/em\u003e., 142(7), 1390-1401. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/jn.112.160176\"\u003e10.3945\/jn.112.160176\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eCooper, D.N., Kable, M.E., Marco, M.L., De Leon, A., Rust, B., Baker, J.E. … Keim, N.L. (2017). The Effects of Moderate Whole Grain Consumption on Fasting Glucose and Lipids, Gastrointestinal Symptoms, and Microbiota.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients, 9(2). ).\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003ca href=\"https:\/\/doi.org\/10.3390\/nu9020173\"\u003e10.3390\/nu9020173\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eEswaran S., Muir J., \u0026amp; Chey W.D. (2013). Fiber and functional gastrointestinal disorders.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAm J Gastroenterol,\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e108, 718–727. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1038\/ajg.2013.63\"\u003e10.1038\/ajg.2013.63\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ede Vries, J., Birkett, A., Hulshof, T., Verbeke, K., Gibes, K. (2016). Effects of Cereal, Fruit and Vegetable Fibers on Human Fecal Weight and Transit Time: A Comprehensive Review of Intervention Trials.\u003cem\u003eNutrients, 8\u003c\/em\u003e(3), 130\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu8030130\"\u003e10.3390\/nu8030130\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHoll, R.M. (2014). Bowel movement: the sixth vital sign.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eHolist Nurs Pract\u003c\/em\u003e, 28(3), 195-7. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1097\/HNP.0000000000000024\"\u003e10.1097\/HNP.0000000000000024\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKing, D.E., Mainous, A.G. 3\u003csup\u003erd\u003c\/sup\u003e, Lambourne, C.A. (2012). Trends in dietary fiber intake in the United States, 1999-2008.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAcad Nutr Diet\u003c\/em\u003e, 112(5), 642-8. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jand.2012.01.019\"\u003e10.1016\/j.jand.2012.01.019\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKranz, S., Dodd, K.W., Juan, W.Y., Johnson, L.K., Jahns, L. (2017). Whole Grains Contribute Only a Small Proportion of Dietary Fiber to the U.S. Diet.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutrients, 9\u003c\/em\u003e(2).DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3390\/nu9020153\"\u003e10.3390\/nu9020153\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKamar, M., Evans, C., Hugh-Jones, S. (2016). 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Do large intestinal events explain the protective effects of whole grain foods against type 2 diabetes?\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCrit Rev Food Sci Nutri\u003c\/em\u003e, 53(6), 631-40. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1080\/10408398.2010.550388\"\u003e10.1080\/10408398.2010.550388\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLi, S., Flint, A., Pai, J.K., Forman, J.P., Hu, F.B, Willett, W.C…. Rimm, E.B. (2014). Dietary ifber intake and mortality among survivors of myocardial infarction: prospective cohort study.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBMJ\u003c\/em\u003e.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003edoi:\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003ca href=\"https:\/\/doi.org\/10.1136\/bmj.g2659\"\u003e\u003cem\u003ehttps:\/\/doi.org\/10.1136\/bmj.g2659\u003c\/em\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRoss, A.B., Godin, J.P., Minehira, K., \u0026amp; Kirwan, J.P. (2013). 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DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.foodchem.2016.07.010\"\u003ehttps:\/\/doi.org\/10.1016\/j.foodchem.2016.07.010\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eChia (Salvia hispanica L.) Whole seed\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eChicco, A.G., D'Alessandro, M.E., Hein, G.J., Oliva, M.E., Lombardo, Y.B. (2009).Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBr J Nutr, 101\u003c\/em\u003e(1), 41-50.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1017\/S000711450899053X\"\u003e10.1017\/S000711450899053X\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eda Silva, B.P., Dias, D.M., de Castro Moreira, M.E., Toledo, R.C., da Matta, S.L. … Pinheiro-Sant'Ana, H.M.(2016). Chia Seed Shows Good Protein Quality, Hypoglycemic Effect and Improves the Lipid Profile and Liver and Intestinal Morphology of Wistar Rats.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePlant Foods Hum Nutr. 71\u003c\/em\u003e(3), 225-30.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s11130-016-0543-8\"\u003e10.1007\/s11130-016-0543-8\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMarchinek, K. Kreipcio, Z. (2017). Chia seeds (Salvia hispanica): health promoting properties and therapeutic applications – a review.\u003cem\u003eRocz Panstw Zaki Hig, 68\u003c\/em\u003e, (2), 123-29.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28646829\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMohd Ali, N., Yeap, S.K., Ho, W.Y, Beh, B.K., Tan, S.W., Tan, S.G. 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(2016).Nutritional and therapeutic perspectives of Chia (Salvia hispanica L.): a review.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJ Food Sci Technol, 53\u003c\/em\u003e(4), 1750-8.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s13197-015-1967-0\"\u003e10.1007\/s13197-015-1967-0\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eValdivia-López, M.Á., Tecante, A. (2015).\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003eChia\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(Salvia hispanica): A Review of Native Mexican Seed and its Nutritional and Functional Properties.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAdv Food Nutr Res, 75\u003c\/em\u003e, 53-75. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/bs.afnr.2015.06.002\"\u003e10.1016\/bs.afnr.2015.06.002\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMillet (Panicum Miliaceum) Whole Seed\/Grain\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eAmadou, I., Gounga, M. E., \u0026amp; Le, G. W. (2013). Millets: Nutritional composition, some health benefits and processing-A review.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eEmirates Journal of Food and Agriculture\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e25\u003c\/em\u003e(7), 501.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/search.proquest.com\/openview\/378a0554193bb03c39bca4a80b69c050\/1?pq-origsite=gscholar\u0026amp;cbl=237826\"\u003eProQuest\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChandrasekara, A.\u003cem\u003e,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eShahidi, F\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e(2012)\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eBioaccessibility and antioxidant potential of millet grain phenolics as affected by simulated in vitro digestion and microbial fermentation\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003cem\u003eJ Funct Foods\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e4\u003c\/em\u003e\u003cem\u003e,\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e226\u003cem\u003e–\u003c\/em\u003e37\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jff.2011.11.001\"\u003ehttps:\/\/doi.org\/10.1016\/j.jff.2011.11.001\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eChandrasekara, A., \u0026amp; Shahidi, F. 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DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1021\/jf100868b\"\u003e10.1021\/jf100868b\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGeervani, P., \u0026amp; Eggum, B. O. (1989). Nutrient composition and protein quality of minor millets.\u003cem\u003ePlant Foods for Human Nutrition (Formerly Qualitas Plantarum)\u003c\/em\u003e,\u003cem\u003e39\u003c\/em\u003e(2), 201-208.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2548175\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eGupta, S., Shrivastava, S. K., \u0026amp; Shrivastava, M. (2014). Proximate composition of seeds of hybrid varieties of minor millets.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eInt. J. Res. Eng. Technol\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e3\u003c\/em\u003e, 687-693.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/esatjournals.net\/ijret\/2014v03\/i02\/IJRET20140302122.pdf\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eHabiyaremye, C., Matanguihan, J. B., Guedes, J. D. A., Ganjyal, G. M., Whiteman, M. R., Kidwell, K. K., \u0026amp; Murphy, K. M. (2016). Proso Millet (Panicum miliaceum L.) and Its Potential for Cultivation in the Pacific Northwest, US: A Review.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFrontiers in plant science\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e7\u003c\/em\u003e. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.3389%2Ffpls.2016.01961\"\u003e10.3389\/fpls.2016.01961\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKalinova, J., \u0026amp; Moudry, J. (2006). Content and quality of protein in proso millet (Panicum miliaceum L.) varieties.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePlant Foods for Human Nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e61\u003c\/em\u003e(1), 43. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1007\/s11130-006-0013-9\"\u003e10.1007\/s11130-006-0013-9\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKam, J., Puranik, S., Yadav, R., Manwaring, H. R., Pierre, S., Srivastava, R. K., \u0026amp; Yadav, R. S. (2016). Dietary interventions for type 2 diabetes: how millet comes to help.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eFrontiers in plant science\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e7\u003c\/em\u003e. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3389\/fpls.2016.01454\"\u003e10.3389\/fpls.2016.01454\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eLu, H., Zhang, J., Liu, K. B., Wu, N., Li, Y., Zhou, K., ... \u0026amp; Shen, L. (2009). Earliest domestication of common millet (Panicum miliaceum) in East Asia extended to 10,000 years ago.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eProceedings of the National Academy of Sciences\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e106\u003c\/em\u003e(18), 7367-7372.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/www.pnas.org\/content\/106\/18\/7367.abstract\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eNishizawa, N., Sato, D., Ito, Y., Nagasawa, T., Hatakeyama, Y., Choi, M. R., ... \u0026amp; Wei, Y. M. (2002). Effects of dietary protein of proso millet on liver injury induced by D-galactosamine in rats.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBioscience, biotechnology, and biochemistry\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e66\u003c\/em\u003e(1), 92-96.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/dx.doi.org\/10.1271\/bbb.66.92\"\u003ehttp:\/\/dx.doi.org\/10.1271\/bbb.66.92\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePark, K. O., Ito, Y., Nagasawa, T., Choi, M. R., \u0026amp; Nishizawa, N. (2008). Effects of dietary Korean proso-millet protein on plasma adiponectin, HDL cholesterol, insulin levels, and gene expression in obese type 2 diabetic mice.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBioscience, biotechnology, and biochemistry\u003c\/em\u003e,\u003cem\u003e72\u003c\/em\u003e(11), 2918-2925.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18997420\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003ePathak H. C. (2013).\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eRole of Millets in Nutritional Security of India.\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eNew Delhi: National Academy of Agricultural Sciences, 1–16.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.google.com\/url?sa=t\u0026amp;rct=j\u0026amp;q=\u0026amp;esrc=s\u0026amp;source=web\u0026amp;cd=1\u0026amp;ved=0ahUKEwja44L57tzVAhVPyGMKHdcjCIAQFggmMAA\u0026amp;url=http%3A%2F%2Fmillets.res.in%2Fbooks%2FPolicy66.pdf\u0026amp;usg=AFQjCNGoQU5ezUDxS0zjiptDCYpDAVPsiQ\"\u003ePolicy Paper 66 : Role of millets in Nutritional Security of India NAAS\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSreeremya, S. (2017). Nutritional Aspects of Chiya Seeds. International journal of advance research and development, 2(2).\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ijarnd.com\/manuscripts\/v2i1\/V2I1-1146.pdf\"\u003eNutritional Aspects of Chiya Seeds\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eShahidi, F., \u0026amp; Chandrasekara, A. (2013). Millet grain phenolics and their role in disease risk reduction and health promotion: A review.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eJournal of Functional Foods\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e5\u003c\/em\u003e(2), 570-581.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.jff.2013.02.004\"\u003ehttps:\/\/doi.org\/10.1016\/j.jff.2013.02.004\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSaleh, A. S., Zhang, Q., Chen, J., \u0026amp; Shen, Q. (2013). Millet grains: nutritional quality, processing, and potential health benefits.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eComprehensive Reviews in Food Science and Food Safety\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e12\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(3), 281-295.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1541-4337.12012\/full\"\u003eArticle\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eZhang, L., Liu, R., \u0026amp; Niu, W. (2014). Phytochemical and antiproliferative activity of proso millet.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ePloS one\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e9\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(8), e104058.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1371\/journal.pone.0104058\"\u003ehttps:\/\/doi.org\/10.1371\/journal.pone.0104058\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eDietary Fiber: Energy and Weight Loss Support\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eGiacco, R., Della Pepa, G., Luongo, D., \u0026amp; Riccardi G. (2011). Whole grain intake in relation to body weight: from epidemiological evidence to clinical trails.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eNutr Metab Cardiovasc Dis\u003c\/em\u003e, 21(12), 901-8. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.numecd.2011.07.003\"\u003e10.1016\/j.numecd.2011.07.003\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKarl, J.P., Meydani, M., Barnett, J.B., Vanegas, S.M., Goldin, B., Kane, A. … Roberts, S.B. (2017). Substituting whole grains for refined grains in a 6-wk randomized trial favorably affects energy-balance metrics in healthy men and postmenopausal women.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAm J Clin Nutr\u003c\/em\u003e,\u003cem\u003e\u003cspan\u003e \u003c\/span\u003e105\u003c\/em\u003e(3), 589-599\u003cem\u003e.\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eDOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/ajcn.116.139683\"\u003e10.3945\/ajcn.116.139683\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eKarl, J.P., Saltzman E. (2012). The role of whole grains in body weight regulation.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eAdv Nutr\u003c\/em\u003e, 3(5), 697-707. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/an.112.002782\"\u003e10.3945\/an.112.002782\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eMa, X., Tang, W.G., Yang, Y., Zhang, Q.L., Zheng, J.L., Xiang, Y.B. (2016). Association between whole grain intake and all-cause mortality: a meta-analysis of cohort studies.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eOncotarget\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e7\u003c\/em\u003e(38), 61996-62005.DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.18632\/oncotarget.11491\"\u003e10.18632\/oncotarget.11491\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eDietary Fiber and the Microbiome\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eMartinez, I., Lattimer, J.M., Hubach, K.L., Case, J.A., Yang, J., Weber, C.G….Walter, J. (2013). Gut microbiome composition is linked to whole grain-induced immunological improvements.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eISME J\u003c\/em\u003e. 7(2), 269-80. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1038\/ismej.2012.104\"\u003e10.1038\/ismej.2012.104\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSonnenburg, E.D., Sonnenburg, J.L. (2014). Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eCell Metab\u003c\/em\u003e, 20(5), 779-86. doi: 10.1016\/j.cmet.2014.07.003. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1016\/j.cmet.2014.07.003\"\u003e10.1016\/j.cmet.2014.07.003\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eSpeliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., ... \u0026amp; Randall, J. C. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.\u003cem\u003eNat Genet\u003c\/em\u003e, 42(11), 937-48. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1038\/ng.686\"\u003e10.1038\/ng.686\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eWalter, J., Martinez, I, Rose, D.J. (2013). Holobiont nutrition: considering the role of the gastrointestinal microbiota in the health benefits of whole grains.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eGut Microbes\u003c\/em\u003e, 4(4), 340-6. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.4161\/gmic.24707\"\u003e10.4161\/gmic.24707\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eDietary Fiber, Prebiotic and Cancer Support\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eO'Keefe, S. J., Ou, J., Aufreiter, S., O'Connor, D., Sharma, S., Sepulveda, J., ... \u0026amp; Mawhinney, T. (2009). Products of the colonic microbiota mediate the effects of diet on colon cancer risk.\u003cem\u003eThe Journal of nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e139\u003c\/em\u003e(11), 2044-2048. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.3945\/jn.109.104380\"\u003e10.3945\/jn.109.104380\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eO'keefe, S. J., Chung, D., Mahmoud, N., Sepulveda, A. R., Manafe, M., Arch, J., ... \u0026amp; van der Merwe, T. (2007). Why do African Americans get more colon cancer than Native Africans?.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eThe Journal of nutrition\u003c\/em\u003e,\u003cem\u003e137\u003c\/em\u003e(1), 175S-182S.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17182822\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eRoberfroid, M., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R., Rowland, I., ... \u0026amp; Guarner, F. (2010). Prebiotic effects: metabolic and health benefits.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBritish Journal of Nutrition\u003c\/em\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e104\u003c\/em\u003e(S2), S1-S63.\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20224145\"\u003eAbstract\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eDietary Fiber and Diverticulosis Support\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003eCrowe, F.L., Appleby, P.N., Allen, N.E., \u0026amp; Key T.J. (2011). Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eBMJ, 343\u003c\/em\u003e:d4131. doi:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/dx.doi.org\/10.1136%2Fbmj.d4131\"\u003e10.1136\/bmj.d4131\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003eStrate, L.L., Keeley, B.R., Cao, Y., Wu, K., Giovannucci, E.L., \u0026amp; Chan, A.T. (2017). Western Dietary Pattern Increases, and Prudent Dietary Pattern Decreases, Risk of Incident Diverticulitis in a Prospective Cohort Study.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eGastroenterology, 152\u003c\/em\u003e(5), 1023-30. DOI:\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/doi.org\/10.1053\/j.gastro.2016.12.038\"\u003e10.1053\/j.gastro.2016.12.038\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e† Dietary Fibers are found in whole seeds such as Quinoa, Amaranth, Buckwheat, Chia, and Millet (which some consider as whole grain). Dietary fiber are also found in whole grains such as Oats in the Beta Glucan Synbiotic, as well as in vegetables and roots, such as Inulin from Chicory Root (Original Synbiotic, Beta Glucan Synbiotic, and No 7 Systemic Booster), and red beetroot, (see Beta Glucan Synbiotic).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch6\u003e\u003cspan\u003eIngredients\u003c\/span\u003e\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cspan\u003eOne 30 Scoop Contains: \u003cbr\u003eCalories 107g\u003cbr\u003eWater 2.4g \u003cbr\u003eProtein 4.59g \u003cbr\u003eCarbohydrates 21.1g \u003cbr\u003eFat (Total) 1.52g\u003cbr\u003eAsh 0.43g\u003cbr\u003eSugars 0.31g\u003cbr\u003eOther Carbohydrates 13.1g \u003cbr\u003eDietary Fiber 7.66g\u003cbr\u003eSaturated Fat 0.14g \u003cbr\u003eMonounsaturated Fat 0.11g \u003cbr\u003ePolyunsaturated Fat 0.34g \u003cbr\u003eThiamin B1 0.05mg \u003cbr\u003eRiboflavin B2 0.05mg \u003cbr\u003eNiacin B3 0.61mg \u003cbr\u003eNiacin Equiv. 1.02mg \u003cbr\u003eVitamin B6 0.02mg \u003cbr\u003eFolate 4.16mg \u003cbr\u003ePantothenic Acid 0.08mg \u003cbr\u003eVitamin C 0.39mg \u003cbr\u003eVitamin E Alpha 0.07mg \u003cbr\u003eCalcium 20.8mg \u003cbr\u003eCopper 0.057mg \u003cbr\u003eIron 1.69mg \u003cbr\u003eMagnesium 19.43mg \u003cbr\u003eManganese 0.17mg \u003cbr\u003ePhosphorus 94.72mg \u003cbr\u003ePotassium 80.15mg \u003cbr\u003eSodium 4.14mg \u003cbr\u003eZinc 0.25mg \u003cbr\u003eAmino Acids 4,419 mg (per 36g) \u003cbr\u003e  Aspartic Acid 315mg \u003cbr\u003e  Threonine 139mg \u003cbr\u003e  Serine 211mg \u003cbr\u003e  Glutamic Acid 744mg \u003cbr\u003e  Proline 173mg \u003cbr\u003e  Glycine 200mg \u003cbr\u003e  Alanine 219mg \u003cbr\u003e  Valine 152mg \u003cbr\u003e  Isoleucine 140mg \u003cbr\u003e  Leucine 288mg \u003cbr\u003e  Tyrosine 135mg \u003cbr\u003e  Phenylalanine 173mg \u003cbr\u003e  Lysine 164mg \u003cbr\u003e  Histidine 86mg \u003cbr\u003e  Arginine 321mg \u003cbr\u003e  Cystine 77mg \u003cbr\u003e  Methionine 54mg \u003cbr\u003e  Tryptophan 53mg\u003c\/span\u003e\u003c\/p\u003e\n\u003ch6\u003e\u003cspan mce-data-marked=\"1\"\u003eProtocols\u003c\/span\u003e\u003c\/h6\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cb\u003eStaff of Life\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003e— Staff of Life is a nutritional powerhouse of organic indigenous seeds designed to nourish your body deeply, encourage a daily bowel movement, increase energy and endurance during exercise, and in research shows a host of health benefits.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eDaily regularity\u003c\/i\u003e:  Take 1-2 tablespoons, mix in diluted juice.  Add to cereals, or other baked goods. For a chronic state of constipation, add the\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eBeta Glucan\u003c\/b\u003e, flax seeds, berries, and greens. Take 1 teaspoon of the\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eNo 7\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003ein the evenings.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eVegans\u003c\/i\u003e: As a meal replacement, Staff of Life offers a deep nutritional value. Excellent as a drink to increase vitality.\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eSports\u003c\/i\u003e: mix in water or diluted juice twenty minutes before exercise for more energy and endurance.*\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eOur favorite\u003c\/i\u003e: Our morning smoothie with Staff of Life and Beta Glucan, along with berries, fruits, and greens, flax seeds and diluted juice is meant to bring in more fiber, probiotics, and nutrients to the whole microbiome system.*\u003c\/p\u003e\n\u003ch6\u003e\u003c\/h6\u003e\n\u003cdiv class=\"boxed\"\u003e\n\u003cdiv id=\"lipsum\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"BioImmersion Inc.","offers":[{"title":"Default Title","offer_id":43712316473388,"sku":"TF023","price":94.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Staff-Of-Life---Front.jpg?v=1723214891"},{"product_id":"option-set-696916-select-2","title":"Add Ons","description":null,"brand":"Scoutside Sandbox","offers":[{"title":"Add on 2","offer_id":43713205338156,"sku":"","price":10.0,"currency_code":"USD","in_stock":true},{"title":"Add on 3","offer_id":43713205370924,"sku":"","price":20.0,"currency_code":"USD","in_stock":true}]},{"product_id":"group-test","title":"CL Test Group","description":null,"brand":"Scoutside Sandbox","offers":[{"title":"7 Keto \/ Green","offer_id":44051449184300,"sku":"TF028","price":49.98,"currency_code":"USD","in_stock":true},{"title":"7 Keto \/ Tan","offer_id":44051449217068,"sku":"TF029","price":49.98,"currency_code":"USD","in_stock":true},{"title":"Beta Glucan","offer_id":43712316407852,"sku":"TF011","price":100.98,"currency_code":"USD","in_stock":true},{"title":"Blueberry","offer_id":43712316112940,"sku":"TF008","price":141.98,"currency_code":"USD","in_stock":true},{"title":"Chlorium","offer_id":43712315883564,"sku":"TF012","price":37.98,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/7-KETO-DHEA---Front.jpg?v=1723214710"},{"product_id":"4kit-gluten-free","title":"4Kit - Gluten Free","description":null,"brand":"Scoutside Sandbox","offers":[{"title":"4 \/ 4","offer_id":43853532332076,"sku":null,"price":12.0,"currency_code":"USD","in_stock":false}]},{"product_id":"riviera-shelf","title":"Riviera Shelf","description":"","brand":"Scoutside Sandbox","offers":[{"title":"Default Title","offer_id":43897651724332,"sku":"150","price":567.86,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0576\/4779\/2172\/files\/Black-Riviera-_Glass-_Half-2_hqfzdc.jpg?v=1730750244"},{"product_id":"monty-shelving-unit","title":"Monty Shelving Unit","description":"","brand":"Scoutside Sandbox","offers":[{"title":"Default Title","offer_id":43897670500396,"sku":"","price":0.0,"currency_code":"USD","in_stock":true}]}],"url":"https:\/\/stratia-sandbox.myshopify.com\/collections\/do-not-delete-all-products-generated-by-extend-commerce.oembed?page=6","provider":"Scoutside Sandbox","version":"1.0","type":"link"}