7-Keto DHEA

7-Keto DHEA, or 7-Keto DHEA is named after the compound 3-acetyl-7-Keto dehydroepiandrosterone, a substance found naturally in the body that is metabolized from the hormone DHEA (Marwah et al., 2002). Studies have indicated that 7-Keto is stable (does not convert to testosterone or estrogens), safe and effective as part of a weight loss program (Lardy et al., 1995, Davidson et al., 2000; Humanetics Corps, 2005, respectively). In fact, 7-Keto has shown in studies to activate 3 thermogenic enzymes, known to help the body convert stored fat to energy (Zenk et al., 2007, 2004). But since levels of DHEA and 7-Keto decline in our body with age, supplementation with 7-Keto helps maintain healthy levels for weight management (Lardy et al., 1998; 1995).*

7-Keto DHEA turns on fat burning mechanism and supports sustained energy. Take 1-2 capsules a half hour before meals.*

7-Keto DHEA has no fillers, binders, or other additives, it is purely 7-Keto. 

Description

In the pre-clinical development (see Bobyleva et al., 1993), 7-Keto was found to behave similarly to the thyroid hormone which also activates the thermogenic enzymes in our body. 7-Keto DHEA showed similar ability to restore mitochondrial function (Bobyleva et al., 1997) and support weight loss by enhancing thermogenic enzyme activity.*

Clinical trials have been ongoing since 1999, in specific, two randomized, double-blinded, placebo-controlled (“RDBPC”) in 1999 and 2000 have shown that 7-keto significantly increased weight loss over a period of eight weeks compared to the placebo group (Zenk et al., 2002; see also Kaiman et al., 2000; Bobyleva et al., 1997).*

Thermogenesis is the creation of heat in the body; a form of energy that is produced when we eat and metabolize food. Kaiman et al. (2000; see also Zenk et al., 2002) conducted a RDBPC study of 30 healthy overweight adults for 8 weeks. The group taking the supplement of 7-Keto showed a significantly reduced body weight. The study included exercise (three times a week) and a reduced caloric diet for both placebo and 7-Keto groups. Zenk et al. (2004; 2007) similarly found that 7-Keto increased metabolism, which is shown in research to promote weight lose and support the management of weight overall. By up-regulating the activity of fat burning enzymes (the thermogenic effect), energy expenditure is increased, enhancing the process of weight loss (Gomez et al., 2002).*

Moreover, 7-Keto DHEA is also shown in research to enhance memory in young and old rats (Shi et al., 2000), immune modulation in older men (Hampl et al., 2000), and significantly enhance depressive symptoms and hypo-immunity of mice when induced by chronic mild stress (Liu et al., 2003).*

BioImmersion's 7-Keto is encapsulated without any other additives (binders, fillers of any kind). It is in its pure form, active, powerful, and at the same time, gentle. 

research 

Bobyleva, V., Bellei, M., Kneer, N., & Lardy, H. (1997). The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. Archives of biochemistry and biophysics, 341(1), 122-128. Abstract

Davidson, M., Marwah, A., Sawchuk, R. J., & Maki, K. (2000). Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clinical and investigative medicine, 23(5), 300. Abstract [French]

Hampl, R., Lapcik, O., Hill, M., Klak, J., Kasal, A., Novacek, A., ... & Starka, L. (2000). 7-Hydroxydehydroepiandrosterone-a natural antiglucocorticoid and a candidate for steroid replacement therapy? Physiological Research, 49, S107-S112. Article

Humanetics Corporation (2005). 7 Keto Innovative Weight Loss. Retrieved from www.humaneticscorp.com.

Kaiman, D. S., Colker, C. M., Swain, M. A., Torina, G. C., & Shi, Q. (2000). A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Current therapeutic research, 61(7), 435-442. Abstract

Lardy, H., Kneer, N., Wei, Y., Partridge, B., & Marwah, P. (1998). Ergosteroids II: biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. Steroids, 63(3), 158-165. Article

Lardy, H., Partridge, B., Kneer, N., & Wei, Y. (1995). Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. Proceedings of the National Academy of Sciences, 92(14), 6617-6619. Abstract

Lamont, B. J., Waters, M. F., & Andrikopoulos, S. (2016). A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice. Nutrition & diabetes, 6(2), e194. DOI: Article

Liu, Y. Y., Yang, N., Kong, L. N., & Zuo, P. P. (2003). Effects of 7-oxo-DHEA treatment on the immunoreactivity of BALB/c mice subjected to chronic mild stress. Yao xue xue bao= Acta pharmaceutica Sinica,38(12), 881-884. Abstract

Shi, J., Schulze, S., & Lardy, H. A. (2000). The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice. Steroids, 65(3), 124-129. Article

Šulcová, J., Hill, M., Mašek, Z., Češka, R., Nováček, A., Hampl, R., & Starka, L. (2001). Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men. Physiol Res, 50, 9-18. Article

Zenk, J. L., Helmer, T. R., Kassen, L. J., & Kuskowski, M. A. (2002). The effect of 7-Keto Naturalean™ on weight loss: A randomized, double-blind, placebo-controlled trial. Current therapeutic research, 63(4), 263-272. Abstract

Zenk, J. L., Helmer, T. R., & Kuskowski, M. A. (2004, March). The use of 3-acetyl-7-oxo-dehydroepiandrosterone for augmenting immune response in the elderly. In FASEB JOURNAL (Vol. 18, No. 5, pp. A794-A794). 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA: FEDERATION AMER SOC EXP BIOL.

Zenk, J. L., Frestedt, J. L., & Kuskowski, M. A. (2007). HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. The Journal of nutritional biochemistry , 18(9), 629-634. Article

Ingredients 

One Capsule Contains:
7-Keto DHEA 25mg

protocol

For weight Loss Support: Start with 1-2 capsules three times a day, preferably, 10-20 minutes before the meal. 7-Keto is known to activate fat burning mechanism in the body.

Add Weight Less to lower glycemic levels of meals, 1-2 capsules, preferably 10-20 minutes before the meal or snack. 

For Energy and Exercise: Take 1 capsule of 7-Keto and 1 capsule of Energy.